Browsing by Author "Uzuner N."

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    Landau-Kleffner syndrome: Relation of clinical, EEG and Tc-99m-HMPAO brain SPECT findings and improvement in EEG after treatment
    (Japanese Society of Nuclear Medicine, 1999) Sayit E.; Dirik E.; Durak H.; Uzuner N.; Anal Ö.; Çevik N.T.
    Landau-Kleffner syndrome (LKS) is a rare childhood disorder characterized by acquired aphasia with seizures and electroencephalogram (EEG) abnormalities. Tc-99m-HMPAO SPECT was performed in three right handed children with LKS. A relative decrease in perfusion was found in the left temporal cortex of all three patients and also in the left frontoparietal cortex of one patient with hyperkinetic behavior. Degree of regional cerebral perfusion impairment did not correlate with the severity of clinical and EEG abnormalities. Asymmetrical temporoparietal perfusion appears characteristic of LKS. SPECT findings in LKS were evaluated as useful in elucidating the pathogenic features of the disorder in the brain.
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    Economic impact of primary headaches in Turkey: A university hospital based study: Part II
    (2006) Karli N.; Zarifoǧlu M.; Ertaş M.; Saip S.; Öztürk V.; Biçakçi Ş.; Boz C.; Selçuki D.; Oǧuzhanoǧlu A.; Neyal M.; Siva A.; Irkeç C.; Kaleaǧasi H.; Kansu T.; Sarica Y.; Taşdemir N.; Uzuner N.
    This study was planned to investigate the economic impact of headache on Turkish headache sufferers attending a tertiary care outpatient headache clinic. A total of 937 headache patients were included in this study and questioned using a questionnaire for the profile of patients and headache, quality of life of patients and economic impact of headache. The median total direct cost was found to be 88.0 USD and the median total cost was 160.7 USD. The drug treatment cost was the highest item followed by the specialist outpatient care cost. The average lost and inefficient work/school days was 1.5 (0-45) and 8.4 (0-100) days for one year. It was shown that loss of productivity was higher for migraine without aura group when compared with the episodic and chronic tension-type headache groups. The results of this nationwide university hospital based study showed that headache, especially migraine, has considerable economic impact on patients. © Springer-Verlag Italia 2006.
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    Successful use of inhaled steroids for the management of radiation pneumonitis in an infant: Case repot; [Radyasyon pnömonisinin tedavisinde i̇nhale steroidlerin bir süt çocuǧunda başarı ile kullanımı]
    (Turkiye Klinikleri, 2010) Mutafoǧlu Uysal K.; Uzuner N.; Çetingöz R.; Özgüven A.A.; Babayiǧit A.; Ölmez D.; Güneş D.; Olgun N.
    Radiation pneumonitis and subsequent pulmonary fibrosis are among the serious complications of thoracic irradiation and can have severe implications on patients' quality of life. Systemic corticosteroids are commonly used agents to treat radiation pneumonitis. However, the potential adverse effects of systemic corticosteroids, particularly in growing children, are consid-erable. An infant with lung metastatic Ewing sarcoma developed severe radiation pneumonitis following chemoradiotherapy. Systemic prednisolone was started first. However, due to the prolonged need for corticosteroid therapy, inhaled budesonide was administered with reduced systemic corticosteroid dose in an attempt to avoid the adverse effects of systemic corticosteroid treatment. The treatment was then continued exclusively with budesonide with a good clinical response. To our knowledge, this is the first pediatric case reported to benefit from inhaled steroids for severe radiation pneumonitis. This response suggested that inhaled steroids might serve as a adjunct or even an alternative to systemic corticosteroids in radiation pneumonitis. © 2010 by Türkiye Klinikleri.
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    Characteristics and prognosis of childhood atopic dermatitis: A multicenter study in Turkey
    (2010) Yuksel H.; Can D.; Reisli S.; Uzuner N.; Orhan F.; Cevit O.; Tahan F.; Canitez Y.; Kuyucu S.; Boz A.B.; Akcay A.; Yilmaz O.
    Background:Childhood atopic dermatitis (AD) is classically accepted as initial finding of atopic march; however, nonatopic cases do not follow this course. The aim of this study was to determine the characteristics and prognosis of AD in childhood in Turkey. Methods:The study included 531 children with AD that presented to pediatric allergy departments in 11 different regions of Turkey. Age at diagnosis, total serum and inhalant-specific immunoglobulin E (IgE) levels and allergen skin prick test results were recorded retrospectively. Clinical characteristics like additional allergic diseases at presentation or during follow-up were recorded as well as duration of follow-up. Results:Mean age at diagnosis was 37.8 ± 36.2 months. Mean IgE level was 318.3 ± 677.8 IU/ml (median 100 IU/ml). Skin prick tests yielded positive results in 47% of children. At presentation, 31.6% of children reported additional allergic disease, while 11.7% developed allergic disease during follow-up. Among all, 46.6% had additional allergic disease at any point. IgE levels were significantly higher in children with additional allergic diseases (p = 0.001). Allergen skin prick test positivity and family history of allergic diseases increased the risk of additional allergic diseases significantly (OR = 3.90, 95% CI = 2.3-6.6 and OR = 1.89, 95% CI = 1.3-2.8, respectively). Conclusions: Allergic sensitization is not present in all cases of AD. Coexistence of additional allergic diseases is not as high as expected but more common in children who have been demonstrated to have atopic sensitization with high IgE levels and allergen skin prick test positivity. Copyright © 2010 S. Karger AG.
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    (Un)Awareness of allergy
    (BioMed Central Ltd, 2011) Kalpaklioglu A.F.; Kalkan I.K.; Akcay A.; Reisli I.; Can D.; Uzuner N.; Yuksel H.; Kirmaz C.; Gulen F.; Ediger D.
    Background: Allergy is associated with considerable morbidity. Objective: The aim of this multicenter study was to provide insight into allergy knowledge and perceptions among the population. Methods: During the World Allergy Day, several allergy clinics conducted public meetings to encourage the awareness of and education in allergy. At the beginning, participants filled out a questionnaire to assess their knowledge about what is allergy and to determine by whom those symptoms are cared. Results: A total of 256 participants (187 women/69 men, mean age, 31.2 ± 12.5 years) completed the survey. Of the 202 participants with symptoms, 58.9% had physician-diagnosed allergic disease. Among the 19 symptoms evaluated, 56.5% of the symptoms were recognized as related with allergy, and this increased in compliance with education level (r = +0.427; P < 0.001) but not with diagnosed allergy (P = 0.34). Sneezing was the most common symptom thought to be related with allergy-related symptom (77.5%), whereas loss of smell was the least one (37.9%). Participants were more likely to be cared by an allergologist (72.9%) followed by other specialties, when experiencing allergy. Conclusions: Increasing the awareness for allergic symptoms is the key not only for the diagnosis but also for the optimal treatment. Therefore, education is an important component of prevention and control of allergic diseases. Copyright © 2011 by World Allergy Organization.
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    The reliability and validity of Turkish version of Childhood Asthma Control Test
    (2012) Sekerel B.E.; Soyer O.U.; Keskin O.; Uzuner N.; Yazicioglu M.; Kiliç M.; Artaç H.; Ozmen S.; Can D.; Zeyrek D.; Cokugras H.; Canitez Y.; Aydogan M.; Kuyucu S.; Inal A.; Gurkan F.; Orhan F.; Yilmaz O.; Boz A.B.; Tahan F.; Cevit O.
    Introduction: The reliability and validity of Turkish version of Childhood Asthma Control Test (C-ACT). Purpose: The management of asthma is an important as well as difficult issue of physician's daily practice particularly in busy clinical settings. C-ACT was created to identify asthma control levels in children aged 4-11 years. Our aim was to evaluate the reliability, validity and responsiveness of C-ACT in a Turkish sample of children with asthma. Method: In this multicenter study, 368 children were enrolled. C-ACT was completed every month by parents and patients who were evaluated in 3 visits within 2 month intervals. At each visit, physicians interpret the control level and decided for the treatment step as established in GINA guidelines. Results: The internal consistency reliability of the Turkish version of C-ACT (C-ACT1 to C-ACT5) was found to be 0.82, 0.83, 0.82, 0.82 and 0.80, respectively (reliability statistics, Cronbach's alpha). Test-retest reliability was 0.71. There was significant correlation between C-ACT and physician's assessment of asthma control at visit 1 (r = 0.65, P <0.001). Conclusions: Turkish version of C-ACT is an accurate and reliable tool to evaluate asthma control in children aged 4-11 years. Its widespread use may facilitate appropriate assessment of asthma control and may lead to decrease the number of uncontrolled patients. © Springer Science+Business Media B.V. 2011.