Browsing by Author "Yalcin A."
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Item Asthma control test via text messaging: Could it be a tool for evaluating asthma control?(2013) Uysal M.A.; Mungan D.; Yorgancioglu A.; Yildiz F.; Akgun M.; Gemicioglu B.; Turktas H.; Ozkan G.; Yilmaz I.; Incioglu M.; Boyaci H.; Atis S.; Yalcin A.; Bayram N.G.; Deveci F.; Pulur D.; Ozgur E.S.; Dursun B.; Bulbul Y.; Sulu E.; Yilmaz V.Introduction: Originally, the Asthma Control Test (ACT) was designed for English-speaking patients using a paper-and-pencil format. The Turkish version of the ACT was recently validated. This article compares the paper-and-pencil and web-based texting formats of the Turkish version of the ACT and evaluates the compatibility of these ACT scores with GINA-based physician assessments of asthma control. Methods: This multicentre prospective study included 431 asthma patients from outpatient clinics in Turkey. The patients were randomized into a paper-and-pencil group (n=220) and a text messaging group (n=211). Patients completed the ACT at Visit 1, after 10±2 days, and at 5±1 week to demonstrate the reliability and responsiveness of the test. At each visit, physicians assessed patients' asthma control levels. Results: The ACT administered via texting showed an internal consistency of 0.82. For the texting group, we found a significant correlation between the ACT and physician assessments at Visit 1 (r=0.60, p<0.001). The AUC was 0.87, with a sensitivity of 78.0% and a specificity of 77.5% for a score of ≤19 for screening "uncontrolled" asthma in the texting group. Conclusion: When the Turkish version of the ACT was administered via either the paper-and-pencil or text messaging test, scores were closely associated with physician assessments of asthma control. © 2013 Informa Healthcare USA, Inc.Item Programmed cell death ligand-1 expression in gastroenteropancreatic neuroendocrine tumors(Zerbinis Publications, 2019) Oktay E.; Yalcin G.D.; Ekmekci S.; Kahraman D.S.; Yalcin A.; Degirmenci M.; Dirican A.; Altin Z.; Ozdemir O.; Surmeli Z.; Diniz G.; Ayhan S.; Bulut G.; Erdogan A.; Uslu R.Purpose: Gastroenteropancreatic tumors (GEPNETs) is a heterogeneous disease with variable clinical course. While promising therapeutic options exist for other adult cancers, there are no new molecular-based treatments developed for GEPNETs. One of the main targets of cancer immunotherapy is the Programmed Cell Death Ligand-1 (PD-L1) pathway. Our purpose was to investigate the profile of PD-L1 expression in different organs of GEPNETs and compare the conventional immunohistochemistry (IHC) with the RNA expression analysis via real time polymerase chain reaction (RT-PCR) in order to determine which patients might be appropriate for immune check point-targeted therapy. Methods: A total of 59 surgically or endoscopically resected GEPNET tissues were retrospectively collected. The expression of PD-L1 and mRNA was evaluated with IHC. Results: The expression of PD-L1 was significantly associated with the high-grade classification (p=0.012). PD-L1 mRNA expression in tumor samples appeared to be higher compared to the corresponding normal tissues. In appendix, stomach and small intestine, the expression of PD-L1 mRNA was higher in the tumor tissues compared to the respective controls. In pancreas and colon, control tissues tend to have a higher PD-L1 mRNA expression compared to tumor tissues. PD-L1 mRNA expression was higher in GEP carcinomas (p=0.0031). Conclusion: RT-PCR was found to be more sensitive in detecting PD-L1 expression than conventional IHC. This study may provide an important starting point and useful background information for future research about immunotherapy for appendix, stomach and small intestine neuroendocrine carcinomas. © 2019 Zerbinis Publications. All rights reserved.Item Best Practice Recommendations for Geriatric Dysphagia Management with 5 Ws and 1H(Korean Geriatrics Society, 2022) Umay E.; Eyigor S.; Bahat G.; Halil M.; Giray E.; Unsal P.; Unlu Z.; Tikiz C.; Vural M.; Cincin A.T.; Bengisu S.; Gurcay E.; Keseroglu K.; Aydeniz B.; Karaca E.C.; Karaca B.; Yalcin A.; Ozsurekci C.; Seyidoglu D.; Yilmaz O.; Alicura S.; Tokgoz S.; Selcuk B.; Sen E.I.; Karahan A.Y.; Yaliman A.; Ozkok S.; Ilhan B.; Oytun M.G.; Ozturk Z.A.; Akin S.; Yavuz B.; Akaltun M.S.; Sari A.; Inanir M.; Bilgilisoy M.; Çaliskan Z.; Saylam G.; Ozer T.; Eren Y.; Bicakli D.H.; Keskin D.; Ulger Z.; Demirhan A.; Calik Y.; Saka B.; Yigman Z.A.; Ozturk E.A.Background: Dysphagia is a geriatric syndrome. Changes in the whole body that occur with aging also affect swallowing functions and cause presbyphagia. This condition may progress to oro-pharyngeal and/or esophageal dysphagia in the presence of secondary causes that increase in incidence with aging. However, no study has been published that provides recommendations for use in clinical practice that addresses in detail all aspects of the management of dysphagia in geriatric individuals. This study aimed to answer almost all potential questions and problems in the management of geriatric dysphagia in clinical practice. Methods: A multidisciplinary team created this recommendation guide using the seven-step and three-round modified Delphi method via e-mail. The study included 39 experts from 29 centers in 14 cities. Results: Based on the 5W and 1H method, we developed 216 detailed recommendations for older adults from the per-spective of different disciplines dealing with older people. Conclusion: This consensus-based recommendation is a useful guide to address practical clinical questions in the diagnosis, rehabilita-tion, and follow-up for the management of geriatric dysphagia and also contains detailed com-mentary on these issues. © 2022 by The Korean Geriatrics Society.Item A new possible marker: can pennation angle defined by ultrasound predict the frailty?(Springer Science and Business Media Deutschland GmbH, 2024) Yurumez B.; Metin Y.; Atmis V.; Karadavut M.; Ari S.; Gemci E.; Yigit S.; Ozalp Ates F.S.; Gozukara M.G.; Kaplankiran C.; Cosarderelioglu C.; Yalcin A.; Aras S.; Varli M.Background: Frailty indicates older people who are vulnerable to stressors. The relation between ultrasonographic parameters of muscle and frailty among older people has yet to be investigated. Aims: The aim of the study is to investigate the relationship between frailty and the ultrasonographic measurements of the rectus femoris muscle (RFM). Methods: This cross-sectional study included 301 participants who were ≥65 years. The FRAIL questionnaire assessed frailty. The thickness, cross-sectional area (CSA), fascicle length, pennation angle (PA), stiffness, and echogenicity of RFM were assessed by ultrasound. The accuracy of parameters in predicting the frailty was evaluated by ROC analysis. Results: Of all 301 participants, 24.6% were frail. Pre-frail and frail participants had significantly lower thickness (p = 0.002), CSA (p = 0.009), and fascicle length (p = 0.043) of RFM compared to robust. PA was significantly lowest in frails (p < 0.001). The multivariate logistic regression analysis showed that PA values lower than 10.65 degrees were an independent predictor of frailty (OR = 0.83, 95% Cl: 0.70–0.97, p = 0.019). Results of ROC analysis demonstrated a satisfactory result between the PA and frailty (AUC = 0.692, p < 0.001). Discussion: Thickness, CSA, and PA of RFM were found to be lower in frail subjects, which may indicate the changes in muscle structure in frailty. Among all parameters, lower PA values were independent predictors of frailty. These findings may indicate a novel ultrasound-based method in frailty, that is more objective and unrelated to the cross-sectional evaluation. Conclusions: Ultrasonographic measurements of RFM, especially the lower PA may predict frailty in older people. As an objective and quantitative method, PA may be used to define frailty with acceptable sensitivity. © The Author(s) 2024.