Browsing by Author "Yener A.S."

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    The comparison of insülin resistance, laboratory results and clinical factors in gestational diabetes mellitus patients with normal pregnant women without glucose intolerance; [Gestasyonel Diabetes Mellitus ve Normal Glukoz Toleransna Sahip Gebelerde nsülin Direnci, Laboratuvar Bulgular ve Klinik Faktörlerin Karşilaştirilmasi]
    (2013) Pala H.G.; Özalp Y.; Saatli Gerçeklioglu G.; Yener A.S.; Uysal S.; Önvural A.
    Objective: To compare insulin resistance, laboratory results and clinical factors in gestational diabetes mellitus (GDM) patients with normal pregnant women without glucose intolerance. Material and Methods: 55 GDM patients and 50 normal pregnant women who were between 24th and 28th week of gestation included in this study. 25 patients who had not completed antenatal visits or had developed complications during pregnancy period were excluded from study. Statistical analysis was performed for the rest of 40 GDM and 40 normal pregnant women without glucose intolerance. Total cholesterol, triglyceride, high density lipoprotein (HDL), low density lipoprotein (LDL), HbAlc, glucose, insulin and c-peptide levels were measured between 24th-28th week of gestation after starvation in maternal blood sample which included into study. The relationship between these groups' measurements and the other established clinical-laboratory factors were investigated. Results: HbAlc, c-peptide, insulin, glucose, triglyceride and LDL levels were significantly higher in GDM patients compared with the group of patients with normal glucose tolerance. There was not significant difference in terms of total cholesterol and HDL levels. Calculated HOMA-IR score was significantly higher and c-peptide/insulin and c-peptide/glucose ratio were lower in GDM patients compared with the group of patients with normal glucose tolerance. Conclusion: It is accepted that increased maternal adipocyte and plasental hormones' effect aganist insulin combination had an important role in GDM pathogenesis. In this study; we ascertained that HOMA-IR was raised GDM probability 8 fold and showed that insulin resistance was one of the basic factor in GDM pathogenesis. Copyright © 2013 by Türkiye Klinikleri.
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    Adiponectin levels in gestational diabetes mellitus and in pregnant women without glucose intolerance
    (Wroclaw University of Medicine, 2015) Pala H.G.; Ozalp Y.; Yener A.S.; Gerceklioglu G.; Uysal S.; Onvural A.
    Objectives: The aim of the study was to determine serum adiponectin levels among patients with gestational diabetes mellitus (GDM) and normal pregnant women without glucose intolerance, and to investigate the relationship between these levels and clinical factors at the time of the diagnosis, at delivery and in the post-partum period. Material and Methods: The subjects' serum adiponectin concentration was measured using the enzyme-linked immunosorbent assay (ELISA) method at 24th-28th week of gestation, at delivery (in maternal circulation and the umbilical cord) and 24 h after delivery. The relationship between these groups' measurements and other established clinical-laboratory factors were investigated. Results: Serum adiponectin concentrations were significantly lower (p = 0.02) in GDM patients compared with patients with normal glucose tolerance at 24th-28th week of gestation. During delivery, maternal serum adiponectin concentrations were significantly lower (p = 0.03) in GDM patients compared with patients with normal glucose tolerance. In the post-partum period, serum adiponectin concentrations were significantly higher (p = 0.009) in GDM patients compared with patients with normal glucose tolerance. Umbilical cord adiponectin concentrations were significantly lower (p = 0.005) in GDM patients compared with patients with normal glucose tolerance. Conclusions: Adiponectin concentrations in GDM patients' circulation were regulated by changes in glucose and insulin metabolism. A reduction in serum adiponectin levels seems to play a role in GDM patients' insulin resistance. © Copyright by Wroclaw Medical University.