MCBÜ Açıkerişim Sistemi :: Browsing by Publisher "Ankara University"

Browsing by Publisher "Ankara University"

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Occupational asthma in welders and painters
(Ankara University, 2010) Temel O.; Şakar Coşkun A.; Yaman N.; Sarioǧlu N.; Alkaç Ç.; Konyar I.; Özgen Alpaydin A.; Çelik P.; Cengiz Özyurt B.; Keskin E.; Yorgancioǧlu A.
We aimed to investigate the frequency of occupational asthma (OA) and the factors associated with OA development in a bicycle factory, subsequently after the diagnosis of OA in three workers at the same department. Forty one welders, 23 painters and 46 controls (office workers), a total number of 110 cases were included in the study. Turkish Thoracic Society Occupational and Environmental Diseases Evaluation Questionnaire and physical examination, chest-X ray, pulmonary function tests were performed as needed. Peak expiratory flow (PEF) follow-up was done in welders and painters. Cases having symptoms related with work and ≥ 20% PEF variability were diagnosed as OA. Wheezing were more frequent in welders and painters than the control group, although there wasn't a statisticall significance. Dyspnea, cough and sputum production were more frequent in welders and painters with respect to controls (p< 0.05). Nine (22%) welder, 4 (18%) painter were diagnosed as OA. Working duration of welders and painters with OA (72, 156 months, respectively) were longer than the welders and painters without OA (45, 76 months, respectively), but it did not have any statistically significance. We suggest that working in welding and painting departments may cause respiratory symptoms and OA.
Turkish thoracic society asthma management and prevention guideline: Key points; [Türk toraks derneǧi astım tanı ve tedavi rehberi: Anahtar noktalar]
(Ankara University, 2011) Yildiz F.; Oǧuzülgen I.K.; Dursun B.; Mungan D.; Gemicioǧlu B.; Yorgancioǧlu A.
Asthma still has high morbidity and cost despite all advances in pathogenesis, diagnosis and treatment. Although asthma can be controlled with proper diagnosis and treatment, the low rates of control in our country and in the world can not be attributed to the variable course of the disease and patients' psycho-social behaviours for chronic disease. In this context, Turkish Thoracic Society (TTS) has decided to update Asthma Diagnosis and Management Guide latest published in 2000. National data were collected, compiled and prepared by authors, and final form given by the TTS Asthma and Allergy Study Group, after presenting to consultant individuals and institutions. In June 2009, the National Asthma Management and Prevention Guideline were published in Turkish. In this paper, we aimed to present the national guide in English with its basics and individual differences.
Long acting beta-2 agonists in the treatment of asthma and their safety; [Astım tedavisinde uzun etkili beta-2 agonistlerin yeri ve güvenilirliǧi]
(Ankara University, 2011) Türktaş H.; Şekerel B.; Karakaya G.; Yildiz F.; Yorgancioǧlu A.
Inhaled corticosteroids are the preferred primary long-term treatment for asthma. The first option in patients who are uncontrolled with inhaled steroids is adding long-acting beta-2 agonists. The addition of a long-acting beta-agonist to an inhaled corticosteroid has been accepted as effective therapy for almost two decades Despite the widespread use and their clinical benefit, controversy regarding their safety arose after their introduction. Concerns about the safety of long-acting beta-2 agonist therapy, has led to the appearance of multiple publications and recommendations. The evidence supports the use of long-acting beta-2 agonists plus inhaled corticosteroids in a single inhaler device to increase adherence and reduce the potential use of long-acting beta-2 agonists monotherapy. This review examines and commands on the available clinical data and safety concerns of long-acting beta-2 agonists use in patients with asthma.
Validity and reliability of "asthma quality of life questionnaire" in a sample of Turkish adult asthmatic patients; ["Asthma quality of life questionnaire" yaşam kalitesi anketinin erişkin astımlı Türk hasta örneǧinde geçerliliǧi ve güvenilirliǧi]
(Ankara University, 2011) Özgen Alpaydin A.; Yorgancioǧlu A.; Yilmaz O.; Bora M.; Göktalay T.; Çelik P.; Yüksel H.
We aimed to investigate the validity and reliability and of "Asthma Quality of Life Questionnaire (AQLQ)" in Turkish adult asthmatic patients. New or previously diagnosed [according to Global Initative for Asthma (GINA) 2008] symptomatic 118 consecutive stable asthmatic patients between 18 and 55 years old were included. Asthma severity was determined and Turkish adaptation of the AQLQ was administered. Lara asthma symptom scales (LASS), pulmonary function tests, Turkish adaptation of Medical Outcomes Survey Short Form-36 (SF-36) were evaluated. All assessments were done twice at recruitment and after 10 weeks. During this period patients were allowed to make modifications on their medication when necessary. Among the recruited 118 patients 95 were female and 14 were lost in the follow-up. Sixty-two percentages of the patients had mild and 38% moderate asthma. The internal consistency of AQLQ was high (Cronbach's alpha 0.81-0.87) and item-total score correlations were ranging from 0.75-0.89. The cross-sectional and longitudinal correlations between AQLQ total and domain scores and SF36 domain scores were in a range of little or fair degree (r= 0.241-0.626, p< 0.005). Total AQLQ scores were observed significantly different according to disease severity and LASS both in the first (p< 0.001, both) and 10 weeks follow-up visits (p= 0.006, p< 0.001 respectively). A statistical significant change was observed in AQLQ symptom score as in total LASS changed (p< 0.001, both) in the follow-up. Our results demonstrated that Turkish version of AQLQ is feasible, reliable, valid and sensitive to changes in adult asthmatics.
Effects of some organic fertilizers and Agryl cover on yield, quality and leaf nutrient content and soil productivity in organic lettuce growing; [Organik Salata-Marul Yetiştiriciliǧinde Agryl Örtü ve Bazı Gübrelerin Verim, Kalite, Yaprak Besin Madde İçeriǧi ve Toprak Verimliliǧi Özelliklerine Etkileri]
(Ankara University, 2011) Tüzel Y.; Öztekin G.B.; Duyar H.; Eşiyok D.; Kiliç O.G.; Anaç D.; Kayikçioǧlu H.H.
This study was carried out at the organic land of Ege University Faculty of Agriculture, Department of Horticulture during the spring and autumn seasons. Three organic fertilizers were tested under two growing systems to determine yield, quality, plant growth and soil fertility in Romaine lettuce (cv. Yedikule) and lettuce (cv. Arapsaçi{dotless}) production. Experiments were conducted with 6 groups composed of two growing systems [under Agryl cover (A+) or open field conditions without Agryl (A-)] and three fertilizers [Biofarm (B), Biofarm + Humic Acid (BHa) and Biofarm + Leonardite (BL)] in two years and growing seasons (2005-spring and 2006-autumn) with factorial design. In both years, total yield and average plant weight increased with the use of agryl cover while among the tested fertilizers, BHa and B applications gave the highest yields in the 1st and 2nd year, respectively. Agryl cover affected plant length among the measured quality characteristics. Mean nitrate content of organic lettuces was found quite low than the limits. Effects of agryl cover and fertilizers on leaf nutrient content were significant whereas fertilizer treatments increased soil microbial biomass-C and organic matter content in the first yield. It was concluded that these treatments could be recommended to use in organic lettuce production due to the positive effects of agryl cover on yield and organic fertilizers on yield, quality and soil fertility. © Ankara Üniversitesi Ziraat Fakültesi.
Clinical presentations and diagnostic work-up in sarcoidosis: A series of Turkish cases (clinics and diagnosis of sarcoidosis); [Sarkoidozlu olgularda klinik görünüm ve tanısal yaklaşım: Türk olgu serisi (sarkoidoz kliniǧi ve tanı yaklaşımları)]
(Ankara University, 2011) Kiter G.; Müsellim B.; Çetinkaya E.; Türker H.; Kunt Uzaslan A.E.; Yentürk E.; Uzun O.; Saǧlam L.; Özdemir Kumbasar O.; Çelik G.; Okumuş G.; Arbak P.M.; Altiay G.; Tabak L.; Şakar Coşkun A.; Erturan S.; Türktaş H.; Yalniz E.; Akkoçlu A.; Öǧüş C.; Doǧan O.T.; Özkan M.; Özkan S.; Uzel F.I.; Öngen G.
Sarcoidosis is an idiopathic granulomatous disease. It usually affects the lung. The diagnosis may be problematic since the known causes of granulomatous inflammation must be excluded. This multicenter study aimed to evaluate the clinical presentations and diagnostic approaches of sarcoidosis. The study protocol was sent via internet, and the participants were asked to send the information (clinical, radiological and diagnostic) on newly diagnosed sarcoidosis cases. 293 patients were enrolled within two years. Pulmonary symptoms were found in 73.3% of the patients, and cough was the most common one (53.2%), followed by dyspnea (40.3%). Constitutional symptoms were occured in half of the patients. The most common one was fatigue (38.6%). The most common physical sign was eritema nodosum (17.1%). The most common chest radiograhical sign was bilateral hilar lymphadenomegaly (78.8%). Staging according to chest X-ray has revealed that most of the patients were in Stage I and Stage II (51.9% and 31.7%, respectively). Sarcoidosis was confirmed histopathologically in 265 (90.4%) patients. Although one-third of the bronchoscopy was revealed normal, mucosal hyperemi (19.8%) and external compression of the bronchial wall (16.8%) were common abnormal findings. The 100% success rate was obtained in mediastinoscopy among the frequently used sampling methods. Transbronchial biopsy was the most frequently used method with 48.8% success rate. Considering sarcoidosis with its most common and also rare findings in the differential diagnosis, organizing the related procedures according to the possibly effected areas, and the expertise of the team would favor multimodality diagnosis.
Level of smoking of 3rd and 4th grade students studying health and related factors: Follow-up study; [Saǧlık eǧitimi alan 3 ve 4. sınıf öǧrencilerinde sigara kullanımı ve etkileyen faktörler: Izlem araştırması]
(Ankara University, 2011) Göktalay T.; Cengiz Özyurt B.; Şakar Coşkun A.; Çelik P.
The levels of smoking of 1st and 2nd year students at Faculty of Medicine and Manisa School of Health at Celal Bayar University were investigated in 2006-2007. This study is carried out in order to see if there is a change in the same students' level of smoking while they are in 3rd and 4th year. In addition, the study aimed to examine the factors affecting the level of use and attitudes towards the law effectuated in July 19, 2009. This is a follow-up study with 80.42% return rate. A 26-item structured questionnaire was administered. The participants filled out the questionnaires under supervision of the researchers in their classrooms. The University Institutional Review Board approved the study. The total of participants (263) of the follow-up study included 189 female and 74 male. The rate of experimenting with smoking was 49% with the mean age of 15.7 (SD= 4.01 years). The mean age of experimenting with smoking was the earliest on male students studying at faculty of medicine. The level of smoking was found to be the most on females, studying at faculty of medicine and staying at the dormitory, with smoking parents (p< 0.05). The most important reason to begin smoking was curiosity (55.2%) while bad breath and yellowing of teeth were the reasons to quit (91.7%). 83.3% of the students thought that the law will be effective on quit smoking. The level of both experimenting and use of smoking has been increased over time. It is suggested that medical students' awareness about the danger of smoking should be raised at earlier grades. In addition, lectures should be offered to students at School of Health and they should be encouraged to unite in order to fight with smoking.
Antioxidant properties of kefir produced from different cow and soy milk mixtures; [Farklı inek ve Soya Sütü Karışımlarından Üretilen Kefirlerin Antioksidan Özellikleri]
(Ankara University, 2011) Kesenkaş H.; Dinkçi N.; Seçkin K.; Kinik O.; Gönç S.
The aim of this study is to determine the antioxidant properties of kefir samples produced from different cow/soy milk mixtures. Antioxidative activities such as the inhibition of ascorbate autoxidation, reducing activity, the scavenging effect of superoxide anion radicals and hydrogen peroxide of kefir samples were determined. Kefirs produced from whole soymilk had the highest inhibition rate of ascorbate autoxidation. Reducing activities of kefir samples, expressed as equivalent amounts of cysteine, were found statistically different and elevated by increased soymilk ratio. Results of the inhibition of superoxide radical generation of cow, cow/soy and soymilk kefir samples were found statistically different. However, the effect of fermentation on this activity neither with kefir grain nor culture was significant. Results indicated that none of kefir samples exhibit a hydrogen peroxide scavenging activity. © Ankara Üniversitesi Ziraat Fakültesi.
Serum and pleural fluid N-Terminal-Pro-B-Type natriuretic peptide concentrations in the differential diagnosis of pleural effusions; [Plevral efüzyonların ayırıcı tanısında serum ve plevral sıvı n-terminal-pro-B-tip natriüretik peptid konsantrasyonunun yeri]
(Ankara University, 2011) Yorgancioǧlu A.; Özgen Alpaydin A.; Yaman N.; Taneli F.; Bayturan O.; Şakar Coşkun A.; Çelik P.
Currently, new biomarkers like N-Terminal-Pro-B-Type natriuretic peptide (NT-proBNP) have been used in the differential diagnosis of pleural effusions. In our study, we aimed to investigate the diagnostic value of NT-proBNP, especially in cardiac originated pleural effusions. Forty-five patients with pleural effusions were included in the study. NT-proBNP levels and biochemical markers involved in the Light's criteria were analyzed in pleural fluid and serums of the patients. Pleural fluid culture, AFB smear, cytology were performed where they were indicated according to the clinical evaluation. In patients, to whom cardiac pathology was considered to be; cardiological evaluation and echocardiography were also done. Thirtyeight pleural effusions were exudative and, 7 were transudative according to the Light's criteria. Final diagnosis were malignant effusion in 13, infection (tuberculosis/pneumonia) in 10, congestive heart failure in 21, and other conditions related with pleural effusion in 1 of the patients. Median (25th to 75th percentiles) NT-proBNP levels of serum and pleural fluid due to congestive heart failure (CHF) were 4747 pg/mL (931-15754) and 4827 pg/mL (1290-12.430) while median NTproBNP levels of serum and pleural fluid related with non-cardiac reasons were 183 pg/mL (138-444) and 245 pg/mL (187-556) respectively. NT-proBNP levels of serum and pleural fluid were significantly high in CHF (p< 0.001 for both). When four groups were compared serum and pleural fluid NT-proBNP levels were highest in the CHF group which was followed by malignancy, infection and others (p< 0.001 for both). Fourteen of 21 patients who were accepted to have congestive heart failure as the final diagnosis by a cardiological evaluation had an exudative pleural fluid according to the Light's criteria. Serum and pleural fluid NT-proBNP levels were higher in transudates and this reached statistically significance for pleural fluid (p= 0.009). We suggest that measurement of pleural fluid NT-proBNP is a smart approach and pleural fluid NTproBNP can reflect cardiac origin of effusions better than serum NT-proBNP and Light's criteria.
Reliability and validity of Turkish version of COPD Assessment Test; [KOAH deǧerlendirme testinin Türkçe geçerlilik ve güvenilirliǧi]
(Ankara University, 2012) Yorgancioǧlu A.; Polatli M.; Aydemir Ö.; Yilmaz Demirci N.; Kirkil G.; Nayci Atiş S.; Köktürk N.; Uysal A.; Akdemir S.E.; Özgür E.S.; Günakan G.
Introduction: This study is aimed to evaluate the reliability and validity of the Turkish version of chronic obstructive pulmonary disease (COPD) Assessment Test (CAT) in seven centers. Materials and Methods: 321 patients between 4-75 years of age, diagnosed and staged by Global Initiative for Obstructive Lung Disease (GOLD) 2011 criteria were included. The Breathlessness, Cough, Sputum scale (BCSS), mMRC (Modified Medical Research Council) dyspnea index, St. George Respiratory Questionnaire (SGRQ), CAT and Short Form-36 (SF-36) were used concurrently. In the statistical analyses, internal consistency, item-total score correlation, explorative factor analysis, correlation with other scales were calculated. Results: The mean age was 62.4 ± 8.9 years and 89.7% of the patients were male (n= 288). Mean FEV 1% was 51.9 ± 19.2 and most of the patients were in Stage 3. CAT total score was 17.8 ± 9.5. In the internal consistency, Cronbach alpha coefficient was found as 0.9116 and item-total score correlation coefficients were between 0.62-0.79 and all were statistically significant (p< 0.0001). The correlation of the test-retest score calculated after two weeks with the initial score was 0.96 (p< 0.0001). In the structural validity, factor analysis with principle component analysis and varimax rotation was performed. One factor solution was achieved with eigenvalue of 4.956 and it represented 61.9% of the total variance. All the items were contained in the factor and the factor loads were between 0.71-0.85. The correlation coefficients of CAT with other indexes were moderate to good. The discrimination of CAT among disease stages has been shown to be significant (p< 0.0001) and a significant correlation was found with pulmonary function tests (p< 0.0001). Conclusion: It is demonstrated The Turkish version of COPD Assessment Tool is reliable and valid.
ARIA (Allergic rhinitis and its impact on asthma) Achievements in 10 years and future needs; [ARIA (Allerjik rinit ve astım üzerine etkisi) 10 yıldaki kazanımlar ve gelecekteki gereksinimler]
(Ankara University, 2012) Yorganciog̀lu A.; Özdemir C.; Kalayci O.; Kalyoncu A.F.; Bachert C.; Baena-Cagnani C.E.; Casale T.B.; Chen Y.Z.; Cruz A.A.; Demoly P.; Fokkens W.J.; Lodrup Carlsen K.C.; Mohammad Y.; Mullol J.; Ohta K.; Papadopoulos N.G.; Pawankar R.; Samolinski B.; Schünemann H.J.; Yusuf O.M.; Zuberbier T.; Bousquet J.
Allergic rhinitis and asthma represent global health problems for all age groups. Asthma and rhinitis frequently co-exist in the same subjects. Allergic Rhinitis and its Impact on Asthma (ARIA) was initiated during a World Health Organization (WHO) workshop in 1999 and was published in 2001. ARIA has reclassified allergic rhinitis as mild/moderate-severe and intermittent/persistent. This classification schema closely reflects the impact of allergic rhinitis on patients. In its 2010 Revision, ARIA developed clinical practice guidelines for the management of allergic rhinitis and asthma co-morbidities based on GRADE (Grading of Recommendation, Assessment, Development and Evaluation). ARIA has been disseminated and implemented in over 50 countries of the world. In Turkey, it is important to make a record of ARIA achievements and to identify the still unmet clinical, research and implementation needs in order to strengthen the 2011 EU Priority on allergy and asthma in children.
Is the diagnosis of asthma different in elderly?; [Yaşlılarda astım tanısı farklı mıdır?]
(Ankara University, 2012) Yorgancioǧlu A.; Şakar Coşkun A.
Asthma is mis-diagnosed, under-diagnosed and under-treated in older populations but has a high mortality rate. The physiological changes due to aging of lung, the co-morbid situations and poly pharmacy may change the typical presentation of asthma in older people and cause diagnostic difficulties. But it therefore should be diagnosed properly by taking of all differential situations especially chronic obstructive pulmonary disease into consideration since the appropriate management of the disease will alter the morbidity and mortality.
The knowledge and considerations of the physicians regarding the inhaler devices in asthma and COPD: The INTEDA-1 study; [Asti{dotless}m ve koah tedavisinde kullani{dotless}lan inhaler cihazlar hakki{dotless}nda hekimlerin bilgi düzeyleri ve görüşleri: INTEDA-1 Çali{dotless}şmasi{dotless}]
(Ankara University, 2013) Çalişkaner A.Z.; Öztürk C.; Ceylan E.; Pekcan S.; Yilmaz Ö.; Öztürk S.; Can C.; Şener O.; Yilmaz Turay Ü.; Koç N.; Ersoy R.
The knowledge and considerations of the physicians regarding the inhaler devices in asthma and COPD: the INTEDA-1 study Introduction: The present paper was aimed at indicating and discussing the possible problems related to inhaler devices by considering the knowledge and practices of the physicians regarding the inhalation therapies. Materials and Methods: The present study is a prospective, cross-sectional survey carried out by Turkish Respiratory Society Inhalation Therapy Group between February 2010 and February 2011 with a participation of ten individual centres. Seven inhaler devices that were available on the market in the country were assessed. The data on the problems that 684 clinicians actively attending patients with respiratory disorders experienced in daily clinical practice or their evaluations of their patients were obtained through the questionnaire. Results: The respondents, most of whom were pulmonologist (37.5%), and pediatrist (38.1%), had been,on average, 11.6 years in profession. The source of information on inhalers and administration techniques were reported to be mainly the internet and patient leaflets. Of the participants only 18.5% reported to have had adequate knowledge of inhaler devices and proper administration techniques. Most of the participants stated that they themselves provided the instructions of administration and that the method was often verbal explanation. The physicians believed that although approximately 60% of the patients used the drug correctly, 40.7% made critical mistakes to have adverse effects on the therapeutic outcome. The most important criteria on which the physians lay greater emphasis in choosing the inhaler devices were the physical capability, skills and age of the patients. Conclusion: The awareness of proper use of inhaler devices is a fundamental prerequisite for effective inhalation therapy has been improved in physicians. The results of the present study have shown that more effort is required for professional training. Assisting the physicans with medical personnel for training of the patients and educational motivation are required.
A health survey in the workers of municipality; [Belediye çalışanlarında akciǧer saǧlıǧı taraması]
(Ankara University, 2013) Göktalay T.; Şakar Coşkun A.; Havlucu Y.; Akdemir S.E.; Datli U.; Gümeli F.; Yorgancioǧlu A.
Introduction: Internal and external air pollution that is gradually increasing due to urbanization and industrialization has a negative impact on the lung health. A health survey has been applied to evaluate the respiratory symptoms, respiration functions and smoking habits of the workers of Izmir Konak Municipality whom have been reported to have a high rate of smoking habit and be affected by the external air pollution due to their being working in the field by the Municipality's doctor. Materials and Methods: Questionnaire that are composed of the topics of work anamnesis, environmental anamnesis, curriculum vitae, symptoms (coughing, sputum, wheezing, dyspnea, hemoptysis) and smoking have been executed to 301 workers by face to face interview and their chest X-rays have been reviewed. Results: Dyspnea on exertion, sputum in the morning, wheezing and morning cough have been the most frequently observed complaints (respectively 37.2%, 32.2%, 27.9% and 24.9%). Sanitary workers have reported sputum in the morning more while maintenance shop workers have reported wheezing more (p values respectively 0.009, 0.008). No significance has been observed while the workers are evaluated one by one regarding to their work groups. No significant difference was identified between the addiction of smoking and nicotin addiction or pulmonary function test and chest X-rays (p> 0.05) but active smoking was much more seen in drivers (p= 0.047). Conclusion: Although working on the hazardous work branch does not institute a sharp distinction, it becomes significant to trace and lead the workers in order to obtain their lung health protection in long term. Informing and influencing the workers about the harms of smoking and the ways to quit has been the most considerable acquisition of this survey.
Treatment of severe asthma: Expert opinion; [Aǧi{dotless}r asti{dotless}m tedavisi: Uzman görüşü]
(Ankara University, 2014) Türktaş H.; Bavbek S.; Çelik G.; Demir T.; Gemicioǧlu B.; Günen H.; Kiyan E.; Mungan D.; Oǧuzülgen I.K.; Polatli M.; Saryal S.; Sayiner A.; Şen E.; Yildirim N.; Yildiz F.; Yorgancioǧlu A.
Severe asthmatics account 10% of the all asthmatic population. Those asthmatics whose disease is inadequately controlled account for up to half of the cost for asthma, because they have more emergency room visits, more hospital admission and greater absenteeism from work. New therapeutic options were tried in those patients whose asthma was uncontrolled with standart high dose inhaled corticosteroid and long acting beta-2 agonsit combination therapy. In this paper taking into account the conditions of our country, current literature was reviewed and treatment options was discussed and graded recommendations are made for daily clinical practice in patients with severe treatment-refractory asthma.
Is obesity related to worse control in children with asthma?; [Asti{dotless}mli{dotless} çocuklarda obezite daha kötü kontrol ile i̇lişkili mi?]
(Ankara University, 2014) Yilmaz O.; Söǧüt A.; Bozgül A.; Türkeli A.; Kader Ş.; Yüksel H.
Introduction: Asthma and obesity are related diseases however the influence of obesity on asthma severity is not clear yet. Therefore, the aim of our study was to evaluate the association between obesity and asthma control evaluated on the basis of symptoms and asthma control questionnaire (ACQ). Materials and Methods: We enrolled 98 children with asthma aged 4 to 14 years consecutively and recorded their disease characteristics and severity parameters as well as the symptom scores. All children filled in the ACQ. Children were classified as obese and non-obese according to body mass index. Obesity was defined as body mass index over 90th percentile. Results: Mean age of the children in the obese group (n= 27) was 8.1 ± 2.6 while that in the non-obese group (n= 71) was 8.6 ± 2.9 (p= 0.41). Asthma symptom score in obese and non-obese groups were not significantly different (p= 0.73). Children in the obese group had lower ACQ scores when compared to the non-obese group (1.2 ± 0.9 vs 1.7 ± 1.0, p= 0.04) however this significance was lost when controlled for age and gender in the regression model. Conclusion: The results of this study suggest that obesity is not significantly associated with worse asthma control when adjusted for age and gender.
Asthma-KOAH overlap syndrome; [Astım-KOAH overlap sendromu]
(Ankara University, 2015) Şen E.; Oğuzülgen K.; Bavbek S.; Günen H.; Kiyan E.; Türktaş H.; Yorgancioğlu A.; Polatli M.; Yildiz F.; Çelik G.; Demir T.; Gemicioğlu B.; Mungan D.; Saryal S.; Sayiner A.; Yildirim N.
Asthma and chronic obstructive pulmonary disease (COPD) are common lung diseases characterized by chronic airway inflammation and airway obstruction. Among patient with COPD and asthma; there is a group of patients with an overlap between clinical, functional characteristics and airway inflammation patterns, named “Asthma-COPD Overlap Syndrome” (ACOS). ACOS is a syndrome characterized by reversible but persistant airflow limitation (postbronchodilator FEV1/FVC < 70%) which has some features of both asthma and COPD. ACOS should be suspected in a patient > 40 years, with smoking history, previous asthma diagnosis or history of childhood asthma who has persistant airflow limitation and reversible ariway obstruction (defined by an increase of > %12 of FEV1 pred or increase of FEV1 > 200 mL after inhalation of 400 mcg salbutamol or 1000 mcg terbutaline). The prevalence for ACOS has been reported 11-55% in different case series to date and increases by age and is more frequent in females in different age groups. Patients with ACOS are younger than COPD patients and older than asthma patients. Frequent and severe exacerbations and related hospitalization and emergency room visits are common in ACOS and this causes an impaired quality of life. Current recommendations of guidelines for pharmacologic treatment of ACOS have been composed of a combination with optimal COPD and asthma treatment. Future therapeutic approaches should be based on endotypes. Clinical phenotype and underlying endotype driven clinical studies may be the base of ACOS guidelines. © 2015, Ankara University. All rights reserved.
Stigma of tuberculosis scale: Validity and reliability; [Tüberküloz Damgalanma Ölçeği: Geçerliliği ve güvenilirlik]
(Ankara University, 2015) Özpinar S.; Taner Ş.; Yildirim G.; Mahleç Anar C.; Altiparmak O.; Baydur H.
Introduction: In many health conditions, stigma is receiving increasing attention. Public stigmatization toward social illness can affect particularly the patients and family memberships to help seeking behavior and treatment. This study, the aim of this study was to investigate the validity and reliability of the Turkish “Stigma of Tuberculosis Scale ” which was developed to evaluate of perception of stigma with tuberkulosis patient. Patients and Methods: This methodological study was conducted with 150 with tuberculosis disease people who above 18 age and without known psychological and mental disability. In the study, “Stigma of Tuberculosis Scale” was used as data collection tool. During the study, language equivalence, content validity, reliability and construct validity of the scale was performed. The data was assessed by using mean, median, standard deviation, Spearman Correlation, Cronbach Alpha coefficient and confirmatory factor analysis. Results: The mean age of study participants was 45.6 ± 16.1 (20-85). years. Spearman correlation coefficient of the scale for testretest reliability was 0.853 and the Cronbach Alpha coefficient was 0.95. According to fit indexes of confirmatory factor analysis [x2/ SD= 481.38/230= 2.09; RMSEA= 0.087; GFI= 0.776; CFI= 0.776; NNFI= 0.875] it was found that one factors were appropriate for the scale. Conclusion: The adoption of the translated “Stigma of Tuberculosis Scale”in Turkey is found reliable and valid to evaluate of perception of stigma with tuberkulosis patient. © 2015, Ankara University. All rights reserved.
Koah ve astımda atak; [KOAH ve astımda atak]
(Ankara University, 2015) Yildirim N.; Demir T.; Gemicioğlu B.; Kiyan E.; Oğuzülgen K.; Polatli M.; Saryal S.; Sayiner A.; Yorgancioğlu A.; Bavbek S.; Çelik G.E.; Günen H.; Mungan D.; Şen E.; Türktaş H.; Yildiz F.
Chronic obstructive pulmonary disease (COPD) and asthma are airway diseases with acute exacerbations. Natural course of both disease are affected by exacerbations. COPD exacerbations may be caused by infections and other causes; indoor and outdoor pollution, cardiovascular diseases, asthma-COPD overlap syndrome, COPD- obstructive sleep apnea syndrome, pulmonary embolism, gastro-oesophageal reflux, anxiety-depression, pulmonary hypertension. Exposure to triggering factors, viral infections, treatment insufficiency may cause asthma exacerbations. Smoking cessations, prevention of infections, long-acting anticholinergics, long-acting β2 agonists, inhaled corticosteroids, phosphodiesterase-4 inhibitors, mucolytics, prophilactic antibiotics can be effective on the prevention of COPD exacerbations. Asthma exacerbations may be decreased by the avoidance of allergens, viral infections, occupational exposures, airpollution, treatment of comorbid diseases. Effective treatment of asthma is required to prevent asthma exacerbations. Inhaled steroids and combined treatments are the most effective preventive therapy for exacerbations. Patient education and cooperation is an element of the preventive measures for asthma attacks. Compliance to therapy, inhalation techniques, written asthma plans are required. The essential of COPD and asthma exacerbation treatment is bronchodilator therapy. Steroids are also implemented to the therapy, targeting the inflammation. Specific treatments of the cause (infection, airpollution, pulmonary embolism etc.) should be administered. © 2015, Ankara University. All rights reserved.
Evaluation of "polatlı negotiator mediator leader students" project; [Polatlı Müzakereci-Arabulucu-Lider öğrenci yetişiyor projesinin değerlendirilmesi]
(Ankara University, 2016) Yıldız D.G.; Çetin H.; Türnüklü A.; Tercan M.; Çetin C.; Kaçmaz T.
The purpose of this study was to investigate the effectiveness of "Polatlı Negotiator Mediator Leader Students" project which aimed to identify student conflicts among high school students in Polatlı, Ankara, based on changing world values and help them manage and transform their conflicts using innovative and peaceful procedures. During the project, a total of 829 students (394 female and 435 male) from 10 high schools in Polatlı were presented “Conflict Resolution, Peer Mediation and Negotiation Training Program”. The study utilized qualitative research methods and Process Evaluation Interview Questions, Peer-mediation Forms, and Program Evaluation Questionnaire were used for data collection. Research findings showed that mediation training had positive contributions to students’ problem-solving skills, their relationships, their socialization and self-confidence and also led to a decrease in disciplinary incidents at schools. Furthermore, it was also found that 96.5% of the mediation meetings resulted in settlement and agreements. © 2016, Ankara University. All rights reserved.

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