MCBÜ Açıkerişim Sistemi :: Browsing by Author "Yuksel M.B."

Browsing by Author "Yuksel M.B."

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A unique case of bilateral synchronous testicular tumor with concomitant bilateral diffuse intratubular germ cell neoplasia: Testis sparing surgery and local radiotherapy
(S. Karger AG, 2012) Yuksel M.B.; Gumus B.; Özbek E.; Nese N.
Synchronous bilateral testicular germ cell tumors (TGCTs) are seen in exteremely rare cases. Although there is still no standard therapy for bilateral TGCTs, bilateral orchiectomy is recommended as the gold standard treatment. Nevertheless, it has some long-term problems, such as infertility and psychosocial difficulties, and thus some clinicians prefer to perform testis-sparing surgery in appropriate cases. We reviewed the first case of bilateral synchronous TGCT with concomittant bilateral diffuse intratubular germ cell neoplasia in a young single patient, who was treated by a left radical orchiectomy and right testis sparing-surgery with following local radiotherapy to the right residual testicular tissue with previous semen cryopreservation to maintain the ability to father children. We supposed that testis-sparing surgery can be a feasible therapeutic alternative to radical orchiectomy in patients with bilateral TGCTs in terms of improving the quality of life and continuing fertility and normal hormonal status with no medications. However, while the long-term effects are not yet known, this type of treatment should be perpormed in carefully selected cases with longlife expectancy. © 2012 S. Karger AG, Basel.
Analysis of radiofrequency ablation of small renal tumors in patients at high anesthetic and surgical risk: Urologist experience with follow-up results in the initial six months
(Asian Pacific Organization for Cancer Prevention, 2013) Yuksel M.B.; Karakose A.; Gumus B.; Tarhan S.; Atesci Y.Z.; Akan Z.
Background: To evaluate the results of various types of radiofrequency ablation (RFA) treatment of renal tumors in patients with excessive anesthetic and surgical risk. Materials and Methods: Data for RFA performed in in high risk patients were retrospectively evaluated. Other RFA applications in patients with no anesthetic and/or surgical risk were excluded. RFA was by ultrasound or CT guided percutaneous (USG/CT-PRFA) and retroperitoneally or transperitoneally laparoscopic (R/T-LRFA) techniques under general or local anethesia. Follow-up data of enhanced CT or MRI after 1, 3 and 6 months were analysed for twelve RFA applications. Results: The RFA applications included 4 (40%) left-sided, 5 (50%) right-sided and 1 (10%) bilaterally RFA (simultaneously 1 right and 2 left). The localizations of tumors were 2 (16.6%) upper, 5 (41.6%) mid and 5 (41.6%) lower pole. The RFA applications included 9 (75%) USG-PRFA, 1 (8.3%) CT-PRFA, 1 (8.3%) T-LRFA and 1 (8.3%) R-LRFA. The mean age was 65.3±8.5 (52-76) years. The mean tumor size was 29.6±6.08 (15-40) mm. No complications related to the RFA were encountered in any of the cases. Failure (residual tumour) was determined in 8.3% (1/12) of USG-RFA application. The success rate was thus 91.7% (11/12). Other 1st, 3rd and 6th months follow-up data revealed no residua and recurrence. Conclusions: RFA application appears to be safe as a less invasive and effective treatment modality in selected cases of small renal tumors in individuals with excessive anesthetic and also surgical risk.
Epididymoorchitis as the first finding in patients with brucellosis
(Hindawi Publishing Corporation, 2013) Karaköse A.; Yuksel M.B.; Aydoǧdu Ö.; Hamidi A.A.
Purpose. Acute scrotal pain as the first symptom of brucellosis is rarely observed. We aimed to evaluate the data of male patients with brucellosis and epididymoorchitis as the initial diagnosis. Material and Methods. The data of seven patients presented with testicular pain, hyperemia, swelling, and increased fever were reviewed. Concomitant focal diseases as well as clinical, laboratory, and radiological findings were retrospectively evaluated. Results. The mean age of the patients was 22.28 ± 7.78 (16-35) years. All patients presented with scrotal pain, swelling, and increased sweating. Additional findings included fever, asthenia, arthralgia, dysuria, shiver and rash, weight loss, and vomiting in 6, 5, 4, 4, 3, 2, and 1 patient, respectively. In all of 7 patients, the agglutination tests of Rose-Bengal and Wright were positive. Coombs test was positive only in 3 patients. The patients underwent antibiotic and conservative treatment. No relapse was observed following the treatment. Conclusion. In endemic regions, epididymoorchitis caused by brucellosis should be considered in the differential diagnosis of patients presenting with acute scrotal pain. Clinical and serological findings are sufficient for the diagnosis. Conservative management combined with antibiotic therapy is adequate for managing brucellar epididymoorchitis. © 2013 Ayhan Karaköse et al.
A rare complication of prolonged bisphosphonate treatment: The osteonecrosis of jaw in a patient with metastatic prostate cancer
(2013) Yuksel M.B.; Gumus B.; Borazan S.; Muezzinoglu T.
Bisphosphonates are frequently used for the treatment of bone metastases. We described a 71 years old male with the previous diagnosis of bone metastatic prostate cancer and who underwent hormonotherapy combined with zolendronic acid treatment during 7.5 years and presented the complaints of severe jaw pain and inability of chewing. It was determined that the findings of increased PSA with osteonecrotic area on jaw at radiological imaging. He was urgently diagnosed with the diagnosis of osteonecrosis of jaw related to the long-term zolendronic acid treatment. Bisphosphonate treatment was stopped, and he was treated with conservative treatment, and the disorder was improved by this management. This unclear disorder is required more detailed studies on the terms of ethiology, treatment style, follow-up at the treatment period, and management of complications with the aim of applying these agents more safely.
The comparison of short term results of transobturatour tape and single incision midurethral sling procedures
(Aras Part Medical International Press, 2013) Yuksel M.B.; Kose O.; Karakose A.; Gorgel S.N.; Yılmaz Y.; Gumus B.
Objectives: We aimed to evaluate the efficacy of transobturatortape (TOT) and single incision mini sling (SIMS) procedures in the treatment of stress urinary incontinence (SUI).; Materials and Methods: The data of 32 patients who underwent TOT(Promedon®) or SIMS (Ophira®) operations related to SUI between January 2010 - August 2012 were retrospectively evaluated. The sample divided in two groups according to the operation type. The demographical features, preoperative, perioperative, and postoperative data were analysed and compared between two groups to evaluate the efficacy of the operations in SUI. All patients were assessed with a detailed history, physcical examination, cough test, Q-tip test, ultrasonography, postvoiding residual measurement, cystometry and UDI-6, IIQ-7 questionares. Postoperatively, the patients without any incontinence on cough test or sistometry were defined as the success.; Results: The parameters of age, menapousal status, number of vaginal delivery, and body mass index were similar in two groups. The mean operation time was significantly shorter in SIMS group (16±3 vs 27±5, p<0.05). Postoperative succes was not different between two groups (88% , %80 respectively, p>0.05). Postoperative UDI-6 and IIQ-7 scores were 3.5 ± 3.4 vs 3.8 ± 4.8 and 4.4 ± 4.2 vs 5.1 ± 5,6 respectively, and they were similar (p>0.05 in both). In addition, the improvement in these scores were not statistically significant between two groups (p> 0.05 in both).; Conclusion: SIMS procedure is safe and as effective as TOT with shorter operation time in the surgical teratment of female SUI. © 2014 / PMCARAS. All rights reserved.
Preoperative levels of matrix metalloproteinase-7 and -9 and tissue inhibitor of matrix metalloproteinase-1 relation to pathologic parameters in bladder carcinoma patients
(Asian Pacific Organization for Cancer Prevention, 2013) Gunes M.; Kemik A.S.; Pirincci N.; Gecit I.; Taken K.; Yuksel M.B.; Kaba M.; Eryilmaz R.
Our aim was to test the hypothesis that preoperative serum levels of matrix metalloproteinase-7 (MMP-7) and -9 (MMP-9) and tissue inhibitor of matrix metalloproteinase (TIMP-1) levels correlate with pathological features. Serum levels of MMP-7, and MMP-9 and TIMP-1 were determined in 90 bladder cancer patients and 40 healthy controls using an enzyme linked immunosorbent assay. Preoperative serum MMP-7 and MMP-9 levels were significantly higher in cancer patients than control groups (p<0.001). In contast, serum TIMP-1 levels were lower (p<0.001). Alteration in MMP-7, and MMP-9, and TIMP-1 production may contribute to tumor angiogenesis and be associated with clinic-pathological features.
The analysis of the efficacy and safety of transobturator sling operation by using an adjustable sling device in the treatment of stress urinary incontinence
(Aras Part Medical International Press, 2014) Temeltas G.; Yuksel M.B.; Tatlı V.; Gumus B.
Objectives: We aimed to evaluate the safety and efficacy of a transobturator sling (TOT) procedure by using an adjustable TOT device in the treatment of stress urinary incontinence (SUI).; Materials and Methods: The data of 89 patients who had the diagnosis of SUI and underwent TOT operation by using an adjustable MUS device of SAFYRE t plus (Promedon®) between June 2005-November 2012, were retrospectively evaluated. The pateints were evaluted by the parametres of physical examination, stress test, ultrasonography, uroflowmetry, residual urine measurement, cystometry, subjective incontinence scoring (VASi), patients' satisfaction scoring (VASs), and ICQ-SF questionare. The preoperative, perioperative, and postoperative collected data were statistically analysed to determine the efficacy and safety of TOT application by using SAFYRE t plus.; Results: The mean age, account of parity, and body mass index was 55.3±10.1, 2.34 ± 1.43, and 24.97 ± 3.7, respectively. While the pre- and postoperative results of stress test, VASi, and ICIQ-SF scores were significantly different (P=0.00 in all), the pre- and postoperative results of Qmax and PVR account were similar (P= 0.84, P= 0.79, respectively). The severity of subjective incontinence (VASi score) significantly improved after the operation. The mean VASs score at postoperative 12th month was 7.75±1.11. The subjective and objective cure rates were %89.9 (80/89) and %78.6 (70/89), respectively.; Conclusion: The TOT operation by using SAFYRE t plus, which was an adjustable sling device, seemed to be an efficient, reasonably safe, minimally invasive treatment alternative for the surgical management SUI in women. © 2014 / PMCARAS . All rights reserved.
Can cancer detection rate increase when transrectal biopsies were taken from the laterally?
(Yuzuncu Yil Universitesi Tip Fakultesi, 2014) Karakose A.; Yuksel M.B.; Pirincci N.; Gorgel S.N.; Atesci Y.Z.; Gumus B.
Acording to general opinion when biopsy is taken from the prostate’s lateral peripheral zone. More cancer is seen. In our study, the incidence of cancer in the lateral peripheral zone biopsies was investigated. In our study, 93 patients were analyzed retrospectively transrectal prostate biopsy. 12 core biopsies were taken from each patient. Medial peripheral zone (MPZ) and lateral peripheral zone (LPZ) biopsies compared the detection of prostate cancer. The average age of the patients was 67.2±10.3. Total PSA value in patients was found as 13.7 ng/mL. Prostate cancer was detected at the rate of 22.5% (21 patients) in 93 patients. 3 patients (14.3%) had prostate cancer in MPZ and 8 patients (38%) had prostate cancer in LPZ. Prostate cancer was detected at MPZ and LPZ at the rate of 47.7% (10 patients) in patients. Prostate cancer was more commonly detected in LPZ (p<0.05). Prostate biopsies of the LPZ biopsies more commonly cancer is seen. We believe it will increase the capture rate for prostate cancer if a sufficient number of biopsies were taken from the LPZ. © 2014, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Dickkopf-1 levels in Turkish patients with bladder cancer and its association with clinicopathological features
(Asian Pacific Organization for Cancer Prevention, 2014) Kaba M.; Pirincci N.; Benli E.; Gecit I.; Gunes M.; Yuksel M.B.; Tok A.; Kemik A.S.
Background: Evidence indicates that Dickkopf-1 (DKK-1) levels may be a biomarker for cancer risk. The aim of this study was to assess DKK-1 and its correlation with clinic-pathological features in patients with bladder cancer. Materials and Methods: DKK-1 levels were determined in serum samples from 90 patients with bladder cancer before transurethral tumor resection. The concentrations of DKK-1 were determined by using enzyme linked immune-sorbent assay (ELISA). Results: Elevated preoperative DKK-1 levels were associated with tumor stage (p<0.001), grade (p<0.001) and histological grade (p<0.001). Conclusions: The results of our study demonstrated that the level of serum DKK-1 is correlated with both disease progression and increase in the tumor grade. Preoperative serum DKK-1 elevation may thus represent a novel marker for the determination of bladder cancer and the detection of patients with a likely poor clinical outcome.
Serum levels of trace elements in patients with prostate cancer
(Asian Pacific Organization for Cancer Prevention, 2014) Kaba M.; Pirincci N.; Yuksel M.B.; Gecit I.; Gunes M.; Ozveren H.; Eren H.; Demir H.
Background: Trace elements are major components of biological structures; however, excessive levels of these elements can be toxic. Materials and Methods: In the present study, serum levels of trace elements were measured in 30 patients with newly diagnosed as prostate cancer and 32 healthy volunteer by using furnace atomic absorption spectrophotometry. Results: It was found that there was an increase in serum levels of Co, Cu, Mg and Pb (p<0.05), whereas a decrease in serum levels of Fe, Mn, and Zn levels in patients with prostate cancer (p<0.05). Conclusions: These changes may be important in the pathogenesis of prostate cancers; however, further prospective studies are needed to identify relationships between prostate cancer and trace elements.
Environmental radioactivity and high incidence rates of stomach and esophagus cancer in the Van Lake Region: A causal relationship?
(Asian Pacific Organization for Cancer Prevention, 2014) Akan Z.; Baskurt B.; Asliyuksek H.; Kam E.; Yilmaz A.; Yuksel M.B.; Biyik R.; Esen R.; Koca D.
This study examined the incidence rates of cancer cases (averages for 2006-2010) and relationships with environmental radioactivity levels. Soil and water samples were collected from provincial and district centers of Van city and the outdoor gamma doses were determined using a portable gamma scintillation detector. Gross alpha and beta, (226)Ra, (232)Th, and (40)K activities were measured in both tap water and soil samples. Although high rates of stomach and esophagus cancers have been reported previously in Van the underlying reasons have not hitherto been defined. Incidences of cancers were highest in the Gurpinar (326.0) and Ozalp (377.1) counties (p<0.001). As to the results of the gross alpha and gross beta radioactivity measurements in the drinking water, these two counties also had high beta radionuclide levels: Gurpinar (140 mBq/dm3) and Ozalp (206 mBq/dm3). Even if within the normal range, a relation between the higher rate of the incidence of stomach and esophagus cancers with that of the higher rate of beta radionuclide activity was clear. On Spearman correlation analysis, the relation between higher beta radionuclide levels and cancer incidence was found to be statistically significant (p<0.01). According to the results of the analysis, Van residents receive an average 1.86 mSv/y annual dose from outdoor gamma radiation, ingestion of radionuclides in the drinking water, and indoor 222Rn activity. Moreover, gross alpha and beta activities were found to be extremely high in all of the lakes around the city of Van, Turkey. Further investigations with long-term detailed environmental radiation measurements are needed regarding the relationship between cancer cases and environmental radioactivity in the city of Van.
Giant hydronephrosis
(eScholarship, 2014) Golcuk Y.; Ozsarac M.; Eseroglu E.; Yuksel M.B.
[No abstract available]
The effect of antibiotherapy on high serum PSA levels
(Yuzuncu Yil Universitesi Tip Fakultesi, 2015) Karakose A.; Yuksel M.B.; Pirincci N.; Gorgel S.N.; Atesci Y.Z.; Gumus B.
This study investigated the effect of antibiotics in patients with PSA value high than 4 ng/mL on tPSA, fPSA and fPSA/tPSA ratio without missing cancer and avoiding unnecessary biopsies. A total of 96 patients were included into the study with detected high level than 4 ng/mL serum PSA. Patients were divided into 2 groups according to the high level of PSA value. Group 1 included 49 patients with PSA level between 4-10 ng/mL. Group 2 included 47 patients with PSA level higher than 10 ng/mL. Patients were treated with Ciprofloxacin (500mg b.i.d.) orally for 2 weeks. All patients' PSA levels were evaluated and analyzed before and after antibiotic treatment. Statistical analyses were performed with SPSS version 18. A p value <0.05 was considered as significant. The mean age was 61.6 ±5.7 (51-75) years in group 1 and 63.1 ±8.7 (55-74) years in group 2. Suspicious DRE findings were significantly high in group 2. The mean tPSA values were 6.82±0.42 and 5.93±0.36 before and after antibiotic treatment in group 1 respectively. There was no significant differences in tPSA value before and after antibiotic treatment in group 1. The mean tPSA values were 32.53±8.23 and 11.72±5.61 before and after antibiotic treatment in group 2 respectively. The mean tPSA value decreased significantly after antibiotic treatment in group 2. Prostate cancer was detected in 32 patients after TRUS guided prostate biopsy. Prostate cancer was identified in 13 patients in group 1 and 19 patients in group 2. Antibiotic treatment in patients with PSA levels higher than 10 ng/mL is effective on prostate biopsy decision and antibiotic treatment can prevent unnecessary prostate biopsies. © 2015 Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
The long-term results of temporary urethral stent placement for the treatment of recurrent bulbar urethral stricture disease
(Brazilian Society of Urology, 2016) Temeltas G.; Ucer O.; Yuksel M.B.; Gumus B.; Tatli V.; Muezzinoglu T.
Aim: To evaluate the long term outcomes of temporary urethral stent placement for the treatment of recurrent bulbar urethral stricture. Materials and Methods: Twenty-eight patients who underwent temporary polymer coated urethral stent placement due to recurrent bulbar urethral stricture between 2010 and 2014 were enrolled in the study. The long term outcomes of the patients were analyzed. Results: The mean age of the patients was 62.3±6.4 (44-81). The overall clinical success was achieved in 18 (64.2%) of the 28 patients at a median (range) follow-up of 29 (7-46) months. No patient reported discomfort at the stent site. Stone formation was observed at the urethral stent implantation area only in one patient. Stenosis occurred in the distal end of the stents in two patients and took place in bulbar urethra in seven patients after removed the stents. The mean maximum urine flow rates were 6.24±2.81mL/sec and 19.12±4.31mL/sec before and at 3 months after the procedure, respectively. Conclusion: In this study, the success rate of temporary urethral stent placement has remained at 64.2% at a median follow-up of 29 months. Therefore, our outcomes have not achieved desired success rate for the standard treatment of recurrent bulbar urethral stricture.

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