Browsing by Author "Yilmaz I."
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Item A case study of crushing resistance of Anatolian sands at lower and higher density(2008) Erzin Y.; Yilmaz I.Particle breakage occurs when the stresses imposed on soil particles exceed their strength. In order to determine the crushing resistance, Anatolian sands were collected from three different locations in Turkey. Mineralogical, particle shape and size characteristics were first determined by laboratory testing and compaction and triaxial tests then undertaken. Particle breakage factors were calculated from the initial and final gradations of the samples. It was noted that the sample containing a third calcite experienced higher particle breakage. © Springer-Verlag 2007.Item Asthma control test via text messaging: Could it be a tool for evaluating asthma control?(2013) Uysal M.A.; Mungan D.; Yorgancioglu A.; Yildiz F.; Akgun M.; Gemicioglu B.; Turktas H.; Ozkan G.; Yilmaz I.; Incioglu M.; Boyaci H.; Atis S.; Yalcin A.; Bayram N.G.; Deveci F.; Pulur D.; Ozgur E.S.; Dursun B.; Bulbul Y.; Sulu E.; Yilmaz V.Introduction: Originally, the Asthma Control Test (ACT) was designed for English-speaking patients using a paper-and-pencil format. The Turkish version of the ACT was recently validated. This article compares the paper-and-pencil and web-based texting formats of the Turkish version of the ACT and evaluates the compatibility of these ACT scores with GINA-based physician assessments of asthma control. Methods: This multicentre prospective study included 431 asthma patients from outpatient clinics in Turkey. The patients were randomized into a paper-and-pencil group (n=220) and a text messaging group (n=211). Patients completed the ACT at Visit 1, after 10±2 days, and at 5±1 week to demonstrate the reliability and responsiveness of the test. At each visit, physicians assessed patients' asthma control levels. Results: The ACT administered via texting showed an internal consistency of 0.82. For the texting group, we found a significant correlation between the ACT and physician assessments at Visit 1 (r=0.60, p<0.001). The AUC was 0.87, with a sensitivity of 78.0% and a specificity of 77.5% for a score of ≤19 for screening "uncontrolled" asthma in the texting group. Conclusion: When the Turkish version of the ACT was administered via either the paper-and-pencil or text messaging test, scores were closely associated with physician assessments of asthma control. © 2013 Informa Healthcare USA, Inc.Item A retrospective multicenter evaluation of cutaneous melanomas in Turkey(Asian Pacific Organization for Cancer Prevention, 2014) Gamsizkan M.; Yilmaz I.; Buyukbabani N.; Demirkesen C.; Demiriz M.; Cetin E.D.; Ince U.; Akalin T.; Demirkan N.C.; Lebe B.; Erdem O.; Gokoz O.; Sakiz D.; Demireli P.T.; Astarci H.M.; Adim S.B.; Zemheri I.E.; Acikalin A.; Yaman B.; Aydin O.; Bassorgun C.I.Background: We defined melanoma distribution in a large series of Turkish patients and evaluated the prognostic parameters of melanomas. Materials and Methods: A total of 1574 patients' data was retrospectively collected at 18 centers in Turkey. Demographic characteristics were questioned and noted. Prognostic parametres were evaluated based on sentinel lymph node involvement. Results: Mean age was 56.7 (4-99) years. While 844 (53.6%) cases were male, 730 (46.4%) cases were female. One thousand four hundred forty-seven (92%) cases were invasive melanoma and 127 (8%) cases were in-situ melanoma. The most common histopathological form was the superficial spreading melanoma (SSM) which was found in 549 patients (37.9%). It was followed by nodular melanoma in 379 (26.2%), acral lentiginous melanoma (ALM) in 191 (13.2%) and lentigo maligna melanoma in 132 (9.1%), respectively. On univariate analysis, lymphovascular invasion (p < 0.001), tumor thickness (p < 0.001), histopathological subtype (p < 0.001), Clark level (p = 0.001), ulceration (p < 0.001), ≥ 6/mm2 mitosis (p = 0.005), satellite formation (p = 0.001) and gender (p = 0.03) were found to be associated with sentinel lymph node positivity. Regression was associated with sentinel lymph node negativity (p = 0.017). According to multivariate analysis, lymphovascular invasion and tumor thickness were significant independent predictive factors of SLN positivity. Patient age, tumor localization, precursor lesions, lymphocytic infiltration and neurotropism were not related with sentinel lymph node involvement. Conclusions: In this retrospective analysis, it was found that the prevalence of SSM is at a lower rate while the prevalence of ALM is at a higher rate when compared to western countries. According to Breslow index; most of the melanoma lesions' thickness were greater than 2 mm, corresponding Clark IV. Vascular invasion and tumor thickness are the most important factors for sentinel lymph node involvement.Item Investigations into factors influencing the CBR values of some Aegean sands(Sharif University of Technology, 2016) Erzin Y.; Türköz D.; Tuskan Y.; Yilmaz I.The California Bearing Ratio (CBR) value of the soils is very important for geotechnical engineering and earth structures. A CBR value is affected by the soil type and different soil properties. With this in view, in this paper, an attempt has been made for investigating the factors that affect the CBR values of some Aegean sands collected from nine different locations in Manisa (Turkey). The sand samples were tested for mineralogy, particle shape and size, and specific gravity. The CBR tests were then performed on these samples at different dry densities to examine the influence of dry density, relative density, water content, and particle shape and size on the CBR value. Multiple Regression Analysis (MRA) was performed to predict the CBR value of the sands by using the experimental results. Moreover, several performance indices, such as coefficient of correlation and variance account for mean absolute error and root mean square error, were calculated to check the prediction capacity of the proposed MR equation. The obtained indices make it clear that the equation derived from the samples used in this study applies well, with an acceptable accuracy, to the CBR estimation at the preliminary stage of site investigations. © 2016 Sharif University of Technology. All rights reserved.Item Picturing asthma in Turkey: results from the Turkish adult asthma registry(Taylor and Francis Ltd., 2023) Celik G.E.; Aydin O.; Gokmen D.; Koycu Buhari G.; Celebi Sozener Z.; Gemicioglu B.; Bulut I.; Beyaz S.; Orcen C.; Ozdemir S.K.; Keren M.; Damadoglu E.; Yakut T.; Kalpaklioglu A.F.; Baccioglu A.; Yalim S.A.; Yilmaz I.; Koca Kalkan I.; Uysal M.A.; Ozgun Niksarlioglu E.Y.; Kalyoncu A.F.; Karakaya G.; Erbay M.; Nayci S.; Tepetam F.M.; Gelincik A.A.; Dirol H.; Goksel O.; Karaoglanoglu S.; Oner Erkekol F.; Isik S.R.; Yildiz F.; Yavuz Y.; Karadogan D.; Bozkurt N.; Seker U.; Oguzulgen I.K.; Basyigit I.; Baris S.A.; Yilmazel Ucar E.; Erdogan T.; Polatli M.; Ediger D.; Gunaydin F.E.; Turk M.; Pur L.; Katran Z.Y.; Sekibag Y.; Aykac E.F.; Mungan D.; Gul O.; Cengiz A.; Akkurt B.; Ozden S.; Demir S.; Unal D.; Aslan A.F.; Can A.; Gumusburun R.; Bogatekin G.; Akten H.S.; Inan S.; Erdinc M.; Ogus A.C.; Kavas M.; Polat Yulug D.; Cakmak M.E.; Kaya S.B.; Alpagat G.; Ozgur E.S.; Uzun O.; Tas Gulen S.; Pekbak G.; Kizilirmak D.; Havlucu Y.; Donmez H.; Arslan B.; Cetin G.P.; Soyyigit S.; Kara B.Y.; Pasaoglu Karakis G.; Dursun A.B.; Kendirlinan R.; Ozturk A.B.; Sevinc C.; Omeroglu Simsek G.; Abadoglu O.; Cerci P.; Yucel T.; Yorulmaz I.; Tezcaner Z.C.; Tatar E.C.; Suslu A.E.; Ozer S.; Dursun E.; Yorgancioglu A.Introduction: National data on asthma characteristics and the factors associated with uncontrolled asthma seem to be necessary for every country. For this purpose, we developed the Turkish Adult Asthma Registry for patients with asthma aiming to take a snapshot of our patients, thereby assigning the unmet needs and niche areas of intervention. Methods: Case entries were performed between March 2018 and March 2022. A web-based application was used to record data. Study outcomes were demographic features, disease characteristics, asthma control levels, and phenotypes. Results: The registry included 2053 patients from 36 study centers in Turkey. Female subjects dominated the group (n = 1535, 74.8%). The majority of the patients had allergic (n = 1158, 65.3%) and eosinophilic (n = 1174, 57.2%) asthma. Six hundred nineteen (32.2%) of the patients had obese asthma. Severe asthma existed in 670 (32.6%) patients. Majority of cases were on step 3–5 treatment (n: 1525; 88.1%). Uncontrolled asthma was associated with low educational level, severe asthma attacks in the last year, low FEV1, existence of chronic rhinosinusitis and living in particular regions. Conclusion: The picture of this registry showed a dominancy of middle-aged obese women with moderate-to-severe asthma. We also determined particular strategic targets such as low educational level, severe asthma attacks, low FEV1, and chronic rhinosinusitis to decrease uncontrolled asthma in our country. Moreover, some regional strategies may also be needed as uncontrolled asthma is higher in certain regions. We believe that these data will guide authorities to reestablish national asthma programs to improve asthma service delivery. © 2023 Taylor & Francis Group, LLC.Item Socioeconomic status has direct impact on asthma control: Turkish adult asthma registry(John Wiley and Sons Inc, 2025) Arslan B.; Türk M.; Hayme S.; Aydin Ö.; Gokmen D.; Buhari G.K.; Sozener Z.C.; Gemicioglu B.; Bulut I.; Beyaz S.; Orcen C.; Ozdemir S.K.; Keren M.; Damadoglu E.; Yakut T.; Kalpaklioglu A.F.; Baccioglu A.; Yalim S.A.; Yilmaz I.; Kalkan I.K.; Ozgun Niksarlioglu E.Y.; Kalyoncu A.F.; Karakaya G.; Erbay M.; Nayci S.; Tepetam F.M.; Gelincik A.A.; Dirol H.; Goksel O.; Karaoglanoglu S.; Erkekol F.O.; Isik S.R.; Yildiz F.; Yavuz Y.; Karadogan D.; Bozkurt N.; Seker U.; Oguzulgen I.K.; Basyigit I.; Baris S.A.; Ucar E.Y.; Erdogan T.; Polatli M.; Ediger D.; Gunaydin F.E.; Pur L.; Katran Z.Y.; Sekibag Y.; Aykac E.F.; Mungan D.; Gul O.; Cengiz A.; Akkurt B.; Ozden S.; Demir S.; Unal D.; Aslan A.F.; Can A.; Gumusburun R.; Bogatekin G.; Akten H.S.; Inan S.; Erdinc M.; Ogus A.C.; Kavas M.; Yulug D.P.; Cakmak M.E.; Kaya S.B.; Alpagat G.; Ozgur E.S.; Uzun O.; Gulen S.T.; Pekbak G.; Kizilirmak D.; Havlucu Y.; Donmez H.; Cetin G.P.; Soyyigit S.; Kara B.Y.; Karakis G.P.; Dursun A.B.; Kendirlinan R.; Ozturk A.B.; Sevinc C.; Simsek G.O.; Abadoglu O.; Cerci P.; Yucel T.; Yorulmaz I.; Tezcaner Z.C.; Tatar E.C.; Suslu A.E.; Ozer S.; Dursun E.; Yorgancioglu A.; Celik G.E.; Uysal M.A.Background: Asthma is one of the most common causes of chronic respiratory disease, and countries with low socioeconomic status have both a high prevalence of asthma and asthma-related death. Objective: In this study, we aimed to determine socioeconomic levels of asthmatic patients according to a national database and investigate the effects of social markers on disease control in our region. Methods: This is an analysis of data from 2053 adult asthma patients from a multicentre chart study in Turkey. Socioeconomic status (SES) data were collected from questionnaires and this form was sent to the patients via e-mail. Parameters related to social status and poor disease control were analyzed. Results: Illiteracy (OR:2.687 [95% CI: 1.235–5.848]; p = 0.013) and lower household income (OR:1,76 [95% CI: 1.002–3.09]; p = 0.049) were found as independent risk factors for hospitalization in the multivariate logistic regression analysis. Therewithal, being aged between 40 and 60 (OR: 1.435 [95% CI: 1.074–1.917]; p = 0.015), illiteracy (OR: 2.188 [95% CI: 1.262–3.795]; p = 0.005) and being employed (OR: 1.466 [95% CI: 1.085–1.847]; p = 0.011) were considered as independent risk factors for systemic corticosteroid use at least 3 days within last 1 year. Conclusion: As a result of our national database, education level, household income and working status briefly socioeconomic status have impacts on asthma control. Identification of social markers in asthma and better recognition of risk factors based on the population gives us clues to provide better asthma control in the future. © 2025 The Author(s). Clinical and Translational Allergy published by John Wiley & Sons Ltd on behalf of European Academy of Allergy and Clinical Immunology.Item Asthma patients with obesity have a unique phenotype: a subanalysis of the Turkish adult asthma registry(Taylor and Francis Ltd., 2025) Celebi Sozener Z.; Oguzulgen I.K.; Ozalp Ates F.S.; Baccioglu A.; Argun Barıs S.; Ediger D.; Gunaydın F.E.; Sevinc C.; Seker U.; Yılmaz Kara B.; Beyaz S.; Mungan D.; Aydin O.; Gokmen D.; Buhari G.K.; Gemicioglu B.; Bulut I.; Orcen C.; Kepil Ozdemir S.; Keren M.; Damadoglu E.; Yakut T.; Kalpaklioglu A.F.; Alan Yalim S.; Yilmaz I.; Koca Kalkan I.; Uysal M.A.; Ozgun Niksarlioglu E.Y.; Kalyoncu A.F.; Karakaya G.; Erbay M.; Nayci S.; Tepetam F.M.; Akkor Gelincik A.; Dirol H.; Goksel O.; Karaoglanoglu S.; Oner Erkekol F.; Isik S.R.; Yildiz F.; Yavuz Y.; Karadogan D.; Bozkurt N.; Basyigit I.; Yilmazel Ucar E.; Erdogan T.; Polatli M.; Turk M.; Pur L.; Yegin Katran Z.; Sekibag Y.; Aykac E.F.; Gul O.; Cengiz A.; Akkurt B.; Ozden S.; Demir S.; Unal D.; Aslan A.F.; Can A.; Gumusburun R.; Bogatekin G.; Akten H.S.; Inan S.; Erdinc M.; Ogus A.C.; Kavas M.; Polat Yulug D.; Cakmak M.E.; Kaya S.B.; Alpagat G.; Ozgur E.S.; Uzun O.; Gulen S.T.; Pekbak G.; Kizilirmak D.; Havlucu Y.; Donmez H.; Arslan B.; Cetin G.P.; Soyyigit S.; Pasaoglu Karakis G.; Dursun A.B.; Kendirlinan R.; Ozturk A.B.; Omeroglu Simsek G.; Abadoglu O.; Cerci P.; Yucel T.; Yorulmaz I.; Tezcaner Z.C.; Cadalli Tatar E.; Suslu A.E.; Ozer S.; Dursun E.; Yorgancioglu A.; Celik G.E.Objective: The obese-asthma phenotype has gradually increased in the last few years. We aimed to assess the differences between obese and non-obese patients with asthma. Methods: This research is a subanalysis of the Turkish Adult Asthma Registry (TAAR). Clinical presentation, disease control, severity, and demographics of obese and non-obese (normal-weight, overweight) patients were compared. Results: The obesity rate in TAAR was 32.2% (n = 619/1919; 18-83 years; 527 F/92 M). Patients with asthma and obesity had higher rates of childhood obesity, longer symptom duration, later onset of asthma, and more severe asthma. These patients were more likely to be female, older, less educated, and live in rural areas. Patients with obesity had more scheduled visits and emergency visits compared with non-obese patients, but similar asthma control, oral corticosteroid use, hospitalizations, intensive care unit admissions, and unscheduled visits. They also had a higher frequency of T2-high but lower frequency of possible T2-low phenotypes compared with normal-weight asthmatics. The risk of severe asthma in patients with obesity was 6.04 times higher for allergic than non-allergic patients and 3.58 times higher for the T2-high phenotype than for possible T2-low phenotypes. A one-unit increase in the asthma control test reduced the risk of severe asthma by 22%. Conclusions: A good definition of this phenotype is important to ensure that appropriate treatment strategies are implemented to achieve the control goal. We also believe that prevention of childhood obesity is an effective and pivotal strategy to achieve the goal of asthma control. © 2025 Taylor & Francis Group, LLC.Item Factors influencing the prescription of add-on long-acting muscarinic antagonists in real-world asthma management: Insights from a national registry(W.B. Saunders Ltd, 2025) Gemicioglu B.; Gokmen D.; Can A.; Sevinc C.; Oguzulgen I.K.; Soyyigit S.; Yakut T.; Havlucu Y.; Aydin O.; Buhari G.K.; Sozener Z.C.; Bulut I.; Beyaz S.; Orcen C.; Ozdemir S.K.; Keren M.; Damadoglu E.; Kalpaklioglu A.F.; Baccioglu A.; Yalim S.A.; Yilmaz I.; Kalkan I.K.; Uysal M.A.; Ozgun Niksarlioglu E.Y.; Kalyoncu A.F.; Karakaya G.; Erbay M.; Nayci S.; Tepetam F.M.; Gelincik A.; Dirol H.; Goksel O.; Karaoglanoglu S.; Erkekol F.O.; Isik S.R.; Yildiz F.; Yavuz Y.; Karadogan D.; Bozkurt N.; Seker U.; Basyigit I.; Baris S.A.; Ucar E.Y.; Erdogan T.; Polatli M.; Ediger D.; Gunaydin F.E.; Turk M.; Pur L.; Katran Z.Y.; Sekibag Y.; Aykac E.F.; Mungan D.; Gul O.; Cengiz A.; Akkurt B.; Ozden S.; Demir S.; Unal D.; Aslan A.F.; Gumusburun R.; Bogatekin G.; Akten H.S.; Inan S.; Erdinc M.; Ogus A.C.; Kavas M.; Yulug D.P.; Cakmak M.E.; Kaya S.B.; Alpagat G.; Ozgur E.S.; Uzun O.; Gulen S.T.; Pekbak G.; Kizilirmak D.; Donmez H.; Arslan B.; Cetin G.P.; Kara B.Y.; Dursun A.B.; Karakis G.P.; Kendirlinan R.; Ozturk A.B.; Simsek G.O.; Abadoglu O.; Cerci P.; Yucel T.; Yorulmaz I.; Tezcaner Z.C.; Tatar E.C.; Suslu A.E.; Ozer S.; Dursun E.; Yorgancioglu A.; Çelik G.E.Current guidelines recommend adding long-acting muscarinic antagonists (LAMAs) in patients with uncontrolled asthma, despite the use of moderate to high doses of inhaled steroid-long-acting beta agonists (ICS/LABA). This study aims to analyze the factors related to the prescription of add-on LAMA in clinical practice for asthma patients, shedding light on physicians’ preferences. This study included adult asthma patients on add-on LAMA and ICS/LABA monitored for at least one year in a national registry comprising 2053 asthmatics. Patients’ characteristics and disease profiles were analyzed to identify factors associated with the prescription of add-on LAMA across the entire cohort. A comparative analysis was performed among three groups: MART (ICS/formoterol as a maintenance and reliever therapy) plus LAMA, Conventional (ICS/LABA as a maintenance and short-acting beta agonist as reliever) plus LAMA and Triple (ICS/LABA/LAMA single inhaler). LAMAs were added to ICS/LABA in 11.7 % of patients in the national registry. Logistic regression analysis revealed that older age, low FEV1 (%), Asthma Control Test (ACT) scores less than 20, and severe exacerbation were the main factors influencing the initiation of LAMA in our registry. However, demographic characteristics of asthma, control status, pulmonary function test results were similar among the three groups of LAMA users (p > 0.05). Physicians used LAMAs without phenotyping based on allergic status or eosinophil levels (p > 0.05). Mepolizumab was added after LAMA in all patients, while omalizumab was initiated before LAMA in 16.9 % of the patients receiving LAMA along with biologics. Add-on LAMAs were predominantly prescribed for older, uncontrolled, and exacerbated asthma patients with low FEV1. © 2024 Elsevier Ltd