Araştırma Çıktıları | Scopus

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The effect of 8-week different-intensity walking exercises on serum hepcidin, IL-6, and iron metabolism in pre-menopausal women
(Akademiai Kiado ZRt., 2017) Buyukyazi G.; Ulman C.; Çelik A.; Çetinkaya C.; Sisman A.R.; Çimrin D.; Dogru Y.; Kaya D.
Objective: Hepcidin may be an important mediator in exercise-induced iron deficiency. Despite the studies investigating acute exercise effects on hepcidin and markers of iron metabolism, we found no studies examining the chronic effects of walking exercises (WE) on hepcidin and markers of iron metabolism in premenopausal women. The chronic effects of two 8-week different-intensity WE on hepcidin, interleukin 6 (IL-6), and markers of iron metabolism in pre-menopausal women were examined. Methods: Exercise groups (EG) [moderate tempo walking group (MTWG), n = 11; brisk walking group (BWG), n = 11] walked 3 days/week, starting from 30 to 51 min. Control group (CG; n = 8) did not perform any exercises. BWG walked at ∼70%-75%; MTWG at ∼50%-55% of HRRmax. VO2max, hepcidin, IL-6, and iron metabolism markers were determined before and after the intervention. Results: VO2max increased in both EGs, favoring the BWG. Hepcidin increased in the BWG (p < 0.01) and CG (p < 0.05). IL-6 decreased in the BWG and the MTWG (p < 0.05; p < 0.01). While iron, ferritin, transferrin, and transferrin saturation levels did not change in any group, total iron binding capacity (p < 0.05), red blood cells (p < 0.05), and hematocrit (p < 0.01) increased only in the BWG. Conclusion: Both WE types may be useful to prevent inflammation. However, brisk walking is advisable due to the positive changes in VO2max and some iron metabolism parameters, which may contribute to prevent iron deficiency. The increase in hepcidin levels remains unclear and necessitates further studies. © 2017 Akadémiai Kiadó, Budapest.
Immune responses elicited by the recombinant Erp, HspR, lppX, Mmaa4, and OmpA proteins from Mycobacterium tuberculosis in mice
(Akademiai Kiado ZRt., 2018) Okay S.; Çetin R.; Karabulut F.; Dogan C.; Sürücüoglu S.; Kizildogan A.K.
Immunogenic potency of the recombinant Erp, HspR, LppX, MmaA4, and OmpA proteins from Mycobacterium tuberculosis (MTB), formulated with Montanide ISA 720 VG adjuvant, was evaluated in BALB/c mice for the first time in this study. The five vaccine formulations, adjuvant, and BCG vaccine were subcutaneously injected into mice, and the sera were collected at days 0, 15, 30, 41, and 66. The humoral and cellular immune responses against vaccine formulations were determined by measuring serum IgG and serum interferon-gamma (IFN-γ) and interleukin-12 (IL-12) levels, respectively. All formulations significantly increased IgG levels post-vaccination. The highest increase in IFN-γ level was provided by MmaA4 formulation. The Erp, HspR, and LppX formulations were as effective as BCG in enhancement of IFN-γ level. The most efficient vaccine boosting the IL-12 level was HspR formulation, especially at day 66. Erp formulation also increased the IL-12 level more than BCG at days 15 and 30. The IL-12 level boosted by MmaA4 formulation was found to be similar to that by BCG. OmpA formulation was inefficient in enhancement of cellular immune responses. This study showed that MmaA4, HspR, and Erp proteins from MTB are successful in eliciting both humoral and cellular immune responses in mice. © 2018 Akadémiai Kiadó, Budapest
Geodetic evidence for aseismic fault movement on the eastern segment of the Gediz Graben system (western Anatolia extensional province, Turkey) and its significance for settlements
(Akademiai Kiado ZRt., 2022) Doğan A.; Kaygusuz Ç.; Tiryakioğlu İ.; Yigit C.O.; Sözbilir H.; Özkaymak Ç.; Turgut B.
Aseismic dip-slip normal fault displacement related to numerous fast-slipping active faults was recently observed in several localities in the western Anatolia extensional province. Still, the characteristics of displacements along with the behavior of individual fault segments are poorly known. Here we analyze an aseismically active normal fault affecting the settlement area of the Sarıgöl district, Turkey, at the surface rupture area of the 1969 magnitude 6.5 Alaşehir earthquake. A precise leveling method was implemented in this area between July 2017 and 2020, to determine the vertical movements of the hanging wall relative to the footwall of the Sarıgöl fault. The yearly vertical movement on the surface along Profile 1 was − 7.0, − 7.3, and − 7.0 cm, respectively, for the three years starting in July 2017, and on Profile 2 it was − 7.7, − 8.7, and − 7.8 cm for the same time period. This persistent deformation, especially in the summer and fall seasons, suggests that may be related to groundwater level changes. Intensive agriculture is conducted in the region and a high level of irrigation activity in the summer period causes a decrease in groundwater levels. In addition, the continued deformation together with intensive precipitation in winter and spring despite high groundwater levels leads to the idea that tectonic creep movement could be a second reason for the deformation in the area. In the current study, the most important result is that the aseismic deformation starting after the 1969 Mw6.5 Alaşehir earthquake still continues rapidly today with a velocity of 70–80 mm/year down-dip. This indicates that the damage zone of the Sarıgöl fault is not appropriate for settlements in the Sarıgöl district due to continuous high amounts of vertical displacement, and that appropriate building policy and awareness campaigns are needed. © 2022, Akadémiai Kiadó.
Synthesis of silver nanoparticles using Alpinia officinarum rhizome extract induces apoptosis through down-regulating Bcl-2 in human cancer cells
(Akademiai Kiado ZRt., 2022) Atmaca H.; Çamlı Pulat Ç.; Ilhan S.
In this study, silver nanoparticles were synthesized using Alpinia officinarum rhizome extract via an eco-friendly green synthesis method. The silver nanoparticles (AO-AgNPs) were characterized by UV–Vis spectrometry, scanning electron microscopy, energy-dispersive X-ray spectroscopy, and dynamic light scattering. Further, the cytotoxic and apoptotic effects of AO-AgNPs were investigated in human cancer cells with different tissue origins via 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay and flow cytometric analyses, respectively. The expression levels of anti-apoptotic Bcl-2 protein were evaluated via a real-time polymerase chain reaction. The synthesized AO-AgNPs induced a significant cytotoxic effect in all tested cancer cells but not in normal cells. AO-AgNPs induced the percentage of apoptotic cells and reduced the levels of anti-apoptotic Bcl-2 mRNA levels in cancer cells. These results demonstrate the potential application of AO-AgNPs in cancer treatment. © 2022, Akadémiai Kiadó Zrt.
Electrophysiological detection of exam stress in health schools' students
(Akademiai Kiado ZRt., 2024) Kazdagli H.; Ozel H.F.; Ozturk S.; Ceylan D.; Erdeniz B.; Ozbek M.; Semin M.I.
Anxiety is a common issue among university students, many of them experience anxiety, depression, and stress during their school life. This study aimed to compare the acute physiological stress responses of students divided into two groups according to their perceived anxiety levels (positive test anxiety, PTA+, and negative test anxiety, PTA-). Heart rate variability (HRV) and electrodermal activity (EDA) were used to assess stress. Thirty-one healthy volunteers participated in the study. Participants completed anxiety assessments, including the Westside Test Anxiety Scale (WTAS), the State-Trait Anxiety Inventory (STAI), and the Test State Anxiety Inventory (TSAI). Based on their scores, participants were categorized into PTA+ and PTA-groups. All participants underwent 24-h continuous recordings of pulse and electrodermal activity (EDA) on two separate occasions: one day prior to a written exam and during a designated exam-free day serving as a baseline control. We compared the HRV and EDA data obtained on a regular day and on an exam day between the two groups. Results showed that the PTA+ group had significantly higher heart rate, stress index, low frequency, and short-Term detrended fluctuation analysis (DFAα1) on the exam day. The tonic EDA component was also higher in the PTA+ group. Stress-related HRV and EDA parameters were negatively correlated with exam scores. In conclusion, the study found that physiological stress indicators obtained from HRV and EDA are associated with perceived exam anxiety in students. © 2024 Akadémiai Kiadó, Budapest.
The radiolabeling of [161Tb]Tb-PSMA-617 by a novel radiolabeling method and preclinical evaluation by in vitro/in vivo methods
(Akademiai Kiado ZRt., 2024) Uygur E.; Sezgin C.; Parlak Y.; Karatay K.B.; Arıkbaşı B.; Avcıbaşı U.; Toklu T.; Barutça S.; Harmanşah C.; Sözen T.S.; Maus S.; Scher H.; Aras O.; Gümüşer F.G.; Biber Muftuler F.Z.
Prostate cancer (PC) is the most prevalent cancer in elderly men, exhibiting a positive correlation with age. As resistance to treatment has developed, particularly in the progressive stage of the disease and in the presence of microfocal multiple bone metastases, new generation radionuclide therapies have emerged. Recently introduced for treating micrometastatic foci, Terbium-161 ([161Tb]) has shown great promise in prostate cancer treatment. This study investigated the in vitro and in vivo cytotoxicity of Terbium-161 ([161Tb])-radiolabeled prostate-specific membrane antigen (PSMA)-617. [161Tb]Tb-PSMA-617 (7.4 MBq/nmol) demonstrated a radiochemical yield of 97.99 ± 2.01% and hydrophilicity. [161Tb]Tb-PSMA-617 was also shown to have good stability, with a radiochemical yield of over 95% up to 72 h. In vitro, [161Tb]Tb-PSMA-617 exhibited cytotoxicity on LNCaP cells but not on PC3 cells. In vivo, scintigraphy imaging visualized the accumulation of [161Tb]Tb-PSMA-617 in the prostate, kidneys, and bladder. The results suggest that [161Tb]Tb-PSMA-617 can be an effective radiolabeled agent for the treatment of PSMA positive foci in prostate cancer. © Akadémiai Kiadó, Budapest, Hungary 2024.
Use of zeolite in reducing environmental risk of polonium: kinetic models
(Akademiai Kiado ZRt., 2025) Hicsonmez U.; Erenturk S.A.; Gorgun A.U.; Aslani M.A.A.
A study was conducted to understand the mechanism of adsorption kinetic that is effective in removal of 209Po by clinoptilolite, a natural zeolite, from aquatic environments. Studies of the adsorption kinetics of 209Po were carried out by interacting zeolite with 209Po at different time intervals. Experimental polonium adsorption data obtained in our previous article were applied to some known kinetic models such as pseudo-first order, pseudo-second order, Elowich, Bangham, Homogeneous particle diffusion and Shell step models. The data obtained from the models revealed that the rate-limiting step is more compatible with the pseudo-second order model, which is based on the assumption that chemical sorption. According to the results obtained, the calculated the amount of 209Po adsorbed at equilibrium (qe) and the equilibrium rate constant of pseudo-second-order sorption (k2) were found to be 0.3302 ng g−1, − 4.4 × 10–5 ng g−1 min−1, respectively. © The Author(s) 2025.

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