Browsing by Author "Yasar, A"
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Item Effect of Subcutaneous Immunotherapy on The Natural Course of Allergic Diseases in Pediatric Patients: A Real-Life CohortYilmaz, O; Yasar, A; Simsek, Y; Alpdogan, S; Kunay, B; Yuksel, HAim: Specific allergen immunotherapy (SIT) is the only disease-modifying therapy for allergic diseases. We aimed to examine the effect of subcutaneous specific allergen immunotherapy (SCIT) applications on the prognosis of asthma and allergic rhinitis in pediatric cases in real-life settings. Methods: The study was designed as a retrospective cohort study. Patients with asthma and/or allergic rhinitis aged between 5 and 18 years old were enrolled between 2010 and 2015. The groups who received SCIT and who did not receive were compared in terms of disease severity parameters in follow-up recorded in their files. Results: A total of 298 cases, among which 140 received subcutaneous specific allergen immunotherapy. The frequency of asthma, allergic rhinitis, and co-morbidity was similar between the two groups. In the first year of the follow-up, asthma symptoms severity was not significant between the two groups; however, both asthma and allergic rhinitis symptoms were significantly lower in the SCIT patients at the end of the third year of follow-up. While the follow-up rate for three years or more was 62% in the group that received subcutaneous specific allergen immunotherapy, it was 38% in the group that did not receive. Conclusion: These results showed that SIT is an effective treatment modality in real-life settings with low side effects in pediatric patients with uncontrolled asthma and allergic rhinitis despite medical treatment.Item Comparing mesh and compressor nebulizers in pulmonary function test in pediatric asthma attacks: A double-blind randomized comparative clinical trialOkay, B; Hatipoglu, HU; Okay, ZU; Sahin, K; Yasar, AObjective: Asthma is a prevalent global health issue, especially affecting children in numerous countries. Our study aimed to determine the most effective nebulizer type by comparing the effects of mesh nebulizers (MNs) and compressor nebulizers (CNs) on spirometry tests in pediatric asthma attacks. Methods: The prospective, double-blind, randomized comparative study was conducted with patients aged 7-15 presenting with asthma attacks. The participating patients were divided into two groups by randomization: those using CNs and those using MNs. A pulmonary function test was performed before and after giving the patients three doses of salbutamol inhaler at 20-minute intervals, and changes in the test were recorded. Results: The increase in peripheral oxygen saturation was higher in the MN group, although this difference was not statistically significant (p = 0.391). However, statistically significant differences were observed in the decrease in respiratory rate (RR;/min; p = 0.002) and the increase in heart rate (/min; p = 0.022). The respiratory function test indicated a higher change in forced vital capacity (FVC) and peak expiratory flow in the MN group than the CN group, although this difference was not statistically significant (p = 0.258 and 0.256). However, statistically significant changes were observed in the forced expiratory volume in 1 second (FEV1) and forced expiratory flow at 25%-75% of FVC (FEF25-75; p = 0.001 and 0.043). Conclusion: MNs show superior improvement in vital signs and pulmonary function, particularly in RR, FEV1, and FEF25-75. MNs may be preferred for more effective treatment despite heart rate elevation.Item Epithelial Barrier Dysfunction and Innate Immune System Interaction in Allergic ResponseYuksel, H; Tayanc, E; Yilmaz, O; Yasar, A; Inan, SItem Tetranectin and Cortisol as Markers of the Relationship Between Perinatal Maternal Depression-Anxiety Symptoms and Recurrent Wheezing in the First Year of LifeYilmaz, O; Polat, AC; Cingoz, FO; Ay, P; Alkin, T; Taneli, F; Yasar, A; Hasdemir, S; Simsek, Y; Yuksel, HItem Quality of life, anxiety and depression in patients with androgenetic alopeciaBilaç, C; Kutlubay, Z; Öztürkcan, S; Serdaroglu, S; Sahin, MT; Yasar, A; Dinç, GBackground: Androgenetic alopecia (AGA) is a common form of hair loss, which can result in body image disorder and negative social feelings. Aim: The aim of this study was to evaluate the quality of life (QoL) and the risk of anxiety and depression in AGA patients. Method: Sociodemographic data of the patients and clinical severity of the disease were recorded. The QoL score of patient and controls was evaluated with DLQI and SF-36 instruments, their anxiety and depression risks were evaluated with HAD (HAD-A and HAD-D) instruments. Results: Sixty-eight patients with AGA were included in our study. Young male AGA patients' quality of life levels were found to be low according to role limitations due to emotional problems, emotional wellbeing and emotional scores of SF-36 scale and younger female AGA patients quality of life levels were also found to be low according to role limitations due to emotional problems, and emotional scores of SF-36 scale. The DLQI scores of patients of both sex were found to be significantly higher compared to control group. According to anxiety and depression risk assessment with HAD scale, it was found that 28.6% and 73.5% of patients were prone to suffer from anxiety and depression respectively. Conclusion: Apart from managing alopecia, practitioners should be aware of the possible psychosocial distress of AGA patients and manage accordingly.Item Nicotine-Induced Epithelial-Mesenchymal Transformation (EMT): Difference Between Normal and Asthmatic Bronchial EpitheliumYuksel, H; Ocalan, M; Yilmaz, O; Tunca, S; Yasar, A; Akogullari, D; Vatansever, SItem Maternal psychiatric status and infant wheezing: The role of maternal hormones and cord blood cytokinesYilmaz, O; Yasar, A; Polat, AC; Ay, P; Alkin, T; Taneli, F; Cingoz, FO; Hasdemir, PS; Simsek, Y; Yuksel, HRationale Maternal psychosocial stress might be associated with development of allergic diseases in the offspring. Objectives To evaluate the association of maternal depression and anxiety with ever wheezing and recurrent wheezing among infants and to assess the role of maternal hypothalamo-pituatary-adrenal axis changes and fetal immune response in this association. Methods This study encompasses two designs; cohort design was developed to evaluate the association of prenatal depression with development of wheezing in infants while nested case-control design was used to assess the role of maternal cortisol and tetranectin and cord blood interleukin 13 and interferon gamma. Results We enrolled 697 pregnant women. Elementary school graduate mother (odds ratio [OR] = 1.5, p = .06), maternal smoking during pregnancy (OR = 3.4, p = .001), familial history of asthma (OR = 2.7, p < .001) increased the risk of ever wheezing. Elementary school graduate mother (OR = 2.6, p = .002), maternal smoking during pregnancy (OR = 4.8, p < .001) and familial history of asthma (OR = 1.7, p = .01) increased the risk of recurrent wheezing. Maternal previous psychiatric disease, or Edinburgh Postnatal Depression Scale or Spielberger State-Trait Anxiety Inventory scores were not associated with wheezing. Maternal tetranectin levels were significantly higher among never wheezers compared to the ever wheezers (264.3 +/- 274.8 vs. 201.6 +/- 299.7, p = .04). Conclusions In conclusion, the major risk factors for ever wheezing and recurrent wheezing were maternal smoking, level of education and family history of asthma. However, maternal depression and anxiety were not determined as risk factors for wheezing. Maternal tetranectin carries potential as a biomarker for wheezing in the infant.Item Prevalence of and factors related to tobacco smoking in children with asthmaYüksel, H; Yasar, A; Türkeli, A; Kalkiner, CS; Yilmaz, OItem Cord blood Interleukin-13 and IFN-Gamma levels As Biomarkers of Ever-Wheezing in the First Year of LifeYilmaz, Ö; Yasar, A; Ay, P; Polat, AC; Cingöz, FO; Alkin, T; Taneli, F; Hasdemir, S; Basbay, YS; Yüksel, HItem IMPULSE OSCILLOMETRY REFERENCE VALUES FOR TURKISH CHILDREN AGED THREE TO EIGHT YEARSYilmaz, O; Tunca, S; Lombardi, E; Yasar, A; Yuksel, HItem Infantile Glottic Hemangioma Bronchoscopic Evaluation and Propranolol TreatmentYüksel, H; Yasar, A; Gürbüz, N; Bizbirlik, ZI; Yilmaz, ÖItem URINARY STONE RELATED URINARY TRACT INFECTION CAUSED BY RAOULTELLA ORNITHINOLYTICA IN A CHILD: A CASE REPORTKaraci, M; Yasar, ARaoultella ornithinolytica is one of the three species of Raoultella. The present case report describes a two-year-old child who had complaints of discomfort and fever, and Raoultella ornithinolytica in his urinary culture. Grade-2 hydronephrosis and a 7.5-mm urinary stone were detected in the patient's left ureter. The stone was expelled upon consultation with pediatric urology department. The patient was treated according to culture antibiotic sensitivity report and continued to be followed-up.Item Effect of subcutaneous allergen immunotherapy on the natural course of allergic diseases: a retrospective cohort studyYilmaz, O; Yasar, A; Simsek, Y; Alpdogan, S; Kunay, B; Yuksel, HItem Is Allergic Rhinitis Associated with Enuresis Nocturna in Childhood?Yasar, A; Yilmaz, Ö; Yüksel, HObjektive:Allergic rhinitis is the most common form of non-infectious rhinitis and is manifested with the symptoms of nasal congestion, sneezing, nasal discharge, and itching. Primary enuresis nocturna is involuntary urination while asleep after five years, at which bladder control usually begins. Our objective was to evaluate the relationship between allergic rhinitis and primary enuresis nocturna in childhood in this research.Methods:We included 300 children with allergic rhinitis and 300 control cases between the age of 5 and 17 years. With allergic rhinitis cases, age, gender, body mass index percentile, other allergic disorders, allergic rhinitis diagnosis age, allergic rhinitis severity and distribution, presence of primary enuresis nocturna, and presence of primary enuresis nocturna in the family were recorded. Subjects with disorders causing enuresis were excluded from the study.Results: The mean age in the allergic rhinitis and control groups was 9.6 & PLUSMN; 3.4 vs. 10.0 & PLUSMN; 3.1 years, respectively (p=0.15). There was no statistical difference between the two groups in terms of gender, age, body mass index percentile, and primary enuresis nocturna presence in the family (p=0.29, p=0.15, p=0.46, p=0.17; respectively). Primary enuresis nocturna was significantly higher in allergic rhinitis cases (p=0.02). Primary enuresis nocturna was significantly higher in boys than in girls (p=0.007). There is a significant difference in age and gender between those with and without primary enuresis nocturna in allergic rhinitis groups (p=0.001, p=0.01, respectively)Conclusion: We conclude that as allergic rhinitis increases the incidence of primary enuresis nocturna and worsens the quality of life, its treatment should not be neglected.Item Inflammatory markers in exhaled breath condensate in nonasthmatic children with food allergyYilmaz, O; Tunca, S; Yasar, A; Ocalan, M; Taneli, F; Yuksel, HAllergy is a systemic inflammation; therefore, although the allergic symptom may be seen in a specific organ system, the effects of this inflammation may be seen in other organs. interleukin (IL) IL4, IL5 and IL13 are the major Th2 cytokines and e-cadherin is an epithelial barrier protein. The objective of this research was to assess indicators of inflammation specific to Th2 responses and proteins related to the protective barrier of the airway's inner lining. These assessments were conducted using exhaled breath condensate (EBC), which provides insights into peripheral airway conditions of children suffering from food allergies. The study had 24 patients with food allergy and 24 control individuals younger than three years of age with no history of food reaction. The diagnosis of food allergy was based on food allergen-specific IgE and skin prick test positivity in our clinic and oral food testing in selected cases. EBC samples were obtained by Ecoscreen (Jaegar, Hoechberg, Germany). IL4, IL5, IL13 and E-cadherin levels were measured in these samples by enzyme linked immunoassay. The group of children with food allergies, consisting mainly of 14 girls, had a median age of 16 months, whereas the control group, which included 11 girls, had a median age of 15 months (p = 0.89). Comparing the two groups, children with food allergies exhibited notably lower levels of IL-13 in the EBC compared to the control group (median values of 59.14 and 76.36, respectively, p = 0.02). Conversely, the concentration of IL-4 in the EBC was significantly higher in children with food allergies (median values of 1.94 and 1.29, respectively, p = 0.003). However, the levels of IL-5 and e-cadherin showed no significant differences between the two groups (with p-values of 0.74 and 0.09, respectively) as shown in table 1. High level of IL-4 despite the low level of IL-13 in the EBC of children having food allergy may be indicative of an early inflammatory phase that is not yet in the effector phase. Studies about the evolution of this process later in life are needed to assess the role of airway inflammation in children with food allergy who develop asthma.Item Verrucous hemangiomaYasar, A; Ermertcan, AT; Bilaç, C; Bilaç, DB; Temiz, P; Öztürkcan, SItem Pilot Study: Prognostic Value of Impulse Scillometry for Recurrence of Wheezing in Children with First Episode of WheezingYilmaz, O; Yasar, A; Ocalan, M; Saglik, K; Yuksel, HItem Hypohidrotic Ectodermal Dysplasia Associated with Glucose-6-Phosphate Dehydrogenase DeficiencyErmertcan, AT; Yasar, A; Kayhan, TC; Gülen, H; Ertan, PHypohidrotic ectodermal dysplasia (HED) is a syndrome characterized by hypodontia, hypotrichosis, and partial or total ecrine sweat gland deficiency. The most prevalent form of HED is inherited as an X linked pattern. Glucose-6-phosphate dehydrogenase (G-6-PD) deficiency is an X-linked recessive disease, which leads to hemolytic anemia and jaundice. It is expressed in males, while heterozygous females are usually clinically normal. A 12-year-old boy with the complaints of hair and eyebrow disturbances, teeth disfigurement, decreased sweating, and xerosis presented to the outpatient clinic. Dermatological examination revealed sparse hair and eyebrows, conical- shaped teeth, xerosis, syndactylia, transverse grooves, and discoloration of nails. Laboratory findings indicated anemia. His 3-year-old sister also had sparse hair and eyebrows, xerosis, and syndactylia. We learned that the patient had a previous history of neonatal jaundice and a diagnosis of G-6-PD deficiency. Although it has been shown that loci of ectodermal dysplasia and G-6-PD deficiency genes are near to one another, we did not find any case study reporting on occurrence of these two genetic diseases together. With the aspect of this rare and interesting case, the relationship between HED and G-6-PD deficiency was defined. (Ann Dermatol 23(S1) S8 similar to S10, 2011)Item Serum homocysteine, vitamin B12, folic acid levels and methylenetetrahydrofolate reductase (MTHFR) gene polymorphism in vitiligoYasar, A; Gunduz, K; Onur, E; Calkan, MThe aim of this study was to determine serum vitamin B12, folic acid and homocysteine (Hcy) levels as well as MTHFR (C677, A1298C) gene polymorphisms in patients with vitiligo, and to compare the results with healthy controls. Forty patients with vitiligo and 40 age and sex matched healthy subjects were studied. Serum vitamin B12 and folate levels were determined by enzyme-linked immunosorbent assay. Plasma Hcy levels and MTHFR polymorphisms were determined by chemiluminescence and real time PCR methods, respectively. Mean serum vitamin B12 and Hcy levels were not significantly different while folic acid levels were significantly lower in the control group. There was no significant relationship between disease activity and vitamin B12, folic acid and homocystein levels. No significant difference in C677T gene polymorphism was detected. Heterozygote A1298C gene polymorphism in the patient group was statistically higher than the control group. There was no significant relationship between MTHFR gene polymorphisms and vitamin B12, folic acid and homocysteine levels. In conclusion, vitamin B12, folate and Hcy levels are not altered in vitiligo and MTHFR gene mutations (C677T and A1298C) do not seem to create susceptibility for vitiligo.Item Two different methods of lidocaine inhalation before diagnostic flexible bronchoscopy: effects on post-bronchoscopy respiratory symptomsYüksel, H; Yasar, A; Açikel, A; Topçu, I; Yilmaz, ÖBackground/aim: Use of topical anesthesia before flexible bronchoscopy for the evaluation of the upper airways prevents cough and stridor during and after the procedure while reducing the need for sedation. In practice, lidocaine is the medication of choice before bronchoscopy. There various types of nebulizers used for inhalation treatments. In this study, we compared the respiratory tract symptoms after flexible bronchoscopy between children who received pre-procedure topical lidocaine with mesh or jet nebulizers. Materials and methods: We enrolled 4-18 years old subjects that underwent flexible bronchoscopy due to treatment-resistant asthma in this retrospective case-control study. Twenty subjects received topical lidocaine with jet nebulizers while 20 received it with mesh nebulizers. Age, sex, duration of bronchoscopy, duration of anesthesia, time to awaken, and time to recovery were recorded as well as cough and laryngospasm scores after flexible bronchoscopy. Results: Severe cough after flexible bronchoscopy was not encountered in the mesh nebulizers group but was seen in 10% of the jet nebulizers group (p = 0.027). On the other hand, age, sex, duration of bronchoscopy, duration of anesthesia, time to awaken, and time to recovery were not significantly different between the mesh and jet nebulizer groups (p = 0.44, 0.34, 0.51, 0.88, 0.88, and 0.22, respectively). Moreover, croup and laryngospasm scores between the two groups were similar (p = 0.62, 0.50 respectively). Cough score was significantly worse jet nebulizers group (p = 0.03). Conclusion: Topical lidocaine application with mesh nebulizers decreases the most common complication, cough, after flexible bronchoscopy in children more effectively compare to jet nebulizers. Thus, mesh nebulizers may be a faster way of nebulization before flexible bronchoscopy as an alternative to jet nebulizers.