Browsing by Author "Yener G.O."

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    Mortality risk factors among critically ill children with MIS-C in PICUs: a multicenter study
    (Springer Nature, 2023) Sık G.; Inamlık A.; Akçay N.; Kesici S.; Aygun F.; Kendırlı T.; Atay G.; Sandal O.; Varol F.; Ozkaya P.Y.; Duyu M.; Bırbılen A.Z.; Ozcan S.; Arslan G.; Kangın M.; Bayraktar S.; Altug U.; Anıl A.B.; Havan M.; Yetımakman A.F.; Dalkıran T.; Zengın N.; Oto A.; Kıhtır H.S.; Gırgın F.İ.; Telhan L.; Yıldızdas D.; Yener N.; Yukselmıs U.; Alakaya M.; Kılınc M.A.; Celegen M.; Dursun A.; Battal F.; Sarı F.; Ozkale M.; Topal S.; Kocaoglu C.; Yazar A.; Alacakır N.; Odek C.; Yaman A.; Cıtak A.; Bıngol I.; Annayev A.; Sevketoglu E.; Katlan B.; Durak C.; Gun E.; Erdogan S.; Seven P.; Sahın E.; Arı H.F.; Boyraz M.; Durak F.; Emeksız S.; Ozdemır G.; Duman M.; Talay M.N.; Yener G.O.; Luleyap D.; Harmanogulları S.; Başar E.Z.; Mercan M.; Bal A.; Kılıc N.; Ongun E.A.; Ozturk M.N.; Ekıncı F.; Udurgucu M.; Arslankoylu A.E.; Kutlu N.O.; Bukulmez A.; Özsoylu S.; Celık T.; Ozkale Y.; Kılıc A.O.
    Background: This study evaluated of clinical characteristics, outcomes, and mortality risk factors of a severe multisystem inflammatory syndrome in children admitted to a the pediatric intensive care unit. Methods: A retrospective multicenter cohort study was conducted between March 2020 and April 2021 at 41 PICUs in Turkey. The study population comprised 322 children diagnosed with multisystem inflammatory syndrome. Results: The organ systems most commonly involved were the cardiovascular and hematological systems. Intravenous immunoglobulin was used in 294 (91.3%) patients and corticosteroids in 266 (82.6%). Seventy-five (23.3%) children received therapeutic plasma exchange treatment. Patients with a longer duration of the PICU stay had more frequent respiratory, hematological, or renal involvement, and also had higher D-dimer, CK-MB, and procalcitonin levels. A total of 16 patients died, with mortality higher in patients with renal, respiratory, or neurological involvement, with severe cardiac impairment or shock. The non-surviving group also had higher leukocyte counts, lactate and ferritin levels, and a need for mechanical ventilation. Conclusions: In cases of MIS-C, high levels of D-dimer and CK-MB are associated with a longer duration of PICU stay. Non-survival correlates with elevated leukocyte counts and lactate and ferritin levels. We were unable to show any positive effect of therapeutic plasma exchange therapy on mortality. Impact: MIS-C is a life-threatening condition.Patients need to be followed up in the intensive care unit.Early detection of factors associated with mortality can improve outcomes.Determining the factors associated with mortality and length of stay will help clinicians in patient management.High D-dimer and CK-MB levels were associated with longer PICU stay, and higher leukocyte counts, ferritin and lactate levels, and mechanical ventilation were associated with mortality in MIS-C patients.We were unable to show any positive effect of therapeutic plasma exchange therapy on mortality. © 2023, The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc.
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    Frequency of rheumatic diseases in patients with familial Mediterranean fever; [Ailesel Akdeniz ateşi hastalarında romatizmal hastalıkların sıklığı]
    (Pamukkale University, 2023) Yener G.O.; Yüksel S.; Tekin Z.E.; Türkmen H.
    Purpose: Mutations in the Mediterranean FeVer (MEFV) gene, which causes familial Mediterranean fever (FMF), may also cause the emergence of other specific rheumatic diseases. This study aims to determine the frequency of other rheumatologic diseases in paediatric FMF patients, evaluate whether there are clinical and genetic differences between those with and without concomitant rheumatologic diseases, and compare the data with previous studies. Materials and methods: The files of FMF patients who were followed up at the paediatric rheumatology department were reviewed retrospectively. Demographic data, MEFV mutations, treatment, disease severity scores, and concomitant rheumatic diseases were recorded from the files. Results: There were 303 FMF patients (154 female/149 male). The mean age at diagnosis was 7.04±3.9 years. The mean disease duration was 5.33±3.13 years. In the cohort, 41 FMF patients (13.5%) were diagnosed with another rheumatic disease. There were 22 cases of juvenile idiopathic arthritis (53.6%), seven cases of vasculitis (17%), six cases of periodic fever aphthous stomatitis and adenitis syndrome (14.6%), three cases of Behçet's disease (7.3%), two cases of acute rheumatic fever (4.8%), and one case of systemic lupus erythematosus (2.4%). Thirty-two of these of these 41 FMF patients (78%) had the M694V mutation (homozygous in 11, heterozygous in 21). Disease activity scores Pras and ISSF scores were higher in FMF patients with rheumatic diseases (p=0.002 and p<0.001, respectively). Conclusion: Other rheumatologic diseases should be evaluated in FMF patients. Regarding other accompanying rheumatic diseases, the M694V mutation and disease severity scores are notable factors. © 2023, Pamukkale University. All rights reserved.