Browsing by Author "Vural H."

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    The prevalence of microalbuminuria and relevant cardiovascular risk factors in Turkish hypertensive patients
    (2011) Kozan Ö.; Özcan E.E.; Sancaktar O.; Kabakci G.; Sözcüer A.H.; Kerpeten A.; Delice A.; Içli A.; Sökmen A.; Gürlek A.; Abaci A.; Bayram A.; Köşüş A.; Çamsari A.; Sakalli A.; Sert A.; Temizhan A.; Yilmaz A.; Daver A.; Aydinlar A.; Ergin A.; Kiliçoǧlu A.E.; Birdane A.; Aribaş A.; Lazoǧlu A.; Özdemir A.; Fiskeci A.; Çelik A.; Bitigen A.; Keskin A.; Yavuz A.; Akyüz A.; Karanfil A.; Ünsal A.; Sinci A.; Gülmez A.U.; Irmak A.; Vural A.; Güven A.; Ilerigelen B.; Erol B.; Polat B.; Tosun B.; Aǧçal C.; Genç C.; Kirdar C.; Rezzagil C.; Köz C.; Nazli C.; Ceyhan C.; Örem C.; Uyan C.; Türkoǧlu C.; Gaffari D.; Aytekin D.; Ural D.; Yeşilbursa D.; Aras D.; Semiz E.; Koçak E.; Atalar E.; Varol E.; Onrat E.; Şensoy E.; Acartürk E.; Akarca E.; Aygün E.; Ertaş F.S.; Koca F.; Özmen F.; Ulusoy F.V.; Özerkan F.; Inceer F.K.; Dönmez G.; Topkara G.; Daş G.; Bozkurt H.; Kültürsay H.; Tikiz H.; Akgöz H.; Kaymak H.; Öney H.; Yeǧin H.; Boǧa H.; Gök H.; Vural H.; Atasever H.; Arinç H.; Bozdemir H.; Gündüz H.; Tunar H.; Atmaca H.; Doǧru I.; Özdoǧru I.; Susal I.; Kurt I.T.; Dinçer I.; Biyik I.; Tandoǧan I.; Jordan J.; Kulan K.; Şahna K.; Öztaş K.; Dönmez K.; Övünç K.; Kaya K.; Aytemir K.; Özdemir K.; Tigen K.; Saraç L.; Sirkeci M.T.; Çakmak M.; Şahin M.; Kutlu M.; Bilge M.; Bostan M.; Melek M.; Sunay M.Ö.; Şeker M.; Güçel M.Ş.; Yazici M.; Kayikçioǧlu M.; Öç M.; Gürsürer M.; Daǧalp M.; Bilaloǧlu M.; Yalçin M.; Şerifi M.; Gökçe M.; Kiliçkap M.; Polat M.; Şan M.; Tahtasiz M.; Yilmaz M.; Etemoǧlu M.; Coşkun N.; Aran N.S.; Ata N.; Sönmez N.; Çam N.; Koylan N.; Özer N.; Keser N.; Döven O.; Tartanoǧlu O.; Ergene O.; Elönü O.H.; Onbaşili O.A.; Özbek Ö.; Pinar P.; Akdemir R.; Kargin R.; Topsakal R.; Yoldaş R.; Uçar R.; Ateşal S.; Toktaş S.; Cinsoy S.; Güleç S.; Aytekin S.; Çolak S.; Mecit S.; Sakalli S.; Sevimli S.; Topaloǧlu S.; Aydoǧdu S.; Turan S.C.; Kahraman S.; Yorganci S.; Coşkun Ş.; Ünal Ş.; Durmaz T.; Ulusoy T.; Keleş T.; Kirat T.; Gündoǧdu T.T.; Peker T.; Sümerkan U.; Aytekin V.; Koca V.; Çam V.; Gökçe V.; Gürlertop Y.; Balbay Y.; Çavuşoǧlu Y.; Erzurum Y.; Selçoki Y.; Yakar Y.; Işilak Z.; Tosun Z.; Kaplan Z.; Tartan Z.
    Objectives: A growing body of data illustrates the importance of microalbuminuria (MAU) as a strong predictor of cardiovascular risk in the hypertensive population. The present study was designed to define the prevalence of MAU and associated cardiovascular risk factors among Turkish hypertensive outpatients. Study design: Representing the Turkish arm of the multinational i-SEARCH study involving 1,750 sites in 26 countries around the world, a total of 1,926 hypertensive patients from different centers were included in this observational and cross-sectional survey study. Patients with reasons for a false-positive MAU test were excluded. The prevalence of MAU was assessed using a dipstick test, and patients were inquired about comorbidities, comedication, and known cardiovascular risk factors. Results: The overall prevalence of MAU was 64.7% and there was no difference between genders. Most of the patients (82.5%) had uncontrolled hypertension, 35.6% had dyslipidemia, and 35.5% had diabetes, predominantly type 2. Almost one-third of the patients (26.4%) had at least one cardiovascular-related comorbidity, with 20.3% having documented coronary artery disease (CAD). Almost all patients (96.8%) had one or more risk factors for cardiovascular disease in addition to hypertension, including family history of myocardial infarction or CAD, diabetes, dyslipidemia, lack of physical exercise, and smoking. A trend towards higher MAU values in the presence of CAD was determined. Conclusion: Microalbuminuria tests should be routinely used as a screening and monitoring tool for the assessment of subsequent cardiovascular morbidity and mortality among hypertensive patients. © 2011 Turkish Society of Cardiology.
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    High-pressure processing for freshness, shelf-life quality of meat products and value-added meat products
    (CRC Press, 2014) Tokuşoğlu Ö.; Vural H.
    Consumers demand products that are safe, nutritious, convenient, varied, attractive (in appearance, texture, and flavor), and also innovative. High-pressure processing (HPP) can be used as an alternative process to heat pasteurization and for shelf-life extension of a wide range of products. © 2015 by Taylor & Francis Group, LLC.
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    Coffee toxicology, processing of the coffee and liver diseases (is it a miracle of nature?)
    (Blackwell Publishing Ltd, 2021) Ergin E.; Tokusoglu O.; Vural H.
    The present study aimed to investigate the beneficial effects of coffee on the liver. The results show that coffee has beneficial effects on the liver and can reduce liver disease progression due to its antioxidant properties. Coffee contains antioxidant capacities of chlorogenic acid, hydrophilic components, hydrophobic components, lactones, and diterpenes. There are also rich amounts of potassium and magnesium in coffee. Roasting of the green coffee beans at high temperatures will make unique components due to the chemical reactions between carbohydrates and amino acids as Maillard reactions. Caffeine with a purine derivative is found in several dietary sources, including tea, chocolate bars, coffee, cocoa beverages, energy, and soft drinks. Caffeine can pass all biological membranes due to the hydrophobic properties of caffeine. Three primary metabolites, such as theophylline, theobromine, and paraxanthine, are caused by metabolizing caffeine in the liver. Caffeine at normal consumption doses mainly acts among humans as an antagonist of adenosine receptors. Two cups of coffee per day should be consumed to show its beneficial effects. Coffee drinkers experience a lower incidence of advanced cirrhosis and fibrosis. There are also differences between males and females in their responses to caffeine due to changes in circulating steroid hormones. Practical applications: This article investigates the beneficial effects of coffee on the liver and summarizes the potential preventive or positive effects of coffee on the liver. Coffee has beneficial effects on the liver and can reduce the progression of liver disease due to its antioxidant properties. © 2021 Wiley Periodicals LLC.
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    Nutmeg nutraceutical constituents: In vitro and in vivo pharmacological potential
    (John Wiley and Sons Inc, 2022) Malik T.; Sharma R.; Panesar P.S.; Gehlot R.; Tokusoglu O.; Dhull S.B.; Vural H.; Singh A.
    Spices consumptions are in direct relation with the healthy survivability of consumers throughout life as they are loaded with lists of phytoconstituents of human values. Nutmeg owes to its essential, volatile, and fixed oil is in prime most interest by researchers to explore for its benefits through food utilization. Besides being loaded with these phytochemical-based benefit traits it is also rich on the mineral side preferably with potassium, magnesium, and phosphorous. As for as the oil variation is concern, nutmeg essential oil composition behaves as per the geographical and varietal factors. Its beneficial aspect highlighted wherein oil of nutmeg contains Myristicin (phenylpropene organic compound) can exhibit anti-inflammatory response and have the cytotoxic activity against human colorectal carcinoma (HCT-116) and human breast carcinoma Michigan Cancer Foundation (MCF-7). Associated benefits of being on antiangiogenic compounds such as myristicin in Myristica fragrans essential oil resulted in antiangiogenic activity with an IC50 of 77.64 g/ml. Practical applications: Nutmeg has its wider acceptability among medicinal and therapeutic uses in today's world. Indeed, many would say that nutmeg use has increased. Nutmeg's traditional applications in treating stomach conditions, curing rheumatic pain, soothing skin wounds and illnesses, and acting as a relaxing agent have resulted in extensive research into its various extracts and fractions. One of the most commonly observed habits is the influence of nutmeg essential oil and extracts on the central nervous system. Nutmeg acetone extract's antioxidant and antimicrobial properties can help to prevent or delay oxidative stress-related diseases and infections caused by opportunistic pathogenic microorganisms. Nutmeg requires further work on several fronts, including the advancement of analytical approaches, reproducible separation procedures, and successful synthetic methods for promising secondary metabolites, as a source of complex secondary metabolites with substantial potential as prototype agents for drug testing. © 2021 Wiley Periodicals LLC.
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    Formula refining through composite blend of soya, alfalfa, and wheat flour; A vegan meat approach
    (John Wiley and Sons Inc, 2022) Sharma A.; Rawat K.; Jattan P.; Kumar P.; Tokusoglu O.; Kumar P.; Vural H.; Singh A.
    Present project involves the formula development by way of standardization for vegan meat through Central Composite Rotatable Design (CCRD) of Response Surface Methodology (RSM) of Design Expert 12 (DX-12). Soya chunks, alfalfa sprouts, and wheat flour were used as base ingredients. Preliminary experimental screening to fix the levels of these base ingredients were the basis to work ahead for formula refining through numerical optimization by way of RSM. The optimization tactics were revealed against a given set of responses viz; physico-chemical (polyphenol, % crude protein) and sensory properties (mouthfeel and texture, color and appearance and overall acceptability) as dependent variable. Obtained product with (75.35%) soya, (1.25%) alfalfa, and (22.73%) wheat flour were evaluated for their crude protein, fiber, polyphenol, antioxidant level, water holding capacity, hardness, chewiness, and springiness as 26.13, 7.88, 0.52, 7.03, 3.962%, 1500 g, 2812 g, and 0.60 g, respectively. Practical applications: Vegan meat analogue obtained herewith is also competitive in its sensory preferences in alongwith embedded high protein, elevated fiber and antioxidant potential features too. Fortified alfalfa seeds boost it with meaty flavor thus proven to be competitive among commercial demand. Least fat utilization put it in another healthier trait owe to be a better option for obese and calorie conscious patients. Thus in nutshell, stated combination was ideal in terms of textural and sensory attributes as meat mimic. © 2021 Wiley Periodicals LLC.