Browsing by Author "Yorgancioglu, A"

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    Asthma Control Test and Asthma Quality of Life Questionnaire Association in Adults
    Alpaydin, AO; Bora, M; Yorgancioglu, A; Coskun, AS; Celik, P
    Asthma control and quality of life are expected to be correlated. We aimed to evaluate the association of asthma control test (ACT) with asthma quality of life questionnaire (AQLQ) and guideline based control assessment. We also aimed to investigate the impact of therapy adjustment according to ACT score on AQLQ A total of 101 asthmatic patients were included. ACT, AQLQ and Global Initiative for Asthma (GINA) based control assessments were performed. Based on ACT, treatment was adjusted by stepping down in controlled and stepping up in uncontrolled/partly controlled patients. In some controlled/partly controlled patients, no therapy adjustment was done. After 3-months the same parameters were reevaluated. We found a statistically significant association between ACT and AQLQ, a one point increase in ACT was associated with a 0.129 point increase in AQLQ. ACT scores increased significantly in the step-up group; however AQLQ total scores were not affected after therapy adjustment. We found that ACT was concordant with GINA recommended control classification in the first (kappa=0.511, 7.718) and third months (kappa=0.599, 7.912) (P<0.001 for both). We determined an association between ACT and AQLQ. ACT was also found fairly concordant with GINA. However, treatment adjustment according to ACT was not found satisfactory in terms of quality of life.
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    Omalizumab in patients with severe persistent asthma in real life setting in Manisa, Turkey
    Havlucu, Y; Yorgancioglu, A; Kurhan, F; Özdemir, L; Coskun, S; Goktalay, T; Yilmaz, O; Celik, P
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    Long term efficacy of fixed-dose omalizumab for patients with severe chronic urticaria
    Havlucu, Y; Yorgancioglu, A; Havlucu, DY; Madak, B; Kurhan, F
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    The validity and reliability of the Turkish version of the Leicester Cough Questionnaire in COPD patients
    Kurhan, F; Göktalay, T; Havlucu, Y; Sari, S; Yorgancioglu, A; Çelik, P; Coskun, AS
    Background/aim: The reliability and validity of the Turkish version of the Leicester Cough Questionnaire (LCQ) have been evaluated before. This study aimed to validate the Turkish version of the LCQ in chronic obstructive puhnonary disease (COPD) patients with cough. Materials and methods: COPD (GOLD B, C, D) patients over age 40 (n = 75) and healthy volunteers as a control group (n = 75) were included. A sociodeinographic data form, the LCQ, the Short Form-36 (SF-36) quality of life questionnaire, and the World Health Organization Quality of Life Brief Form for Turkish people were completed. The internal reliability of the LCQ was determined using the Cronbach alpha coefficient (>0.6) and its repeatability by the intraclass consistency coefficient (P < 0.05) was accepted as significant. Results: For internal consistency, Cronbach alpha coefficients of all subscales of the LCQ, physical, psychological, and social, were found as 0.72, 0.86, and 0.83, respectively, with 0.92 for the total index. There was significant internal consistency for all subscales and the total index (Cronbach alpha coefficients of >0.6). In test-retest reliability, the correlation coefficient ranged between 0.71 and 0.80 for each question and was calculated as r = 0.89 for total LCQ score (P < 0.001). Conclusion: The Turkish version of the LCQ has been found to have acceptable reliability and validity for use in Turkish COPD patients with chronic cough.
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    Quality of life in asthma (SF-36 questionnaire)
    Yorgancioglu, A; Aydemir, Ö; Çelik, P; Topçu, F
    This study is aimed to evaluate the quality of life (QoL)in 52 asthmatics using the SF-36 health status questionnaire which is based on 36 items to represent 8 health domains. These domains were evaluated according to age, gender, status of education, duration and severity of asthma, day and night symptoms, FEV1 and PEF values, emergency admissions, usage of steroids The emotional and physical role difficulties, and social and physical functions were worse in the group of poorly educated. General health perception was strongly and inversely correlated with the duration of asthma, the patients with PEFR values over 80% were significantly better in the physical role difficulties Physical and social functions were worse in patients having day symptoms. As the severity of airway obstruction increases, the emotional role difficulties become more significant. Emotional and functional role difficulties were also more frequent in patients on steroid therapy. As asthma may impair the daily life so severely, QoL questionnaires should always be used in the management of asthma.
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    Evaluation of silicosis in ceramic workers
    Sakar, A; Kaya, E; Çelik, P; Gencer, N; Temel, O; Yaman, N; Sepit, L; Yildirim, ÇA; Dagyildizi, L; Coskun, E; Dinç, G; Yorgancioglu, A; Çimrin, AH
    This study is aimed to evaluate the incidence of silicosis and the relation of it with personal and work-related factors among workers exposed to silica in ceramic factory. Workers were evaluated by respiratory symptoms, physical examination, pulmonary function and radiological findings. Occupational and Enviromental Pulmonary Disease Evaluation Questionnaire of the Turkish Thoracic Society Enviromental and Occupational Pulmonary Diseases Working Group was used. 365 of 626 workers had exposure to silica and the rest 261 were concerned as control group. There was no difference between mean age, duration of work and smoking pack year among the groups (p> 0.05). Cough and sputum rates were higher in silicosis group FEV1 and FVC values were lower in silica group but this was not statistically significant. When the two subgro-ups of silica group (the workers in high dust concentration and the ones in low concentration) were compared, the high concentrated group had significantly more sputum but the other symptoms and pulmonary functional parameters were not different significantly. 24 workers had parenchymal densities adjusted with pneumoconiosis. The workers with the pneumoconistic finding, had a higher mean age and longer duration of work. As a conclusion, ceramic industry has risk for silicosis. And the risk increase by time and age.
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    Validity and reliability of asthma quality of life questionnaire in a sample of Turkish adult asthmatic patients
    Alpaydin, AO; Yorgancioglu, A; Yilmaz, O; Bora, M; Göktalay, T; Çelik, P; Yüksel, H
    We aimed to investigate the validity and reliability and of Asthma Quality of Life Questionnaire (AQLQ) in Turkish adult asthmatic patients. New or previously diagnosed [according to Global Initative for Asthma (GINA) 2008] symptomatic 118 consecutive stable asthmatic patients between 18 and 55 years old were included. Asthma severity was determined and Turkish adaptation of the AQLQ was administered. Lara asthma symptom scales (LASS), pulmonary function tests, Turkish adaptation of Medical Outcomes Survey Short Form-36 (SF-36) were evaluated. All assessments were done twice at recruitment and after 10 weeks. During this period patients were allowed to make modifications on their medication when necessary. Among the recruited 118 patients 95 were female and 14 were lost in the follow-up. Sixty-two percentages of the patients had mild and 38% moderate asthma. The internal consistency of AQLQ was high (Cronbach's alpha 0.81-0.87) and item-total score correlations were ranging from 0.75-0.89. The cross-sectional and longitudinal correlations between AQLQ total and domain scores and SF36 domain scores were in a range of little or fair degree (r= 0.241-0.626, p<0.005). Total AQLQ scores were observed significantly different according to disease severity and LASS both in the first (p<0.001, both) and 10 weeks follow-up visits (p=0.006, p<0.001 respectively). A statistical significant change was observed in AQLQ symptom score as in total LASS changed ( p<0.001, both) in the follow-up. Our results demonstrated that Turkish version of AQLQ is feasible, reliable, valid and sensitive to changes in adult asthmatics.
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    Patient education in asthma
    Yorgancioglu, A; Celik, P; Topcu, F
    The day and night symptoms, medical therapy requirements, PEFR monitorizing : hospital admisssions, pulmonary function parameters and the seventy of disease of 80 asthmatics were compared before and after an education program which was repeated 3 times with a 4 month interval in groups of 20 people in order to evaluate the impact of education. The mean age of 63 female, 17 male patients was 40.52 +/- 10.89 (18-70). Day and night symptom scores were significantly decreased (p < 0.05). Self-recording of PEFR values was increased from 22.7% to 66.7% (p<0.05). Mean PEF% was changed from 65.59 +/- 24.32 (20-129) to 78.91 +/- 22.15 (31-144) and FEV1% pred. from 70.35 +/- 20.71 to 80.55 +/- 22.05 (p = 0.0000). Mild intermittan, mild, moderate and severe persistan groups were changed from 25.3% to 70.3%, 27.8% to 18.9%, 26.6% to 2.7% and 20.3% to 8.1% respectively (p < 0.05). These results strongly suggest the importance of education on management in asthma.
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    Relation between COPD assessment testCAT™ and functional parameters and quality of life in COPD patients
    Erkan, S; Yorgancioglu, A; Havlucu, Y; Ozdemir, L; Goktalay, T; Sakar, A; Celik, P
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    Effect of severity of asthma on quality of life
    Sakar, A; Yorgancioglu, A; Aydemir, O; Sepit, L; Çelik, P
    This study is aimed to evaluate the health related quality of life (HRQL) in asthmatics and the probable association between HRQL and disease severity and also other demographic factors by using a generic scale, SF-36 questionnaire. One-hundred and two asthmatics were enrolled. The scores of the 8 domains of SF-36 questionnaire were evaluated according to age, gender, status of education and compared with the severity of asthma. The mean age of 84 (83%) female and 18 (17%) male patients was 42.86 +/- 11.15. Fifty-two of them was well educated (51%) and 50 was poorly educated (49%). Atopy ratio was 81%. Mild intermittent, mild persistent and moderate-severe persistent groups were 27 (26%), 46 (45%) and 29 (29%) respectively. Female gender were worse in physical functioning (p= 0.000), physical role difficulties (p= 0.0049), vitality (p= 0.045) and social functioning (p= 0.025). Poorly educated group were worse in physical functioning (p= 0.001), physical role difficulties (p= 0.039), vitality (p= 0.045), emotional role difficulties (p= 0.046), general health (p= 0.030) and mental health (p= 0.044). Mental health was worse in the presence of atopy (p= 0.035). Physical functioning was better in mild intermittent group than moderate and severe persistent group (p= 0.024). General health was better in mild intermittent group than mild persistent group (p= 0.018), moderate and severe persistent group (p= 0.015). Vitality and emotional role difficulties was better in mild intermittent than mild persistent group (p= 0.042, p= 0.007). The HRQL scores and severity of asthma is well correlated like other objective parameters. So one of the primary goals in management of asthma should also improve QOL as well as functional parameters.
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    Short-term effects of montelukast in stable patients with moderate to severe COPD
    Celik, P; Sakar, A; Havlucu, Y; Yuksel, H; Turkdogan, P; Yorgancioglu, A
    This study aims to investigate the possibility of additional value of leukotriene receptor antagonist (LTA) on dyspnea score, arterial blood gases (ABG), pulmonary function tests (PFTs), and quality of life (St. George QoL) in chronic obstructive pulmonary disease (COPD) patients. In this randomized, prospective, single-blind, and controlled study, 117 non-reversible COPD patients defined by global initiative for chronic obstructive lung disease (GOLD) criteria were randomized to receive ipratropium bromide, formoterol and montelukast (n:58, montelukast group) or ipratropium bromide and formoterol (n:59, control group) after a 2-week run-in period. There was no significant demographic difference between the two groups (P > 0.05). Baseline ABG, PFT, visual analoque scores r(VAS), and QoL scores were obtained and at first month and second month, PFT, VAS, and QoL scores were repeated and ABG was obtained at second month and the values were compared with baseline values. As the result of the comparision, there was significant increase in vital capacity, FVC, FEV1, VAS, and PaO2 parameters (P < 0.05), and a significant decrease in the QoL scores (P < 0.05) in the montelukast group. These parameters did not show any difference in the control group (P > 0.05). Sputum samples that could be obtained in 24 of the COPD patients were evaluated and in the montelukast group, there was a decrease in neutrophitic activity after treatment (n:13) (P <= 0.059). These results suggest that LTA that is used additionally in routine treatment protocol can produce additive improvement on PFr, dyspnea score and especially QoL in patients with stable COPD and for these reasons, LTA may be taken into account when there is need for an additional anti-inflammatory treatment in COPD patients. (c) 2004 Elsevier Ltd. All rights reserved.
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    Pulmonary function parameters in patients with diabetes mellitus
    Özmen, B; Çelik, P; Yorgancioglu, A; Özmen, B; Özmen, D; Çok, G
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    Global initiative for asthma: 30 years of promoting evidence-based asthma care
    Yorgancioglu, A; Reddel, HK; GINA Board Directors; GINA Sci Comm
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    A Case of Bilateral Tuberculosis with a Presenting Symptom of Massive Haemoptysis
    Özgen, A; Çelik, P; Gülcü, A; Konyar, I; Coskun, AS; Göktan, C; Yorgancioglu, A
    Haemoptysis may be observed in one third of patients with pulmonary tuberculosis at any time during their disease. Tuberculosis may present with atypical radiological findings in patients with underlying diseases such as Diabetes Mellitus (DM). We presented a 58-year-old male with DM who haemorrhaged from the right bronchial artery although having a radiological lesion in the left lung. He had a glassful of haemoptysis in a single episode lasting two days. Chest computarized tomography (CT) showed a consolidation partially forming a massive lesion in the left upper lobe. Bronchoscopy revealed a haemorrhagic residue in the right main bronchus and a blood clot in the left upper lobe. After aspiration a major hemorrhage was observed and bronchial arterial embolization (BAE) was performed to the right bronchial artery where extravasion of the contrast agent was determined. However, in the follow-up, as the findings of BAE were not consistent with the bronchoscopic and radiological findings, a CT angiography was performed for the evaluation of the vascular structures. No vascular pathology was determined although there were acinary infiltrations in both lungs. Also, the mycobacterial culture of the sputum was positive. Radiological, bronchoscopic and angiographic findings may not always correlate in patients with haemoptysis. Heamoptysis may result from different causes in pulmonary tuberculosis and bronchial arterial system is usually the source.
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    The Role of Endobronchial Biopsy in the Diagnosis of Pulmonary Sarcoidosis
    Göktalay, T; Çelik, P; Alpaydin, AÖ; Havlucu, Y; Coskun, AS; Isisag, A; Yorgancioglu, A
    OBJECTIVES: This study aimed to investigate the additional diagnostic value of endobronchial biopsy (EBB) in the diagnosis of pulmonary sarcoidosis. MATERIALS AND METHODS: This retrospective cross-sectional study included 59 patients with a preliminary diagnosis of sarcoidosis who were admitted to the Pulmonary Diseases Outpatient Clinic of a tertiary healthcare center between January 2005 and October 2012. The socio-demographic characteristics of the patients as well as clinical and radiological findings were recorded. All patients, irrespective of the presence of an endobronchial lesion (EBL), underwent fiberoptic bronchoscopy (FOB); two to four specimens were taken using EBB from the carina of the right middle lobe in the patients with EBL. RESULTS: Of the patients, 39 (66.1%) had normal bronchoscopic findings, while 5 had EBL. Diagnosis was based on EBB in 11 patients (18.6%). Six patients (15.3%) with normal bronchial mucosae were pathologically diagnosed by EBB. There was no statistically significant relationship between the diagnostic ratio of EBB and disease stage, extrapulmonary involvement, FOB findings, elevated lymphocyte rate in bronchoalveolar lavage (>= 13%), a CD4/CD8 ratio of >= 3.5, and serum angiotensin-converting enzyme (ACE) level (p > 0.05). CONCLUSION: EBB not only offers the advantage of a high diagnostic ratio in patients with mucosal abnormalities but also contributes to pathological diagnosis in patients with normal mucosa. We recommend using EBB to support diagnosis with a low complication rate for patients undergoing FOB with a preliminary diagnosis of sarcoidosis in healthcare centers, where endobronchial ultrasound (EBUS) is unavailable.
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    The Global Alliance against Chronic Respiratory Diseases: journey so far and way ahead
    Yorgancioglu, A; Khaltaev, N; Bousquet, J; Varghese, C
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    Economic burden of short-acting beta-2 agonist (SABA) overuse among asthma patients in Türkiye: a cost analysis with respect to the updated GINA treatment recommendations
    Yorgancioglu, A; Aksu, K; Cura, C; Yaman, Y; Dinç, M; Malhan, S
    BackgroundThis cost of illness study aimed to determine economic burden of short-acting beta 2-agonist (SABA) overuse in T & uuml;rkiye from payer perspective with respect to the updated GINA 2022 treatment recommendations.MethodsA total of 3,034,879 asthma patients comprised the study population, via estimations extrapolated from the T & uuml;rkiye arm of the global SABINA III study. The economic burden (costs related to the drug use and severe exacerbations) was compared in subgroups of overall (>= 0 canisters/year) vs. GINA-recommended (0-2 canisters/year, hypothetical population) SABA use and in subgroups of appropriate use (0-2 canisters/year, real population) vs. overuse (>= 3 canisters/year) of SABA with extrapolation of SABINA T & uuml;rkiye data to the T & uuml;rkiye asthma population.ResultsRecommended SABA use was predicted to prevent 127,505 of 157,512 severe exacerbations per year in mild asthma patients and 2,668,916 of 3,262,800 severe exacerbations per year in moderate-severe asthma patients. Annual cost burden of not applying recommended SABA use (overall [>= 0 canisters/year] vs. GINA-recommended [0-2 canisters/year] SABA use) in mild asthma and moderate-severe asthma patients was calculated to be 20.43 million and 427.65 million in terms of severe exacerbations, and to be 829,352 and 7.20 million in terms of drug costs, respectively. The total annual economic burden arising from not applying recommended SABA use was estimated to be 456.11 million. Appropriate use (0-2 canisters/year) vs. overuse (>= 3 canisters/year) of SABA was associated with decreased frequency of severe exacerbations per year in mild asthma (from 129,878 to 27,634) and moderate-severe asthma (from 2,834,611 to 428,189) patients. SABA overuse in mild and moderate-severe asthma patients was estimated to yield an additional annual cost of 16.38 million and 385.59 million, respectively in terms of severe exacerbations, and a total 11.30 million additional drug cost. The overall annual economic burden arising from SABA overuse was estimated to be 413.27 million.ConclusionsThe estimated annual total economic burden arising from not applying recommended SABA use (456.11 million) and SABA overuse (413.27 million) with respect to the updated GINA 2022 treatment recommendations indicates the substantial cost burden of SABA overuse to the Turkish National Health System, corresponding up to 26% of the total direct cost of asthma reported in our country.
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    Relation Between Quality of Life and Morbidity and Mortality in COPD Patients: Two-Year Follow-Up Study
    Yorgancioglu, A; Havlucu, Y; Celik, P; Dinc, G; Saka, A
    Quality of life (QoL) is being recognized as an important outcome when evaluating chronic obstructive pulmonary disease (COPD) patients. This study aims at identifying the relation between QoL parameters and mortality and morbidity in COPD patients by using the St. George Respiratory Questionnaire (SGRQ). In this prospective study, 251 COPD patients as defined by American Thoracic Society (ATS) criteria were included. A total of 218 patients (86.85%) were male and mean age was 65.55 years. A pulmonary function test (PFT) and SGRQ were performed at the beginning, first, and second years. During a two-year follow-up, the first exacerbation day, the number of exacerbations and intubations, the number and duration of hospitalizations, hospitalizations in an intensive care unit, and exitus day were recorded. When the correlation between FEV1, SGRQ scores, and these parameters was investigated, there was significant correlation between these parameters, and this correlation was more significant in SGRQ scores than FEV1 (Pearson correlation test). The activity score of SGRQ was found to be more useful than other scores (Cox regression analysis). Not only PFT but also QoL questionnaires are useful in determining the prognosis of COPD. QoL questionnaires provide a valid and standardized estimate of the overall impact of COPD, and can complement spirometric measurements of baseline assessment of patients in routine practice.