Browsing by Author "Yigitoglu M.R."

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    The effect of FAD on erythrocyte glutathione reductase activity in undialyzed uremic patients and healthy subjects
    (1997) Ari Z.; Uyanik B.S.; Yigitoglu M.R.; Kutlu N.; Pirim I.
    The erythrocyte glutathione reductase (GSSG-R) activity with and without FAD supplementation (Act. A and Act. B, respectively) was studied in 24 undialyzed uremic patients and 25 healthy subjects. Mean erythrocyte GSSG-R activity from normal subjects was 5.39 ± 1.43 U/g Hb (the active form). After the addition of FAD to the hemolysates, this increased to 7.79 ± 1.07 U/g Hb, an increase of 1.88 ± 0.84 U/g Hb (the inactive from) (p < 0.001). In patients with FAD supplementation, erythrocyte GSSG-R activity increased from 9.26 ± 1.19 U/g Hb to 10.06 ± 1.06 U/g Hb, an increase of 0.80 ± 0.76 U/g Hb (p < 0.01). In addition, there were significant positive correlations between the enzyme activities and plasma urea level, and negative correlations between the enzyme activities and hemoglobin concentrations in patients, but not in the controls. It was concluded that further cross-sectional in vivo studies should be made to determine whether riboflavin administration may or not be useful in preventing renal anemia.
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    Relationship between serum lipoprotein (a) levels and retinopathy in patients with type 2 diabetes
    (American Society of Contemporary Ophthalmology, 2002) Kurt E.; Öztürk F.; Ari Z.; Yigitoglu M.R.; Sari R.A.; Ilker S.S.
    We studied whether there was an association between development of background or proliferative retinopathy and changes in plasma lipid, lipoprotein, and lipoprotein (a) levels in 112 patients with type 2 diabetes mellitus and in 57 controls. Serum lipoprotein (a) levels were higher in patients with retinopathy than in individuals without retinopathy. Increased serum lipoprotein (a) levels correlated with higher degrees of retinopathy. Thus, lipoprotein (a) may play a role in the development of diabetic retinopathy.