Browsing by Publisher "ASEAN Neurological Association"
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Item Evaluation of the effect of botulinum neurotoxin type A (BoNT/A) on daily activity performance in chronic migraine patients using VAS, MIDAS AND HIT-6 tests(ASEAN Neurological Association, 2018) Zeybek S.; Kisabay A.; Sari U.S.; Selcuki D.Background & Objectives: According to ICHD-III beta 2013 criteria, chronic migraine is defined as having headaches more than 15 times a month, for a period of more than 3 months, at least 8 must have migrainous features or good response to migraine-specific treatment; there must also be a history of 5 or more migraine attacks. The aim of the present study was to evaluate the effect of Botulinum Neurotoxin A (BONT/A) on headache and daily activities in chronic migraine patients using VAS, MIDAS and HIT-6 tests. Methods: Twenty five patients admitted to Hospital Department of Neurology were reviewed retrospectively. In order to evaluate the severity of headache and effects on daily performance, MIDAS (Migraine Disability Assessment Test), VAS (Visual Analogue Scale for Pain) and HIT-6 results after the baseline assessment, first and second administration of (BONT/A) were examined retrospectively from patients’ records. Results: VAS, MIDAS and HIT-6 scores were compared after baseline assessment and the first and second administrations. Results showed that VAS, MIDAS and HIT-6 scores decreased. This difference was statistically significant (p<0.05). Correlation analysis was conducted and significant correlations between scores on these three tests were found. Conclusions: The results showed that BoNT/A is an important and effective treatment option for chronic migraine patients not responding to migraine-specific prophylactic treatment and having alterations in daily life due to frequency and severity of pain. © 2018, ASEAN Neurological Association. All rights reserved.Item Airplane headache: An atypical case with autonomic symptoms and long duration(ASEAN Neurological Association, 2020) Ataç C.; Kısabay Ak A.; Çetin G.; Batum M.; Gökçay F.; Selçuki D.Airplane Headache (AH) which is classified under headache attributed to disorder of homeostasis in International Classification of Headache Disorders (ICHD)-3 is a severe, unilateral, orbitofrontal headache that occurs during and caused by airplane travel. It remits after landing. AH cases with autonomic symptoms had rarely been reported. We present a 35-year-old male complained of five attacks of right-sided, unilateral, orbitofrontal headache accompanied with lacrimation, conjunctival injection and eye redness ipsilaterally, starting 20-30 minutes prior to landing. The headache duration varied between 30-90 minutes. AH diagnosis was made in the light of anamnesis and neurological examination. The secondary causes and primary headaches with autonomic symptoms were ruled out. As far as we know this is the first reported longer duration AH case with autonomic symptoms in the literature. AH is an underdiagnosed headache. We report this atypical AH case to call attention to this rare but treatable headache. © 2020, ASEAN Neurological Association. All rights reserved.Item Exercise-induced acute renal failure with posterior reversible encephalopathy syndrome(ASEAN Neurological Association, 2020) Toraman A.; Kısabay A.; Eren B.G.; Batum M.; Kursat S.Posterior reversible encephalopathy syndrome (PRES) is characterized by headache, mental changes, epileptic seizures, visual disturbances, and transient changes in the posterior circulation system of the brain. Rhabdomyolysis is a clinical condition characterized by muscle pain, weakness, dark-colored urine, and elevated creatine kinase levels. The common causes of rhabdomyolysis are trauma, excessive fatigue and intense exercise. A 23-year-old male soldier developed rhabdomyolysis-induced acute kidney injury after intense exercise and secondary PRES. The patient also had generalized convulsive seizures. There is no similar case of PRES from acute renal failure induced by muscle injury previously reported in the literature. © 2020, ASEAN Neurological Association. All rights reserved.Item What is the optimal dose of acetazolamide in the treatment of idiopathic intracranial hypertension(ASEAN Neurological Association, 2020) Aysin Kisabay A.; Tata G.; Gokcay F.; Celebisoy N.Objective: Acetazolamide is preferred as the first-line drug for the medical treatment of idiopathic intracranial hypertension. In this study, the efficacy of different doses of the drug on visual functions; visual acuity, optic disc appearance-papilledema grade and visual field-mean deviation (VF-MD) were evaluated. Methods: The medical records of 73 patients diagnosed as idiopathic intracranial hypertension based on Modified Dandy Criteria and treated with acetazolamide who were on follow-up between 2010 and 2017 at the Neuro-ophthalmology Unit of Ege University Medical School, Department of Neurology were analyzed. Improvement in the visual functions at the end of the sixth month in three groups taking different doses of the drug; low (500, 750, 1000 mg/day), moderate (1500, 1750, 2000 mg/day) and high (3000, 4000 mg/day) were compared. Results: Improvement in visual acuity (p: 0.784), was not affected from different doses of the drug whereas papilledema grade (p: 0.014) and VF-MD (p<0.001) were affected. Binary comparisons revealed significant improvement in the high dose group when compared with the moderate and low dose groups both for the papilledema grade (low-high: p: 0.003, moderate-high: p: 0.024) and VF-MD (low-high: p<0.001, moderate-high: p: 0.001) Conclusion: Treatment with high doses of acetazolamide is associated with improvement in visual field defects and regression of optic disc edema in idiopathic intracranial hypertension. © 2020, ASEAN Neurological Association. All rights reserved.Item Evaluation of cognitive functions in idiopathic Parkinson’s disease and multiple system atrophy(ASEAN Neurological Association, 2021) Batum M.; Ak A.K.; Ari M.S.; Selçuki D.Background & Objective: Cognitive impairment is one of the non-motor symptoms impairing life quality in idiopathic Parkinson’s disease (PD) and multiple system atrophy (MSA). In our study, both groups’ possible cognitive impairments were evaluated and compared, and the relationship between cognitive profile and motor, non-motor scores, and disease duration was evaluated. Methods: Fifty two PD, 18 MSA, 30 healthy controls were included in the study. Demographic information, scores of Unified Parkinson’s Disease Rating Scale (UPDRS), Parkinson’s Disease Questionnaire (PDQ), Addenbrooke’s Cognitive Examination-Revised (ACE-R), and Frontal Assessment Battery (FAB) tests were recorded. In addition to the ACE-R test’s total scores, sub-scores measuring attention-orientation, memory, verbal fluency, language, and visual-spatial abilities were also evaluated. Results: There was no difference between the groups in age, gender, years of education, and levodopa dose in treatment (p> 0.05). In the inter-group comparison, FAB, ACE-R total, ACE-R sub-scores and PDQ values were significantly different (p <0.05). Significant impairment was found in FAB, ACE-R total, memory, verbal fluency, speaking, and PDQ scores in PD and in all tests in MSA compared to the control group (p <0.05). All tests except memory were more impaired in the MSA group than the PD group. The motor scores in PD showed a strong correlation with FAB, ACE-R total, visual-spatial abilities, speaking, and PDQ scores, whereas motor scores in MSA only correlated poorly with PDQ scores. Conclusion: MSA progressing with multi-systemic involvement showed worse cognitive performance than PD in executive functions and visual-spatial functions, regardless of the disease duration. © 2021, ASEAN Neurological Association. All rights reserved.Item Reversible lesion of the corpus callosum associated with COVID-19: A case report(ASEAN Neurological Association, 2021) Gemici Y.I.; Tasci I.Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may affect the central nervous system and peripheral nervous system. Major central nervous system manifestations of SARS-CoV-2 infection include seizures, meningoencephalitis, ischemic stroke, anosmia, and hypogeusia. The reversible splenial lesion syndrome was first described in 2004. Although reversible splenial lesion syndrome was initially recognized as a benign phenomenon, a second type of reversible splenial lesion syndrome was identified in later years, which has a poorer prognosis and potentially serious sequela. Reversible splenial lesion syndrome can be caused by numerous etiologies including viruses. In this report, we present a rare case of COVID-19 with reversible splenial lesion, who presented with ataxia and dizziness. © 2021, ASEAN Neurological Association. All rights reserved.Item Role of acetazolamide in treatment of patients with menstrual migraine(ASEAN Neurological Association, 2021) Çetin G.; Ak A.K.; Özyurt B.C.; Selçuki D.Objective: According to the ICHD-3 criteria, menstrual migraine (MM) is divided into two groups: pure menstrual migraine (PMM) and menstrually-related migraine (MRM). The present study aimed to evaluate and compare the severity of headache using a visual analog scale (VAS) and the effect on quality of life using the Headache Impact Test (HIT) and Migraine Disability Assessment (MIDAS) tests before and after 3 months of treatment in using short-term prophylaxis with acetazolamide. Methods: Patients who presented to the headache outpatient clinic of the neurology department with a diagnosis of MM were retrospectively reviewed. Acetazolamide was given at a dosage of 500 mg daily for 5 days starting two days before the predicted onset of the menstrual cycle as a short-term prophylactic treatment. VAS, MIDAS, and HIT assessments were performed before and after treatment. Results: A total of 26 patients with PMM and 26 patients with MRM were identified. After acetazolamide treatment, statistically significant improvement was found in MIDAS, VAS and HIT scores in both groups of patients. The post-treatment MIDAS score was significantly lower in the MRM group, but there was no significant difference in post-treatment VAS and HIT scores between the groups. Conclusion: Using acetazolamide for short-term prophylaxis in patients with MM leads to decreased severity and frequency of headache and improvement in quality of life. The study is the first in the literature to use acetazolamide for short-term prophylaxis in patients diagnosed with MM. © 2021, ASEAN Neurological Association. All rights reserved.Item Two siblings with horizontal gaze palsy and ROBO3 gene mutation: A double case study(ASEAN Neurological Association, 2022) Orak S.A.; Erdogan M.; Yilmaz C.; Atasever A.K.; Kubur C.C.; Polat M.Horizontal gaze palsy along with progressive scoliosis (HGPPS) is rare and autosomal recessive disease related to the mutations in the ROBO3 gene located on chromosome 11q23-25. We present here two siblings from parents of consanguineous marriage, who were diagnosed with bilateral horizontal gaze restriction and scoliosis associated with homozygous mutation within ROBO3 gene and at the same time having neuroimaging findings. With HGPSS’s typical findings, we detected a homozygous c.1366G> T (p.Gly456Ter) variant in the ROBO3 gene in our patients. HGPPS should be confirmed by ROBO3 gene analysis, and the brain MRI may be the first diagnostic technique. © 2022, ASEAN Neurological Association. All rights reserved.Item The impact of the COVID-19 pandemic on patients with tension-type headache: A multicenter survey(ASEAN Neurological Association, 2022) Fırat Y.E.; Karşıdağ S.; Neyal A.M.; Cengiz E.K.; Ergin N.; Ak A.K.; Sarıtaş A.Ş.; Gölen M.K.; Okuyan D.Y.; Bakar E.E.; Eren F.; Neyal A.; Çınar N.; Kendirli S.; Yılmaz B.Ö.; Şahin Ş.; Ateş M.F.; Bülbül N.G.; Demir A.; Doğan B.; Demirel E.A.; Erdemoğlu A.K.; Seven S.; Çomruk G.Background & Objective: Tension-type headache (TTH) is the most common primary headache. TTH worsens quality of life and is related to various psychosocial factors. We aimed to examine the severity of headache (intensity, frequency, and duration), analgesic use, quality of life (QoL), and the impact of COVID pandemic-induced stress in TTH patients. Methods: TTH cases seen at neurology outpatient clinics in 15 centers in Turkey were included in the study. A questionnaire incorporating sociodemographic and medical information, headache features, sleep quality, general quality of life, and impact of the pandemic event was administered to the subjects. Results: A total of 975 TTH patients were evaluated. Headache severity was higher in women as well as in patients with a history of COVID-19 contact. Women, those with chronic diseases, and cases with a COVID-19 contact history had worse perceptions of quality of life and were affected to a greater extent by the pandemic. The factors affecting the impact of the pandemic were female gender and difficulty in access to health services for headache. Co-existing chronic diseases and lost productive time due to headaches were negative determinants for both QoL and the impact of the pandemic. Conclusion: Our results show that the COVID pandemic severely worsened the headache burden, quality of life and mental health of TTH patients. These findings can guide us in the clinical approach to TTH cases. © 2022, ASEAN Neurological Association. All rights reserved.Item Can vestibular migraine development be predicted in patients with new onset migraine headaches?(ASEAN Neurological Association, 2022) Çelebisoy N.; Ak A.K.; Ataç C.; Özdemir H.N.; Gökçay F.; Durmaz G.S.; Kartı D.T.; Toydemir H.E.; Yayla V.; Işıkay A.İ.Ç.; Erkent İ.; Sarıtas A.S.; Özçelik P.; Akdal G.; Bıçakcı Ş.; Göksu E.O.; Uyaroğlu F.G.Objective: This study aims to determine the clinical features associated with the development of vestibular migraine (VM) in patients with migraine headaches. Methods: A cross-sectional, multicenter study was performed in nine tertiary neurology clinics. Patients with migraine without vestibular symptoms were classified as having migraine only (MO) and compared with patients with VM to determine any differences in clinical features, associated disorders, past medical history, and family history of migraine headaches. Moreover, we investigated the features that might predict the development of VM. Results: Two hundred forty-four patients with MO and 461 patients with VM were included. The age of onset of headache attacks was later in life for patients with VM (p<0.001). Migraine without aura (MwoA) was significantly more common than migraine with aura (MwA) in patients with VM (p=0.016). All associated features of migraine headaches were significantly more frequent in patients with MO than patients with VM (p<0.005). The same was true for all triggers, including fasting, sleep disturbances, menstruation, stress, flickering lights, and smartphones/computer games (p<0.005). A family history of migraine headaches was more common in MO patients (p=0.002). However, a previous history of motion sickness was significantly more common in patients with VM (p<0.001), as was aural fullness/tinnitus accompanying attacks (p<0.001). Logistic regression analysis indicated that aural fullness/tinnitus accompanying attacks and a previous history of motion sickness were risk factors for the development of VM. Conclusion: Patients with migraine reporting aural symptoms accompanying attacks and motion sickness in their past medical history are at increased risk of vestibular attacks fulfilling the diagnosis of VM later in life. © 2022, ASEAN Neurological Association. All rights reserved.Item A preliminary study evaluating the response to greater occipital nerve (GON) blockage therapy in patients with vestibular migraine(ASEAN Neurological Association, 2024) Ayşın Kısabay A.; Sarıtas A.S.; Gemici Y.I.; Çağ E.C.; Çelebisoy N.[No abstract available]