Browsing by Publisher "Blackwell Publishing Inc."
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Item Two-Piece Extraoral Prosthetic Rehabilitation to a Perineural Invasion Lip Cancer(Blackwell Publishing Inc., 2018) Şahan M.H.; Eskiizmir G.; Ateş P.Lip cancers can severely affect a person in terms of function, esthetics, and psychological trauma. After surgical resection, lip defects require special rehabilitation. This clinical report describes a neck prosthesis of a male patient diagnosed with lower lip squamous cell carcinoma with perineural involvement. The neck prosthesis was connected to the mandibular complete denture with cobalt samarium magnets. Both prostheses improved the patient's mastication, deglutition, and esthetics. © 2016 by the American College of ProsthodontistsItem Bilateral plasmacytoma of the breast(Blackwell Publishing Inc., 2018) Orguc S.; Akin M.; Aydogdu I.; Nese N.[No abstract available]Item A rare vasculitis type in a patient with acute myeloblastic leukemia: Annular leukocytoclastic vasculitis as a paraneoplastic syndrome?(Blackwell Publishing Inc., 2020) Çetinarslan T.; Türel Ermertcan A.; Aydoğdu İ.; Temiz P.[No abstract available]Item Mycosis fungoides mimicking pigmented purpuric dermatosis(Blackwell Publishing Inc., 2020) Gökyayla E.; Çetinarslan T.; Temiz P.; Türel Ermertcan A.[No abstract available]Item Dermoscopy of scalp cutaneous metastasis of sarcomatoid renal cell carcinoma(Blackwell Publishing Inc., 2020) Çetinarslan T.; Ermertcan A.T.; Temiz P.; Evrenos M.K.; Müezzinoğlu T.[No abstract available]Item Successful treatment of severe refractory post-cesarean pyoderma gangrenosum with intravenous immunoglobulin(Blackwell Publishing Inc., 2020) Gündüz K.; Gülbaşaran F.; Hasdemir P.S.; Temiz P.; Inanır I.Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis characterized by rapidly progressing necrolytic ulceration of the skin. Proper treatment is crucial since it can result in devastating consequences. First-line treatments include systemic corticosteroids or cyclosporine. However, no standardized treatment regimens for refractory cases exist and treatment outcomes are affected by underlying conditions. PG after cesarean section, which is believed to occur in association with underlying pregnancy- and parturition-related immune changes, is extremely rare, and all reported cases in the literature have been successfully treated with systemic or topical corticosteroids. We report a case of a 32-year-old patient with severe PG occurring on her cesarean scar 3 days after the cesarean delivery. Treatment with systemic corticosteroids and first-line immunomodulatory agents resulted in insufficient response and serious complications. Intravenous immunoglobulin (IVIG) was then initiated, and a rapid clinical response was seen. Corticosteroid dose was gradually decreased and ceased. IVIG infusion was continued for 3 months until complete recovery. Reactivation was not observed in a 1-year follow-up period. Due to its cost, IVIG infusion is less suitable as a first-line agent. However, IVIG may be an important therapeutic option in resistant postpartum PG, in which first-line agents have failed or led to complications. © 2020 Wiley Periodicals LLC.Item Evaluation of the effect of surgical treatment on quality of life with the Dermatology Life Quality Index in patients with facial nonmelanoma skin cancer(Blackwell Publishing Inc., 2020) Çetinarslan T.; Evrenos M.K.; Bilaç C.; Özyurt B.; Türel Ermertcan A.Skin cancers are the most common type of cancer. Nonmelanoma skin cancers (NMSCs) are more common than melanoma. Although the mortality rate is low, cancer word can be frightening for patients. Surgery is the main treatment. As skin cancers are most commonly located on the face, undesirable cosmetic results can occur as a result of treatments or due to primary disease. Therefore, the quality of life of patients could be affected. To determine the effect of surgical treatment on quality of life of the patients with facial NMSC using the Dermatology Life Quality Index (DLQI) at baseline and 3 months after surgery. We aimed to see if there was any improvement in quality of life scores after surgery, and to identify factors affecting quality of life. A total of 255 patients; 174 basal cell carcinoma (BCC) (68.2%) and 81 squamous cell carcinoma (SCC) (31.8%) were included in our study. All participants completed DLQI at baseline and 3 months after surgery. The mean total DLQI scores were 6.37 ± 6.28 in patients with BCC, and 6.35 ± 6.16 in patients with SCC. The mean total DLQI scores were 3.96 ± 5.14 in patients with BCC (P <.001), and 4.49 ± 5.24 in patients with SCC (P <.001) 3 months after surgery. In patients with primary skin cancer, all subscale scores and total DLQI scores were worse than the recurrent skin cancer group in both BCC and SCC at baseline. According to the treatment modalities, total DLQI scores and all subscales were worse in the graft group in BCC and SCC patients at baseline. Interestingly, the sex and the type of skin cancer did not affect quality of life, but tumor localization ([auricula OR: 6.45 [95% CI: 1.28-37.47] and eyelid OR:0.20 [95% CI: 0.04-0.96]) treatment procedure ([flap procedure OR: 7.90 [95% CI: 2.64-23.62] and graft procedure OR: 5.47 [95% CI: 1.60-18.71]) and, primary tumor OR:3.86 (95% CI: 1.01-14.78) were significant. The quality of life of skin cancer patients was affected by tumor localization, treatment procedure, primary, or recurrent tumor. The quality of life showed a significant improvement in patients with facial NMSC after surgical treatment. However, the type of NMSC seems to have no effect on the quality of life. © 2020 Wiley Periodicals LLC.Item The reliability of tuberculin skin test in the diagnosis of latent tuberculosis infection in psoriasis patients: A case-control study(Blackwell Publishing Inc., 2020) Sürücüoğlu S.; Türel Ermertcan A.; Çetinarslan T.; Özkütük N.Tuberculin skin test (TST), which is used in the diagnosis of latent tuberculosis infection, may cause Koebner's phenomenon and false-positive results in psoriasis patients. The purpose of this study is to compare TST with QuantiFERON-TB Gold Plus (QFT-plus) test in psoriasis patients and to determine the effects of psoriasis on TST results. Ninety-two psoriasis patients and 30 control subjects were included in the study. QFT-plus test, TST, and prick test to distinguish the increase of induration because of the skin trauma were performed on both groups. The demographics, risk factors for latent tuberculosis infection, BCG vaccination history, Koebner's history, psoriasis severity, and treatment history of the patients were recorded. The effects of these variables on test results were investigated by comparing those with control group. The criteria of National Tuberculosis Diagnosis and Treatment Guidelines were used in the evaluation of test results, and threshold value of positivity for TST was taken as 10 mm in BCG-vaccinated patients who are planned to start biological treatment. Prick test results were negative in the control group. There was no significant relation between the results of prick test and TST induration diameters in the patient group. Although TST positivity was significantly higher in patients (62%) compared with control group (33%), QFT-plus test results were not statistically different between two groups. Agreement between two tests was determined to be low in patient group with 48% (K = 0.1), and it was determined to be moderate with 77% in control group (K = 0.4). QFT-plus test was found to be negative in 46 of 57 TST-positive patients (80.7%) in patient group. It was determined in both groups that vaccination did not have any effect on test results. When threshold value was lowered to 5 mm in patient group without considering BCG reaction, the number of TST-positive patients increased from 57 to 65. Mean TST induration diameter was 10 mm and 14 mm in cases with mild and moderate to severe clinical manifestation, respectively (P =.04). However, no effect of disease period and treatment was determined on both test results. TST positivity was higher in psoriasis patients compared with control group. It was considered due to the increased reaction of the skin to mycobacterial antigens rather than the Koebner's response. Although TST results were not affected by BCG, it was concluded that a 10-mm threshold value of positivity was a suitable approach in order to reduce the number of patients receiving unnecessary preventive treatment in patients who are considered to initiate biologic agents. Furthermore, it was also concluded that QFT-plus test may be preferred in psoriasis patients since it is applied in vitro and its specificity is higher and not affected by disease severity. © 2020 Wiley Periodicals LLC.Item Functional medicine with dermatology insite: A systematic approach for diagnosis and treatment of chronic diseases(Blackwell Publishing Inc., 2020) Gökyayla E.; Türel Ermertcan A.; Bilaç C.[No abstract available]Item Comparison of the fabrication methods, formation dynamics, structure, and delivery performance of solid nanoparticles and hollow layer-by-layer edible/biodegradable nanodelivery systems(Blackwell Publishing Inc., 2020) Turasan H.; Bonilla J.; Bozkurt F.; Maldonado L.; Li X.; Yilmaz T.; Sadeghi R.; Kokini J.Aim: This article summarizes and reviews recent studies on nanoparticulation of solid and hollow nanoparticles using edible proteins and carbohydrates from plant and animal origin and shares new research conducted in our laboratory on fabrication of biopolymer-based nanodelivery systems. Methods: We compare the properties of nanoparticles fabricated using desolvation, coacervation, and layer-by-layer assembly. The parameters affecting the morphological and physical states of the nanodelivery systems as well as their abilities to encapsulate bioactive compounds, and the mechanisms of the nanoparticulation process are discussed in detail. Results: The article offers methods that need to be used with each nanoparticulation technique along with key characterization data obtained. The effect of varying a wide range of parameters on particle size, size distribution, morphology, effect of solvents and non-solvents, effect of surface charge of polyelectrolytes, effect of fabrication conditions are presented. Conclusions: We believe the article gives enough detail to give the reader useful information related to the performance of all the different nanoparticles studied in our laboratory over the last 6 years. Practical applications: Biopolymer based nanodelivery systems presented in this article, have great potential to be used in the nutraceutical, food, pharmaceutical industries as well as agriculture. The biodegradable and edible nature of these nanodelivery systems make them safe for incorporating into food and nutraceutical materials, because, the biopolymers used in their fabrication are biocompatible polymers of food origin that are generally recognized as safe (GRAS) (Food and Drug Administration, The Daily Journal of the United States Government, 2016). Therefore, use of edible polymer-based nanoparticles would be safer and less toxic and consequently better for all these industries. For example, in the food industry, antioxidant compounds can be encapsulated which would then be incorporated into packaging materials and that would help maintain freshness and good quality and would prevent oxidative deterioration of foods to increase shelf life. Pesticides and insecticides can also be encapsulated in these nanodelivery systems for agricultural applications. Because they are biodegradable and originated from natural biopolymers, their impact on the environment and the quality of the soil would be minimized compared to current applications that use some burdensome chemicals. Biopolymer based nanodelivery systems would also be of high interest for the pharmaceutical industry. Through the efficacy and extra stability gained with encapsulation, drugs and bioactives would be better protected from the acidic environment of the stomach and be released more controllably in the intestines. Further functionalization of nanodelivery systems with recognition elements, such as antibodies or aptamers, would enable more specifically targeted delivery. © 2020 Wiley Periodicals, Inc.Item Factors that predict the perception of spirituality and spiritual care of nurses working in high-risk units and the effect of death anxiety(Blackwell Publishing Inc., 2021) Rahman S.; Elbi H.; Cakmakci Cetinkaya A.; Altan S.; Ozan E.; Pirincci E.Purpose: Spirituality contributes to the health and well-being of individuals. This study investigates the factors that predict the spirituality perceptions and the effect of death anxiety of nurses. Design and Methods: This was a cross-sectional study, 382 nurses working in four public hospitals intensive care and emergency departments setting in two different cities in Turkey. Findings: Variables predicting the total and subscale scores of the Spirituality and Spiritual Care Rating Scale of nurses were determined by linear multiple regression analysis. Except for the religiousness subscale, the satisfaction level of nurses was found to be a significant predictor in total of Spirituality and Spiritual Care Scale. Practice Implications: Nurses working in high-risk units are unclear about their perception of spirituality and spiritual care. © 2020 Wiley Periodicals LLCItem Evaluation of the laboratory parameters in hidradenitis suppurativa: Can we use new inflammatory biomarkers?(Blackwell Publishing Inc., 2021) Çetinarslan T.; Türel Ermertcan A.; Özyurt B.; Gündüz K.Hidradenitis suppurativa (HS) is a chronic, recurrent, and debilitating skin disease. Recent studies showed that inflammatory biomarkers, such as neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), Lymphocyte/HDL ratio (LHR), Neutrophil/HDL ratio (NHR), and Monocyte/HDL ratio (MHR) are an indicator of inflammatory diseases and may be associated with disease severity and disease activity. To investigate NLR, PLR, LHR, NHR, and MHR in HS patients. In addition, to compare erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), complete blood count, leukocyte profile, and biochemical parameters between the control and the patient group. Clinical and biochemical data of patients and healthy subjects were collected from medical records, retrospectively. In total, 166 patients with HS and 124 control subjects were included. We found no significant difference in NLR (P =.207) and PLR (P =.257). LHR (P <.001), NHR (P <.001), and MHR (P <.001) were significantly higher in the patient group. No positive correlation was found between any of these markers and disease severity according to Hurley staging system. However, MCV (Mean corpuscular volume), RDW (Red cell distribution width), and CRP showed a significant positive correlation with disease severity. Among these markers, only MHR was positively correlated with disease duration. Our study shows that CRP still maintains its value for HS patients compared to new inflammation markers. Unlike the studies in other inflammatory diseases, no significant relationship was found with most of these inflammatory parameters. MHR may be more useful in patients with HS as an indicator of inflammation compared to other parameters. © 2021 Wiley Periodicals LLC.Item Amlodipine-induced generalized fixed drug eruption clinically mimicking mycosis fungoides(Blackwell Publishing Inc., 2021) Çetinarslan T.; Ermertcan A.T.; Temiz P.[No abstract available]