Browsing by Author "Yalin Sapmaz S."
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Item Metabolic syndrome and features in children and adolescents diagnosed with mood disorders and psychotic disorders; [Duygudurum bozukluğu ve psikotik bozukluğu olan çocuk ve ergenlerde metabolik sendrom ve özellikleri](Cukurova University, Faculty of Medicine, 2019) Kavurma C.; Kara H.; Yalin Sapmaz S.; Öztürk Kara D.; Önder A.Objective: Metabolic syndrome (METS) is described as cluster of risk factors including central obesity, hyperten-sion, low high-density lipoprotein (HDL), hypertriglyceridemia and hyperglycemia. The prevalence of METs has been associated with increased symptom severity and antidepressants utilization in many psychopathologies among adult population. We aimed to evaluate the effect of psychopathologies and antipsychotics in METs devel- opment, additionally to determine METs characteristics in children and adolescents diagnosed with bipolar and psychotic disorders. Methods: Thirty children and adolescents aged between 13-20 years old of whom were diag-nosed with bipolar mood disorders, schizophrenia, schizoaffective disorder and schizophreniform according to Diag-nostic and Statistical Manual of Mental Disorders, Fourth Edition Text Revision (DSM-IV-TR) criteria were compared with a 30 healthy children and adolescents in present study. The anthropometric measurements including body weight, height, body mass index (BMI), waist circumference (WC) as well as blood pressure measurements were documented. In addition, total cholesterol, triglyceride (TG), HDL, low-density lipoprotein (LDL) and fasting blood glucose (FBG) levels were measured and METs assessed according to the IDF (International Diabetes Foundation) criteria in participants. Results: Overall the prevalence of METs was 20% (n=12) in our study. Among the METs patients, nine were (27%) in the case group, three were (10%) were in control group. The mean BMI, body weight, WC, serum TG and FBG values of the METs group were found to be statistically higher than the healthy control group. Moreover it was also found that utilization of mood-stabilizing drugs has a statistically significant effect on the development of METs. Conclusion: Psychopathologies and antipsychotic utilization have associated with an increased risk for the development of metabolic disorders and METs in the children and adolescents population. In this respect our findings may provide a new approach with the management of treatment strategies particularly in children and adolescents with high risk of METs. © 2019, Cukurova University, Faculty of Medicine. All rights reserved.Item Evaluation of the Depression, Anxiety Levels and Attitudes of Mothers of Children with Celiac Disease; [Çölyak Hastalığı Olan Çocukların Annelerinin Depresyon, Kaygı Düzeyleri ve Tutumlarının Değerlendirilmesi](Galenos Publishing House, 2020) Dogan G.; Yalin Sapmaz S.; Cagan Appak Y.; Ozturk M.; Yigit Y.; Kasirga E.Objective: In celiac disease, a gluten-free diet is required for lifelong. Difficulties experienced by children with celiac disease can also negatively affect caregivers. The aim of this study is to evaluate the anxiety and depression of mothers having a child with celiac disease, and evaluate mothers’ attitude towards their children. Method: Thirty-six children with celiac disease, their mothers, and 36 healthy controls were included in the study. The Parent Attitude Research Instrument, State–Trait Anxiety Inventory, and the Beck Depression Inventory were completed by all mothers. Results: The mothers of children with celiac disease had significantly higher scores in depression and state-trait anxiety than the mothers of the healthy children. Mothers of children with celiac disease had significantly higher scores in the attitude of overparenting, authoritarian attitude and attitude of hostility and rejection than the mothers of healthy children. Conclusion: This study revealed that having a child with celiac disease might have negative effects on mothers and their attitudes towards their children. Because of psychopathologic risks appropriate psychologic support should be provided for mothers. © Copyright Health Sciences University Bakırköy Sadi Konuk Training and Research Hospital.Item Effect of Impairment on the Prevalence and Comorbidities of Attention Deficit Hyperactivity Disorder in a National Survey: Nation-Wide Prevalence and Comorbidities of ADHD(SAGE Publications Inc., 2022) Ercan E.S.; Unsel-Bolat G.; Tufan A.E.; Karakoc Demirkaya S.; Bilac O.; Celik G.; Kılıç B.G.; Akyol Ardic U.; Yalin Sapmaz S.; Aksu H.; Yolga Tahiroglu A.; Karacetin G.; Tural U.; Aktepe E.; Rodopman Arman A.; Başgül S.; Coşkun M.; Dursun O.B.; Durukan İ.; Perdahli Fiş N.; Gençoğlan S.; Gökçen C.; Sarı Gokten E.; Görker I.; Görmez V.; Yıldız Gündoğdu Ö.; Hesapçioğlu S.T.; Kandemir H.; Mutluer T.; Nasiroğlu S.; Özcan Ö.; Şahin N.; Toros F.; Perçinel Yazici İ.; Yazici K.U.; Yulaf Y.; Yüksel T.; Bilgic A.; Altun H.; Akdemir D.; Mazlum B.; Çakın Memik N.; Foto Özdemir D.; Üneri Ö.; Ünal F.Objective: This study aimed to determine the prevalence and comorbidities of attention-deficit hyperactivity disorder (ADHD) by evaluating a large-scale nation-wide sample of children. Method: The inclusion criterion was being enrolled as a 2nd, 3rd, or 4th-grade student. A semi-structured diagnostic interview (K-SADS-PL), DSM-IV-Based Screening Scale for Disruptive Behavior Disorders, and assessment of impairment (by both parents and teachers) were applied to 5,842 participants. Results: The prevalence of ADHD was 19.5% without impairment and 12.4% with impairment. Both ADHD with and without impairment groups had similar psychiatric comorbidity rates except for oppositional defiant disorder (ODD) and conduct disorder (CD) diagnoses. Impairment in the ADHD group resulted in significantly higher ODD and CD diagnoses. Conclusion: Even when impairment is not described, other psychiatric disorders accompany the diagnosis of ADHD and may cause impairment in the future. Impairment in the diagnosis of ADHD significantly increases the likelihood of ODD and CD. © ©The Author(s) 2021.Item Neutrophil-to-lymphocyte ratio and platelet distribution width: A potential new peripheral biomarker in adolescent depression; [Nötrofil-lenfosit oranı ve trombosit dağılım genişliği: Adolesan depresyonunda potansiyel yeni bir periferik biyobelirteç](ANP Publishing, 2022) Ozturk M.; Ozkan Y.; Yalin Sapmaz S.; Kandemir H.Objective: The aim of this study is to evaluate the role of inflammation in the underlying pathophysiology of adolescent depression by evaluating neutrophile-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and hemogram parameters and also to determine whether there is a relationship between depression severity and inflammatory parameters. Method: This retrospective study was carried out on 93 major depressive disorder (MDD) patients and 65 healthy control. Clinical features such as diagnosis date, diagnosis during admission to hospital using DSM-5 diagnostic criteria, comorbid physical and psychiatric illness, drug use, previous psychiatric diagnosis, history of suicide attempt were determined. In addition, hemogram parameters of the participant included in the study in the hospital data system were used. Results: NLR and platelet distribution width (PDW) were found to be statistically significantly higher in the patient group than in the control group (p<0.05). A weakly significant positive correlation (p=0.039, r=0.165) was found between NLR and depression severity scale; a positive correlation was found between PDW and depression scale scores and depression severity scale total scores (p<0.001, r=0.317; p<0.001, r=0.320, respectively). Discussion: NLR and PDW were found to be significantly higher in patients with MDD than in healthy controls, and it supports the possible role of low-grade inflammation in the pathophysiology of MDD. In the next years, prospective studies in which hemogram parameters are evaluated together with proinflammatory cytokines will more clearly illuminate the role of inflammation and platelet activation in the etiology of MDD in adolescents. © 2022 Authors. All rights reserved.Item Exploring the Association between Depression, Suicidality, and Serum Brain-Derived Neurotrophic Factor, FAM19A5, Total Antioxidant Status, Total Oxidant Status, Oxidative Stress Index, and Cytokine Levels: A Case-Control Study of Drug-Naive Adolescents with First-Episode Major Depressive Disorder(S. Karger AG, 2024) Uzun Çakir A.D.; Çakir B.; Yalin Sapmaz S.; Bilaç Ö.; Taneli F.; Kandemir H.Introduction: Considering the importance of neuroinflammation and neurodegeneration in the pathophysiology of major depressive disorder (MDD), peripheral blood biomarkers are promising for the prediction of diagnosis and treatment outcomes. We aimed to elucidate the neuroinflammatory pathophysiology of depression by evaluating serum levels of FAM19A5 as a new biomarker of inflammatory activation, proinflammatory cytokines, brain-derived neurotrophic factor (BDNF), and oxidative stress parameters. Methods: Adolescents diagnosed with first-episode drug-naive MDD (n = 35) were compared neurobiologically healthy control group (n = 33). Serum FAM19A5 levels, cytokine levels, BDNF and oxidative stress parameters were evaluated using the enzyme-linked immunoassay method. All participants were assessed with the Level-2 Depression Severity Scale, Sleep Disturbance Scale, Somatic Symptom Scale. Results: BDNF levels were significantly higher in the patient group compared to the control group. While BDNF showed a positive correlation with all scale scores; BDNF was significantly higher in the suicide risk groups than the control group. IL-1ß levels displayed a negative correlation with the severity of sleep disturbances. Conclusions: In adolescents with MDD, inflammatory and oxidative stress markers were not raised in peripheral blood, unlike in adults. However, BDNF levels, which typically decrease in neurodegenerative conditions, were higher in those with MDD. © 2024 S. Karger AG, Basel.