Browsing by Author "Uz U."
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Item Herpes zoster oticus associated with varicella zoster virus encephalitis(2009) Eskiizmir G.; Uz U.; Taşkiran E.; Ürdü H.Ramsay-Hunt syndrome, herpes zoster oticus (HZ0), derived its name from James Ramsay Hunt, who first described it in 1907. It is classically characterized by acute peripheral facial paralysis, herpetic eruptions on the auricle, and vestibulocochlear dysfunction due to the reactivation of varicella zoster virus (VZV). In this Case Report, the authors describe an HZO patient with simultaneous VZV encephalitis. To date, only eight cases of HZO associated with VZV encephalitis have been reported in the English literature. Therefore, the authors discuss all the aspects of this rare entity, including clinical examination, radiological evaluation, laboratory evaluation, and treatment options. © 2009 The American Laryngological, Rhinological and Otological Society, Inc.Item Impact of nasal polyposis on erectile dysfunction(2011) Gunhan K.; Zeren F.; Uz U.; Gumus B.; Unlu H.Background: Our male patients with chronic rhinosinusitis with nasal polyposis (NP) declare a better sexual function after functional endoscopic sinus surgery (FESS) with polypectomy. This study was planned to conduct the first prospective, controlled trial evaluating the possible relation between erectile dysfunction (ED) and NP by subjective and objective parameters. Methods: Thirty-three male patients with NP and thirty randomly selected male control subjects were evaluated. All subjects underwent assessments of nasal endoscopy, rhinomanometry, body mass index (BMI), Epworth Sleepiness Scale, full in-laboratory polysomnograpy and serum levels of glucose, thyroid hormones, lipid profile, and testosterone. ED was evaluated by the erectile function domain of the International Index of Erectile Function (IIEF-EF) subjectively and nocturnal penile tumescence (NPT) objectively. The NP group was reassessed 6 months after FESS. Results: The mean age, BMI, and laboratory tests of the patients and the control subjects had no significant difference. The well-recognized risk factors for ED were eliminated. Preoperative evaluation of the patients revealed that ED was present in 34 and 24% of the patients by IIEF-EF and NPT, respectively, which was significantly higher than the control group (p = 0.009 and p = 0.018, respectively). There was a significant improvement of ED in the assessment of IIEF-EF and NPT postoperatively (p = 0.014 and p = 0.037, respectively). Conclusion: ED was determined in a high percentage of patients with NP and significantly ameliorated after FESS. NP might present a risk factor in the development of ED. Copyright © 2011, OceanSide Publications, Inc.Item Microscopic transnasal approach: A new technique for the reconstruction of frontoethmoidal meningoencephalocele(Lippincott Williams and Wilkins, 2016) Celik O.; Eskiizmir G.; Duran A.V.; Yeniel T.; Uz U.Frontoethmoidal meningoencephalocele is a rare congenital malformation, which occurs due to a deficiency in neural tube closure. It may present as an external mass over the nose, nasal obstruction, rhinorrhea and attacks of central nervous system infections. Herein, the authors present a 3-month-old infant with naso-ethmoidal form of frontoethmoidal meningoencephalocele, who was operated on using a newly described approach that was performed under microscope. Copyright © 2016 Mutaz B. Habal, MD.Item A comparison of thresholds of auditory steady-state response and auditory brainstem response in healthy term babies(AVES İbrahim KARA, 2016) Çelik O.; Eskiizmir G.; Uz U.OBJECTIVE: The goal of this study was to assess the effectiveness of auditory steady-state response (ASSR), determine the cut-off values for each frequency, and detect the best correlated frequencies when compared with the auditory brainstem response (ABR) thresholds in term babies under the age of 12 months. MATERIALS and METHODS: In total, 88 term babies with a mean age of 2.98 (1–11) months (174 ears) underwent ASSR and ABR tests. The ASSR thresholds for the frequencies of 500, 1000, 2000, and 4000 Hz were compared with the hearing level of the ABR thresholds. In the ABR test, a cutoff value of 30 dB nHL was selected for normal hearing. In addition, the best correlation between the ABR and ASSR thresholds and the estimated cut-off thresholds of ASSR for each of the abovementioned frequencies were obtained. RESULTS: In total, 135 ears had values indicating normal hearing ability and 39 ears had hearing loss according to the ABR thresholds. Although statistically significant correlations were found between the ABR and ASSR thresholds at all frequencies in all groups, these correlations were not strong. On the other hand, a strong correlation was found between the responses of the ABR and ASSR thresholds at 4000 Hz in the hearing-impaired subjects. CONCLUSION: Our findings suggest that ASSR may not be beneficial or reliable as a screening test. Thus, it is likely to be considered as a complementary test rather than an alternative to the ABR test. © 2016 by The European Academy of Otology and Neurotology and The Politzer Society.Item The evaluation of pattern and quality of sleep in patients with chronic rhinosinusitis with nasal polyps(Elsevier Ireland Ltd, 2017) Uz U.; Günhan K.; Yılmaz H.; Ünlü H.Objective The goal of this study is to evaluate the impact of chronic rhinosinusitis with nasal polyps (CRSwNP) on sleep pattern and sleep quality before and after functional endoscopic sinus surgery using subjective and objective parameters. Methods Twenty-two patients with CRSwNP were evaluated. All subjects underwent assessment by nasal endoscopy, rhinomanometry and computed tomography. Sleep pattern and sleep quality were evaluated by Pittsburgh sleep quality index (PSQI) and polysomnography (PSG). All patients were reassessed 6 months after surgery. Results Nasal resistance decreased after the surgery (p < 0.001). Postoperative PSQI scores were significantly lower than preoperative scores (p < 0.001). The preoperative mean values of total apnea index and apnea-hypopnea index were 25.4 and 13.3, respectively. After surgery, the total apnea and apnea-hypopnea index had decreased significantly to 7.8 and 11.2, respectively (p = 0.009 and 0.019, respectively). Conclusion In patients with CRSwNP, functional endoscopic sinus surgery significantly ameliorates sleep pattern and sleep quality. CRSwNP may be a predisposing factor for sleep related respiratory disorders. © 2017 Elsevier B.V.Item Pleomorphic adenoma of the posterior surface of the soft palate causing sleep disturbance: A case report(International Scientific Information, Inc., 2017) Uz U.; Celik O.Objective: Rare disease Background: Pleomorphic adenoma is the most common benign tumor arising in the salivary gland. The signs and symptoms of pleomorphic adenoma of the minor salivary glands vary, depending on the anatomical site involved. A rare case of pleomorphic adenoma of the posterior surface of the soft palate is reported that caused sleep disturbance, which was resolved with endoscopic surgical treatment. Case Report: A 32-year-old woman experienced snoring and mouth-breathing during sleep. Flexible fiberoptic nasopharyngoscopy imaging of the oropharyngeal passage showed obstruction by a tumor the soft palate, which obstructed the oropharyngeal passage. The tumor was excised using endoscopic-assisted transoral surgery and measure 3×2 cm in diameter. Histopathology showed a benign pleomorphic adenoma of the minor salivary gland. Following surgical excision of the tumor, the patient’s sleep improved. Conclusions: To our knowledge, this is the first case of a pleomorphic adenoma of the posterior surface of the soft palate, causing sleep disturbance, removed by endoscopic-assisted transoral surgery following pre-operative flexible fiberoptic nasopharyngoscopy imaging of the oropharyngeal passage. © Am J Case Rep, 2017.Item 13-93B3 Bioactive Glass: A New Scaffold for Transplantation of Stem Cell-Derived Chondrocytes(Lippincott Williams and Wilkins, 2018) Gunhan K.; Bariskan S.; Uz U.; Vatansever S.; Kivanc M.Research using animal models gives human trials hope for recovery in many fields of regenerative medicine, although they are sometimes poor predictors for human experiences. Our goal was to investigate whether rat chondrocytes, differentiated from adipose-derived stem cells, could be transplanted using a new, easily shaped, bioactive glass scaffold, and to show the immunohistochemical results. Intraperitoneal and retroperitoneal adipose tissue was extracted from 6 male Wistar albino type rats. The fatty tissue samples were fragmented and incubated. Chondrogenic differentiation was carried out and collagen type II, bFGF, and Sox-9 immunohistochemical characterization analysis was performed. Differentiated chondrocytes were implanted on 13-93B3 bioactive glass scaffolds and transplanted into the right ears of the rats. As control, only the biomaterial was transplanted into the left ears of the rats. After 1 month, the rats were sacrificed and transplantation areas were examined immunohistochemically. Histological examination of control samples from the left ears revealed that the biomaterial was covered with connective tissue, its general structure was preserved, and resorption of the scaffold had started. In specimens from the right ears, the biomaterial was covered with connective tissue, its structure was preserved, cartilage cells were present around the biomaterial, and the presence of cartilage tissue was demonstrated immunohistochemically. In conclusion, 13-93B3 bioactive glass scaffold contributed to the formation of new collagen and the survival of chondrocytes, and is a promising new biomaterial that will prove very useful in regenerative medicine. © Copyright 2017 by Mutaz B. Habal, MD.Item Grafting in Nasal Reconstruction(Springer International Publishing, 2019) Uz U.; Eskiizmir G.; Sherris D.Nasal reconstruction after tissue loss requires understanding of multiple complex surgical techniques and principles aimed at restoring anatomic integrity, function, and aesthetics of the nose. The reconstruction form and function of the nose are generally challenging when compared to other regions of the face. The outer skin and soft tissue envelope the cartilaginous and bony structure, and the mucosal lining should be considered in the reconstruction of each defect. This chapter is mainly focused on graft materials that are commonly used for nasal reconstruction. A graft is any type of tissue that is harvested from a donor site and transferred to a recipient site without carrying its own blood supply. After transplantation, a newly formed blood supply (angiogenesis) grows toward the graft. Grafts are divided into three categories according to their sources: (1) autografts, (2) homografts, and (3) xenografts. Autografts, or autogenous grafts, designate tissues that are harvested from a site and transplanted on other site of the same patient. Skin, cartilage, fascia, fat, and bone grafts can be used for the reconstruction of various nasal defects or deformities. Indeed, autogenous grafts are the gold standard graft materials for nasal reconstruction due to low rates of rejection, infection, and extrusion. If the donor and recipient are the same species but a different host, the graft is called as homograft. Homograft is divided into two groups: (1) isograft (donor and recipient have the same genetic material as in monozygotic twins) and (2) allograft (the tissue is transferred between genetically nonidentical members of same species). Xenografts are tissue that is harvested from one species and transplanted into another species. Xenografts are generally indicated for closure of post-Mohs surgery in massive wounds, and act as biological dressings to allow for wound granulation and epithelialization. © Springer Nature Switzerland AG 2020.Item Regenerative Medicine in Rhinology(Springer International Publishing, 2019) Günhan K.; Uz U.Regenerative medicine, using stem cells with or without scaffolds, allows surgeons to treat congenital or acquired defects with normal structure and functions. Although stem cell and regenerative medicine are nowadays used quite often in some areas of medicine, it is obvious that they are in their crawling stage in reconstructive surgery and in rhinology. However, it is not difficult to predict that it will become popular in the next few decades and will be among the treatment regimens in the guidelines. The various developments in isolation, duplication, and differentiation of stem cells and three-dimensional scaffolds suggest that some of the more frequently applied therapies may be shelved in the close future. Stem cells are categorized as embryonic stem cells, induced pluripotent stem cells and adult stem cells. Adult stem cells are generally preferred in practice nowadays due to ease of isolation and differentiation stages. The purpose of this section is to provide information on stem cell applications and regenerative medicine in rhinology at present and in close future. © Springer Nature Switzerland AG 2020.Item Clinical Assessment of Mucociliary Disorders(Springer International Publishing, 2019) Uz U.; Günhan K.; Cohen N.There has been growing appreciation of the significant role played by the mucociliary transport system in the body. Mucociliary clearance is a critical host defense mechanism of the airways. Effective mucociliary clearance requires appropriate mucus production and coordinated ciliary activity. Mucociliary transport is responsible for primary innate immunity in the respiratory tract. In order to assess mucociliary transport and diseases resulting from mucociliary transport dysfunction, it is first necessary to understand the cellular anatomy and physiology that drive mucociliary function. The primary function of this epithelium is as a protective barrier. There are two different liquid layers coating the epithelial surface: the viscous outer gel layer and the thin inner periciliary layer. The gel layer of the mucus consists of mucin glycoproteins, secreted by goblet cells and submucosal glands. The mucin traps the bacterial compounds, pathogens, and inhaled debris, and coordinated ciliary activity propels the debris-laden mucus toward the glottis for elimination. This action is called mucociliary clearance. Ciliary disorders are divided into two categories: primary (inherited) and secondary (acquired). Primary ciliary dyskinesia (PCD) is a collection of genetic defects in cilia structure resulting in defective ciliary activity. Secondary ciliary dyskinesia (SCD) or acquired ciliary dyskinesia is a transient defect immunociliary clearance that occurs after viral or bacterial infection, tobacco smoke, pollutant exposure, as well as during allergic inflammation. In this chapter, clinical assessment of mucociliary disorders are discussed. © Springer Nature Switzerland AG 2020.Item Does a smartphone application make it easier to evaluate the dizziness handicap inventory?(AVES, 2019) Uz U.; Uz D.; Çelik O.Objective: The Dizziness Handicap Inventory (DHI) is a questionnaire that is frequently used for patients with vestibular system disorders. The aim of this study was to evaluate the feasibility and reliability of the “e-DHI” smartphone application, which calculates DHI scores. Methods: Web-based iOS and Android smartphone applications (e-DHI) were developed to evaluate the DHI. After completing the questionnaire, the DHI total score and subscores (physical, functional and emotional) were assessed and results were noted and sent to the e-mail address. Twenty-five otorhinolaryngologists and neurologists were enrolled in the study to apply the DHI to the authors sequentially using the conventional assessment method and the e-DHI (randomized by priority). The questionnaire was applied by both methods, and for each method, the time required to complete the questionnaire, to calculate the DHI score, and the total time required were noted. Results: Three of the 25 doctors were excluded from the study due to a calculation error with the conventional evaluation method. The mean total time required for completing and scoring the questionnaire was shorter when the DHI was evaluated with the e-DHI application (160±32.2 seconds) compared with the classic assessment method (289±65.9 seconds) (p<0.001). There was no significant difference between the two methods in terms of the time taken to complete the questionnaire (p=0.269). However, the calculation periods were statistically significantly shorter with the digital application compared with the conventional method (p<0.001). Conclusion: The present study showed that the DHI could be applied more quickly, more comfortably, and safely (with higher accuracy) using the e-DHI smartphone application. © 2019, AVES. All rights reserved.Item The evaluation of pretreatment neutrophil–lymphocyte ratio and derived neutrophil–lymphocyte ratio in patients with laryngeal neoplasms; [Avaliação da relação neutrófilo-linfócito e relação neutrófilo-linfócito derivada no pré-tratamento em pacientes com neoplasias laríngeas](Elsevier Editora Ltda, 2019) Eskiizmir G.; Uz U.; Onur E.; Ozyurt B.; Karaca Cikrikci G.; Sahin N.; Oran A.; Celik O.Introduction: Systemic inflammatory biomarkers are promising predictive and prognostic factors for solid cancers. The neutrophil–lymphocyte ratio and derived neutrophil–lymphocyte ratio are used to predict inflammation and used as biomarker in several malignancies. Objective: The purpose of this study was to demonstrate the diagnostic, predictive and prognostic role of neutrophil–lymphocyte ratio and derived neutrophil–lymphocyte ratio in patients with laryngeal neoplasms. Methods: A retrospective study was conducted on medical records involving 229 patients with benign, premalignant and malignant laryngeal neoplasms between 2002 and 2015. The diagnostic, predictive and prognostic role of neutrophil–lymphocyte ratio and derived neutrophil–lymphocyte ratio were evaluated using uni– and multivariate analysis. Results: The neutrophil–lymphocyte ratio and derived neutrophil–lymphocyte ratio were not statistically different between patients with benign, premalignant and malignant laryngeal neoplasms. Both neutrophil–lymphocyte ratio and derived neutrophil–lymphocyte ratio were predictive factors for stage, lymph node metastasis, and distant metastasis. Patients with high neutrophil–lymphocyte ratio value (≥4) had a poor prognosis when compared with patients with low neutrophil–lymphocyte ratio value (5 year, Overall Survival: 69.0% vs. 31.1%, p < 0.001; 5 year, disease free survival: 70.0% vs. 32.7%, p ˂ 0.001; 5 year, locoregional recurrence free survival: 69.7% vs. 32.0%, p < 0.001). Furthermore, neutrophil–lymphocyte ratio was an independent prognostic factor for 5 year: Overall survival (HR = 2.396; 95% CI 1.408–4.077; p = 0.001), Disease free survival (HR = 2.246; 95% CI 1.322–3.816; p = 0.006) and locoregional recurrence free survival (HR = 2.210; 95% CI 1.301–3.753; p = 0.003). Conclusion: Pretreatment neutrophil–lymphocyte ratio is a useful and reliable predictive and prognostic biomarker for patients with laryngeal carcinoma. © 2018 Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-FacialItem Efficacy of epley maneuver on quality of life of elderly patients with subjective BPPV(AVES, 2019) Uz U.; Uz D.; Akdal G.; Çelik O.OBJECTIVES: This study aimed to evaluate the efficacy of the repositioning maneuver on quality of life in elderly patients with dizziness and/or vertigo. MATERIALS and METHODS: This controlled, prospective randomized clinical trial was conducted in elderly patients aged 65 years and above with a positive history of benign paroxysmal positional vertigo (BPPV), presence of vertigo, and no observable nystagmus during the Dix-Hallpike test, so-called Subjective BPPV (S-BPPV). Individuals were evaluated by visual analog scale (VAS) and dizziness handicap inventory (DHI). Groups were defined as treatment (treated with Epley maneuver bilaterally) or no treatment control (no treatment modality or canalith repositioning maneu-ver). Ten days after the first assessment, all patients were reassessed using VAS and DHI. RESULTS: A total of 50 patients were randomized into two groups: 25 to the treatment group, and 25 to the control group. No significant differences were observed for baseline VAS and total DHI scores between the groups (p=0.636, p=0.846, respectively). On the other hand, after the reassessment, VAS and total DHI scores were both significantly reduced in the treatment group (p<0.001, p<0.001, respectively), but no reduction in either score was found in the control group (p=0.216, p=0.731, respectively). CONCLUSION: This study showed that elderly patients with S-BPPV benefit from the Epley maneuver, in particular global and disease-specific quality of life. © 2019, AVES. All rights reserved.Item Novel simple strategy for cartilage tissue engineering using stem cells and synthetic polymer scaffold(Lippincott Williams and Wilkins, 2019) Uz U.; Gunhan K.; Vatansever S.; Kivanc M.; Yuceturk A.V.Cartilage created by tissue engineering is a promising new development in facial reconstructive surgery. The purpose of this study was to evaluate the histological results of implantation of synthetic polymer scaffold with chondrocytes differentiated from adipose-derived mesenchymal stem cells. Adipose tissue obtained from Wistar albino rats was dissociated, incubated and placed in culture medium. After a sufficient level of stem cell proliferation, the differentiation phase was started. Cells were collected on the 7th and 21st day of culture for chondrogenic characterization. After the 21st day of the differentiation phase of chondrocytes, they were transferred onto poly(dl-lactide-epsilon-caprolactone) synthetic polymer and culture continued for 24 hours. The scaffold with chondrocytes was then implanted into a subcutaneous area of skin on the back of the neck of the rat. Six weeks after implantation, all rats were sacrificed and the implantation areas were analyzed. Chondrocytes derived from adipogenic mesenchymal stem cells were stained positively with collagen II, aggrecan and Sox-9 after the differentiation stages. Histological examination of the excised material showed that chondrocytes were present, and the scaffold had been completely absorbed. The results of this study indicate that the differentiation method from mesenchymal stem cells to chondrogenic lineage was straightforward and scaffold with cells was easily accessible. This technique may be a good option for cartilage tissue engineering. © 2019 by Mutaz B. Habal, MDItem Association between interleukin-6 and head and neck squamous cell carcinoma: A systematic review(Korean Society of Otolaryngology, 2021) Uz U.; Eskiizmir G.Interleukin-6 (IL-6) is a proinflammatory cytokine which plays an important role in several regulatory mechanisms of can-cer. Moreover, experimental and clinical studies have reported that IL-6 targeted therapies might provide significant bene-fits for cancer treatment. The purpose of this systematic review is to evaluate IL-6 activity in patients with head and neck squamous cell carcinoma (HNSCC). A systematic review of the association between serum, saliva and tumor IL-6 and HN-SCC was developed on PubMed/Medline in the publication range from January 1995 to January 2019. Our literature analysis demonstrated that overexpression and elevated serum and/or saliva IL-6 concentrations in patients with HNSCC are related to poor survival and oncological outcomes. Although there is a correlation between IL-6 concentrations and tumor-igenicity, it is noteworthy that IL-6 targeted therapies are generally performed in vitro and in experimental studies. There-fore, prospective, randomized clinical trials are required that focus on IL-6 targeted therapies for the treatment of HNSCC. © 2021 by Korean Society of Otorhinolaryngology-Head and Neck Surgery.Item The impact of the informed consent process on the anxiety levels of patients undergoing rhinoplasty(Lippincott Williams and Wilkins, 2022) Aysel A.; Uz U.; Karatan B.; Aydin E.; Erdogˇan E.; Yilmaz F.; Müderris T.Septorhinoplasty is one of the most common elective surgical procedures in otolaryngology. The present study aimed to evaluate the anxiety levels of patients who underwent septorhinoplasty at different times, compare the information methods, and determine the understanding of the informed consent through recall rates of the complications explained in the informed consent process. The patients were divided into the following 2 groups: Group 1 (giving information 14 days before the surgery) and Group 2 (giving information 3 days before the surgery). For the preoperative anxiety measurement, the State anxiety scale of the State-Trait Anxiety Inventory (STAI) was used. All patients were asked to recall the complications they remembered from the consent form on the day before the surgery. Each group has consisted of 25 patients. No significant difference was found between the STAI-1 and STAI-2a anxiety scores between groups. In Group 1, the STAI-2b anxiety score was significantly lower than the STAI-1 and STAI-2a scores (P < 0.05). In Group 2, the mean score of STAI-2b was not significantly higher than the STAI-1 and STAI-2 scores (P > 0.05). When the STAI-2b scores of the two groups were compared, the scores of Group 2 were significantly higher (P < 0.05). The most commonly remembered complications were bruising and swelling in both of the groups. In conclusion, the authors believe that long-term cooperation between the surgical team and the patient will reduce the anxiety levels of the patients and increase patients’ satisfaction, resulting in a significant reduction in the amount of potential legal processes. Copyright © 2021 by Mutaz B. Habal, MD.Item Correlation of Disease Severity and Systemic Inflammatory Markers in Patients with Chronic Rhinosinusitis with Nasal Polyps(AVES, 2023) Uz U.; Günhan K.; Eskiizmir G.Objective: The aim of this study is to evaluate the relationship between Lund-Mackay scores, osteitis severity, and neutrophil lymphocyte ratio, platelet lymphocyte ratio, basophil lymphocyte ratio, eosinophil lymphocyte ratio, and systemic immune inflammation index in patients with chronic rhinosinusitis with nasal polyps. Methods: Patients who were diagnosed with chronic rhinosinusitis with nasal polyps and underwent endoscopic sinus surgery between 2014 and 2020 were evaluated retrospectively. Lund-Mackay scores and osteitis severity (Hounsfield Unit) were determined separately for each nasal cavity by examining preoperative computed tomog-raphy images. Lund-Mackay and Hounsfield Unit scores were compared with the preoperative neutrophil lympho-cyte ratio, platelet lymphocyte ratio, basophil lymphocyte ratio, eosinophil lymphocyte ratio, and systemic immune inflammation index. Results: A total of 39 patients (24 males, 15 females) (78 sides) enrolled in the study. There was a positive correlation between right-sided Lund-Mackay scores and ipsilateral Hounsfield Unit (r = 0.343, P =.033). Similarly, there was a positive correlation between left nasal cavity Lund-Mackay scores and ipsilateral Hounsfield Unit (r = 0.376; P =.018). No statistically significant correlation between Lund-Mackay scores and Hounsfield Unit values, and neutrophil lympho-cyte ratio, platelet lymphocyte ratio, basophil lymphocyte ratio, eosinophil lymphocyte ratio, and systemic immune inflammation index values were detected. Conclusion: In the present study, no correlation between chronic rhinosinusitis with nasal polyps severity and systematic inflammatory markers was demonstrated. © Author(s).Item Extraordinary Complication of COVID-19 Swab Testing: CSF Rhinorrhea(Lippincott Williams and Wilkins, 2023) Uz U.; Günhan K.; Pabuşcu Y.; Mutlu S.; Kamiloǧlu U.Coronavirus disease 2019 (COVID-19) is a highly contagious disease that has reached pandemic status. The diagnosis of COVID-19 is made using the polymerase chain reaction test to evaluate a swab taken from the naso/oro-pharyngeal area. Since COVID-19 is still a pandemic, it is thought that the use of this diagnostic test will be on the agenda for a while. A patient with COVID-19 symptoms presented with unilateral cerebrospinal fluid rhinorrhea after a nasopharyngeal swab test. Although nasopharyngeal swabs are taken very frequently, the complication rate is very low. However, life-threatening complications can be observed on rare occasions, and care should be taken. © 2023 Lippincott Williams and Wilkins. All rights reserved.