Browsing by Author "Yerlikaya, T"

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    IMPACT OF YOGA INTERVENTION ON PHYSICAL FITNESS PARAMETERS IN PREADOLESCENT CHILDREN: A RANDOMIZED CONTROLLED TRIAL
    Bagkur, M; Gunay, E; Yerlikaya, T; Oniz, A
    Purpose: This study aims to assess the impact of yoga on physical fitness among healthy primary school children using a randomized control design. Material and Methods: A total of 52 children, aged 8-13, were randomly assigned to either the Yoga Group (n = 27, mean age = 10.48 +/- 1.25 years) or the Control Group (n = 25, mean age = 11.20 +/- 1.50 years). The participants underwent evaluation using the EUROFIT Test Battery as the primary outcome measure The Yoga Group engaged in 45-minute yoga sessions twice a week for a duration of 10 weeks, while the Control Group received no intervention. Outcome assessments were repeated at the conclusion of the 10-week intervention period. Results: Significantly positive enhancements were observed in the Yoga Group across various components of the EUROFIT Test Battery, including balance, speed, flexibility, muscle endurance, and Conclusion: These findings demonstrate that yoga interventions contribute to improvements in physical fitness among preadolescent children. Consequently, incorporating yoga exercises into the school curriculum is recommended, given their efficacy, minimal resource requirements, and positive impact on sports readiness.
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    The prognostic impact of Her2 status in early triple negative breast cancer: a Turkish Oncology Group (TOG) study
    Özyurt, N; Alkan, A; Gülbagci, B; Seyyar, M; Aydin, E; Sahbazlar, M; Türker, M; Kinikoglu, O; Yerlikaya, T; Dinç, G; Aytaç, A; Kalkan, Z; Ebinç, S; Gültürk, I; Keskinkiliç, M; Isleyen, ZS; Çaglayan, D; Türkel, A; Aydin, E; Sakalar, T; Sekmek, S; Yildirim, N; Koçak, S; Okutur, K; Özveren, A; Dursun, B; Kitapli, S; Eren, OÖ; Beypinar, I; Hacibekiroglu, I; Çabuk, D; Karaman, E; Acar, Ö; Paydas, S; Eryilmaz, MK; Demir, B; Oruç, Z; Yilmaz, M; Biricik, FS; Salim, DK; Tanriverdi, Ö; Dogan, M
    The studies evaluating the impact of Her2 levels in neoadjuvant setting have conflicting data. The aim of the study was to evaluate the prognostic impact of Her2 status in early triple negative breast cancer(TNBC). In the study TNBC patients who were treated with neoadjuvant chemotherapy (NAC) and surgery were analyzed retrospectively. The primary aim of the study was to analyze the impact of Her2 status(Her2-0 and Her2-low) on pathological complete response (pCR). The secondary objectives were disease free survival (DFS) and overall survival (OS). 620 female triple negative breast cancer patients were evaluated. 427 patients (68.9%) had Her2-0 and 193(31.1%) had her2-low pathology. The pCR rates were similar between Her2-0 and Her2-low patients (33.0% vs. 27.5%, p = 0.098). Although Her2-0 group has better DFS (106 vs. 50 months, p = 0.002), in multivariate analysis it had a HR of 0.74 (p = 0.06). In addition, OS was similar (131 vs. 105 months, p = 0.13) with a HR of 0.88 (p = 0.61). In multivariate analysis; presence of LVI (HR:2.2 (95% CI 1.1-3.5) p = 0.001), Clinical stage T1/T2 (HR:0.39 (95% CI 0.2-0.6) p < 0.001) and lymph node negativity (HR:0.35 (95% CI 0.1-0.9) p = 0.03) were independent factors for OS. Although there were pathological and clinical differences, the pCR, DFS and OS were similar between Her2-0 and Her2-low TNBC patients. The importance of Her2 status of TNBC in neoadjuvant setting should be further studied.