Browsing by Author "Yucel, ZPK"

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    The trefoil factor family 1 (TFF-1) and 3 (TFF-3) are upregulated in the saliva, gingival crevicular fluid and serum of periodontitis patients
    Yucel, ZPK; Afacan, B; Ilhan, HA; Kose, T; Emingil, G
    Objective This study aimed to investigate the levels of trefoil factor family (TFF)-1, TFF-3 and interleukin (IL)-1 beta in gingival crevicular fluid (GCF), saliva and serum of patients with gingivitis, stage 3 periodontitis and healthy individuals. Materials and Methods A total of 100 individuals consisting of 25 periodontally healthy, 25 gingivitis and 50 stage 3 periodontitis, were enrolled in the study. Clinical periodontal examinations were recorded and GCF, saliva and serum samples were obtained. TFF-1, TFF-3 and IL-1 beta were measured by ELISA. Results TFF-1 and TFF-3 levels in both GCF, saliva and serum were higher in periodontitis patients than healthy controls (p < .001) and gingivitis group (p < .01). The levels of these peptides in all biofluids were similar between gingivitis and healthy control groups (p > .05). GCF, saliva and serum IL-1 beta levels were also higher in periodontitis patients than the controls (p < .01). Periodontitis patients had elevated GCF and saliva IL-beta levels than gingivitis group (p < .001). Conclusion Elevated TFF-1 and TFF-3 levels both locally and systemically in periodontitis in parallel to increased IL-1 beta levels might suggest that these peptides are involved in host response during the periodontal tissue destruction.