MCBÜ Açıkerişim Sistemi :: Browsing by Author "Yilmaz Ö."

Browsing by Author "Yilmaz Ö."

Now showing 1 - 20 of 46

Does sucralfate prevent apoptosis occurring in the ischemia/reperfusion-induced intestinal injury?
(2003) Şencan A.; Yilmaz Ö.; Özer E.; Günşar C.; Genç K.; Ulukuş Ç.; Taneli C.; Mir E.
Background/Purpose: We have shown in a previous study that sucralfate is beneficial in the prophylaxis and treatment of hypoxia/reoxygenation-induced intestinal injury. The aim of this study is to investigate whether sucralfate has any effect on the prevention of apoptosis in the ischemia/reperfusion (I/R)-induced intestinal injury. Methods: Rats were randomized into three groups. Group 1 and 2 were subjected to I/R. Group 1 (treatment group) received sucralfate while group 2 (treatment control group) did not. Group 3 served as a normal control group (sham group). The terminal ileum was harvested for histopathologic investigation by light microscopy. The presence of apoptotic enterocytes (DNA fragmentation in cell nuclei) was detected by terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick-end-labeling (TUNEL) reaction. Results: In treatment control group, 3 of 7 rats had severe inflammation. None of the sucralfate-treated rats showed severe inflammation, 6 of them only showed mild inflammatory changes (p < 0.05). The apoptotic percentage was found to be 37.1 ± 9.4 in the sucralfate-treated group (group 1), whereas it was 45.4 ± 3.9 in the untreated group (group 2) (p < 0.05). The sham group had a completely normal intestinal architecture. Conclusions: The present study shows that 1) the experimental model of I/R-induced intestinal injury induces enterocyte apoptosis; 2) sucralfate decreases enterocyte apoptosis in the experimental model of I/R-induced intestinal injury which may play a key role in the pathophysiological events leading to failure of the intrinsic gut barrier defense mechanisms.
Does high-pressure carbon dioxide insufflation facilitate mucosal dissection in transanal endorectal pull-through? A rabbit model
(2003) Genç A.; Taneli C.; Türkdoǧan P.; Yilmaz Ö.; Arslan O.A.; Mir E.
The aim of the present study was to investigate whether high-pressure carbon dioxide insufflation facilitates mucosal dissection in the transanal endorectal pull-through (TEPT) operation performed in Hirschsprung's disease in a rabbit model. In the study, ten New Zealand rabbits were used. In six of the rabbits, CO2 under 50 mmHg pressure was insufflated into the submucosal area through a 25-gauge scalp needle inserted 0.3 cm over the dentate line. Two of the rabbits were taken for histopathological examination. In four rabbits, the TEPT operation was performed and in another four the operation was performed without CO2 insufflation. Histopathological examination in the CO2-insufflated group of rabbits showed that at transversal incisions mucosa was seen to be separated circumferentially from submucosa by high pressure CO2 and at longitudinal incision the separation was seen to be complete along the anal canal. It was noted that mucosal dissection was rapid, non-bloody and without induced mucosal tears or perforation; however, in the non-insufflated group the operation was time-consuming, bloody and more difficult to perform and needed meticulous care. In the present study, it was seen that submucosal high pressure CO2 insufflation in rabbits facilitates mucosal dissection in the TEPT operation and is easy to perform, time-saving and highly economical.
The effect of circumcision status on periurethral and glanular bacterial flora
(2004) Günşar C.; Kurutepe S.; Alparslan O.; Yilmaz Ö.; Daǧlar Z.; Şencan A.; Genç A.; Taneli C.; Mir E.
Introduction: Circumcision is a historical operation which is still performed for different purposes. The aim of this study is to investigate the changes in periurethral and glanular sulcus flora due to circumcision to determine the role of circumcision on urinary tract infections (UTIs). Patients and Methods: Fifty patients who were circumcised for social-religious reasons between January 2000 and January 2001 were evaluated in this prospective study. Two swabs were taken from the periurethral and glanular sulcus regions both just before circumcision and 4 weeks after, and the bacteria cultured were recorded. Results: We isolated pathogenic bacteria in the periurethral region of 32 (64%) patients (enterococci in 14 cases; Escherichia coli in 12 cases) before circumcision, and this number decreased to 5 (10%) after circumcision. Similarly, pathogenic bacteria were cultured from the glanular sulcus swabs of 33 (68%) patients (enterococci in 14 cases; E. coli in 10 cases), as well as coagulase-negative staphylococci in another 15 patients before circumcision. Following circumcision, we detected pathogenic bacteria in the glanular cultures of only 4 cases, whereas 40 children had non-pathogenic skin flora. Only 1 of 5 children with history of UTIs (n = 1) and retractable phimosis (n = 4) had periurethral pathogenic bacteria (Proteus spp.) in the post-circumcision period. The differences between pre- and post-circumcision values of the pathogenic bacterial colonizations were statistically significant in both groups sampled (p < 0.05). Conclusion: Non-circumcised patients have similar pathogenic bacterial colonizations in the periurethral and the inner preputial regions, although they have no phimosis. The origin of periurethral flora should be the deeper preputial regions. The flora greatly changed with skin commensals after circumcision. Circumcision might be beneficial from this point of view. Copyright © 2004 S. Karger AG, Basel.
Testis-fixation in prepubertal rats: Fibrin glue versus transparenchymal sutures reduces testicular damage
(2004) Şencan A.; Genç A.; Günşar C.; Daǧlar Z.; Yilmaz Ö.; Ulukuş Ç.; Özer E.; Taneli C.; Mir E.
Experimental studies have shown that different suture materials used in testis fixation cause some degree of inflammation in the testis. This study was planned to compare the histological changes that were caused by fibrin glue which is a tissue sealant and by silk and polypropylene for transparenchymal testis fixation. 28 prepubertal rats were divided into 4 groups. Testis was fixed to the tunica vaginalis by fibrin glue in group 1, by silk in group 2 and by polypropylene in group 3. Group 4 was planned as a control. Testicular inflammation and seminiferous tubular diameter were evaluated for histological changes. The least inflammation was observed in the fibrin glue group, while the most inflammation occurred in the silk group. Seminiferous tubular diameter was 241.55 ± 45.90 in the fibrin glue group, 151.90 ± 8.34 in the silk group and 161.36 ± 9.96 in the polypropylene group. In conclusion, fibrin glue, when used for testis fixation, causes less inflammation and less destruction of seminiferous tubular diameter compared with silk and polypropylene.
Symptoms of the olive pollen allergy: Do they really occur only in the pollination season?
(2005) Kirmaz C.; Yuksel H.; Bayrak P.; Yilmaz Ö.
Background: Olive (Olea europaea; O.e.) pollen is a major cause of seasonal respiratory allergy. The O.e. pollination season lasts two months from the beginning of May till the end of June. It was expected that patients with allergic disease from O.e. sensitization were symptomatic only during this period. However, during the last few years, we have observed that the clinical symptoms appear not only during the O.e. pollination season but also during the rest of the year. Objective: The aim of this study was to observe and document symptoms of respiratory allergic diseases in the O.e. sensitized patients during the O.e. pollination season and after it. Methods: One hundred and twenty-seven patients with respiratory allergic disease were enrolled in the study. Allergenic sensitizations were shown by SPT. Finally, patients were split into two groups as monosensitized with O.e. (n=19) and polysensitized (n=108). Patients were assessed by using scores of respiratory allergic disease symptoms and percentage of peak expiratory flow rate values (PEFR %) (only for asthmatic patients) during the O.e. pollination season and after it. Results: Of the patients with O.e. monosensitization, 13 had allergic rhinitis (AR) only while six had allergic asthma (AA) additionally. AR alone and accompanied by AA was present in 84 and 24 polysensitized patients respectively. Eleven patients with O.e. sensitization (57.9 %) and 86 patients with polysensitization (79.6 %) had AR symptoms throughout the year irrespective of the O.e. pollination season. Similarly, three of the O.e. monosensitized and ten of the polysensitized patients with AA had asthmatic symptoms during the O.e. pollination season and also after it. Conclusions: In the patient group sensitive to O.e. along with other pollen extracts, it was possible to observe symptoms outside the pollination season. However, patients with O.e. monosensitization also had symptoms to a great extent outside the season. © 2005 Esmon Publicidad.
CHARGE association: Case report; [CHARGE birlikteliǧi: Olgu sunumu]
(2005) Yilmaz Ö.; Arslan O.A.; Genç A.; Kücükoǧlu T.; Günşar C.; Şencan A.; Mir E.; Taneli C.
CHARGE association is a combination of a number of related birth defects and acronyme of the first letter of each defect. A 5-year-old male admitted to our hospital with complaint of passing urine through a stenotic hypospadic meatus. Physical examination showed that his weight was 10-20th percentiles and his height was 10-20th percentiles. He had a left sided bad ear. Ophthalmologic examination revealed microphthalmia, iris coloboma, choroid coloboma and lens coloboma of both eyes. External genital examination revealed a coronal hypospadias and a ventral chordee. His mental development was found 3.5 years in social, 4 years in motor skills. An urethroplasty was performed by the Snodgrass technique. Four of the 7 components of the CHARGE association were present in present case.
Frequency and characteristics of mongolian spots among Turkish children in Aegean region
(2006) Egemen A.; Ikizoǧlu T.; Ergör S.; Asar G.M.; Yilmaz Ö.
Mongolian spots, which are benign congenital lesions observed in the first years of life, can cause distress for parents due to aberrant localization as well as unexpected number and size. Therefore, efficient differential diagnosis is necessary. The aim of this study was to determine the frequency and characteristics of mongolian spots in 1-12-month-old children in a west Anatolian city and to evaluate parental approach to these lesions. The study included 924 children who presented to Ege University Hospital Healthy Child Outpatient Department between January and August 2003. A questionnaire was applied to the families while all children were examined scrupulously for the presence of mongolian spots. The frequency of these lesions in the study population was determined to be 26%; this rate was 20% and 31% in boys and girls, respectively. No lesion was detected in blond-haired children; however, it was detected in 47% of brunettes. Most common localizations were lumbosacral, gluteal, and back, though knee, scalp and feet were also encountered. Upon questioning, most parents stated it was a birth mark; however, 10% accepted to consult a doctor about the issue. In conclusion, identifying mongolian spots and informing parents are essential to strengthen the family-doctor relationship.
Evaluation of voiding dysfunctions in children with chronic functional constipation
(2006) Kasirga E.; Akil I.; Yilmaz Ö.; Polat M.; Gözmen S.; Egemen A.
There are controversial results about the role of dysfunctional bowel emptying in disorders of the urinary tract like urinary tract infection (UTI), vesicoureteral reflux (VUR) and enuresis. Constipation may cause UTI, enuresis and VUR due to the uninhibited bladder contraction. The aim of this study was to investigate the frequency of nocturnal enuresis, UTI and instability symptoms in chronic functional constipation (CFC). This study included 38 children with CFC and 31 children as the control group. Detailed past and present history of UTIs or symptoms pointing to this diagnosis, enuresis, encopresis, urgency and urge incontinence was obtained from both groups as well as the family history of UTI. Urinalysis, urine culture and stool parasite analysis as well as abdominal ultrasonography were performed on both groups. Age range of the children with CFC was 6-192 months (mean±standard deviation (SD) 63.5±51 months); that of the control group was 4-180 months (mean±SD 82±46.2 months). Frequency of UTI and urgency was significantly higher in the CFC group. However, frequencies of urge incontinence, nocturnal enuresis, and genitourinary abnormalities were not different between the two groups. In conclusion, risk of UTI and urgency is increased in CFC, but that of other voiding dysfunctions like urge incontinence do not change significantly. Therefore, we suggest that UTI and urgency should be questioned in children with CFC and vice versa.
Evaluation of association between hepatitis A and Helicobacter pylori infections and routes of transmission
(2006) Egemen A.; Yilmaz Ö.; Akil I.; Altuǧlu I.
Previous research about coexistence of Helicobacter pylori (HP) and hepatitis A virus (HAV) infections and the factors that increase their prevalence has suggested that the route of transmission of HP infection includes oral-oral and water-foods as well as the fecal-oral route. The aim of this study was to evaluate the routes of transmission of HP by comparing the seroprevalences of HP and HAV in children. One hundred and two children aged 1-18 years living in rural and urban regions of İzmir were included in this study. Anti-HP IgG and anti-HAV IgG antibodies were measured via enzyme immunoassay method. Seropositivities for HP and HAV were 56.8% and 51.9%, respectively. Seroprevalence for both infections increased with increasing age. However, a significant difference could not be detected between rural and urban areas. Sex did not have a significant effect. There was no infection in 22.1% of children, while 30.8% had both of the infections. 21.1% were positive only for HAV while 26% were positive only for HP. No significant correlation between seroprevalences of HP and HAV was detected. This study suggests the existence of various other routes of transmission of HP apart from the fecal-oral route.
Improved efficacy of aerosol delivery to distal airways in pediatric subjects using a new spacer mouth-mask
(Meditions Carline, 2007) Yüksel H.; Berardino L.; Yüksel D.; Yilmaz Ö.; Burak Z.
Aerosol nebulization is one of the safest and most effective ways of treating airway diseases especially in children. Failure of inhaled asthma treatment is mainly due to inadequate deposition of drugs in the peripheral area of the lungs. The aim of this study was to compare the efficacy of a traditional mask and that of a new spacer mouth-mask (Nebula, Markos Mefar, Italy) when used with a jet nebulizer, by measuring aerosol deposition in the lungs, oropharynx, upper airways, and gastrointestinal tract. Twelve children without respiratory disease aged between 8 and 13 years were included in the study. Aerosol inhalation was performed using a jet nebulizer with 2 mL of saline solution containing 20 Mci of Tc99m-DTPA. The first group initially performed aerosol inhalation using a traditional facemask and then, one week later, using the new spacer mouth-mask. The second group performed aerosol inhalation using the new spacer mouth-mask first and then, one week later, using a traditional mask. Scintigraphic ventilation images ware then obtained, and aerosol deposition in the trachea, oropharynx, lungs and stomach was measured. In the first group, the radioaerosol deposition in the peripheral lung area using the new spacer mouth-mask was greater 97.8±7.0 vs 68.5*7.9 (p=0.04). On the other hand, the oropharyngeal radioaerosol deposition was greater using the traditional mask: 50.2±5.2 vs 20.3±11.8 (p = 0.028). Similarly, in the second group the peripheral lung deposition was greater and the oropharyngeal deposition was less using the new spacer mouth-mask: 97.3±9.4 vs 70.2*11.2 and 20.7 ± 8.9 vs 46.3±16.8 (p=0.028 and 0.046 respectively). In conclusion, the new design of the spacer mouth-mask allows greater aerosol deposition in the peripheral lung area and less in other parts such as the oropharyngeal area, the central airways and the stomach.
A case of congenital midline cervical cleft treated with single Z-plasty; [Z-plasti ile onarim yapilan konjenital orta hat servikal kleft olgusu]
(2007) Yilmaz Ö.; Genç A.; Demireli P.; Özcan T.; Taneli C.
Congenital midline cervical cleft (CMCC) is a rare developmental anomaly in the ventral aspect of the neck. The most excepted theories of embryologic development is impaired fusion of the distal branchial arches in the midline. If the lesion is remain untreated, it causes cicatrical contracture in the neck over time. For this reason complete excision is necessary. We present a case of CMCC treated with Z-plasty closure, because it is very rare. 3 day old male infant was brought to the hospital due to the lesion at his neck, and diagnosed as thyroglossal sinus and recommended to have an operation. When the patient presented to our clinic, his physical examination showed lineer cleft lined with atrophic pink epithelium on the ventral mid-cervical line. The patient underwent elliptically complete excision of the lesion at 3 months of age with intratracheal general anesthesia. The closure of the vertical deficiency was accomplished by single-Z-plasty. As, CMCC is reported as a rare abnormality diagnosis can be assess difficultly. Diagnosis and the treatment of this abnormality should be managed as soon as possible, in order to prevent the neck contracture highly likely to develop in the future.
Rapunzel syndrome: A case report; [Rapunzel sendromu: Olgu sunumu]
(2007) Yilmaz Ö.; Genç A.; Taşkin E.O.; Dilşen Ş.; Kasirga E.; Taneli C.
Bezoars are rare and often reported in patients with some psychiatric disorders. The Rapunzel syndrome is a rare form of gastric trichobezoar with a tail like extension into the intestine. 12 year old girl applied to the clinic with abdominal firmness. She was treated for alopecia areate one year ago. A firm, mobile and approximately 20 cm. diameter epigastric mass was palpated. A massively enlarged, firm stomach was encountered at surgical exploration. Gastrotomy revealed a large trichobezoar, which was taken out totally. She was referred to a child psychiatrist for assessment and therapy. Her diagnosis was major depression. In conclusion, trichophagy must be considered in children who suffer alopecia and psychiatric support must be provided.
The effects of transparenchymal suture material and fibrine-a tissue adhesive-on the contralateral testis
(Turkiye Klinikleri, 2008) Dilşen Ç.; Şencan A.; Neşe N.; Kandiloǧlu A.R.; Yilmaz Ö.; Günşar C.; Genç A.; Taneli C.; Mir E.
Objective: Experimental studies showed that fibrin glue (FG) which was used in orchidopexy and testicular torsion caused less tissue damage in the ipsilateral testis when compared with the transparenchymal suture materials. However, whether the usage of the FG in testis fixation causes any histological changes in the contralateral testis is not known. The aim of this study was to compare the effects of FG and other suture materials on the contralateral testis where no surgical procedure is performed. Material and Methods: Fifty prepubertal rats were randomly divided into 5 groups and the tunica vaginalis of all the right testes were longitudinally incised. In group 1, the incision line was closed with FG, whereas silk, catgut and polypropylene were used respectively in the groups 2, 3 and 4. Group 5 was the control group and no surgical procedure was performed on the left testes. The rats were sacrificed 3 weeks later and the diameters of the right and left testes were measured. Testes were evaluated by means of inflammation, seminiferous tubular diameter (STD), spermatogenetic activity and epididymal inflammation. Result: In group 2, 3 and 4, spermatogenetic activity, STD and the testis diameter of the ipsilateral testes decreased, whereas testicular and epidydimal inflammation increased. When the contralateral testis was evaluated, STD of the FG group decreased and FG had no extra benefit on testicular histology when compared to other suture materials. Conclusion: Surgical procedures performed on the ipsilateral testis cause only a decrease in the contralateral STD, which is observed by light microscope, but this decrease seems to have no effect on the spermatogenetic activity. Besides, the usage of FG instead of other materials in testis fixation has no extra benefit. However, it must be kept in mind that these results might vary when ultrastructural and immunological evaluations are performed. Copyright © 2008 by Türkiye Klinikleri.
A rare cause of persistent atelectasis in childhood: Mucoepidermoid carcinoma
(2008) Söǧüt A.; Yilmaz Ö.; Yüksel H.
A 12-year-old boy presented to our clinic with recurrent lower respiratory tract symptoms that are wheezing, cough, bronchopneumonia, and fever and with a diagnosis of bacterial endocarditis. Physical examination revealed that breath sounds diminished in the left lower lobe. Because cardiac sounds and echocardiography were normal bacterial endocarditis was excluded. Chest radiograph and computerized tomography scan showed a left lower lobe atelectasis and consolidation. Despite medical therapy including antibiotics, bronchodilator etc, atelectasis persisted. Fiberoptic flexible bronchoscopy (FFB) revealed a tumor that totally obstructed the left lower lobe bronchus. Open lung biopsy revealed a low-grade mucoepidermoid carcinoma. Left lower lung lobectomy was performed. The patient is in good condition 12 months after the operation. We proposed that FFB should be performed earlier in patients with recurrent lower respiratory symptoms who have persistent atelectasis or unifocal infiltration.
Unusual association of omphalocele and wandering spleen
(2008) Yilmaz Ö.; Genc A.; Ozcan T.; Aygoren R.S.; Taneli C.
A wandering spleen is a rare anomaly and its association with omphalocele has been reported in the literature only once. We present a female infant that has a wandering spleen associated with omphalocele. The patient was admitted with the diagnosis of omphalocele. Primary repair was performed and the patient was discharged on the 6th postoperative day. Nine months later, the girl was referred to our emergency unit with complaints about abdominal distention and restlessness. After 2 days of clinical observation, an immobile, firm abdominal mass was palpated. Ultrasonographic evaluation revealed that the mass was the spleen and it was found exactly under the left side of the umbilicus, instead of its original location. During the operation, the spleen was beneath the left side of the umbilicus, with its upper surface completely adhered to the peritoneum, and it was rotated 180° clockwise. Then the spleen was rotated back and placed in its normal anatomic location. At 1 month postoperatively, a radionuclide scan was performed and splenic perfusion was evaluated to be normal. In conclusion, herniations and eventrations of organs through defects on the abdominal wall may either result in restriction of normal rotations of the stomach and the spleen or in inefficient fusion after the rotation has been completed. Copyright © 2008 S. Karger AG.
Kidney stone and urinary bladder telangiectasia in a patient with TAR syndrome
(2008) Akil I.; Gözmen S.; Yilmaz Ö.; Taneli C.
TAR syndrome is a congenital malformation syndrome characterized by bilateral absence of the radius and thrombocytopenia. The known urinary anomalies are duplex ureter, dilatation of renal pelvis, horseshoe kidney and functional problems like vesicoureteral reflux and pyelonephritis. In this report of a case with TAR syndrome, a kidney stone and bladder telangiectasia were found coincidentally during the investigation of hematuria. TAR syndrome is discussed in the light of the medical literature. To our knowledge, no case has been reported demonstrating nephrolithiasis and bladder telangiectasia in TAR patients.
Common viral etiologies of community acquired lower respiratory tract infections in young children and their relationship with long term complications; [Küçük çocuklarda toplum kökenli viral alt solunum yolu enfeksiyonu etkenlerinin sιklιǧι ve uzun dönem komplikasyonu ile ilişkileri]
(2008) Yüksel H.; Yilmaz Ö.; Akçali S.; Söǧüt A.; Yilmaz Çiftdoǧan D.; Urk V.; Ertan P.; Şanlidaǧ T.
Viral lower respiratory tract infections (LRTIs) and their late complications are important causes of morbidity and mortality in childhood. The aims of this study were the detection of viral agents that cause community-acquired LRTIs in young children and investigation of the relationship between viral etiology and bronchiolitis obliterans (BO) which is one of the late complications of LRTIs. A total of 151 children (86 male, 65 female; mean age: 2.9 ± 1.9 years) who were diagnosed to have LRTIs between the period of 2002-2004, at Pediatric Allergy and Pulmonology Department of a University Hospital in Manisa (located in the Aegean region of Turkey) were included to the study. The presence of respiratory viruses [respiratory syncytial virus (RSV), influenza virus type A and B, parainfluenza virus types 1, 2 and 3, adenovirus] in the nasopharyngeal aspirate specimens collected from children have been searched by direct fluorescence antibody test (Biotrin, Ireland). Respiratory viruses were detected in 25.2% (38/151) of the patients with LRTIs, while this rate was 46.8% (22/47) for 2002 period, 13.3% (8/60) for 2003 period and 18.2% (8/44) for 2004 period. RSV and adenoviruses both detected with a frequency of 31.5% (n= 12/38); were the most common agents encountered, and followed by parainfluenza (10/38, 26.3%) and influenza (9/38, 23.6%) viruses. Postinfectious BO have been diagnosed in 7.3% (11/151) of the patients; seven in 2002, one in 2003 and three in 2004 periods. Viral etiology were present in all of the patients who developed BO in 2002, while viral infection was detected in one of the patients who developed BO in 2003-2004 periods. Adenoviruses were the most frequently detected agents (n= 5) in BO cases with viral etology (n= 8). Viral agents were found positive in 72.7% (8/ 11) and 21.4% (30/140) of the patients with and without BO development, respectively, and this difference was found statistically significant (p= 0.02). Besides, BO development was detected in 21.1% (8/38) and 2.6% (3/113) of LRTI patients with and without viral etiology, respectively, and this difference was also significant (p< 0.05). In conclusion, the long term follow-up is important in young children with viral LRTIS for the early diagnosis of complications. Thus the identification of viruses might aid in estimation of prognosis.
Early renal parenchymal histological changes in an experimental model of vesico-ureteral reflux and the role of apoptosis
(2008) Şencan A.; Vatansever S.; Yilmaz Ö.; Genç A.; Serter S.; Gümüser G.; Kurutepe S.; Pekindil G.; Günsar C.; Mir E.
Objectives. To observe early renal parenchymal cellular changes in an experimental model of vesico-ureteral reflux (VUR) and to show whether the apoptotic pathway plays a role in these cellular changes. Material and methods. Fourteen New Zealand breed rabbits were used and were divided into two equal groups (control and experimental groups). Urine samples were obtained in a sterile manner and cultured. In the study group, reflux was created in the right kidneys surgically. Renal scintigraphy and voiding cystourethrography (VCUG) were performed in both groups on Day 17. The kidneys were examined in terms of histology, apoptotic activity and caspase activity. Results. No growth was observed in urine cultures in either group. VUR was manifested in only two rabbits in the experimental group on VCUG. On renal scintigraphy, no renal scarring was observed in either of the groups and renal uptake values were in the normal range. There was a greater increase in collagen in the right kidneys in the experimental group than in the control group and apoptotic activity was significantly increased in the study group: 0% in the control group, 10.8%±0.7% in the experimental group (p<0.001). Caspase-6 activity was strongly positive and caspase-8 and -9 activities were moderately positive in the right kidneys of the experimental group. Caspase-6 activity was moderately positive, and caspase-8 and -9 activities were weakly positive in the contralateral kidneys of the experimental group. Caspase activities in the control group were negative (p<0.001). Conclusions. In this experimental model of VUR, apoptotic activity was initiated via the caspase-8 and -9 pathway and collagen tissue increased in the renal parenchyma where reflux occurred. The balance of apoptotic activity may play a key role in the occurrence of reflux nephropathy. © 2008 Taylor & Francis.
Borderline phyllodes tumor of the breast in an adolescent girl; [Adölesan kiz olguda memenin "Borderline" fillodes tümörü Olgu Sunumu]
(2008) Genç A.; Yilmaz Ö.; Özgüven A.A.; Ersoy B.; Aygören R.; Kandiloǧlu A.R.; Taneli C.
Phyllodes tumor (PT) is a tumor similar to fibroadenoma, that can reach to enormous sizes. It consistic less than 1 % of all breast neoplasms. Here, a 13 years old female patient is reported due to its rarity. She presented with a mass in the right breast which showed hard consistency and fixation to the thoracic wall by palpation and caused retraction of the nipple. Tomography revealed a solid mass with the diameter of approximately 11 cm. Patient was operated with the presumptive diagnosis of PT or breast carcinoma and the mass was totally excised together with its capsule. Pathologic examination showed 6 mitotic cells in each field, medium cellularity and slight atypia. It was accepted as a borderline tumor but no recurrence or metastasis was observed within postoperative 5 months. As for conclusion, PT should be considered in rapidly expanding masses of breast that present with enormous size.
Evaluation of sleep quality in mothers of children with bronchiolitis obliterans; [Bronşiyolitis obliteransli çocuklarin annelerinde uyku niteliǧinin deǧerlendirilmesi]
(Kare Publishing, 2009) Yüksel H.; Çiftdoǧan D.Y.; Yilmaz Ö.; Söǧüt A.
Aim: The aim of this study was to evaluate the quality of sleep in mothers of children with bronchiolitis obliterans. Material and Method: The study group consisted of 36 mothers with a child who had bronchiolitis obliterans and 62 mothers with healthy children. All mothers enrolled in the study filled in the Pittsburgh Sleep Quality Index (PSQI). Results: The mean ages of the children of the mothers enrolled in the study were statistically similar (3.57±2.58 vs 3.85±1.46 years, p>0.05). Total Pittsburgh Sleep Quality Index scores and subjective sleep quality scores in the mothers of children with bronchiolitis obliterans were significantly higher than those in the mothers of healthy children (both p=0.015). Conclusions: In this study, it was found that mothers of children with bronchiolitis obliterans have poor sleep quality. Therefore, assessment may be needed for the requirement of support regarding sleep quality in them.

Browsing by Author "Yilmaz Ö."

Results Per Page

Sort Options