Browsing by Author "Uz E."

Now showing 1 - 2 of 2
  • No Thumbnail Available
    Item
    The relationship between serum trace element changes and visual function in heavy smokers
    (2003) Uz E.; Sahin S.; Hepsen I.F.; Var A.; Sogut S.; Akyol Ö.
    Purpose: The aim of this prospective study was to evaluate serum manganese (Mn), zinc (Zn) and copper (Cu) levels and visual functions including visual acuity, colour vision, pattern visual evoked potentials (PVEPs), and contrast sensitivity in heavy smokers and to compare these with the equivalent levels and functions in non-smokers. Methods: Data were recorded in 24 healthy, chronic and heavy cigarette smokers and 16 healthy, non-smoking control subjects. Serum Zn, Cu and Mn concentrations in all subjects were measured by atomic absorption spectrophotometry. Results: Both study and control subjects had normal visual acuity and colour vision. Pattern visual evoked potentials were normal in all study and control subjects. Contrast sensitivity was significantly reduced in heavy smokers compared to non-smokers (p < 0.023), despite the fact that central vision and PVEP responses were not affected. Mean serum Mn and Zn levels were significantly lower in smokers than in non-smokers (p < 0.0001 and p < 0.005, respectively). Conclusions: Reduced contrast sensitivity values associated with low levels of serum Mn and Zn, which function as cofactors of superoxide dismutase in erythrocyte and other nucleated cells, suggest a possible role of trace elements in smoking-induced early retinal toxicity.
  • No Thumbnail Available
    Item
    Evaluation of heterozygous deletion of TP53 gene in pleural fluid samples: A case series of 11 patients; [Plevral Sıvı Örneklerinde TP53 Geni Heterozigot Delesyonunun Değerlendirilmesi: 11 Hastalık Bir Seri]
    (Derman Medical Publishing, 2016) Dirican N.; Bagci Ö.; Uz E.; Öztürk Ö.; Bircan H.; Dirican A.
    We described heterozygous deletion of tumor protein 53 (TP53) gene in 11 patients including 2 patients with non-malignant diseases (pneumonia) and 9 patients with malignant diseases [including small cell lung cancer (n = 3), non-small cell lung carcinoma (n = 4), non-Hodgkin’s lymphoma (n=1), and gastric carcinoma (n=1)]. Chromosomal aberrant status was analyzed by fluorescence in situ hybridization with centromere specific and 17p13.1 locus specific probes. In 3 of 9 cancer patients we did not find malignant pleural effusion with histological examination and/or closed pleural biopsy. Heterozygous deletion of TP53 gene was found to be significantly higher in patients with malignant disease when compared to the patients with benign pleural fluid. As a result, we suggest that heterozygous deletion of TP53 may have indicator value for malignancy; however further studies are warranted to confirm this suggestion in large patient cohorts. © 2016, Journal of Clinical and Analytical Medicine. All Rights Reserved.