Browsing by Author "Yilmaz, SK"

Now showing 1 - 3 of 3
  • No Thumbnail Available
    Item
    Pitfalls of diagnosing pituitary hypoplasia in the patients with short stature
    Yilmaz, SK; Ovali, GY; Kizilay, DO; Tarhan, S; Ersoy, B
    PurposeHeight age (HA) and bone age (BA) delay is well known in the patients with short stature. Therefore assessing pituitary hypoplasia based on chronological age (CA) might cause overdiagnosis of pituitary hypoplasia. We aimed to investigate the diagnostic and prognostic value of the PH and PV based on CA, HA, or BA in the patients with GHD.MethodsFifty-seven patients with severe and 40 patients with partial GHD and 39 patients with ISS assigned to the study. For defining the most accurate diagnosis of pituitary hypoplasia, PH and PV were evaluated based on CA, BA and HA. The relationship of each method with clinical features was examined.ResultsThe mean PV was significantly larger in patients with ISS compared to the GH-deficient patients. PV was more correlated with clinical features including height SDS, stimulated GH concentration, IGF-1 and IGFBP-3 SDS, height velocity before and after rGH therapy. We found BA-based PV could discriminate GHD from ISS (Sensitivity: 17%, specificity: 98%, positive predictive value: 94%, negative predictive value: 39%), compared to the other methods based on PH or PV respect to CA and HA. 3% of patients with ISS, 17% of patients with GHD had pituitary hypoplasia based on PV-BA.ConclusionPV based on BA, has the most accurate diagnostic value for defining pituitary hypoplasia. But it should be kept in mind that there might be still misdiagnosed patients by this method. PV is also a significant predictor for the rGH response.
  • No Thumbnail Available
    Item
    Bone mineral density, vitamin D status, and calcium intake in healthy female university students from different socioeconomic groups in Turkey
    Ersoy, B; Kizilay, DÖ; Yilmaz, SK; Taneli, F; Gümüser, G
    Peak bone mass is reached in late adolescence. Low peak bone mass is a well recognized risk factor for osteoporosis later in life. Our data do not support a link between vitamin D status, bone mineral density (BMD), and socioeconomic status (SES). However, there was a marked inadequacy of daily calcium intake and a high presence of osteopenia in females with low SES.PurposeOur aims were to (1) examine the effects of different SES on BMD, vitamin D status, and daily calcium intake and (2) investigate any association between vitamin D status and BMD in female university students.Subjects and methodsA questionnaire was used to obtain information about SES, daily calcium intake, and physical activity in 138 healthy, female university students (age range 18-22years). Subjects were stratified into lower, middle, and higher SES according to the educational and occupational levels of their parents. All serum samples were collected in spring for 25-hydroxyvitamin D concentration (25OHD). Lumbar spine and total body BMD was obtained by dual-energy X-ray absorptiometry (DXA) scan (Lunar DPX series). Osteopenia was defined as a BMD between -1.0 and -2.5 standard deviations (SDs) below the mean for healthy young adults on lumbar spine DXA.ResultsNo significant difference was found between the three socioeconomic groups in terms of serum 25OHD concentration, BMD levels, or BMD Z scores (p>0.05). Both the daily intake of calcium was significantly lower (p=0.02), and the frequency of osteopenia was significantly higher in girls with low SES (p=0.02). There was no correlation between serum 25OHD concentration and calcium intake and BMD values and BMD Z scores (p>0.05). The most important factor affecting BMD was weight (=0.38, p<0.001).ConclusionsLow SES may be associated with sub-optimal bone health and predispose to osteopenia in later life, even in female university students.
  • No Thumbnail Available
    Item