MCBÜ Açıkerişim Sistemi :: Browsing by Author "Yildirim A."

Browsing by Author "Yildirim A."

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Acute necrotizing pancreatitis: The results of the management of 38 patients; [Akut nekrotizan pankreatit: Otuz sekiz hastanin tedavi sonuçlari]
(2006) Tireli M.; Yildirim A.; Güçlü C.; Çalik B.; Diliüz B.
BACKGROUND: We evaluated the patients who underwent surgical or nonoperative treatment for acute necrotizing pancreatitis. METHODS: The study included 38 patients (22 males, 16 females; mean age 51.3 years; range 16 to 79 years) with acute necrotizing pancreatitis. Surgical treatment was performed in 23 patients, while 15 patients were treated conservatively. RESULTS: Gallstone (in 17 patients) was the most common cause of pancreatitis. Twenty-five patients had sterile necrotizing pancreatitis, while 13 patients had infected necrotizing pancreatitis. Fifteen of the 25 cases with sterile necrosis were treated conservatively. The other 10 patients were initially treated by conservative methods, and were later treated surgically (due to six incorrect diagnosis, three organ failures, and one symptomatic pseudocyst). We applied continuous lavage to six of those patients and conventional drainage to four of them. Mortality rate was 23.7% globally; 24.0% in the sterile necrosis group and 23.1% in the infected necrosis group. Mortality rate was 21.7% in the surgical treatment group, and 26.7% in the conservative treatment group. There were no statistically significant differences between those groups (p>0.05). Eleven of the 29 patients who survived had some complications. CONCLUSION: The management of sterile pancreatic necrosis is still a matter of debate. Most patients with sterile necrosis can be treated with conservative methods. Indication for surgery in sterile necrosis should be based on persisting or advancing organ complications and sepsis signs despite intensive care therapy. The patients with infected necrosis should be treated surgically. Surgical intervention is best deferred until the demarcation of necrosis is complete.
Nutritional changes and effects in hospitalized patients
(2006) Yildirim A.; Ellidokuz H.; Ellidokuz E.; Ozer Z.C.
Objective: To determine the effect of hospitalization in the internal disease clinics on nutrition variables. Method: This study was a cohort-type study performed in the Internal Diseases Clinics, University Hospital in Turkey. We included 208 patients who were hospitalized in the Internal Diseases Clinics of the University between June and August 2003. The clinical nutrition parameters of all the patients were evaluated from anthropometric measurements and laboratory results at admission and discharge. Results: Of 208, 105 were females, and 103 were males. The average age was 57 ± 13.5 (18-85) years. Average hospitalization period of the cases was 14 ± 10 (1-73) days. While the average body weight at admission was 71.6 ± 10.9 kg and it was found to be 70.7 ± 1.3 kg at discharge (paired sample t test, p<0.001). We noted the statistically significant decrease in the body mass index, waist and hip measures, muscle-skin folds thickness, and body adipose mass (p<0.05). Decreases were observed in all the clinical parameters of laboratory test results of the patients indicating end products of fat, protein, and carbohydrate metabolism (p<0.05). It was observed that the demographic characteristics of the patients (age, gender, occupation, education, and so forth) did not affect the decrease in nutritional parameters (p>0.05). Conclusion: It was observed that decreases occurred in all the nutrition parameters of the patients who were hospitalized in the internal diseases clinics. It is suggested that these decreases are related to entire fat, protein, and carbohydrate metabolism. Nutritional parameters of patients should be followed during hospitalization with the purpose of preventing regression in nutrition parameters.
A survey of patient preparation and technique of ultrasound-guided prostate biopsy: A multicenter study og urooncological association; [Ultrasonografi kιlavuzluǧunda yapιlan prostat biyopsisinde hasta hazιrlιǧι ve teknik anketi: Üroonkoloji derneǧi çcok merkezli çalιşmasι]
(Turk Uroloji Dernegi, 2007) Bozlu M.; Akduman B.; Mungan U.; Özen H.; Baltaci S.; Türkeri L.; Kirkali Z.; Akdaş A.; Adsan Ö.; Akdoǧan B.; Altinel M.; Ataus S.; Ayan S.; Bilen C.Y.; Çal Ç.; Çek M.; Dündar M.; Işeri C.; Koşan M.; Lekili M.; Müezzinoǧlu T.; Özer G.; Özgök Y.; Perk H.; Soyupak B.; Soyupek S.; Soylu A.; Sözen S.; Şengör F.; Tansuǧ Z.; Tekin A.; Yildirim A.
Introduction: Ultrasound-guided prostate biopsy is the standard method for the diagnosis of prostate cancer. The aim of the present survey is to assess the variability in patient preparation and technique of ultrasound-guided prostate biopsy among Turkish Urologists. Materials and Methods: In July 2004, a questionnaire was sent out to e-mail addresses of the members of Urooncological Association, asking about the details of prostate biopsy protocol of the members. The survey consisted of multiple choice questions about the patient preparation and prostate biopsy technique. Responses were acquired via e-mail and analyzed in detail. Results: Thirty two urologists from 24 centers responded. The biopsy procedure was performed by the urologist only in 54.16% of the centers, both urologist and radiologist in 37.5%, and radiologist only in 8.33%. Transrectal route was the most common method for ultrasound-guided prostate biopsy. A half of the responders performed biopsy when PSA was greater than 4 ng/ml. All of the centers administered antibiotic and a half of them used enema before the procedure. Approximately 37% of responders did not administer any type of analgesia, but 29.1% of all responders administered a periprostatic nerve block for reducing pain during the procedure. Most urologists obtained 10 or 12 biopsy cores and only 20.8% of them obtained routine transitional zone biopsy during the initial biopsy session. Conclusion: This survey demonstrated that patient preparation and technique of ultrasound-guided prostate biopsy is not standardized among Turkish Urologists, and a guideline on prostate biopsy is needed.
Numerical solution to the van der Pol equation with fractional damping
(2009) Konuralp A.; Konuralp Ç.; Yildirim A.
In this study, the van der Pol equation with fractional damping is investigated and the numerical solution of the problem is obtained by means of the variational iteration method. For this purpose, specific α values are considered and the emerged fractional differential equations are solved approximately. Furthermore, these solutions are compared and the relations between them are figured out. © 2009 The Royal Swedish Academy of Sciences.
Some exact solutions to the generalized Korteweg-de Vries equation and the system of shallow water wave equations
(Vilnius University Press, 2013) Dolapci I.T.; Yildirim A.
In this paper, we establish exact solutions for nonlinear evolution equations in mathematical physics. The exp-transform method is proposed to seek solitary solutions, periodic solutions and compaction-like solutions of nonlinear differential equations. The generalized KdV equation and the system of the shallow water wave equation are chosen to illustrate the effectiveness and convenience of the method. © Vilnius University, 2013.
The first monkey malaria in Turkey: A case of plasmodium knowlesi; [Tiirkiye'deki ilk Maymun Sitmasi: Bir Plasmodium knowlesi Olgusu]
(Ankara Microbiology Society, 2016) Özbilgin A.; Çavuş I.; Yildirim A.; Gündüz C.
Plasmodium knowlesi is now added to the known four Plasmodium species (P.vivax, P.falciparum, P.malariae, P.ovale) as a cause of malaria in humans because of the recent increasing rate of cases reported from countries of southeastern Asia. P.knowlesi which infects macaque monkeys (Macaca fascicufaris and M.nemestrina) is transmitted to humans especially by Anopheles leucosphyrus and An.hackeri mosquitos. First human cases of P.knowlesi malaria have been detected in Malaysia which have reached high numbers in recent years and also have been reported from countries of Southeast Asia such as Thailand, Philippines, Myanmar, Singapore and Vietnam. However the number of cases reported from western countries are rare and limited only within voyagers. This report is the first presentation of an imported case of P.knowlesi malaria in Turkey and aims to draw attention to the point that it could also be detected in future. A 33-year-old male patient from Myanmar who has migrated to Turkey as a refugee, was admitted to a health center with the complaints of fever with a periodicity of 24 hours, headache, fatigue, cough, sore throat, anorexia, myalgia and arthralgia. He was prediagnosed as upper respiratory tract infection, however because of his periodical fever and background in Myanmar, thick and thin blood films were prepared and sent to our laboratory for further examinations. Microscopic examination of the thin blood films revealed erythrocytic stages compatible with P.knowlesi (three large early trophozoites in an erythrocyte, three late trophozoites with compact view, and three late band-form trophozoites). Upon this, both real-Time polymerase chain reaction (Rt-PCR) targeting the small subunit ribosomal RNA (SSU-rRNA) genes of Plasmodium genus and DNA sequence analysis targeting P.knowlesi rRNA gene were performed. As a result, the suspected identification of P.knowlesi by microscopy was confirmed by Rt-PCR and DNA sequencing. The patient was treated with chloroquine and primaquine combination and in the follow-up on the seventh day after the treatment, his parasitemia and symptoms had ceased. Although there were some previous reports concerning about imported patients infected with different Plasmodium species in our country, no cases of P.knowlesi have been reported. This first case presented here emphasizes the occurence of P.knowlesi malaria in Turkey hereinafter due to the increasing number of refugees.
Do the rodents have a role in transmission of cutaneous leishmaniasis in Turkey?; [Türkiye’de kutanöz leyşmanyaziste kemiricilerin rolü var mı?]
(Ankara Microbiology Society, 2018) Özbi̇Lgi̇n A.; Çavuş İ.; Yildirim A.; Gündüz C.
Leishmaniasis is a zoonotic/anthroponotic vector borne parasitic infection which is caused by Leishmania species and transmitted by sand flies (Phlebotomus spp.) The reservoirs of Leishmania species in nature are various wild and domestic carnivores, rodents and human. The aim of this study was to investigate whether the rodents in genera Meriones, Mesocricetus, Rattus and Mus which inhabit in the natural habitat of our country could be natural reservoirs of Leishmania tropica, Leishmania infantum, Leishmania major and Leishmania donovani for cutaneous Leishmaniasis (CL)., The rodents Mus musculus (Balb/C mouse), Mesocricetus auratus (hamster), Meriones unguiculatus (gerbil) and Rattus norvegicus (rat) which are part of the natural habitat in Turkey were used in the study. L.tropica, L.infantum, L.major and L.donovani promastigote isolates obtained from CL patients and cultured in enriched media were injected in the footpads of the animals intradermally using the density of 108 promastigote/ml. The scale of the lesions on the footpads of the animals were measured for 12 weeks. At the end of the experiment, the animals were sacrificed and “touch preparations” were prepared using footpad, liver, spleen and testicles of the sacrified animals and were examined using Giemsa stained slides following culturing in enriched NNN medium. Leishmania amastigotes were seen in the slides prepared from the footpads of the all experimental animals and all cultures were positive for promastigotes prepared from the same clinical material. But not all the experiment groups were positive for the liver, spleen and testicle preparations. According to these results it was concluded that while all rodents in the experiment groups were positive for CL, only a part of the experiment groups were positive for internal organ involvement. Accordingly, (a) All Leishmania strains caused both CL and internal organ involvement in M.unguiculatus and M.musculus, (b) only L.tropica caused CL and internal organ involvement in R.norvegicus, while other Leishmania strains only caused CL in this group, (c) in M.auratus only L.donovani caused CL while other strains caused both CL and internal organ involvement. In our study, it was determined that the rodents Meriones, Mesocricetus, Rattus and Mus genera which are part of our country’s natural habitat could serve as natural reservoirs of L.tropica, L.infantum, L.major and L.donovani, thus having the potential for the spreading of Leishmaniasis in our country and important information were gathered concerning the clinical aspects of the infection caused by Leishmania species in their potential reservoir hosts. © 2018 Ankara Microbiology Society. All rights reserved.
Ultra wide-field imaging in patients with diabetic retinopathy and branch retinal vein occlusion: Heidelberg spectralis vs ETDRS-7 fields angiography images; [Diyabetik Retinopati ve Retina Ven Dal Tıkanıklığı Olgularında Ultra Geniş Açılı Görüntüleme: Heidelberg Spectralis’e Karşı ETDRS-7 Alan Anjiografi Görüntüleri]
(Gazi Eye Foundation, 2019) Kayikçioğlu Ö.; Altinişik M.; Mayali H.; Yildirim A.; Kurt E.; İLker S.S.
Purpose: To compare the Heidelberg Spectralis ultra-wide field fluorescein angiography (FA) and Early Treatment Diabetic Retinopathy Study (ETDRS)-7 field images in patients with diabetic retinopathy (DRP) and branch retinal vein occlusion (BRVO). Materials and Methods: FA images, obtained with Spectralis were retrospectively analysed. The images of the DRP and BRVO cases were enrolled in the study. The images were exported to the Microsoft Paint program and the circles pointing to 7-field images were digitally mounted on the wide-field images. ETDRS-7 field and wide field images were compared for distribution of ischemia and neovascularization (NV). Ischaemic areas were classified as mild, moderate or severe ischemia according to the area of one circle of the 7-field image. Results: A total of 136 images of DRP and seven images of BRVO cases were enrolled. 24 images were proliferative DRP while 112 images were nonproliferative DRP according to Spectralis images. ETDRS-7 field images failed to detect severe ischemia in 32 eyes (23.52%), moderate ischemia in 16 eyes (11,76%) and mild ischemia in 36 eyes (26,47%). Also 7-field images could not detect NV in three eyes (11,76%). Also standard 7-field images could not detect severe ischemia in two eyes with BRVO. Conclusion: Ultra-wide field FA images may provide additional informations compared to the ETDRS 7-field images in evaluating retinal vascular diseases which may cause increasing the grading and severity of the diseases. © 2019 Gazi Eye Foundation. All rights reserved.
The Toxicity of Essential Oils From Three Origanum Species Against Head Louse, Pediculus humanus capitis
(Springer Science and Business Media Deutschland GmbH, 2021) Arserim S.K.; Cetin H.; Yildirim A.; Limoncu M.E.; Cinbilgel I.; Kaya T.; Ozbel Y.; Balcioglu I.C.
Purpose: Pediculosis caused by human head louse, Pediculus humanus capitis De Geer (Anoplura: Pediculidae) is a public health problem with a high prevalence, especially among children in school age. Different chemical pediculicides (insecticides) are used against lice but the repeated application of these pediculicides for the treatment of P. humanus capitis infestation in the past decades has resulted in the development of resistance. The plant essential oils have been used as alternative sources of lice treatment agents. Pediculicidal activity of the essential oils of three Origanum species (O. onites, O. majorana and O. minutiflorum) against P. humanus capitis adults was examined in this study. Methods: Essential oils from aerial parts of three Origanum species were obtained by hydrodistillation using a Clevenger-type apparatus. P. humanus capitis specimens used were obtained from infested children by combing method at primary schools. Adult lice were exposed to three dilutions (1%, 0.5% and 0.1% w/v) of tested oils for 5 min using the adult immersion test. Results: According to the results, all Origanum essential oils at 1% concentration have been shown to significantly decrease the rate of limb, bowel and abdomen movements, producing more than 90% mortality after 12 h. Conclusion: Our results indicated that Origanum essential oils can be used for the development of new pediculicides against head louse. © 2021, Witold Stefański Institute of Parasitology, Polish Academy of Sciences.
Peripheral blood smear findings of COVID-19 patients provide İnformation about the severity of the disease and the duration of hospital stay
(Universita Cattolica del Sacro Cuore, 2021) Berber I.; Cagasar O.; Sarici A.; Berber N.K.; Aydogdu I.; Ulutas O.; Yildirim A.; Bag H.G.G.; Delen L.A.
Background: Data about the morphological changes in peripheral blood smears during COVID-19 infection and their clinical severity association are limited. We aimed to examine the characteristics of the cells detected in the pathological rate and/or appearance and whether these findings are related to the clinical course by evaluating the peripheral blood smear at the time of diagnosis in COVID-19 patients. Methods: Clinical features, laboratory data, peripheral blood smear of fifty patients diagnosed with COVID-19 by PCR was evaluated at diagnosis. Peripheral smear samples of the patients were compared with the age and sex-matched 30 healthy controls. Pictures were taken from the patient's peripheral blood smear. Patients were divided into two groups. Mild and severe stage patient groups were compared in terms of laboratory data and peripheral smear findings. The relationship between the laboratory values of all patients and the duration of hospitalization was analyzed. Results: The number of segmented neutrophils and eosinophils were low, pseudo-Pelger-Huet, pseudo-Pelger-Huet/mature lymphocyte ratio, atypical lymphocytes, monocytes with vacuoles, bands, and pyknotic neutrophils rates were higher in the peripheral blood smear of the patient group (p <0.05). Increased pseudo-Pelger-Huet anomaly, pseudo-Pelger Huet/mature lymphocyte ratio, a decreased number of mature lymphocytes, and eosinophils in peripheral blood smear were observed in the severe stage patients (p <0.05). A negative correlation was observed between hospitalization duration and mature lymphocyte and monocytes with vacuoles rates (p <0.05). Conclusion: A peripheral blood smear is an inexpensive, easily performed, and rapid test. Increased Pseudo-Pelger-Huet anomaly/mature lymphocyte rate suggests a severe stage disease, while high initial mature lymphocyte and monocytes with vacuoles rates at the time of diagnosis may be an indicator of shortened duration of hospitalization. © 2021 Universita Cattolica del Sacro Cuore. All rights reserved.
Quantitative Analysis of the Activity in Choroidal Neovascularizations after a Single Anti-VEGF Injection: OCT Versus OCT Angiography
(Taylor and Francis Ltd., 2021) Altinisik M.; Kurt E.; Kayikcioglu O.; Yildirim A.
Purpose: To analyze early quantitative changes in the choroidal neovascularization (CNV) area observed with optical coherence tomography angiography (OCTA) after single anti-vascular endothelial growth factor (anti-VEGF) injection. Materials and Methods: Treatment-naive patients with CNV secondary to neovascular age-related macular degeneration were analyzed immediately before and ~4 weeks after anti-VEGF injection. The primary endpoints of the study included changes in CNV total and vascular area. Secondary endpoints were best-corrected visual acuity (BCVA), central macular thickness (cMT), central total macular thickness (cTMT), and subfoveal choroidal thickness (SFCT). Results: A total of 27 patients (69.19 ± 5.91 years, 21 men/6 women, 14 type 1 NV, 11 type 2 NV, and 2 type 3 NV) were included in the study. There was a significant increase in BCVA and decreases in cMT, cTMT, and SFCT after treatment (p<0.05 for all). CNV total and vascular area changed by −11.55 ± 44.26% (95% confidence interval [CI]: −29.06 and 5.95; p=0.269) and −21.06 ± 41.2% (95% CI: −36.45/−5.67; p=0.786), respectively. The cases with decreased cTMT were accompanied by a decrease in CNV area only in 37% of the cases. No significant correlation was detected between cTMT and CNV total and vascular area percentage changes (r = −0.06, p=0.74; r = 0.02, p=0.9, respectively). Conclusions: Changes in CNV total and vascular area seem to have limited sensitivity as a biomarker in terms of activation, as wide variability was observed in CNV area after anti-VEGF injection. © 2021 Taylor & Francis.
Assessment of in-vitro antileishmanial activities of Cynara scolymus extracts against Leishmania tropica; [Leishmania tropica’ya karşı Cynara scolymus ekstrelerinin in-vitro antileishmanial etkinliğinin değerlendirilmesi]
(Veteriner Fakultesi Dergisi, 2021) Yildirim A.; Aksoy T.; Ceylan Ş.S.; Kayalar H.; Tayfur E.; Balcioğlu İ.C.
It was aimed to investigate in vitro antileishmanial activities of the receptacle, bractea, and stem leaves extracts of Cynara scolymus (artichoke) against Leishmania tropica. The Leishmania isolate, isolated from a cutaneous leishmaniasis patient from Manisa province, Turkey and stored in liquid nitrogen, was identified as L. tropica (MHOM/TR/2012/CBCL-LT) by genotyping. In vitro antileishmanial activities of C. scolymus plant extracts were examined by CelltTiter-glo and hemocytometry, and cytotoxic activities by MTT. IC50 values of receptacle water (WRC), aqueous ethanol (ARC) and ethanol (ERC), bractea leaf water (WBC), aqueous ethanol (ABC) and ethanol (EBC), and stem leaf water (WSC), aqueous ethanol (ASC) and ethanol (ESC) extracts were determined as 2.45 mg/mL, 1.52 mg/mL, 1.66 mg/mL, 3.45 mg/mL, 1.46 mg/mL and 0.58 mg/mL, 0.24 mg/mL, 0.21 mg/mL and 0.08 mg/mL, respectively. When these results are compared with the drug-free control group, it was determined that stem leaf aqueous ethanol (SI: 7.98), ethanol (SI: 4.96) and water (SI: 2.71) extracts with the highest selectivity index (SI) values showed antileishmanial activity (P<0.05). Extracts of C. scolymus did not show cytotoxic activity except for WBC, WRC and ARC. In conclusion, the data presented in the current study indicated that C. scolymus stem leaf extracts (ESC, ASC and WSC) present effective antileishmanial activity. Future studies could focus on the identification and purification of the antileishmanial compounds within these extracts for analysis of their in vivo antileishmanial activity. © 2021, Veteriner Fakultesi Dergisi. All rights reserved.
Evaluation of retinochoroidal tissues in third trimester pregnants: An optical coherence tomography angiography study
(SAGE Publications Ltd, 2022) Yildirim A.; Kurt E.; Altinisik M.; Uyar Y.
Introduction: The structural and vascular changes in the retina and choroid in women in the third trimester of pregnancy were analyzed using optical coherence tomography angiography (OCTA). Methods: Forty women in the third trimester of uncomplicated pregnancy and 40 age-matched healthy women were included. Vascular density (VD) in the superficial and deep capillary plexuses (SCP/DCP), foveal density (FD), and foveal avascular zone (FAZ) area and perimetry measured with OCTA, as well as OCT measurements of central macular thickness (CMT) and choroidal thickness (CT) were compared between the groups. Correlations between structural OCT parameters and vascular OCTA metrics were analyzed. Results: The mean gestational age was 34 (28–41) weeks. Mean age was comparable in the groups (p = 0.732). The pregnant women had significantly higher parafoveal DCP-VD (p = 0.015), FAZ area (p = 0.044), and FD (p = 0.002). Mean subfoveal CT was 21 µm higher in pregnant women but was not significant (p = 0.472). There was no difference in CMT (p = 0.448). FAZ metrics were positively correlated with CT in pregnants and with CMT in the control group (p < 0.05). Parafoveal VD was negatively correlated with CT in the control group (p < 0.05). After adjusting for CT and CMT, the significant difference in VD and FD persisted (p < 0.05), while the difference in FAZ area lost significance (p > 0.05). Conclusions: Considering the effects of the probable covariant factors CMT and CT, systemic changes in pregnant women in their third trimester may cause an increase in VD in the macula and parafoveal DCP. © The Author(s) 2020.
Investigation of Leishmania RNA Virus 2 in Leishmania major and Leishmania tropica Strains Isolated from Cutaneous Leishmaniasis Patients in Türkiye; [Türkiye'deki Kutanöz Leyşmanyazis Hastalarindan Izole Edilen Leishmania major ve Leishmania tropica Izolatlarinda Leishmania RNA Virüsü 2'nin Araştirilmasi]
(Ankara Microbiology Society, 2023) Karabulut C.; Aksoy T.; Yildirim A.; Balcioǧlu I.C.
Leishmania RNA virus (LRV) is a double-stranded RNA (dsRNA) virus that is thought to contribute to the severe inflammatory response of the causative Leishmania parasite in the mammalian host by being present in many isolates of Leishmania spp. In our study, it was aimed to obtain data on the presence of Leishmania RNA Virus 2 (LRV2), which is thought to cause a change in the clinical course of leishmaniasis, in Leishmania major and Leishmania tropica isolates isolated from cutaneous leishmaniasis (CL) patients in Türkiye. Leishmania strains stored in liquid nitrogen tank by cryopreservation in Manisa Celal Bayar University Faculty of Medicine Parasite Bank were resuscitated under suitable conditions and cultivated in NNN and RPMI-1640 media. Then, the isolates were allowed to enter the logarithmic phase in a 26°C incubator and DNA isolations were made using the "High Pure PCR Template Preparation Kit". Real-time polymerase chain reaction (Rt-PCR) melting analyzes were applied to the DNAs obtained by using primers and probes specific to the internal transcribed spacer-1 (ITS-1) gene region of Leishmania. After RNA isolation from promastigote suspension, cDNA synthesis was performed by reverse transcription. After gel electrophoresis with PCR amplification products, dsRNA band formation was evaluated in terms of LRV2 positivity under ultraviolet light. Among the 20 examined Leishmania spp. isolates (10 L.tropica and 10 L.major), four (three L.tropica, one L.major) were found to be positive for the presence of LRV2. Although the mechanism of LRV in recent studies has not been fully understood, it is known that it exacerbates the clinic of the disease and even has an effect on the formation of drug resistance by the parasite. It is important to obtain data on the presence of LRV in our country and to contribute to various clinical, drug development, prevalence studies, diagnosis and treatment of the disease in the future. © 2023 Ankara Microbiology Society. All rights reserved.
A Retrospective Analysis of 83 Patients with Testicular Mass Who Underwent Testis-Sparing Surgery: The Eurasian Uro-oncology Association Multicenter Study
(S. Karger AG, 2023) Keske M.; Canda A.E.; Karadag M.A.; Çiftçi H.; Erturhan S.; Kactan C.; Soytas M.; Özkaya F.; Ozbey I.; Ordek E.; Atmaca A.F.; Yildirim A.; Sahin S.; Colakoglu Y.; Boylu U.; Erol B.; Caskurlu T.; Kiremit M.C.; Cakici O.U.; Sonmez G.; Klllçarslan H.; Akbulut Z.; Kayglslz O.; Bedir S.; Vuruskan H.; Bozkurt Y.E.; Aydin H.R.; Oguz U.; Basok E.K.; Gumus B.H.; Tuncel A.; Aslan Y.; Hamidi N.; Müslümanoǧlu A.Y.; Dinçer M.; Balbay D.; Albayrak S.; Laguna M.P.
Introduction: Herein, we analyzed the histopathological, oncological and functional outcomes of testis-sparing surgery (TSS) in patients with distinct risk for testicular cancer. Methods: This is a multicenter retrospective study on consecutive patients who underwent TSS. Patients were categorized in high- or low-risk testicular germ cell tumor (TGCT) according to the presence/absence of features compatible with testicular dysgenesis syndrome. Histology was categorized per size and risk groups. Results: TSS was performed in 83 patients (86 tumors) of them, 27 in the high-risk group. Fifty-nine patients had a non-tumoral contralateral testis present. Sixty masses and 26 masses were benign and TGCTs, respectively. No statistical differences were observed in mean age (30.9 ± 10.32 years), pathological tumor size (14.67 ± 6.7 mm) between risk groups or between benign and malignant tumors (p = 0.608). When categorized per risk groups, 22 (73.3%) and 4 (7.1%) of the TSS specimens were malignant in the high- and low-risk patient groups, respectively. Univariate analysis showed that the only independent variable significantly related to malignant outcome was previous history of TGCT. During a mean follow-up of 25.5 ± 22.7 months, no patient developed systemic disease. Local recurrence was detected in 5 patients and received radical orchiectomy. Postoperative testosterone levels remained normal in 88% of those patients with normal preoperative level. No erectile dysfunction was reported in patients with benign lesions. Conclusion: TSS is a safe and feasible approach with adequate cancer control, and preservation of sexual function is possible in 2/3 of patients harboring malignancy. Incidence of TGCT varies extremely between patients at high and low risk for TGCT requiring a careful consideration and counseling. © 2023 S. Karger AG, Basel.

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