Browsing by Author "Yüksel, MB"
Now showing 1 - 7 of 7
Results Per Page
Sort Options
Item Serum Levels of Trace Elements in Patients with Testicular CancersKaba, M; Pirinççi, N; Yüksel, MB; Geçit, I; Günes, M; Demir, M; Akkoyun, H; Demir, HIntroduction: Trace elements are primary components of biological structures; however, they can be toxic when their concentrations are higher than those needed for biological functions. Materials and Methods: In the present study serum levels of trace elements were measured in 30 patients (mean age was 26.9 +/- 11.2 years) newly diagnosed with germ cell testicular cancer and 32 healthy volunteers (mean age: 27.4 +/- 10.8) by using furnace atomic absorption spectrophotometer. Serum samples were stored at-20 degrees C until assays. Results: In patients with germ cell testicular cancer, the diagnosis was seminoma in 15, mix germ cell tumor in 7, embryonal carcinoma in 4, yolk sac tumor in 2 and teratoma in 2 patients. There was stage I testicular tumor in 19 patients (63.3%) while stage II in 6 patients (20.0%), stage IIIA in 4 patients (13.3%) and stage IIIC in one patient (3.4%). It was found that serum Co, Cu, Mg and Pb levels were increased (p<0.05), whereas Fe, Mn, and Zn levels were decreased in patients with testicular cancer (p<0.05). Conclusions: These alterations may be important in the pathogenesis of testicular cancers; however, further prospective studies are needed to identify the relationship between testicular cancer and trace elements.Item Serum prolidase activity, oxidative stress, and antioxidant enzyme levels in patients with renal cell carcinomaPirinççi, N; Kaba, M; Geçit, I; Günes, M; Yüksel, MB; Tanik, S; Arslan, A; Demir, HObjectives: Prolidase is a member of the matrix metalloproteinase family. It plays a vital role in collagen turnover, matrix remodeling, and cell growth. Reactive oxygen species (ROS) have been implicated in the pathogenesis of various diseases, including cancers. Oxidative stress can cause tumor angiogenesis and may be carcinogenic. However, the relationship between antioxidant capacity and various cancers has been researched in several clinical trials. In our study, we aimed to identify serum prolidase activity, oxidative stress, and antioxidant enzyme levels in patients with renal tumors and to evaluate their relationships with each other. Materials and Methods: A total of 37 male patients with renal cell cancer and with a mean age of 56.28 +/- 3.1 were included in the study. The control group comprising 36 male patients (mean age 56.31 +/- 2.9) was randomly selected among the volunteers. Serum samples for measurement of superoxide dismutase (SOD), glutathione peroxidase (GSHPx), glutathione-S-transferase (GST), malondialdehyde (MDA), glutathione (GSH), and prolidase levels were kept at -20 degrees C until they were used. Results: Serum prolidase activity and MDA levels were significantly higher in renal cancer patients than in controls (all, p < 0.05), while SOD, GSHPx, and GST levels were significantly lower (p < 0.05). Conclusion: Our results indicate that increased prolidase seems to be related to increased oxidative stress along with decreased antioxidant levels in renal cancer.Item Serum adenosine deaminase, catalase and carbonic anhydrase activities in patients with bladder cancerPirinççi, N; Geçit, I; Günes, M; Yüksel, MB; Kaba, M; Tanik, S; Demir, H; Aslan, MOBJECTIVES: The relationship between adenosine deaminase and various cancers has been investigated in several studies. However, serum adenosine deaminase activity and carbonic anhydrase and catalase activities in patients with bladder cancer have not previously been reported. Therefore, the aim of this study was to measure serum adenosine deaminase, carbonic anhydrase and catalase activities in patients with bladder cancer. MATERIALS AND METHODS: Forty patients with bladder cancer and 30 healthy controls were enrolled in the study. Serum adenosine deaminase, carbonic anhydrase and catalase activities were measured spectrophotometrically. RESULTS: Serum adenosine deaminase, carbonic anhydrase and catalase activities were significantly higher in patients with bladder cancer than controls (all significant, p < 0.001). CONCLUSIONS: These markers might be a potentially important finding as an additional diagnostic biochemical tool for bladder cancer.Item Partial Urethrectomy for Female Urethral Transitional Epithelial Cell CarcinomaÜçer, O; Akdeniz, CB; Yüksel, MB; Temeltas, G; Müezzinoglu, TTo present a female case of partial urethrectomy and the following adjuvant chemo-radio-therapy for urethral transitional epithelial cell carcinoma originating from distal urethra in the light of literature. The patient was a 64-year-old female presented with dysuria, intermittent hematuria and a palpable urethral mass that she first experienced a few months ago. On physical examination of the vagina, papillary tumor was observed at the urethral meatus. During cystoscopy procedure, punch biopsy was performed from the tumoral lesion which lines from the middle urethra to distal. After the pathologic examination result of transitional epithelial cell carcinoma of urethra partial urethrectomy with urethroplasty was performed. On pathologic examination, high grade transitional epithelial cell carcinoma of urethra with squamous differentiation was detected. Three cures of gemcitabine and cisplatin were adminisered. After detecting a local recurrent mass four months after the surgery we planed radiotherapy and then surgical resection of the mass if needed. In women with distal urethral tumors, urethra-sparing surgery is alternative to primary urethrectomy if negative surgical margins can be achieved intra-operatively. Patients with tumor progression usually need to receive chemo-radio-therapy after the surgery.Item Haptoglobin Levels in Turkish Patients with Bladder Cancer and its Association with Clinicopathological FeaturesPiriniççi, N; Geçit, I; Gunes, M; Kemik, AS; Yüksel, MB; Kaba, M; Ceylan, K; Aslan, MAlthough alteration in the haptoglobin phenotype has been reported in patients with bladder cancer, serum haptoglobin levels have not been evaluated. We hypothesized that serum haptoglobin can be used as a biomarker. The aim of this study was to evaluate the expression of haptoglobin in bladder cancer and to determine the relationship with clinicopathological features. A total of 68 serum specimens obtained before surgery were used to investigate haptoglobin expression using the sandwich ELISA technique. Serum haptoglobin levels were higher in the patients with bladder cancer compared to healthy controls (p<0.0001). Additionally, the levels of haptoglobin protein increased with increasing tumor grades (p<0.001) and were significantly higher in patients with metastatic disease and the presence of lymphovascular involvement, lymph node metastases and increasing tumor burden (p<0.0001). This study suggests that elevated haptoglobin levels are associated with a higher stage, grade, and extent of distant metastasis and larger tumor size. Haptoglobin may therefore provide a useful diagnostic and treatment biomarker for patients with bladder cancer.Item Levels of Serum Trace Elements in Renal Cell Carcinoma CasesPirinççi, N; Geçit, I; Günes, M; Kaba, M; Tanik, S; Yüksel, MB; Arslan, H; Demir, HTrace elements which are essential components of biological structures may also be toxic when present at levels above the amounts required for biological function. In our study, trace element levels were measured with furnace atomic absorption spectrophotometry in 33 newly diagnosed renal cell carcinoma cases (preoperative) and 32 healthy controls. When compared with the control group, it was found that the levels of cadmium (Cd), lead (Pb) were higher and the levels of zinc (Zn), iron (Fe) and manganese (Mn) were lower in the patient group. These changes may be important in the formation of renal cell carcinoma, a question which should be explored with postoperative comparative studies.Item The comparison of urodynamic findings in women with various types of urinary incontinenceZeren, MF; Yüksel, MB; Temeltas, GPurpose: We aimed to determine the differences of the urodynamic findings of mix urinary incontinence (MUI), urge urinary incontinence (UUI), and stress urinary incontinence (SUI), and to evaluate the urodynamic findings in different groups by using bladder sensitivity index (BSI). Materials and Methods: The data of 99 patients who underwent urodynamic testing related to the suspicion of SUI, UUI or MUI were analysed. This analysis included a retrospective evaluation of patients' cards, voiding diaries, and urodynamic reports. At filling cystometry, the parameters of first sensation of bladder filling (FSBF), first desire to void (FDV), strong desire to void (SDV), and bladder capacity (V-max)(,) which were related to the bladder sensation, were determined. Subsequently, uroflowmetric findings were recorded during bladder emptying. BSI was defined as the ratio of V-max/FDV. These results were statistically compared among the goups. Results: The sample included 35(35.5%) MUI, 33(33.3%) UUI and 31 (31.1%) SUI. The mean ages were similar in all groups (P = 0.868). The mean FSBF, FDV, SDV and Vmax values were significantly different among groups (p = 0.004, p < 0.001, p < 0.001, p < 0.001 respectively). Nevertheless, there was no statistically significant difference among the mean daily voiding accounts (P = 0.005). Although the mean maximum flow rate (Q(max)) values were similar (P = 0.428), the mean maximum detrusor pressure (Pdet(max)) values were significantly different (P = 0.021). The mean BSI values showed no significant differences (P = 0.097). Conclusions: It was concluded that while the use of urodynamic testing could contribute to the management of urinary incontinence, the indexes including BSI requere more detailed and comprehensive studies.