Browsing by Author "Yetgin, CE"
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Item Synthesis and Characterization of Chloralose-Derived Thiosemicarbazones and Semicarbazones and Investigation of Their Antimicrobial PropertiesYetgin, CE; Oskay, M; Ay, KThiosemicarbazones(7-10)/semicarbazones(11-14) were synthesized in good yields via the condensation of alpha-gluco-, beta-gluco-, galacto-, manno-chloralose derived 1,4-furanodialdoses (1-4) with thiosemicarbazide(5)/semicarbazide(6). The structures of all products were characterized by FTIR, NMR spectroscopic methods and elemental analysis. The compounds have been found to display moderate antimicrobial activity against Gram-positive, Gram-negative bacteria and antifungal activity against a Candida albicans. MIC values of the compounds range from 260 to 1510 mu g/mL.