Browsing by Author "Yaman, M"

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    Clinicopathological characteristics and mutation profile of BRAF and NRAS mutation in cutaneous melanomas in the Western Turkish population
    Evrenos, MK; Temiz, P; Çam, FS; Yaman, M; Yoleri, L; Ermertcan, AT
    Background/aim: Malignant melanoma is the most common cause of death due to skin cancers. The most common mutations in RAF-RAS pathway from tumor oncogenes are BRAF and NRAS. In this study, we analyzed the frequency of BRAF and NRAS gene mutations and investigated their association with clinicopathological features of melanomas in the Turkish population. Materials and methods: 65 primary cutaneous melanoma were included in the study. The mutations were evaluated with real-time PCR-based PCR-array through allele-specific amplification, and the results were correlated with various clinicopathological characteristics. Results: 52.3% of the patients were female and 47.7% were male. The mean age of the patients with a mutation was lower than those without mutation. 16 patients had BRAF mutation. 12 patients had NRAS mutation. NRAS mutation was statistically more common in men (P = 0.036). The number of mitoses increased with the increase of the tumor thickness (P = 0.003). There was more mitosis in the presence of ulceration (P = 0.05). A total of 41.7% of NRAS mutations had adjuvant chemotherapy. Conclusion: We found lower mutation rate when compared to regional studies. NRAS mutation was common in men. This is the first study from our region evaluating the prognostic value of clinical stage and necessity of adjuvant treatment with the presence of BRAF and NRAS mutations.
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    Modified Temporalis Muscle Flap for Eyelid Reanimation
    Evrenos, MK; Bali, ZU; Yaman, M; Yoleri, L
    The reanimation of both upper and lower paralytic eyelids requires dynamic procedures for longevity of correction. Temporalis muscle ensures the criteria for reanimation and is used widely as a result. Many modifications were described to improve the success of the classical technique. One of these modifications was reported by the senior author in 1999. Twice as much muscle mass (in thickness) to the upper eyelid than the lower was taken and passed submuscularly 5 to 6 mm away from the limbus and a thinner split was passed subcutaneously beneath the lower cilia. The aim of this study was to present the outcomes of the technique after 38 operations with 37 patients and to describe deep temporalis musculofascial-fatty flap to recover depression of temporalis muscle split donor area. Seventeen lower eyelids were evaluated as mild, 12 were as moderate, and 9 were as severe ectropion. One upper eyelid was evaluated as mild, 14 were as moderate, and 23 were as severe lagophthalmos preoperatively. Mean follow-up time was 28.8 months. Five patients had mild ectropion and 2 patients had mild lagophthalmos postoperatively at last follow-up. Two patients needed medial canthal tendon reinsertion secondary to relaxation of fixation suture at medial canthus. All patients tolerated the procedure and all complaints were resolved without creating a notable cosmetic deformity.
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    Idiopathic Scrotal Elephantiasis
    Evrenos, MK; Özkaya, M; Yaman, M; Yoleri, L
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    ECCRIN POROCARCINOMA: OUR CLINICAL EXPERIENCES IN TREATMENT AND FOLLOW-UP OF THIS RARE LESION WITH A HIGH INCIDENCE OF LOCAL AND REGIONAL RECURRENCES
    Kerem, H; Yaman, M; Bali, U; Öksüz, M; Yoleri, L
    Introduction: Eccrin porocarcinoma is a rare tumor originating from intraepithelial parts of eccrin sweat glands. It has a bad prognosis and very different biological behaviors with a high recurrence rate and metastasis to both local skin and lymphatics. Five cases with different clinical and histopathological properties treated in our clinic were presented to add some contribution to the literature. Material and Methods: Five cases of eccrin porocarcinoma patients treated in our clinic between 2009 and 2013 were analyzed according to age, sexuality, tumor localization and histopathological records. Results: All patients were women and their mean age was 77. Localization of tumors was as follows: medial of thigh, upper lip, deltoid region, gluteal region and left cheek. Sizes of the tumors were between 3 and 16 cm. Two patients had concurrent regional lymph node metastasis and they had lymphatic dissection procedures. One patient with local recurrence was lost after a two-year follow-up period. Conclusions: Eccrin porocarcinoma is a rare tumor and there are insufficient numbers of reports about its diagnosis, treatment, results and follow-up protocols in the literature. The patients have to be in a close follow-up about the local and regional recurrences.
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    Case Report: Gorham-Stoute Syndrome with Involvement of Majority of Mandible, and Partial Maxillary, Temporal and Zygomatic Bones
    Evrenos, MK; Özkaya, M; Yaman, M; Proff, LY
    The Gorham-Stout syndrome is a rare condition in which spontaneous, progressive resorption of bone occurs. The diagnosis is based on clinical, radiological and histopathological findings after excluding other etiologies and as a result it is often delayed. We present the case of a 21-year-old male diagnosed with Gorham-Stout syndrome with involvement of the majority of the mandible, partial involvement of right maxillary, temporal and zygomatic bones and discuss its diagnostic and therapeutic features.
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    The relationship of anthropometric measurements with psychological criteria in female athletes
    Cangur, S; Yaman, C; Ercan, I; Yaman, M; Tok, S
    Sports and exercise settings as well as other socio-cultural environments emphasize a thin and physically fit female body. However, there is a clear need for a better understanding of the physical and psychological correlates of social physique anxiety and body image dissatisfaction in female athletes. This study aimed to examine the association of the social physique anxiety, body image satisfaction, and personality with the anthropometric measurements in female college athletes according to their sport type using the Co-Plot technique. The sample included 63 female athletes ranging in age from 18 to 26. Results of the Co-Plot analysis revealed a significant association among social physique anxiety, personality and anthropometric measurements. This means that certain physical measurements may lead to greater social physique anxiety and body image dissatisfaction in female athletes. It was found that females having higher levels of social physique anxiety and thus, lower levels of body image satisfaction may be less emotionally stable and more negatively perfectionist. In conclusion, the results of the present study provided evidence to the claim that both physical self-perception and anthropometric measurements may be closely associated with psychological criteria in female athletes.