Browsing by Publisher "AVES İbrahim KARA"
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Item Cerebral venous Thrombosis: A case series and literature review; [Serebral venöz trombozlar: Bir olgu serisi ve literatür derlemesi](AVES İbrahim KARA, 2015) Kısabay A.; Çakıroğlu E.; Selçuki D.In this study, 15 patients who were being followed in a cerebrovascular diseases outpatient clinic with the diagnosis of cerebral venous thrombosis were retrospectively reviewed. The study aimed to assess and review their complaints at the time of presentation and during the clinical course as well as assess the etiological risk factors using new imaging modalities and new and old therapeutic modalities. Cerebral venous thrombosis was recognized as a rare and fatal condition when it was first defined; however, it currently presents with a better prognosis because of increased awareness, advanced neuroimaging techniques, and therapeutic methods. The use of dabigatran, which is a new therapeutic option, remains on the agenda particularly for avoiding drug interaction with warfarin in the patients with comorbidities and history of multiple medications. Dabigatran has a high rate of success with low incidence of side effects. © 2015 by Turkish Society of Medical and Surgical Intensive Care Medicine.Item A comparison of thresholds of auditory steady-state response and auditory brainstem response in healthy term babies(AVES İbrahim KARA, 2016) Çelik O.; Eskiizmir G.; Uz U.OBJECTIVE: The goal of this study was to assess the effectiveness of auditory steady-state response (ASSR), determine the cut-off values for each frequency, and detect the best correlated frequencies when compared with the auditory brainstem response (ABR) thresholds in term babies under the age of 12 months. MATERIALS and METHODS: In total, 88 term babies with a mean age of 2.98 (1–11) months (174 ears) underwent ASSR and ABR tests. The ASSR thresholds for the frequencies of 500, 1000, 2000, and 4000 Hz were compared with the hearing level of the ABR thresholds. In the ABR test, a cutoff value of 30 dB nHL was selected for normal hearing. In addition, the best correlation between the ABR and ASSR thresholds and the estimated cut-off thresholds of ASSR for each of the abovementioned frequencies were obtained. RESULTS: In total, 135 ears had values indicating normal hearing ability and 39 ears had hearing loss according to the ABR thresholds. Although statistically significant correlations were found between the ABR and ASSR thresholds at all frequencies in all groups, these correlations were not strong. On the other hand, a strong correlation was found between the responses of the ABR and ASSR thresholds at 4000 Hz in the hearing-impaired subjects. CONCLUSION: Our findings suggest that ASSR may not be beneficial or reliable as a screening test. Thus, it is likely to be considered as a complementary test rather than an alternative to the ABR test. © 2016 by The European Academy of Otology and Neurotology and The Politzer Society.Item Primary ciliary dyskinesia: Ready for quality of life assessment(AVES İbrahim KARA, 2017) Yılmaz Ö.; Akgün M.[No abstract available]Item Isolation and in vitro cultivation of human urine-derived cells: An alternative stem cell source(AVES İbrahim KARA, 2017) Erden Tayhan S.; Tezcan Keleş G.; Topçu İ.; Mir E.; Deliloğlu Gürhan S.İ.Objective: For in vitro tissue engineering in urology, stem cells are commonly isolated from tissue specimens obtained during open or endoscopic surgery. Within the context of the present study our aim was to isolate cells from human urine by an alternative and safe technique rather than using the indicated method. Material and methods: After human urine samples had been collected from young and healthy donors via urethral catheterization, cells were precipitated by centrifugation and cultured. Following this isolation procedure, cells were characterized by immunocytochemical method using specific antibodies. Results: When these cells were characterized by immunocytochemical methods using specific antibodies some of them were positive for mesenchymal stem cell marker CD90 while the others were labelled with urothelial marker cytokeratin 7. When all these results were taken into consideration, urothelial cells together with stem cells were observed in the urine- derived cell population. Conclusion: According to the results obtained from this study human urine may be preferred as an alternative stem cell and urothelial cell source in that this method is and easily reproducible non-invasive method. © 2017 by Turkish Association of Urology.Item Ginkgo biloba and lycopene are effective on cisplatin induced ototoxicity?(AVES İbrahim KARA, 2018) Esen E.; Özdoğan F.; Gürgen S.G.; Özel H.E.; Başer S.; Genç S.; Selçuk A.OBJECTIVE: The purpose of this study was to examine the anti-ototoxic impact of Ginkgo biloba extract and lycopene on the model of cisplatin-induced ototoxicity in rats. MATERIALS and METHODS: Thirty-two Wistar albino rats were examined with the distortion product otoacoustic emission (DPOAE) test (MADSEN Capella2; GN Otometrics, ICS Medical, Chicago USA), and they were randomly divided into four groups. Group 1 (n=8) was defined as the healthy control group. Cisplatin was given intraperitoneally as single dose of 12 mg/kg to group 2 (n=8), group 3 (n=8), and group 4 (n=8). Group 2 was determined as ototoxic control group. G. biloba extract (100 mg/kg) was given to group 3, and 20 mg/kg lycopene was given to group 4 with oro-gastric feeding tube daily for 10 days. DPOAE test was repeated on day 10 on all the groups. Finally, histopathological examination was performed. The study has been lead in agreement with the principles by the Institutional Animal Care and Use Committee Review Board at Kocaeli University Medical Center (KOÜ HADYEK- 1/9-14). The animals were treated in accordance with protocols approved by this committee. RESULTS: When DPOAE tests were compared, there was no significant difference in the four groups before the application (p>0.05). At the end of day 10, in groups 2 to 4, statistically significant changes were observed (p<0.05). According to the cisplatin group, a significant increase in the DP-grams on G. biloba and lycopene groups was observed (p<00.5). Corti organ and spiral ganglion neurons of groups 1, 3, and 4 were observed to have weak expression. Strong reactions were determined in organum spirale and some spiral ganglions of the cisplatin group. The striae vascularis damage on group 2 was found to be more significant more compared with groups 3 and 4. CONCLUSION: There is a protective effect of G. biloba and lycopene on cisplatin-dependent ototoxic rat model. © 2017 by The European Academy of Otology and Neurotology and The Politzer Society.Item Potential role of chromatin remodeling factor genes in atrophic gastritis/gastric cancer risk(AVES İbrahim KARA, 2018) Bilgiç F.; Gerçeker E.; Boyacioglu S.Ö.; Kasap E.; Demirci U.; Yildirim H.; Baykan A.R.; Yüceyar H.Background/Aims: Atrophic gastritis (AG), intestinal metaplasia (IM), and Helicobacter pylori (HP) are the risk factors for the development of gastric cancer (GC). Chromatin remodeling is one of the epigenetic mechanisms involved in the carcinogenesis of GC. The purpose of this study was to investigate the expression profiles of defined chromatin remodeling genes in gastric mucosal samples and their values as gastric carcinogenesis biomarkers. Materials and Methods: In total, 95 patients were included in the study. Patients were divided into 3 groups as: GC group (n=34), AG group (n=36), and control group (n=25). AG group was further divided into subgroups based on the presence of HP and IM in gastric mucosa. Chromatin remodeling gene expressions were analyzed using real-time PCR (RT-PCR) array in all groups. Data were evaluated using the RT-qPCR primer assay data analysis software. Results: EED, CBX3, and MTA1 were more overexpressed, whereas ARID1A, ING5, and CBX7 were more underexpressed in the AG and GC groups compared with the controls. No significant differences were observed between the AG and GC groups concerning the expression of these 6 genes, although the fold change levels of these genes in the GC group were well above than in the AG group. EED, CBX3, and MTA1 were significantly more overexpressed in HP- and IM-positive AG subgroup compared with the HP- or IM-negative AG subgroup. Conclusion: In conclusion, our results provide an evidence of epigenetic alterations in AG. Expressions of EED, CBX3, MTA1, ARID1A, ING5, and CBX7 may be considered as promising markers to be used in GC screening for patients with AG. © Copyright 2018.Item An adverse event associated with antifungal therapy: Clinic-like posterior reversible encephalopathy syndrome; [Antifungal ilaca bağlı gelişen yan etki: Posterior reversible ensefalopati sendromu benzeri klinik?](AVES İbrahim KARA, 2018) Ak A.K.; Erbüyün S.; Heppekcan D.; Batum M.; Boyacı R.; Mavioğlu H.; Tok D.A.Posterior reversible encephalopathy syndrome (PRES) is a diagnosis characterized by headache, changes in consciousness, epileptic seizures, visual symptoms (decreased visual acuity and blurred vision), vasospasm, and perfusion abnormalities in the posterior systemic vessels of the brain. The most common clinical findings of PRES include headache, epileptic seizure, altered consciousness, motor deficits, and loss of vision. In the patient who presented with symptoms similar to those in PRES after the use of anidulafungin and had a history of trauma, other causes of PRES (like carotid and/or vertebral artery dissection, intra-abdominal trauma, and head trauma etc.) were excluded. In our case, visual disturbance was assessed as being secondary to central nervous system pathology. There are no similar cases in the literature that presented with clinical features of PRES and normal imaging findings. The primary aim of this study was to draw attention to the fact that anidulafungin may cause symptoms similar to those in PRES. © 2018 by Turkish Society of Medical and Surgical Intensive Care Medicine.Item Community-acquired pneumonia: Importance of molecular methods for etiological diagnosis and clinical features; [Toplumda gelişen pnömoni: Etyolojik tanıda moleküler yöntemlerin önemi ve klinik özellikler](AVES İbrahim KARA, 2018) Özer-Türk D.; Tünger Ö.; Şakar-Coşkun A.; Gazi H.; Şanlıdağ T.; Kurhan F.; Çetin Ç.B.; Şenol Ş.Objective: This study aims to make an early identification for the diagnosis of community-acquired pneumonia (CAP), to increase the rate of etiological diagnosis and to distinguish bacterial and viral pathogens with the use of multiplex polymerase chain reaction (PCR) in addition to conventional methods, and to compare cases in the light of clinical and laboratory results. Methods: Ninety two CAP patients who were hospitalized and followed at our hospital between January-November 2013 were included in this study. Conventional culture and multiplex PCR were used to identify the causative microorganisms in the respiratory tract samples of the patients. Demographic data, risk factors, clinical, radiological and laboratory results, treatment and follow-up results of the cases were recorded. Statistical Package for the Social Sciences (SPSS) for Windows. Version 15.0 (SPSS Inc., Chicago, IL, USA) program was used in the analysis of the data. Results: CURB-65 score was determined ≥2 in 80.4% of the cases and 14.1% was followed in the intensive care unit. Of the patients, 42 (45.7%) were found to have bacterial and 20 (21.7%) were found to have viral agents while in 30 (32.6%) patients an agent could not be demostrated. Bacterial etiology was detected with conventional culture methods in 15 (16.3%) and with multiplex PCR in 42 (45.6%) cases. The difference between them was found to be statistically significant (p<0.001). It was found out that mostly bacterial factors were responsible for the CAP cases which were seen in fall or winter, and the etiology of the cases which were seen in spring and summer could not be determined in general (p<0.05). Variables such as sputum production, sore throat, auscultation findings and corticosteroid use were found to be statistically significant among bacterial, viral and unidentified etiology groups. Conclusions: It was demonstrated that molecular methods are beneficial for the early diagnosis of CAP. It was also thought that early diagnosis of viral etiology can prevent the unnecessary use of antibiotics as well as contributing to the patient management. © 2018, AVES İbrahim KARA. All rights reserved.Item Investigating knowledge levels of university students about infertility(AVES İbrahim KARA, 2018) Siyez D.M.; Seymenler S.; Esen E.; Siyez E.; Kağnıcı Y.; Baran B.; Öztürk B.Objective: The aim of this study was to determine the knowledge levels of university students about infertility and investigate the differences in knowledge levels according to sociodemographic variables and some lifestyle factors. Material and methods: The sample of the study consisted of 9693 undergraduate students (5002 females, 4691 males) from 12 regions. Regions were determined according to Statistical Region Units Classifica-tion-1 criteria. Infertility Knowledge Test (IKT) was used as a data collection tool. Results: It was found that university students’ IKT scores significantly differed according to gender (p<0.01); age (p<0.05); body mass index (p<0.05); reproductive health education status (p<0.001), presence of infertile individuals around (p<0.001); having sexual intercourse (p<0.001); smoking (p<0.001) and alcohol consumption frequency (p<0.05). Conclusion: University students’ lack of knowledge about family planning, effects of age and sexual intercourse timing on infertility was remarkable. However, it was determined that the knowledge level of infertility risk factors related to substance use and body mass index was high. It is believed that increasing the level of knowledge about infertility among individuals will positively effect their awareness of risk factors and facilitate their search for timely medical assistance. Sexual health education can be effective in increasing university students' knowledge of infertility. © 2018 by Turkish Association of Urology.