Browsing by Author "Uzunoǧlu S."
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Item Incidence of severe glucose-6-phosphate dehydrogenase (G6PD) deficiency in countryside villages of the central city of Manisa, Turkey(TIP ARASTIRMALARI DERNEGI, 2006) Minareci E.; Uzunoǧlu S.; Minareci O.Aim: The primary objective of this study was to determine the incidence of severe G6PD deficiency in selected countryside villages of central city of Manisa in Turkey. Secondarily to inform and protect G6PD deficient people from acute hemolytic crisis and neonatal jaundice by delivery of the updated protective food and drug list prepared in the light of the WHO- G6PD Working Committe reports. Methods: In this study, the incidence of severe G6PD deficiency were screened by Beutler's Fluorescence Spot test among 1604 people living in the contryside villages of central city of Manisa in Turkey. Results: Thirty five out of 1604 tested people were found to have severe G6PD deficiency. The incidence of severe G6PD deficiency were 2.2 % in sampled population. There was a difference for the incidence between male (3.2%) and female (1.14%) as expected due to X-linked heritance. There was no significant differences in the prevalence of severe G6PD deficiency between the countryside villages connected to central city of Manisa. Conclusion: The high incidence of severe G6PD deficiency implies that this inherited metabolite disorder is an important health problem in Manisa region and it is necessary to carry out large-scale screening in the whole population since severe- full G6PD deficiency related health problems are preventable. For this reason it must be included in the pool of genetic screening tests in regional health policy.Item Evaluation of the association between null genotypes of glutathione-S-transferases and Behcet's disease(2006) Uzunoǧlu S.; Acar H.; Okudan N.; Gökbel H.; Mevlitoǧlu I.; Sari F.Glutathione S-transferases (GST) play an important role in oxidative stress related syndromes. An imbalance of the oxidant and antioxidant systems is important in the pathogenesis of Behcet's disease (BD). The objective of this study was to evaluate the association of null genotypes of GST-M1 and GST-T1 with BD since some preliminary molecular genetic data were recently published. Ninety-four Turkish BD patients (42 male, 52 female, 37.1 ± 10.4 years) and 140 healthy volunteers (70 male, 70 female, 36.8 ± 11.7 years) matched for age and gender with the patients as the control group were included in the study. Distributions of GST-M1 and GST-T1 genotypes were determined by multiplexed PCR using three sets of primers for GST-M1, GST-T1, and β-globulin genes. There was no association between BD and the frequencies of GST-M1 and GST-T1 null genotypes when compared to controls by separate analysis. However, by cross and pooled combination analysis there was a significant association between the frequencies of pooled GSTs with one or both null genotypes in BD and controls. This is the first evidence that the association between the frequencies of GST-M1 and GST-T1 null genotypes and BD might be dependent on the interaction of multiple null allele polymorphisms rather than a single null allele of GST-M1 and GST-T1. © Springer-Verlag 2005.Item New concept in environmental conservation: Ecological ego; [Çevreyi korumada yeni bir kavram: Ekolojik ego](2006) Uzunoǧlu S.The relation of human being with man and nature is built by ego. Ecological ego is critical element in relations between man and nature, while healthy ego with good character is more important in human relations. Ecological ego is thestabile state of ego which gives mentally, emotionally and behaviourly no harm to nature, but also respectful to all creatures. Environmental problems are mainly derived from ill-relations of ego and environment. Understanding the ecology of ego is important as much as the understanding of nature ecology since self survival based attitudes and behaviours of ego affects primarily environmental health. The research data from environmental sciences makes little contribution to environmental conservation, since the primary research objective in environmental sciences are not targeted to controlling of human passions and behaviours damaging to nature. The degree of ecological awareness and consciousness are dependent on the awareness of ego. It is quite difficult to solve environmental problems unless understanding of ecology of ego and building up ecological ego states. If functions of ego regulating internally thinking, emotion and behaviour could be controlled by ethical values of ecopsychology (not to give harm, to be respectful, to make contribution to nature), then it would be possible to control and manage the attitudes and behaviours harmful to environment.Item Some heavy metal determination by ICP-OES in human scalp hair (In three different regions of Manisa); [İnsan saçında bulunan (Manisa İlinin üç farklı yerleşim bölgesinde) Bazı aǧir metallerin ICP-OES yöntemi ile tayini](Ekoloji, 2009) Çelik A.; Abali Y.; Edgünlü G.; Uzunoǧlu S.; Tirtom V.N.The aim of this study was to determine the levels of As, Cd, Mn, Cr, Fe, Pb, Hg, Zn and Se in hair samples collected from the nape of the neck of voluntary people living or working in the industrial region, city center and countryside of Manisa province. The concentrations of As, Cd, Mn, Cr, Fe, Pb, Se, Zn were determined by ICP-OES. The measured values of trace elements in human hair samples were compatible to the reference values given in the literature. The measured values of As, Hg, Cr, Cd, Se and Pb were found below the detection limit of the method. Zn, Mn and Fe were statistically analysed and evaluated. When the Fe and Mn values of the hair samples collected from the industrial region were compared with the data from both the city center and countryside (ANOVA), the differences were meaningful and significant, but the differences for Zn between the industrial region, city center and countryside were found to be insignificant.Item The role of circadian rhythm genes in cancer; [Kanserde sirkadiyan ritim genlerinin rolü](2011) Atmaca H.; Uzunoǧlu S.Circadian (In Latin: Circa=around, Diem=day) rhythm describes the processes of 24 hour oscillations in the living systems. At the cellular level, circadian rhythm is controlled by a molecular network with positive and negative feedbacks. The known critical elements in the positive feedback loop are Clock and Bmal1; the ones in complementary negative feedback are mainly Period and Cryptochrome genes. In cancer, which is an important health problem today, dysregulation of circadian rhythm is an important risk factor. In this review, circadian rhythm genes involved in cell proliferation, apoptosis, DNA repair, metabolism, detoxification and response to DNA damage and their roles in cancer development are summarized.