Browsing by Author "Yaman Y."

Now showing 1 - 7 of 7
  • No Thumbnail Available
    Item
    Congenital amegakaryocytic thrombocytopenia: Three case reports from patients with different clinical diagnoses and somatic abnormalities
    (Lippincott Williams and Wilkins, 2015) Yildirim A.T.; Güneş B.T.; Oymak Y.; Yaman Y.; Özek G.; Carti Ö.; Yeşilipek A.; Vergin C.
    The congenital amegakaryocytic thrombocytopenia (CAMT) is a syndrome characterized by preservation of granulocytic and erythroid cells during genesis, with a gradual or progressive decrease in the number of megakaryocytic series of cells in the bone marrow. At later times, most patients develop aplastic anemia. It is important to rule out specific causes of thrombocytopenia that develop in the early stages of CAMT. Typically, there are no specific somatic abnormalities that accompany this deadly disease. Here we present three CAMT cases that presented with different clinical diagnoses, with various physical anomalies in two of those cases. The first patient was examined because of a cytomegalovirus infection. The second patient had been referred with a suspected neonatal alloimmune thrombocytopenia, whereas the third patient presented with chronic immune thrombocytopenic purpura. Subsequently, all three patients were diagnosed with CAMT. Two of the patients had physical anomalies. In particular, the first patient had a duplex urinary system. To our knowledge, this is the first patient with CAMT to have a duplicated collecting sysem. The second patient had a secundum atrial septal defect, an atypical facial appearance, and growth retardation. Since CAMT could also be observed outside the neonatal period, the differential diagnosis for thrombocytopenia should be considered for all age groups. Moreover, it should be considered that CAMT may also be accompanied with somatic abnormalities. © 2015 Wolters Kluwer Health, Inc.
  • No Thumbnail Available
    Item
    Comparing the quality of life of patients with hemophilia and juvenile idiopathic arthritis in which chronic arthropathy is a common complication
    (Lippincott Williams and Wilkins, 2015) Oymak Y.; Kaygusuz A.; Turedi A.; Yaman Y.; Eser E.; Cubukcu D.; Vergin C.
    Introduction: Hemophilia is a genetic disorder in which recurrent joint bleeding causes arthropathy. Inflammation and degeneration play roles in the pathogenesis of hemophilic arthropathy. Patients with juvenile idiopathic arthritis (JIA) experience a similar inflammatory degenerative joint disease. A comparison of different patients with common pathogenetic features may identify unique features helpful in terms of the follow-up. Aim: We compared the quality of life (QoL) of patients with hemophilia and JIA, and healthy controls, using a generic QoL scale, Kidscreen and Disabkids Questionnaires (KINDL). Differences among groups were evaluated in terms of sociodemographic characteristics and clinical parameters affecting the QoL. Methods: We included 33 hemophilia patients, 19 JIA patients, and 32 healthy individuals aged 4 to 18 years. Sociodemographic characteristics (the age, the maternal educational status, the place of residence, the size of the household, the household income, divorced parents) were noted, and the KINDL was administered to all participants. Clinical parameters associated with arthropathy (the functional independence score [FISH], the hemophilia joint health score [HJHS], the arthropathic joint count, and the painful joint count) were documented. Differences in frequencies and medians among the groups were evaluated using the w2, the Mann- Whitney U, and the Kruskal-Wallis tests. Results: All KINDL dimensions were above 50, reflecting "good conditions" in the 2 patient groups. No difference between patients with hemophilia and JIA was evident in terms of the clinical parameters of FISH, the HJHS, or the arthropathic or painful joint counts (P>0.05). Sociodemographically, only the frequency of literate mothers was lower in patients with hemophilia than in those with JIA and healthy controls (P=0.03). Patients with JIA scored more higher on the KINDL dimension of chronic illness than those with hemophilia (P=0.02). The FISH score correlated with the total QoL score in both patients with hemophilia and JIA (r=0.39, P=0.03 and r=0.48, P=0.04, respectively). Conclusions: Although no difference was evident between the patient groups in terms of clinical parameters associated with arthropathy, JIA patients coped better with illness than those with hemophilia. JIA patients had a higher proportion of literate mothers than hemophilia patients; this may affect a patient's ability to cope with issues relating to chronic illness. Implementation of an educational program for mothers of hemophilia patients, during follow-up, may improve the patient's QoL. Also, hemophilia patients should be assisted to improve their QoL in the dimensions of self-esteem and schooling. Lastly, the evaluation of functional disability by FISH in hemophilia patients is important because the FISH score correlated with the total QoL score, as revealed by KINDL. In JIA patients also, functional disabilities caused by arthropathy affected the QoL. Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.
  • No Thumbnail Available
    Item
    Energy Efficient Buildings with Algae
    (IOP Publishing Ltd, 2021) Yaman Y.; Tokuç A.; Sener I.; Altunacar N.; Köktürk G.; Deniz I.; Ezan M.A.
    The biggest part of the energy consumption of buildings is for thermal comfort. Awareness on climate change and concerns about the depletion of natural resources made the necessity to use renewable energy sources in buildings evident. In this context, microalgae have high surface efficiency and consume inorganic carbon, thus enabling carbon-neutral operation. They can be integrated into building façades with photobioreactors to reduce energy demands. This paper aims to clarify and discuss the role of microalgal technologies in energy-efficient architecture. The thermal performance and energy generation properties of microalgae façades are comprehensively reviewed. The results show that microalgae provide dynamic shading and thermal insulation, thus have the potential to significantly reduce the thermal load and energy demands of buildings and increase the building performance. Consequently, besides the thermal performance of microalgae façades, evaluation of daylight, lighting, environmental and cost performance, technical applicability and aesthetics are necessary. © Published under licence by IOP Publishing Ltd.
  • No Thumbnail Available
    Item
    Effect of an algae integrated water wall on energy consumption and CO2 emission
    (Inderscience Publishers, 2023) Altunacar N.; Ezan M.A.; Yaman Y.; Tokuç A.; Budakoğlu B.; Köktürk G.; Deniz İ.
    This study develops a transient thermal model for an indoor in which a photobioreactor (PBR) is integrated into one of its facades. Thermal comfort, energy consumption, and carbon dioxide (CO2) emissions were interpreted in different design scenarios for Izmir, Turkey. As a result, it was determined that a 20% window-to-wall ratio (WWR) provides the most comfortable results, and the algae usage increases the annual comfort by 19% and reduces the heating/cooling demand. Compared to a water wall, it provides a 17% reduction in energy consumption and CO2 emissions. Copyright © 2023 Inderscience Enterprises Ltd.
  • No Thumbnail Available
    Item
    Economic burden of short-acting beta-2 agonist (SABA) overuse among asthma patients in Türkiye: a cost analysis with respect to the updated GINA treatment recommendations
    (BioMed Central Ltd, 2024) Yorgancıoğlu A.; Aksu K.; Cura C.; Yaman Y.; Dinç M.; Malhan S.; Erbay M.; Pekbak G.; Ediger D.; Anar C.; Sevinç C.; Erel F.; Doğan B.C.; Çilli A.; Erge D.; Ceylan E.; Yormaz B.; Süerdem M.; Gülbaş G.; Yuluğ D.P.; Naycı S.A.; Özer A.; Altunok E.; Hanta İ.; Damadoğlu E.; Kalyoncu A.F.; Karakaya G.; Erkekol F.Ö.; Altuntaş M.; Aksu F.; Baççıoğlu A.; Kalpaklıoğlu F.; Mungan D.; Oğuzülgen K.; İnce Ö.; Gemicioğlu B.; Çağatay T.; Bulut İ.; Altıntaş N.; Kızılırmak D.
    Background: This cost of illness study aimed to determine economic burden of short-acting β2-agonist (SABA) overuse in Türkiye from payer perspective with respect to the updated GINA 2022 treatment recommendations. Methods: A total of 3,034,879 asthma patients comprised the study population, via estimations extrapolated from the Türkiye arm of the global SABINA III study. The economic burden (costs related to the drug use and severe exacerbations) was compared in subgroups of overall (≥ 0 canisters/year) vs. GINA-recommended (0–2 canisters/year, hypothetical population) SABA use and in subgroups of appropriate use (0–2 canisters/year, real population) vs. overuse (≥ 3 canisters/year) of SABA with extrapolation of SABINA Türkiye data to the Türkiye asthma population. Results: Recommended SABA use was predicted to prevent 127,505 of 157,512 severe exacerbations per year in mild asthma patients and 2,668,916 of 3,262,800 severe exacerbations per year in moderate-severe asthma patients. Annual cost burden of not applying recommended SABA use (overall [≥ 0 canisters/year] vs. GINA-recommended [0–2 canisters/year] SABA use) in mild asthma and moderate-severe asthma patients was calculated to be €20.43 million and €427.65 million in terms of severe exacerbations, and to be €829,352 and €7.20 million in terms of drug costs, respectively. The total annual economic burden arising from not applying recommended SABA use was estimated to be €456.11 million. Appropriate use (0–2 canisters/year) vs. overuse (≥ 3 canisters/year) of SABA was associated with decreased frequency of severe exacerbations per year in mild asthma (from 129,878 to 27,634) and moderate-severe asthma (from 2,834,611 to 428,189) patients. SABA overuse in mild and moderate-severe asthma patients was estimated to yield an additional annual cost of €16.38 million and €385.59 million, respectively in terms of severe exacerbations, and a total €11.30 million additional drug cost. The overall annual economic burden arising from SABA overuse was estimated to be €413.27 million. Conclusions: The estimated annual total economic burden arising from not applying recommended SABA use (€456.11 million) and SABA overuse (€413.27 million) with respect to the updated GINA 2022 treatment recommendations indicates the substantial cost burden of SABA overuse to the Turkish National Health System, corresponding up to 26% of the total direct cost of asthma reported in our country. © The Author(s) 2024.
  • No Thumbnail Available
    Item
    Energy Use and Lighting of Algal Green Buildings
    (EDP Sciences, 2024) Tokuç A.; Yaman Y.; Budakoğlu B.; Gülden Köktürk G.; Deniz I.; Ezan M.A.
    Green buildings can provide a growth environment for microalgae growth on their façades, where a closed environment mimicks the organisms' natural environment and functions as a window. This study investigates such a façade's effect on energy saving by optimizing the performances of useful daylight illuminance (UDI) and energy use intensity (EUI) in the Mediterranean climate. The study was carried out in two stages. The first stage is a parametric study using the Colibri tool to look at the algae content and the effect of WWR for the north and south orientations. Meanwhile the second stage adds different design parameters of orientation, window type, WWR, wall type and thickness, insulation thickness. Optimization of UDI and EUI separately allows an in-depth discussion of these parameters for both performances. The obtained parametric results show the effects of WWR and algae content. Regression analysis explains that WWR has a linear relationship with EUI and a polynomial relationship with UDI. There is no such relationship for algae content, yet it changes UDI results the most (%46.22-81.66 for 50% WWR). Then, computational simulations regard effects of other factors for performance optimization. © The Authors.
  • No Thumbnail Available
    Item
    Photobioreactor facade panels: enhancing comfort, reducing energy use, and capturing carbon in temperate continental climates
    (Springer Nature, 2025) Yaman Y.; Tokuç A.; Deniz İ.; Ezan M.A.; Köktürk G.; Dalay M.C.; Demirel Z.
    Buildings contribute around 37% to global carbon emissions, prompting a growing interest in innovative carbon capture technologies. Among these, the integration of microalgae-based photosynthesis into building facades has emerged as a promising solution. This approach offers multiple benefits, including carbon sequestration, reduced energy consumption, dynamic shading, and improved thermal regulation. This paper investigates the impact of integrating photobioreactor (PBR) facade elements, specifically on the south-facing facade of an office building in a temperate continental climate. The study evaluates the system’s effects on indoor thermal and visual comfort, energy production, and carbon dioxide (CO2) sequestration for three distinct PBR facade alternatives and compares them with a commercial curtain wall. The continuous PBR system varies in performance depending on production intensity, necessitating an initial optimization for thermal and visual comfort alongside energy use. Simulations were conducted using Rhinoceros/Grasshopper plug-ins, with optimization performed via the Octopus tool. The results, focusing on the Chlorella vulgaris algae strain, demonstrate that all facade configurations achieve a daylight performance exceeding 50% and meet desired thermal comfort levels. Although the energy generated by the PBR facade does not fully offset the building’s energy consumption, annual CO2 sequestration ranges from 84.87 kg to 770.13 kg. This study concludes that microalgae facades offer a viable strategy for enhancing a building’s energy performance and reducing CO2 emissions, without compromising occupant comfort. Additionally, the findings provide valuable insights for designers, researchers, investors and stakeholders and provides a payback period of these systems (16–24 years) for commercialization in the building industry. © Jiangnan University 2024.