MCBÜ Açıkerişim Sistemi :: Browsing by Author "Yorgancioglu A."

Browsing by Author "Yorgancioglu A."

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Smoking cessation - Two sides of the story [2]
(1999) Esen A.; Celik P.; Yorgancioglu A.; Sen F.S.; Yagiz D.
[No abstract available]
Attitudes of Turkish physicians towards cigarette smoking
(1999) Esen A.; Celik P.; Yorgancioglu A.; Sen F.S.; Yagiz D.
The aim of this study is to investigate the smoking habits of the physicians working in Manisa province and their attitudes towards patients who smoke. A three-part questionnaire was given to 305 of 447 physicians (68.2%). Part 1 investigated the smoking habits of the physicians; part 2 asked about their attitudes towards patients who smoke; and part 3 assessed their knowledge of smoking cessation techniques. Of the physicians 30.2% (n = 92) were female and 69.8% (n = 213) were male, and 41.3% of the total were smokers (37.0% of these were female and 43.2% were male). Almost two thirds of the physicians (64.2%) always or frequently asked questions about the smoking habits of their patients; 60.6% offered suggestions to their patients about quitting smoking, but only 23.9% gave information about smoking cessation techniques, and 18.9% gave information about withdrawal symptoms. The results of this study showed that the physicians working in Manisa province had similar smoking rates compared with those of the general population. They were interested in their patients' smoking habits, but they did not have enough information about smoking cessation programmes.
High resolution computed tomography findings in patients with asthma; [Astimli Olgularda Yüksek Rezolüsyonlu Bilgisayarli Tomografi Bulgulari.]
(2003) Yorgancioglu A.; Sakar A.; Tarhan S.; Celik P.; Göktan C.
Recent studies suggest that thoracal high resolution computed tomography (HRCT) of the thorax can detect the irreversible structural changes in chronic asthma cases. This study is aimed to evaluate these possible changes and their relation with asthma severity. Twenty-eight stable asthmatic patients with normal conventional radiography and 10 healthy controls were included. Twenty of the patients were female (71.4%) and the mean age of the group was 43 +/- 10.5 (30-61). The groups were divided into 2; as group 1 included mild intermittent and mild persistent cases, and group 2 included moderate and severe persistent cases. Asthma and control group, and group 1 and 2 were compared according to the thickness of airwall (T), thickness to outer diameter (T/D), wall area (WA), the percentage wall area (WA%). HRCT showed that air trapping, bronchiectasis, fibrotic lesions and airwall thickening were significantly more common in asthma group (p< 0.05). Emphysema, acinar pattern, collapse and mucoid impact were common in asthma group (p> 0.05). The incidence of T and WA was higher in asthma group but also did not reach statistical significance and the thickening of airwall in small airways was significantly more in asthma group. Any correlation between HRCT findings and asthma severity was not found. So reversible and irreversible bronchial and parenchymal changes, detected by HRCT but not by plain chest radiograms, may be present in asthma cases. The early detection of these changes may lead more aggressive asthma management.
A case of a small cell lung carcinoma presenting with jaundice due to pancreatic metastasis.
(2005) Sakar A.; Kara E.; Aydede H.; Ayhan S.; Celik P.; Yorgancioglu A.
Though the high incidence of pancreatic metastasis of lung cancer has been reported in autopsy series, symptomatic cases with jaundice due to that is very rare. Dominant histological type with pancreatic metastases is small cell carcinoma and prognosis is poor. Hereby, we report a case initially presenting with gastroenterologic symptoms as jaundice, nausea, vomiting, weight loss and abdominal pain and then diagnosed as primary small cell carcinoma of the lung with metastasis to pancreas. He underwent a palliative surgery due to obstructive jaundice. This presented case is a rare one with its priority of gastroenterologic symptoms rather than pulmonary complaints.
Evaluation of silicosis in ceramic workers; [Seramik fabrikasi işçilerinde silikozis.]
(2005) Sakar A.; Kaya E.; Celik P.; Gencer N.; Temel O.; Yaman N.; Sepit L.; Yildirim C.A.; Dagyildizi L.; Coşkun E.; Dinç G.; Yorgancioglu A.; Cimrin A.H.
This study is aimed to evaluate the incidence of silicosis and the relation of it with personal and work-related factors among workers exposed to silica in ceramic factory. Workers were evaluated by respiratory symptoms, physical examination, pulmonary function and radiological findings. Occupational and Enviromental Pulmonary Disease Evaluation Questionnaire of the Turkish Thoracic Society Enviromental and Occupational Pulmonary Diseases Working Group was used. 365 of 626 workers had exposure to silica and the rest 261 were concerned as control group. There was no difference between mean age, duration of work and smoking pack year among the groups (p> 0.05). Cough and sputum rates were higher in silicosis group FEV1 and FVC values were lower in silica group but this was not statistically significant. When the two subgroups of silica group (the workers in high dust concentration and the ones in low concentration) were compared, the high concentrated group had significantly more sputum but the other symptoms and pulmonary functional parameters were not different significantly. 24 workers had parenchymal densities adjusted with pneumoconiosis. The workers with the pneumoconistic finding, had a higher mean age and longer duration of work. As a conclusion, ceramic industry has risk for silicosis. And the risk increase by time and age.
Endobronchial metastasis from urinary bladder cancer.; [Mesane kanserinin endobronşiyal metastazi]
(2005) Sakar A.; Gencer N.; Demireli P.; Müezzinoglu T.; Celik P.; Yorgancioglu A.
A rare case, a case of endobronchial metastasis from urinary bladder carcinoma is reported. A 70 years-old man was admitted with hematuria. He has a mass in urinary bladder and a mass in lung. He has no pulmonologic symptom. He is a smoker with 75 pack-years. Thorax computerized tomography revealed a mass in left lung upper lobe. Bronchoscopy demonstrated an endobronchial tumor in left upper lobe, apikoposterior segment. Histopathologically diagnosis was endobronchial metastasis from urinary bladder carcinoma. He received five courses of chemotherapy (cisplatin + gemcitabine). The mass was regressed after three months. Our patient lived for one year from diagnosis.
Short-term effects of montelukast in stable patients with moderate to severe COPD
(2005) Celik P.; Sakar A.; Havlucu Y.; Yuksel H.; Turkdogan P.; Yorgancioglu A.
This study aims to investigate the possibility of additional value of leukotriene receptor antagonist (LTA) on dyspnea score, arterial blood gases (ABG), pulmonary function tests (PFTs), and quality of life (St. George QoL) in chronic obstructive pulmonary disease (COPD) patients. In this randomized, prospective, single-blind, and controlled study, 117 non-reversible COPD patients defined by global initiative for chronic obstructive lung disease (GOLD) criteria were randomized to receive ipratropium bromide, formoterol and montelukast (n:58, montelukast group) or ipratropium bromide and formoterol (n:59, control group) after a 2-week run-in period. There was no significant demographic difference between the two groups (P > 0.05). Baseline ABG, PFT, visual analoque scores (VAS), and QoL scores were obtained and at first month and second month, PFT, VAS, and QoL scores were repeated and ABG was obtained at second month and the values were compared with baseline values. As the result of the comparision, there was significant increase in vital capacity, FVC, FEV1, VAS, and PaO2 parameters (P < 0.05), and a significant decrease in the QoL scores (P < 0.05) in the montelukast group. These parameters did not show any difference in the control group (P > 0.05). Sputum samples that could be obtained in 24 of the COPD patients were evaluated and in the montelukast group, there was a decrease in neutrophilic activity after treatment (n:13) (P : 0.059). These results suggest that LTA that is used additionally in routine treatment protocol can produce additive improvement on PFT, dyspnea score and especially QoL in patients with stable COPD and for these reasons, LTA may be taken into account when there is need for an additional anti-inflammatory treatment in COPD patients. © 2004 Elsevier Ltd. All rights reserved.
The prevalence of asthma and allergic symptoms in Manisa, Turkey (a western city from a country bridging Asia and Europe)
(2006) Sakar A.; Yorgancioglu A.; Dinc G.; Yuksel H.; Celik P.; Dagyildizi L.; Coskun E.; Kaya E.; Ozyurt B.; Ozcan C.
The aim of this study was to determine the prevalence of asthma and allergic symptoms in Manisa city center, Turkey, to evaluate the determinants effective on those values, and to review the prevalence rates reported from different parts of the country. Data were collected from 610 households and complete interviews were conducted with 1,336 adults over 18 years of age by using European Community Respiratory Health Survey-ECRHS questionnaire. The prevalences of current asthma, cumulative asthma and asthma-like symptoms were found in 1.2, 1.0 and 25.0%, respectively, of the 20-44 years age group and the prevalences of allergic rhinitis, allergic dermatitis and family atopy were found in 14.5, 10.9, and 15.2%, respectively, in all age group. Wheezing with breathlessness, wheezing without cold, woken up with shortness of breath and woken up with cold were reported by 9.1%, 6.9%, 6% and 16.1% of the study population, respectively. Gender, age, active or passive smoking, family atopy and home condition effect on prevalence of asthma and allergic symptoms. In this study prevalence of asthma correlated with the studies reporting low prevalence rates of Turkey.
Does thyroid replacement therapy affect pulmonary function tests in patients with subclinical hypothyroidism?
(2006) Koral L.; Hekimsoy Z.; Yildirim C.; Ozmen B.; Yorgancioglu A.; Girgin A.
Objective: Subclinical hypothyroidism is an elevation in serum thyroid-stimulating hormone (TSH) while having normal serum free thyroxine (FT4) and triiodothyronine (FT3) levels. The purpose of this prospective observational study was to evaluate the pulmonary function of patients diagnosed with subclinical hypothyroidism, both before and after treatment with thyroid hormone. Methods: This study took place at the Medical Faculty, Celal Bayar University, Manisa, Turkey between February 2003 and June 2004. Thirty-eight patients (37 females, one male) with subclinical hypothyroidism between 20 and 65 years of age were included in the study. Most were mildly obese. Arterial blood gases and pulmonary function tests were performed before treatment with thyroid hormone, and afterwards, the TSH value reached the normal range (indicating euthyroidism). Results: Oxygen saturation, but not partial oxygen pressure or partial carbon dioxide pressure, was statistically, but not clinically significantly higher after treatment with thyroid hormone (p=0.01). Pulmonary function tests were not significantly different before and after treatment with thyroid hormone. Conclusion: In our subclinical hy pothyroidism patients, pulmonary function tests were normal and did not significantly change with thyroid hormone replacement. The advantages of thyroid hormone replacement therapy, at least regarding respiratory function, seem to be clearly present in patients with overt, clinical hypothyroidism but not in patients with subclinical hypothyroidism.
Multiple nodular and patchy infiltrations in a 34-year-old male
(Medknow Publications and Media Pvt. Ltd, 2007) Sakar A.; Temel O.; Gulcu A.; Cabuk M.; Goktan C.; Yorgancioglu A.
[No abstract available]
Prevalence and risk factors of allergies in Turkey: Results of a multicentric cross-sectional study in children
(2007) Kurt E.; Metintas S.; Basyigit I.; Bulut I.; Coskun E.; Dabak S.; Deveci F.; Fidan F.; Kaynar H.; Uzaslan E.K.; Onbasi K.; Ozkurt S.; Pasaoglu G.; Sahan S.; Sahin U.; Oguzulgen K.; Yildiz F.; Mungan D.; Yorgancioglu A.; Gemicioglu B.; Fuat Kalyoncu A.
The Prevalence And Risk Factors of Allergies in Turkey (PARFAIT) study was planned to evaluate prevalence and risk factors of asthma and allergic diseases and also to find out which geographical variables and/or climatic conditions play a role determining the prevalence of allergic diseases in Turkish school children. Study was planned as cross-sectional questionnaire-based. About 25,843 questionnaires from 14 centers were appropriate for analysis. Parental history of allergy, having an atopic sibling and other atopic disease in index case was significant risk factors for all allergic diseases. Breast feeding decreased the risk of current asthma (OR: 0.92, CI: 0.86-0.99) and wheezing (OR: 0.93, CI: 0.87-0.99) but not allergic rhinitis and eczema. Respiratory infection in the past was an important risk factor for the occurrence of allergic diseases especially for asthma which was increased 4.53-fold. Children exposed to household smoke were significantly at higher risk of asthma, wheezing, and allergic rhinitis (OR: 1.20, CI: 1.08-1.33; OR: 1.21, CI: 1.09-1.34; and OR: 1.32, CI: 1.21-1.43, respectively). All allergic diseases were increased in those children living in areas which have altitude of below 1000 m and mean yearly atmospheric pressure above 1000 mb. The study has suggested that household and country-specific environmental factors are associated with asthma, wheezing, allergic rhinitis, and eczema risk during childhood in Turkey. © 2007 The Authors.
The frequency of wheezing phenotypes and risk factors for persistence in aegean region of Turkey
(2007) Yuksel H.; Sakar A.; Dinç G.; Yilmaz O.; Gozmen S.; Yorgancioglu A.; Ozcan C.
The aim of the study was to determine the prevalence of wheezing and evaluate the risk factors for its persistence in children. Survey data was collected on 725 children aged 17 years or below. The mean age was 8.94 ± 5.16 years; 22.1% of them were reported to have had a wheezing episode at any point in their lives. A wheezing episode was reported in 18.1% of children 3 years of age or younger and persisted in 51% of these subjects; 69.6% of ever wheezers had late onset wheezing. Persistence was significantly common in males. Perinatal disease, lack of breast feeding, and low income were significant risk factors for persistence. In summary, breast feeding, perinatal disease, and income status may be significant risk factors influencing wheezing peristence and consequent asthma. Copyright © 2007 Informa Healthcare.
Effect of recombinant human activated protein C on apoptosis-related proteins
(2007) Sakar A.; Vatansever S.; Sepit L.; Ozbilgin K.; Yorgancioglu A.
The recombinant human activated protein C (rhAPC) has been reported to reduce mortality in patients with severe sepsis. An anti-apoptotic effect of rhAPC in sepsis is known, but the mechanism through which it acts on the apoptotic pathway is still unclear. Therefore, immunopositivity of the apoptosis-related proteins Bcl-2, an anti-apoptotic protein, c-myc, a proliferative protein, p-21 and p-53, two apoptotic proteins, was determined after rhAPC treatment in a mouse sepsis model. Sepsis was induced by Escherichia coli endotoxin injection. Increased neutrophil infiltration and immunoreactivity to p53 and p21 were observed in the group with sepsis and these immunoreactivities were decreased by rhAPC treatment. In the sepstic group; immunopositivity of Bcl-2 and c-myc was mild and moderate, respectively. In conclusion; p21- and p53-mediated apoptosis was increased in the sepsis model, and for the first time it has been shown that rhAPC decreases sepsis-induced apoptosis resulting from increased p21 and p53 proteins. ©2007 European Journal of Histochemistry.
Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA2LEN and AllerGen)
(Blackwell Publishing Ltd, 2008) Bousquet J.; Khaltaev N.; Cruz A.A.; Denburg J.; Fokkens W.J.; Togias A.; Zuberbier T.; Baena-Cagnani C.E.; Canonica G.W.; Van Weel C.; Agache I.; Aït-Khaled N.; Bachert C.; Blaiss M.S.; Bonini S.; Boulet L.-P.; Bousquet P.-J.; Camargos P.; Carlsen K.-H.; Chen Y.; Custovic A.; Dahl R.; Demoly P.; Douagui H.; Durham S.R.; Van Wijk R.G.; Kalayci O.; Kaliner M.A.; Kim Y.-Y.; Kowalski M.L.; Kuna P.; Le L.T.T.; Lemiere C.; Li J.; Lockey R.F.; Mavale-Manuel S.; Meltzer E.O.; Mohammad Y.; Mullol J.; Naclerio R.; O'Hehir R.E.; Ohta K.; Ouedraogo S.; Palkonen S.; Papadopoulos N.; Passalacqua G.; Pawankar R.; Popov T.A.; Rabe K.F.; Rosado-Pinto J.; Scadding G.K.; Simons F.E.R.; Toskala E.; Valovirta E.; Van Cauwenberge P.; Wang D.-Y.; Wickman M.; Yawn B.P.; Yorgancioglu A.; Yusuf O.M.; Zar H.; Annesi-Maesano I.; Bateman E.D.; Kheder A.B.; Boakye D.A.; Bouchard J.; Burney P.; Busse W.W.; Chan-Yeung M.; Chavannes N.H.; Chuchalin A.; Dolen W.K.; Emuzyte R.; Grouse L.; Humbert M.; Jackson C.; Johnston S.L.; Keith P.K.; Kemp J.P.; Klossek J.-M.; Larenas-Linnemann D.; Lipworth B.; Malo J.-L.; Marshall G.D.; Naspitz C.; Nekam K.; Niggemann B.; Nizankowska-Mogilnicka E.; Okamoto Y.; Orru M.P.; Potter P.; Price D.; Stoloff S.W.; Vandenplas O.; Viegi G.; Williams D.
[No abstract available]
Prevalence and comorbidity of allergic eczema, rhinitis, and asthma in a city in Western Turkey
(2008) Yuksel H.; Dinc G.; Sakar A.; Yilmaz O.; Yorgancioglu A.; Celik P.; Ozcan C.
Background: Allergic diseases co-occur in many patients. There is no published population-based epidemiologic study about allergic diseases in Turkey. Objective: The aim of this population-based study was to investigate the prevalence of allergic eczema, allergic rhinitis, and asthma and their co-occurence in Manisa. Methods: The sample size was calculated using an estimated prevalence of ever wheezing for the analyzed age group. Interviews were conducted with 725 children. The survey instrument consisted of a set of sociodemographic questions plus the questionnaire of the International Study of Asthma and Allergies in Childhood. Results: The mean (SD) age of the children studied was 8.94 (5.16) years. The prevalence of ever having allergic eczema was 4.7% whereas that of current allergic eczema was 3.2%. Current allergic rhinitis and allergic conjunctivitis were present in 14.5% and 13%, respectively. Asthma was reported in 14.7% of the children older than 3 years of age while the prevalence of physician-diagnosed asthma was 7.9%. The burden of allergy was 27.1%. The prevalence of concomitant eczema and rhinitis was 1.9%. Among children aged between 3 and 17 years, 1.5% and 4.7% had asthma along with eczema and rhinitis respectively. Asthma was significantly more common in children with rhinitis (31.5% vs 11.8%; P < .01; odds ratio [OR], 3.45). Asthma was diagnosed in 28.1% of children with eczema and 14% of children without eczema (P = .03; OR, 2.41). Conclusions: Atopic diseases seem to significantly increase the risk of developing another atopic disease with ORs that range from 2.4 to 3.4. © 2008 Esmon Publicidad.
Factors affecting the interval from diagnosis to treatment in patients with lung cancer
(Il Pensiero Scientifico Editore s.r.l., 2009) Yaman N.; Ozgen A.; Celik P.; Ozyurt B.C.; Nese N.; Coskun A.S.; Yorgancioglu A.
Aims and background. We aimed to investigate the factors affecting the interval from the beginning of the symptoms until diagnosis and treatment in patients with lung cancer. Methods. Records of 119 lung cancer patients diagnosed in our pulmonary diseases clinic between 2004 and 2006 were evaluated retrospectively. Demographic data, histopathological tumor type, TNM stage, ECOG performance status, presence of endobronchial lesions, and radiological localization of the tumor were determined. Intervals from the first symptom to contacting a doctor, to diagnosis and to treatment were calculated. The interval from first admission to a clinic and referral to a chest physician was also calculated. Results. Of 119 patients, 74% were diagnosed as non-small cell and 26% were as small cell lung cancer. Forty-eight percent of the patients were at stage 3B and 36% were at stage 4. ECOG performance status was 0 in 6%, 1 in 52%, 2 in 36%, 3 in 3%, and 4 in 2%. Endobronchial lesions were observed in 50% of the patients, and the lesions had a central radiological localization in 59%. Fifty-four percent of the patients presented to a chest physician first. Patients who first presented to an internal medicine clinic were referred to our pulmonary disease clinic significantly later than those who presented to other clinics (P = 0.005). The median period from the beginning of the symptoms until contacting a doctor was 35 days (range, 1-387), until diagnosis was 49 days (range, 12-396), and until beginning the treatment was 57 (range, 9-397) days. The presence of endobronchial lesions, radiological localization, TNM stage and ECOG performance status were not found to be related to the intervals from the first symptom to presentation to a doctor, to diagnosis or to the beginning of the treatment. Conclusions. Lung cancer patients consult a doctor after a relatively long symptomatic period. Patient delays may be shortened by increasing the awareness of patients about lung cancer symptoms. Diagnostic procedures should be performed more rapidly to shorten doctor delays.
Prevalence and risk factors of allergies in turkey (PARFAIT): Results of a multicentre cross-sectional study in adults
(2009) Kurt E.; Metintas S.; Basyigit I.; Bulut I.; Coskun E.; Dabak S.; Deveci F.; Fidan F.; Kaynar H.; Uzaslan E.K.; Onbasi K.; Ozkurt S.; Karakis G.P.; Sahan S.; Sahin U.; Oguzulgen K.; Yildiz F.; Mungan D.; Yorgancioglu A.; Gemicioglu B.; Kalyoncu A.F.
The Prevalence and Risk Factors of Allergies in Turkey (PARFAIT) study was planned to evaluate the prevalence of and risk factors for asthma and allergic diseases in Turkey. The present analysis used data from 25,843 parents of primary school children, obtained from a cross-sectional questionnaire-based study. A total of 25,843 questionnaires from 14 centres were evaluated. In rural areas, the prevalences asthma, wheezing, allergic rhinitis and eczema in males were: 8.5% (95% confidence interval (CI) 7.9-9.1%), 13.5% (95% CI 12.8-14.2%), 17.5% (95% CI 16.7-18.2%) and 10.8% (95% CI 10.211.4%), respectively; and in females were: 11.2% (95% CI 10.9-11.8%), 14.7% (95% CI 14.315.1%), 21.2% (95% CI 20.4-22.0%) and 13.1% (95% CI 2.4-13.8%), respectively. In urban areas, the corresponding prevalences in males were: 6.2% (95% CI 5.8-6.6%), 10.8% (95% CI 10.311.3%), 11.7% (95% CI 11.4-12.0%) and 6.6% (95% CI 6.2-7.0%), respectively; and in females were: 7.5 % (95% CI 7.9-7.1%), 12.0% (95% CI 11.7-12.3%), 17.0% (95% CI 16.4-17.6%) and 7.3% (95% CI 6.9-7.7%), respectively. Having an atopic first-degree relative or any other atopic diseases had significant effects on the prevalence of allergic diseases. Housing conditions, such as living in a shanty-type house, visible moulds at home and use of wood or biomass as heating or cooking material were associated with one or more allergic diseases. Although genetic susceptibility is strongly associated, country-and population-based environmental factors may contribute to increased prevalence rates of allergic diseases. Copyright © ERS Journals Ltd 2009.
Development and implementation of guidelines in allergic rhinitis - an ARIA-GA2LEN paper
(Blackwell Publishing Ltd, 2010) Bousquet J.; Schünemann H.J.; Zuberbier T.; Bachert C.; Baena-Cagnani C.E.; Bousquet P.J.; Brozek J.; Canonica G.W.; Casale T.B.; Demoly P.; Gerth Van Wijk R.; Ohta K.; Bateman E.D.; Calderon M.; Cruz A.A.; Dolen W.K.; Haughney J.; Lockey R.F.; Lötvall J.; O'byrne P.; Spranger O.; Togias A.; Bonini S.; Boulet L.P.; Camargos P.; Carlsen K.H.; Chavannes N.H.; Delgado L.; Durham S.R.; Fokkens W.J.; Fonseca J.; Haahtela T.; Kalayci O.; Kowalski M.L.; Larenas-Linnemann D.; Li J.; Mohammad Y.; Mullol J.; Naclerio R.; O'hehir R.E.; Papadopoulos N.; Passalacqua G.; Rabe K.F.; Pawankar R.; Ryan D.; Samolinski B.; Simons F.E.R.; Valovirta E.; Yorgancioglu A.; Yusuf O.M.; Agache I.; Aït-Khaled N.; Annesi-Maesano I.; Beghe B.; Ben Kheder A.; Blaiss M.S.; Boakye D.A.; Bouchard J.; Burney P.G.; Busse W.W.; Chan-Yeung M.; Chen Y.; Chuchalin A.G.; Costa D.J.; Custovic A.; Dahl R.; Denburg J.; Douagui H.; Emuzyte R.; Grouse L.; Humbert M.; Jackson C.; Johnston S.L.; Kaliner M.A.; Keith P.K.; Kim Y.Y.; Klossek J.M.; Kuna P.; Le L.T.; Lemiere C.; Lipworth B.; Mahboub B.; Malo J.L.; Marshall G.D.; Mavale-Manuel S.; Meltzer E.O.; Morais-Almeida M.; Motala C.; Naspitz C.; Nekam K.; Niggemann B.; Nizankowska-Mogilnicka E.; Okamoto Y.; Orru M.P.; Ouedraogo S.; Palkonen S.; Popov T.A.; Price D.; Rosado-Pinto J.; Scadding G.K.; Sooronbaev T.M.; Stoloff S.W.; Toskala E.; Van Cauwenberge P.; Vandenplas O.; Van Weel C.; Viegi G.; Virchow J.C.; Wang D.Y.; Wickman M.; Williams D.; Yawn B.P.; Zar H.J.; Zernotti M.; Zhong N.
The links between asthma and rhinitis are well characterized. The Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines stress the importance of these links and provide guidance for their prevention and treatment. Despite effective treatments being available, too few patients receive appropriate medical care for both diseases. Most patients with rhinitis and asthma consult primary care physicians and therefore these physicians are encouraged to understand and use ARIA guidelines. Patients should also be informed about these guidelines to raise their awareness of optimal care and increase control of the two related diseases. To apply these guidelines, clinicians and patients need to understand how and why the recommendations were made. The goal of the ARIA guidelines is to provide recommendations about the best management options for most patients in most situations. These recommendations should be based on the best available evidence. Making recommendations requires the assessment of the quality of available evidence, deciding on the balance between benefits and downsides, consideration of patients' values and preferences, and, if applicable, resource implications. Guidelines must be updated as new management options become available or important new evidence emerges. Transparent reporting of guidelines facilitates understanding and acceptance, but implementation strategies need to be improved. © 2010 John Wiley & Sons A/S.
Relationship between BODE index, quality of life and inflammatory cytokines in COPD patients
(BioMed Central, 2010) Sarioglu N.; Alpaydin A.O.; Coskun A.S.; Celik P.; Ozyurt B.C.; Yorgancioglu A.
Background and aims: Recently a multidimensional grading system based on the body mass index (B), degree of airflow obstruction (O), dyspnea (D) and exercise capacity (E) - the BODE index - has begun to be used increasingly for the evaluation of chronic obstructive pulmonary disease (COPD) patients. The aim of our study was to investigate the relationship between the BODE index and disease duration, annual exacerbation and hospitalization rates, health related quality of life and systemic inflammatory markers like C-reactive protein (CRP), tumor necrosis factor (TNF)-α and interleukin (IL)-8. Materials and methods: In 88 stable COPD patients we evaluated the body-mass index, pulmonary function tests, Modified Medical Research Council dyspnea scale and six-minute walk test (6MWT). BODE scores were determined. Disease duration, number of exacerbations and hospitalization in the previous year were recorded. We also performed arterial blood gases analysis, administered the St. George's Respiratory Questionnaire (SGRQ) and measured serum levels of CRP, TNF-α, IL-8. Results: According to BODE score 52% of patients were BODE 1, 21% BODE 2, 15% BODE 3 and 12% were BODE 4. There was a significant relationship between BODE index and COPD stage as classified according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) (p < 0.001). Correlations between BODE score and disease duration (p = 0.011), number of exacerbations (p < 0.001) and hospitalizations (p < 0.001) in the last year were also observed. SGRQ symptom, activity, emotion scores and total scores were found to be significantly correlated to BODE (p < 0.001). Serum CRP levels and BODE were also correlated (p = 0.014); however, no correlation was found between serum levels of TNF-α and IL-8 and BODE. Conclusions: As the BODE index shows a strong correlation with various prognostic and follow up parameters of COPD and systemic inflammation, its use should be considered for the evaluation of COPD patients.
Geo-climate effects on asthma and allergic diseases in adults in Turkey: Results of PARFAIT study
(Taylor and Francis Ltd., 2010) Metintas S.; Kurt E.; Basyigit I.; Bulut I.; Coskun E.; Dabak S.; Deveci F.; Fidan F.; Kaynar H.; Uzaslan E.K.; Onbasi K.; Ozkurt S.; Pasaoglu-Karakis G.; Sahan S.; Sahin U.; Oguzulgen K.; Yildiz F.; Mungan D.; Yorgancioglu A.; Gemicioglu B.; Kalyoncu A.F.
The aim of the study was to evaluate the role of geo-climatic factors on the prevalence of allergic diseases in the adult population in Turkey. A total of 25,843 questionnaires using data from parents of 25,843 primary schoolchildren from 14 cities were evaluated. Mean annual temperature was significantly associated with the prevalence of asthma and wheezing in both sexes [respectively; OR: 1.008 (95% CI: 1.003-1.011) and OR: 1.012 (1.006-1.018 in males), OR: 1.007 (1.003-1.012) and OR: 1.01 (1.002-1.018) in females]. In addition, it was associated with eczema in females [OR: 1.007 (1.001-1.012)]. Asthma in females was associated with mean annual humidity in the air [OR: 1.001 (1.000-1.002)]. Annual number of days with snow is associated with wheezing in both sexes [respectively, OR: 1.001 (1.000-1.002) in males and OR: 1.002 (1.000-1.003) in females]. Protective measures could come into priority in certain areas of the country. Allergic diseases may increase as a cause of climate change in the future. © 2010 Taylor & Francis.

Browsing by Author "Yorgancioglu A."

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