Browsing by Author "Yüksel, S"

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    Clinical characteristics and follow-up results of the children with unilateral renal agenesis and hypoplasia
    Evrengül, H; Ertan, P; Serdaroglu, E; Yüksel, S
    Objective: Children with an inadequate number of nephrons have an increased risk of developing hypertension, proteinuria and chronic kidney disease in later life. This renal injury is caused by glomerular hyperfiltration. The aim of this study is to evaluate clinical characteristics and follow-up results of the children with unilateral renal agenesis and hypoplasia. Methods: We evaluated the clinical, radiological, and nuclear medicine findings of the children with unilateral agenetic or hypoplastic kidneys who were followed at Celal Bayar University School of Medicine and Dr. Behcet Uz Children's Hospital between 2005 and 2012. Results: The study consisted of 30 (60%) males and 20 (40%) females with a mean age of 8.9+/-4 years. A total of 25 patients were with renal agenesis and 25 with renal hypoplasia were diagnosed. On laboratory evaluation, mean serum creatinine level was 0.45+/-0.22 mg/dl and the mean estimated glomerular filtration rate (eGFR) was 144+/-30.3 ml/min. 29 patient (58%) had hyperfiltration according to an eGFR. Proteinuria and hypertension were noted in 1 (4%) patient. Urological anomalies were found in 15 patients (30%). Conclusion: Our study has determined that children with unilateral renal agenesis and hypoplasia had normal serum creatinine values. Howewer 29 patients (58%) had hyperfiltration according to eGFR. Because many children with hiperfiltration develop renal injury in later life, we emphasize the need for clinical follow-up in these patients starting at birth.
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    Trendelenburg Lithotomy Position During Vaginoscopic Office Hysteroscopy Reduces Pain and Procedure Duration
    Gencer, FK; Yüksel, S; Kumbasar, S; Babaoglu, B; Kavsi, B; Salman, S
    Objective: Vaginoscopic office hysteroscopy (VOH) is a gold standard diagnostic method for many uterine disorders. However, it may result in patient discomfort. This study aimed to investigate the effect of the Trendelenburg lithotomy (TL) position, in respect of the level of pain and procedure time during the VOH for diagnostic purposes. Methods: This study included 157 patients between the ages of 20 and 65 years, of whom 74 underwent diagnostic VOH with the lithotomy position (group 1) and 83 with the TL position (group 2). Subsequent evaluation that was conducted on both groups included visual analog scale scores of patients, procedure duration, and the attitudinal Likert-type survey of doctors. Results: A significant difference was found between groups 1 and 2 in pain scores (p<0.001), procedure duration (p<0.001), and attitudinal Likert-type survey of doctors (p=0.002). Group 2 reported lower pain scores than group 1 (3.34 +/- 2.37 and 5.69 +/- 2.33, respectively). Similarly, the procedure duration in group 2 was significantly reduced (60.11 +/- 26.3 and 83.3 +/- 29.5, respectively). The attitudinal Likert-type survey of doctors also showed significant improvement in group 2 (3.48 +/- 0.97 vs. 3.03 +/- 0.86, respectively). Conclusion: VOH with the TL position lowered the pain scores in patients and reduced the procedure duration. The TL position is a good way of increasing the patients' compliance and tolerance. Likewise, it makes the procedure easier for the doctor without any additional price.
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    Renal Agenesis And Hypoplasia In Humans Are Not Associated Glial Cell Line-derived Neurotrophic Factor
    Evrengül, H; Ertan, P; Serdaroglu, E; Yüksel, S; Mir, S; Yangin, E; Berdali, A
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    Pediatric kidney care experience after the 2023 Türkiye earthquake
    Bakkaloglu, SA; Delibas, A; Döven, SS; Taner, S; Yavuz, S; Erfidan, G; Vatansever, ED; Aynaci, F; Yílmaz, K; Tasdemir, M; Akaci, O; Akinci, N; Güven, S; Çiçek, N; Dursun, I; Kelesoglu, E; Sancaktar, M; Alaygut, D; Saygili, S; Yavascan, Ö; Yilmaz, A; Gülleroglu, K; Ertan, P; Demir, BK; Poyrazoglu, H; Pinarbasi, S; Gençler, A; Bastug, F; Günay, N; Çelegen, K; Noyan, A; Parmaksiz, G; Avci, B; Çayci, FS; Bayrakçi, U; Özlü, SG; Aksoy, ÖY; Yel, S; Inal, GA; Köse, S; Bayazit, AK; Atmis, B; Saribas, E; Çagli, Ç; Tabel, Y; Elmas, AT; Selçuk, SZ; Kiliç, BD; Kara, MA; Büyükçelik, M; Balat, A; Tiryaki, BD; Erdogdu, B; Aksu, B; Mahmudova, G; Dursun, H; Candan, C; Göknar, N; Mutlubas, F; Çamlar, SA; Basaran, C; Akbulut, BB; Düzova, A; Gülhan, B; Oruç, Ç; Peru, H; Alpay, H; Türkkan, ÖN; Gülmez, R; Çelakil, M; Dogan, K; Bilge, I; Pehlivanoglu, C; Büyükkaragöz, B; Leventoglu, E; Alpman, N; Zeybek, C; Tülpar, S; Gülsan, RYÇ; Kara, A; Gürgöze, MK; Önder, ENA; Atikel, YÖ; Pul, S; Sönmez, F; Yildiz, G; Akman, S; Elmaci, M; Küçük, N; Yüksel, S; Kavaz, A; Nalçacioglu, H; Alparslan, C; Dinçel, N; Elhan, AH; Sever, L
    Background. Two earthquakes on 6 February 2023 destroyed 10 cities in Turkiye. We report our experience with pediatric victims during these catastrophes, with a focus on crush syndrome related-acute kidney injury (Crush-AKI) and death. Method. Web-based software was prepared. Patient demographics, time under rubble (TUR), admission laboratory data, dialysis, and kidney and overall outcomes were recorded. Results. A total of 903 injured children (median age 11.62 years) were evaluated. Mean TUR was 13 h (interquartile range 32.5, max 240 h). Thirty-one of 32 patients with a TUR of >120 h survived. The patient who was rescued after 10 days survived. Two-thirds of the patients were given 50 mEq/L sodium bicarbonate in 0.45% sodium chloride solution on admission day. Fifty-eight percent of patients were given intravenous fluid (IVF) at a volume of 2000-3000 mL/m(2) body surface area (BSA), 40% at 3000-4000 mL/m(2) BSA and only 2% at >4000 mL/m(2) BSA. A total of 425 patients had surgeries, and 48 suffered from major bleeding. Amputations were recorded in 96 patients. Eighty-two and 66 patients required ventilator and inotropic support, respectively. Crush-AKI developed in 314 patients (36% of all patients). In all, 189 patients were dialyzed. Age >15 years, creatine phosphokinase (CK) >= 20 950 U/L, TUR >= 10 h and the first-day IVF volume <3000-4000 mL/m2 BSA were associated with Crush-AKI development. Twenty-two deaths were recorded, 20 of 22 occurring in patients with Crush-AKI and within the first 4 days of admission. All patients admitted after 7 days survived. Conclusions. These are the most extensive pediatric kidney disaster data obtained after an earthquake. Serum CK level was significantly associated with Crush-AKI at the levels of >20 950 U/L, but not with death. Adolescent age and initial IVF of less than 3000-4000 mL/m(2) BSA were also associated with Crush-AKI. Given that mildly injured victims can survive longer periods in the disaster field, we suggest uninterrupted rescue activity for at least 10 days.
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    COVID-19 IN PEDIATRIC NEPHROLOGY CENTERS IN TURKEY
    Bakkaloglu, SA; Atikel, YÖ; LeventoGlu, E; Nalçacioglu, H; Dursun, I; PoyrazoGlu, H; Dursun, H; Yildirim, ZY; Yildiz, N; Aksoy, GK; Akman, S; Tasdemir, M; Bilge, I; Çelakil, M; Kiliç, BD; Selçuk, SZ; Canpolat, N; Çakici, EK; Özlü, SG; Tülpar, S; Yüksel, S; Atmis, B; Döven, SS; Taner, S; Ertan, P; Kavaz, A; Bayram, MT; Kalyoncu, M; GÜlleroGlu, K; Kabasakal, C; Demir, BK; Çiçek, RY; Dönmez, O; Kara, A; Yavascan, Ö; Özçelik, G; Yildirim, DG; Güler, MA; Sönmez, F; Topaloglu, R; Alpay, H
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    COVID-19 in pediatric nephrology centers in Turkey
    Leventoglu, E; Özdemir Atikel, Y; Nalçacioglu, H; Dursun, I; Dursun, H; Yürük Yildirim, Z; Yildiz, N; Kaya Aksoy, G; Tasdemir, M; Çelakil, M; Demircioglu Kiliç, B; Zirhli Selçuk, S; Canpolat, N; Kargin Cakici, E; Özlü, SG; Tülpar, S; Yüksel, S; Atmis, B; Sürmeli Döven, S; Taner, S; Ertan, P; Kavaz, A; Torun Bayram, M; Kalyoncu, M; Gülleroglu, K; Kabasakal, C; Kasap Demir, B; Çiçek, RY; Bilge, I; Dönmez, O; Kara, A; Yavascan, Ö; Özçelik, G; Gezgin Yildirim, D; Güler, MA; Sönmez, F; Poyrazoglu, H; Akman, S; Topaloglu, R; Alpay, H; Bakkaloglu, SA
    Background/aim: There is limited data on COVID-19 disease in children with kidney disease. We aimed to investigate the characteristics and prognosis of COVID-19 in pediatric nephrology patients in Turkey. Materials and methods: This was a national, multicenter, retrospective cohort study based on an online survey evaluating the data between 11th March 2020 and 11th March 2021 as an initial step of a detailed pediatric nephrology COVID-19 registry. Results: Two hundred and three patients (89 girls and 114 boys) were diagnosed with COVID-19. One-third of these patients (36.9%) were between 10-15 years old. Half of the patients were on kidney replacement therapy: kidney transplant (KTx) recipients (n = 56, 27.5%), patients receiving chronic hemodialysis (n = 33, 16.3%) and those on peritoneal dialysis (PD) (n = 18, 8.9%). Fifty-four (26.6%) children were asymptomatic. Eighty-two (40.3%) patients were hospitalized and 23 (28%) needed intensive care unit admission. Fifty-five percent of the patients were not treated, while the remaining was given favipiravir (20.7%), steroid (16.3%), and hydroxychloroquine (11.3%). Acute kidney injury developed in 19.5% of hospitalized patients. Five (2.4%) had MIS-C. Eighty-three percent of the patients were discharged without any apparent sequelae, while 7 (3.4%) died. One hundred and eight health care staff were infected during the study period. Conclusion: COVID-19 was most commonly seen in patients who underwent KTx and received HD. The combined immunosuppressive therapy and frequent exposure to the hospital setting may increase these patients' susceptibility. Staff infections before vaccination era were alarming, various precautions should be taken for infection control, particularly optimal vaccination coverage.