Browsing by Publisher "Blackwell Publishing Ltd"

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    The evaluation of eustachian tube function in patients with chronic otitis media
    (Blackwell Publishing Ltd, 1997) Yücetürk A.V.; Ünlü H.H.; Okumu̧ M.; Yildiz T.; Fïlïz Ü.
    In this study we evaluated eustachian tube function in patients with chronic otitis media and compared the results with normal subjects. Two different eustachian tube function tests were applied to 60 ears of the chronic otitis media group and 146 ears of the control group. While eustachian tube dysfunction was observed in 71.7% of the chronic suppurative otitis media group, it was only seen in 34.9% of the control group.
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    Duration of obesity is not a risk factor for type 2 diabetes mellitus, arterial hypertension and hyperlipidemia
    (Blackwell Publishing Ltd, 2003) Hekimsoy Z.; Oktem I.K.
    Background: Obesity is known to be a risk factor for type 2 diabetes mellitus (DM), arterial hypertension (HT) and hyperlipidaemia (HL), but the relationship between the duration of obesity and these outcomes is variable in the literature. Aims: The aims of this study were 1) to evaluate whether the duration of obesity is a risk factor for type 2 DM, HT and HL, 2) to determine the incidence of impaired fasting glucose (IFG), impaired glucose tolerance (IGT), type 2 DM, HT and HL in the patients attending our clinic because of obesity and 3) to determine the correlation between DM, HT and HL and age, body mass index (BMI), duration of obesity and waist-hip ratio (WHR). Methods: Informed consent was obtained from 200 consecutive women presenting to our Endocrinology and Metabolism Unit for the first time because of obesity. The patient's history of the age at onset of obesity, HT and family history of DM were obtained. Anthropometric measurements and a 75-g oral glucose tolerance test (OGTT) were performed. Results: On OGTT, 15 (7.5%) had IFG, 36 (18%) had IGT and 18 (9%) had type 2 DM; in addition, 96 (48%) had HT and 76 (38%) had HL. Upon multivariate logistic regression analysis, age was a common risk factor for IGT, type 2 DM, HT and HL, and a family history of diabetes was an additional risk factor for type 2 DM. Conclusion: The duration of obesity, as reported by women presenting for treatment of obesity, is not a risk factor for type 2 DM, HT and HL.
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    Albendazole as an alternative therapeutic agent for childhood giardiasis in Turkey
    (Blackwell Publishing Ltd, 2004) Yereli K.; Balcioĝlu I.C.; Ertan P.; Limoncu E.; Onaĝ A.
    The efficacy of albendazole for the treatment of giardiasis has been indicated by previous in-vitro and in-vivo studies. In order to compare the therapeutic efficacy of albendazole and metronidazole, 107 Giardia-positive children (aged 3-15 years), diagnosed by three consecutive positive stool examinations, were enrolled in the study. Of these children, 52 were given a single daily dose of albendazole 10 mg/kg for 5 days, and 55 were given metronidazole 20 mg/kg daily in three doses for 7 days. Parasite eradication was achieved in 47 (90.4%) of 52 children treated with albendazole and 49 (89.1%) of 55 children treated with metronidazole (p > 0.05). These results suggest that albendazole is an effective treatment option for childhood giardiasis. © 2004 Copyright by the European Society of Clinical Microbiology and Infectious Diseases.
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    Expression of matrix metalloproteinases (MMP-2, MMP-3, and MMP-9) and fibronectin in lichen planus
    (Blackwell Publishing Ltd, 2006) Gunduz K.; Demireli P.; Inanir I.; Nese N.
    Background: Keratinocyte damage and lichenoid-interface reaction are the two major pathologic findings in lichen planus (LP). Matrix metalloproteinases (MMPs) are proteinases that participate in extracellular matrix (ECM) degradation and may play an important role in basal membrane (BM) damage in LP. Fibronectin (FN) mediates a variety of cellular interactions with ECM and plays important roles in cell adhesion, migration, growth and differentiation. Objective: To determine MMP-2, MMP-3, MMP-9 and FN expressions in LP and discuss the possible associations. Materials and methods: Skin biopsy samples of 55 patients with LP and 11 normal skin were investigated. Five discoid lupus erythematosus (DLE) and 5 chronic dermatitis (CD) samples were also examined for comparison. Immunochemical stainings were performed for MMP-2, MMP-3, MMP-9 and fibronectin. Results: Weak or absent expressions of MMP-2 and MMP-3 in epidermis; and dense MMP-9 expression in dermal inflammatory infiltrate cells were detected in LP. FN expression was lost in epidermal basal layer and papillary dermis. Conclusion: Loss of MMP-2, MMP-3 and FN in LP can be explained with the destruction of the epidermal basal layer. Similar expressions of MMP-2 and MMP-3 both in LP and DLE implied that these MMPs may be involved in the pathogenesis of interface dermatitis. © Blackwell Munksgaard 2006.
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    Trombosed solitary angiokeratoma of Mibelli simulating malignant melanoma: The importance of dermoscopy in differential diagnosis [3]
    (Blackwell Publishing Ltd, 2006) Sahin M.T.; Türel-Ermertcan A.; Öztürkcan S.; Türkdogan P.
    [No abstract available]
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    Partial purification and characterisation of polyphenol oxidase from celery root (Apium graveolens L.) and the investigation of the effects on the enzyme activity of some inhibitors
    (Blackwell Publishing Ltd, 2006) Aydemir T.; Akkanli G.
    Polyphenol oxidase (PPO) of celery root was extracted and partially purified by (NH4)2SO4 fractionation and dialysis. Optimum pH and temperature were found at pH 7.0 and 30°C, and Km and Vmax values were 29 mM and 5560 U mL-1 min-1 with catechol, respectively. The activation energy of the enzyme with catechol was 17.9 kJ mol-1 at pH 7.0. In electrophoretic seperation, six isoenzymes were detected with DL-dopa substrate. PPO showed activity to catechol, 4-methylcatechol, pyrogallol, gallic acid, DL-dopa. L-Tyrosine was also tested but was not oxidised by celery root PPO. β-Mercaptoethanol was found to be the most effective inhibitor. (NH 4)2SO4, NaCl, KCl and sucrose appeared to be protective agents of celery root PPO against thermal denaturation. Metal ions (Cu2+, Zn2+, Mn2+) were poor inhibitors of the celery root PPO at 1 mm. PPO activity was also inhibited by CaCl2, NaCl, BaCl2, FeSO4 and NiCl2. © 2006 Institute of Food Science and Technology Trust Fund.
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    Aretaeus of Cappadocia
    (Blackwell Publishing Ltd, 2007) Aydemir O.; Malhi G.S.
    [No abstract available]
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    Melatonin improves methanol intoxication-induced oxidative liver injury in rats
    (Blackwell Publishing Ltd, 2007) Kurcer Z.; Oǧuz E.; Iraz M.; Fadillioglu E.; Baba F.; Koksal M.; Olmez E.
    This study was performed to evaluate the effect of melatonin on methanol-induced liver injury. We evaluated the levels of malondialdehyde (MDA), protein carbonylation (PC), myeloperoxidase (MPO) activities and to assess lipid peroxidation, protein oxidation, neutrophil accumulation and nitrite which is a stable end product of nitric oxide respectively. We also studied superoxide dismutase, catalase, and glutathione peroxidase activities of liver tissue to evaluate the changes in the antioxidant status. Histopathological alterations were also determined. The experiment was performed on Wistar rats, which received intragastric 3 g/kg methanol as a 50% solution in isotonic saline once. After 6 and 24 hr all the drug received and intoxicated rats were killed under anesthesia. Pretreatment with melatonin (10 mg/kg) decreased the MDA levels significantly, restored the PC levels to the control, prevented the increase of nitrite level and MPO activity significantly and reversed to the control levels, prevented the reduction in all of the antioxidant enzyme activities. Additionally in melatonin treated group piecemeal necrosis, lobular lytic necrosis, and portal inflammation returned to normal histologic appearances when compared with methanol administration. In conclusion, melatonin has protective effects against methanol-induced hepatic injury. © 2007 The Authors.
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    Sexual dysfunction in patients with chronic hand eczema in the Turkish Population
    (Blackwell Publishing Ltd, 2007) Ergün M.; Türel Ermertcan A.; Öztürkcan S.; Temeltaş G.; Deveci A.; Dinç G.
    Introduction. Hand eczema can cause considerable psychosocial disorders, such as anxiety, depression, and difficulties at work, and it may also cause sexual dysfunction. Aim. The aim of this study was to investigate sexual function in patients with hand eczema and to find out whether concomitant depression has an additional negative effect on sexual function in these patients. Main Outcome Measures. Sexual functions were evaluated in hand eczema patients. Methods. Ninety-one female (43 patients vs. 48 controls) and 79 male (45 patients vs. 34 controls) subjects were enrolled in the study. Hand eczema severity index was used to determine severity of hand eczema. The Female Sexual Function Index (FSFI) and the International Index of Erectile Function (IIEF) were used to assess sexual function. Quality of life was assessed with the Dermatology Life Quality Index. Diagnosis of depression was made based on the Structured Clinical Interview for the DSM-IV, while the Hamilton Depression Rate Scale was used for grading depression. Results. Among 43 female subjects with hand eczema, 26 had depression (60.46%); of the 45 male patients, 11 had depression (24.44%). FSFI total score was found to be significantly decreased in female patients with both eczema and depression compared with controls (20.84 ± 9.19 vs. 24.04 ± 3.40, P < 0.05). FSFI total score was found to be significantly decreased in female patients with both eczema and depression compared with those without depression (20.84 ± 9.19 vs. 22.23 ± 5.82, P < 0.05). IIEF total score was also found to be significantly decreased in male patients with or without depression compared with controls (52.36 ± 14.83 vs. 59.88 ± 5.65 vs. 62.03 ± 11.04, P < 0.05). Conclusions. The results of the study demonstrated that patients with hand eczema had sexual dysfunction, and concomitant depression had an additional negative effect on sexual dysfunction. Patients with hand eczema should be evaluated with regard to sexual function and depression to provide a better quality of life. © 2007 International Society for Sexual Medicine.
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    Molecular identification and characterization of rifampicin-resistant Mycobacterium tuberculosis isolates by line probe assay: An approach for rapid diagnosis of multidrug-resistant tuberculosis
    (Blackwell Publishing Ltd, 2008) Bicmen C.; Gunduz A.T.; Coskun M.; Senol G.; Ozkutuk N.; Cirak A.K.; Ozacar R.
    Aim: Early identification and characterization of rifampicin-resistant (Rr) Mycobacterium tuberculosis isolates recovered from the samples of tuberculosis (TB) patients in the Aegean (West Anatolian) Region was intended. Methods and Results: Sixty isolates [47 (78·3%) multidrug-resistant (MDR)], which were identified as M. tuberculosis complex and phenotypically resistant to rifampicin by both BACTEC mycobacteria growth indicator tube (MGIT) 960 and 460 systems were analysed by a commercial line probe assay (INNO-LiPA Rif TB). The concordance of LiPA with the in vitro susceptibility test was found as 98·3%. Among the isolates, S531L (R5 pattern; 46·7%) and L511P/R, S512T, Q513L/K (ΔS1 pattern; 11·7%) were the most frequent mutation patterns. As compared with the BACTEC systems and conventional techniques for cultivation, identification and in vitro susceptibility testing, INNO-LiPA Rif TB after cultivation in BACTEC MGIT 960 system provided an average of 20 days early diagnosis of R rM. tuberculosis isolates. Conclusions: Rapid molecular identification and characterization of RrM. tuberculosis isolates after BACTEC MGIT 960 cultivation would be useful for faster diagnosis, infection control and planning of accurate treatment in MDR-TB patients. Significance and Impact of the Study: Patients with MDR-TB need a specified treatment and efficient follow-up strategies. Rapid and practical methodologies to diagnose and follow these patients should be applied in routine use. © 2008 The Authors.
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    A comparison of metronidazole and single-dose ornidazole for the treatment of dientamoebiasis
    (Blackwell Publishing Ltd, 2008) Kurt Ö.; Girginkardeşler N.; Balcioǧlu I.C.; Q̈zbilgin A.; Ok Ü.Z.
    Recent reports of the pathogenic potential of Dientamoeba fragilis have underlined the need for an effective treatment against this colon-dwelling protozoan. Metronidazole is a well-known and commonly used anti-protozoal agent, but another 5-nitroimidazole derivative, ornidazole, may be preferable, where available, because of its longer half-life and fewer side-effects. This study compared the efficacies of metronidazole and ornidazole in a group of 112 patients with dientamoebiasis. Patients were randomised into two treatment groups: group.1 (n = 56) received metronidazole for 5 days, 20 mg/kg/day for children and 1.5 g/day for adults, in three oral doses, while group 2 (n = 56) received a single oral dose of ornidazole, 30 mg/kg for children and 2g for adults. Stool samples were examined on the seventh and 14th days after treatment, and clinical symptoms were recorded to evaluate the efficacy of treatment. A statistically significant difference was recorded between the efficacies of ornidazole and metronidazole, both parasitologically (92.9% vs. 69.6%, p 0.001) and clinically (96.4% vs. 76.8%, p 0.001). Patients in the metronidazole group reported more side-effects than patients in the ornidazole group, none of whom required termination of treatment. These results suggest that single-dose ornidazole may be an important alternative agent for the treatment of dientamoebiasis. © 2008 European Society of Clinical Microbiology and Infectious Diseases.
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    Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA2LEN and AllerGen)
    (Blackwell Publishing Ltd, 2008) Bousquet J.; Khaltaev N.; Cruz A.A.; Denburg J.; Fokkens W.J.; Togias A.; Zuberbier T.; Baena-Cagnani C.E.; Canonica G.W.; Van Weel C.; Agache I.; Aït-Khaled N.; Bachert C.; Blaiss M.S.; Bonini S.; Boulet L.-P.; Bousquet P.-J.; Camargos P.; Carlsen K.-H.; Chen Y.; Custovic A.; Dahl R.; Demoly P.; Douagui H.; Durham S.R.; Van Wijk R.G.; Kalayci O.; Kaliner M.A.; Kim Y.-Y.; Kowalski M.L.; Kuna P.; Le L.T.T.; Lemiere C.; Li J.; Lockey R.F.; Mavale-Manuel S.; Meltzer E.O.; Mohammad Y.; Mullol J.; Naclerio R.; O'Hehir R.E.; Ohta K.; Ouedraogo S.; Palkonen S.; Papadopoulos N.; Passalacqua G.; Pawankar R.; Popov T.A.; Rabe K.F.; Rosado-Pinto J.; Scadding G.K.; Simons F.E.R.; Toskala E.; Valovirta E.; Van Cauwenberge P.; Wang D.-Y.; Wickman M.; Yawn B.P.; Yorgancioglu A.; Yusuf O.M.; Zar H.; Annesi-Maesano I.; Bateman E.D.; Kheder A.B.; Boakye D.A.; Bouchard J.; Burney P.; Busse W.W.; Chan-Yeung M.; Chavannes N.H.; Chuchalin A.; Dolen W.K.; Emuzyte R.; Grouse L.; Humbert M.; Jackson C.; Johnston S.L.; Keith P.K.; Kemp J.P.; Klossek J.-M.; Larenas-Linnemann D.; Lipworth B.; Malo J.-L.; Marshall G.D.; Naspitz C.; Nekam K.; Niggemann B.; Nizankowska-Mogilnicka E.; Okamoto Y.; Orru M.P.; Potter P.; Price D.; Stoloff S.W.; Vandenplas O.; Viegi G.; Williams D.
    [No abstract available]
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    Effects of neuronal and glial restricted precursor cells transplantation on erectile function after experimentally induced spinal cord injury
    (Blackwell Publishing Ltd, 2009) Temeltas G.; Dagci T.; Evren V.; Lekili M.
    Introduction.: Erectile dysfunction is common among patients with spinal cord injury (SCI). Aim.: This study aims to investigate the recovery of penile erectile functions of the rats with spinal cord injury (SCI) following transplantation of endogenous neuronal precursors cell (neuronal restricted precursors [NRP]/glial restricted precursors [GRP]) into the injured area of spinal cord. Methods.: Twenty-two rats were experimented in three groups. Group 1 (N = 6): Sham; Group 2 (N = 10): SCI + NRP/GRP transplanted in day 9 after operation; Group 3 (N = 6): SCI + culture medium transplanted in day 9 after operation.Analysis of penile reflexes and cavernosal nerve stimulation studies were performed in day 28 after transplantation for each group. All rats in three groups were then sacrificed and the injured regions of spinal cords underwent histological investigation. Main Outcome Measures.: These results show improvements to some extent in locomotor and erectile functions although these improvements are far from full functional recovery. Results.: Cavernosal nerve stimulation resulted in significantly higher intracavernosal pressure in Group 3 (SCI) although there was no difference between Group 1 (sham) and Group 2 (SCI + NRP/GRP). Number of clusters was similar between groups. Number of erections was higher in Group 3 (SCI) than Groups 1 and 2, and number of cups was higher in Group 2 (SCI + NRP/GRP) than the other two groups. Number of flips was similar in Groups 1 and 2 but lower in Group 3. Number of long flips was highest in Group 1 and lowest in Group 3. The differences between groups were significant. Conclusion.: This study emphasized the healing potential of NRP/GRP transplantation following experimental SCI. However, further experimental and clinical studies are required to advance this treatment modality. © 2009 International Society for Sexual Medicine.
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    Development and implementation of guidelines in allergic rhinitis - an ARIA-GA2LEN paper
    (Blackwell Publishing Ltd, 2010) Bousquet J.; Schünemann H.J.; Zuberbier T.; Bachert C.; Baena-Cagnani C.E.; Bousquet P.J.; Brozek J.; Canonica G.W.; Casale T.B.; Demoly P.; Gerth Van Wijk R.; Ohta K.; Bateman E.D.; Calderon M.; Cruz A.A.; Dolen W.K.; Haughney J.; Lockey R.F.; Lötvall J.; O'byrne P.; Spranger O.; Togias A.; Bonini S.; Boulet L.P.; Camargos P.; Carlsen K.H.; Chavannes N.H.; Delgado L.; Durham S.R.; Fokkens W.J.; Fonseca J.; Haahtela T.; Kalayci O.; Kowalski M.L.; Larenas-Linnemann D.; Li J.; Mohammad Y.; Mullol J.; Naclerio R.; O'hehir R.E.; Papadopoulos N.; Passalacqua G.; Rabe K.F.; Pawankar R.; Ryan D.; Samolinski B.; Simons F.E.R.; Valovirta E.; Yorgancioglu A.; Yusuf O.M.; Agache I.; Aït-Khaled N.; Annesi-Maesano I.; Beghe B.; Ben Kheder A.; Blaiss M.S.; Boakye D.A.; Bouchard J.; Burney P.G.; Busse W.W.; Chan-Yeung M.; Chen Y.; Chuchalin A.G.; Costa D.J.; Custovic A.; Dahl R.; Denburg J.; Douagui H.; Emuzyte R.; Grouse L.; Humbert M.; Jackson C.; Johnston S.L.; Kaliner M.A.; Keith P.K.; Kim Y.Y.; Klossek J.M.; Kuna P.; Le L.T.; Lemiere C.; Lipworth B.; Mahboub B.; Malo J.L.; Marshall G.D.; Mavale-Manuel S.; Meltzer E.O.; Morais-Almeida M.; Motala C.; Naspitz C.; Nekam K.; Niggemann B.; Nizankowska-Mogilnicka E.; Okamoto Y.; Orru M.P.; Ouedraogo S.; Palkonen S.; Popov T.A.; Price D.; Rosado-Pinto J.; Scadding G.K.; Sooronbaev T.M.; Stoloff S.W.; Toskala E.; Van Cauwenberge P.; Vandenplas O.; Van Weel C.; Viegi G.; Virchow J.C.; Wang D.Y.; Wickman M.; Williams D.; Yawn B.P.; Zar H.J.; Zernotti M.; Zhong N.
    The links between asthma and rhinitis are well characterized. The Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines stress the importance of these links and provide guidance for their prevention and treatment. Despite effective treatments being available, too few patients receive appropriate medical care for both diseases. Most patients with rhinitis and asthma consult primary care physicians and therefore these physicians are encouraged to understand and use ARIA guidelines. Patients should also be informed about these guidelines to raise their awareness of optimal care and increase control of the two related diseases. To apply these guidelines, clinicians and patients need to understand how and why the recommendations were made. The goal of the ARIA guidelines is to provide recommendations about the best management options for most patients in most situations. These recommendations should be based on the best available evidence. Making recommendations requires the assessment of the quality of available evidence, deciding on the balance between benefits and downsides, consideration of patients' values and preferences, and, if applicable, resource implications. Guidelines must be updated as new management options become available or important new evidence emerges. Transparent reporting of guidelines facilitates understanding and acceptance, but implementation strategies need to be improved. © 2010 John Wiley & Sons A/S.
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    The effects of Femore™ cream on sexual dysfunction in Turkish women
    (Blackwell Publishing Ltd, 2014) Sen S.; Guneri S.E.; Sevil U.; Cengel S.
    Aims and objectives: To investigate the effects of Femore™ cream on sexual dysfunction in menopause and women's satisfaction levels. Background: The recent interest of public and the world of medicine in female sexual function have led to a rapid increase in the number of studies on the subject. Design: The study was designed as an observational intervention study. Methods: The research data were collected by using a Women Information Form consisting of 13 items; a Sexual Function Index to measure sexual function; and a Satisfaction Determination Form to determine the level of satisfaction with the medical service the women received for the problems with their reproductive organs. The study was conducted with 29 menopausal women who complied with the inclusion criteria. Results: It was found that women's average age was 52·6; that the average menarche age was 13·0; and that the average menopause age was 46·2. The major complaint of nearly all the women who were aware of their sexual dysfunction was vaginal dryness, and it was concluded that they took no precautions against this problem. The total scores obtained from the Sexual Function Index were reported to be an average of 18·8 ± 4·2 before use of Femore™ cream and an average of 42·3 ± 2·0 after use of Femore™ cream. The average score concerning satisfaction with the use of Femore™ cream was noted to be 9·06 ± 0·40. Conclusions: The study results suggested that applying Femore™ cream had positive influences on sexual dysfunction and all subdomains. Relevance to clinical practice: Women's sexual health can therefore be assessed at primary care centres, and it is considered that health professionals employed at these centres, a majority of whom are female nurses and obstetricians, can play an important role in guiding women on the issue. © 2013 John Wiley & Sons Ltd.
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    Psoriatic uveitis responding to adalimumab therapy
    (Blackwell Publishing Ltd, 2014) Ermertcan A.T.; Emre S.; Öztürk F.; Gençoǧlan G.; Gündüz K.
    [No abstract available]
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    Prevalence of asthmatic smokers: Turkish experience (PASTE Study)
    (Blackwell Publishing Ltd, 2014) Yildiz F.; Dursun A.B.; Disçi R.; Abadoglu O.; Atalay F.; Ates G.; Buyukoglan H.; Ceyhan B.; Ceylan E.; Deveci F.; Ediger D.; Ekici A.; Erdinc M.; Gemicioglu B.; Goktalay T.; Meral M.; Mungan D.; Ogus C.; Ozge C.
    Background: Although both asthma and smoking are major health problems worldwide, smokers are often excluded from asthma studies. Objectives: It was aimed to verify the prevalence of asthmatic smokers in Turkey and assess the effects of smoking based on clinical parameters, exacerbations and hospitalizations because of lack of national data about the prevalence of smoking among asthmatics. Methods: The study protocol was comprised of a retrospective questionnaire. The asthmatic patients were followed in the outpatient clinics of 18 tertiary hospitals selected from seven different geographical regions in Turkey. We evaluated demographic data, smoking habits, asthma-related diseases, respiratory function and emergency visits. Results: The study population included 1385 patients (M/F: 343/1042), and the mean age was 45.1±14.0 years. Current and former smoking prevalence was 11.4% and 15.1%, respectively. Smoker rates were higher in males and younger asthmatics compared with females and older asthmatics (P<0.01 and P<0.05, respectively). Smoking history ranged from 0.20 to 90 pack-years (the mean was 12.9), and smokers had a higher level of education compared with nonsmokers (P<0.01). Socioeconomically, the most developed region had the highest rate of smoker asthmatics (33.9%; P=0.014). There was an increase in the number of exacerbations in smoker asthmatics during the previous year, but it was not statistically significant (P>0.05). Conclusion: We showed that the smoking prevalence in Turkey was lower in asthmatics (11.4%) compared with the general population (44.5%). Nevertheless, every effort should be made to encourage asthmatics to stop smoking because smoking is a modifiable risk factor for adverse asthma health outcomes. © 2013 John Wiley and Sons Ltd.
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    Effects of blueberry, grape seed powder and poppy seed incorporation on physicochemical and sensory properties of biscuit
    (Blackwell Publishing Ltd, 2015) Aksoylu Z.; Çağindi O.; Köse E.
    Blueberry, defatted grape seed powder and defatted poppy seeds were incorporated into biscuits at a level of 5%. Some physicochemical and sensory characteristics were evaluated during 5 months storage period. Diameter, a* (-a=greenness, +a=redness) values, ash, fat, crude fiber, Mg and Ca contents increased, while L* (lightness), b* (-b=blueness, +b=yellowness) values decreased significantly (P<0.05). A significant type of fortification agent×storage time interaction (P<0.05) existed for all physicochemical parameters analyzed. Defatted poppy seed was the most effective agent for preventing increased peroxide values, whereas defatted grape seed powder addition decreased free fatty acid formation better than blueberry and defatted poppy seeds. All fortification agents increased the total phenolic content of biscuits. Biscuits having 5% blueberry exhibited a high percentage of antioxidant activity. Sensory evaluation results revealed that fortificated biscuits cannot be consumed after 5 months. Practical Applications: As the relationship between nutrition and some chronic diseases have been established, the number of research and development studies focusing on functional foods has increased rapidly. Antioxidants became popular because of their positive effects on human health. Grape seed, a by-product of the grape-processing industry, is known as a strong free radical scavenger. Poppy seeds are generally used for their high oil content. Tocopherols found in poppy seeds have strong antioxidative properties. Blueberries, rich in anthocyanins, are widely consumed in different countries. These three botanical ingredients can be used as inexpensive antioxidant sources in snack foods such as biscuits and cookies. © 2015 Wiley Periodicals, Inc.
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    Molecular cytogenetics of Androctonus scorpions: An oasis of calm in the turbulent karyotype evolution of the diverse family Buthidae
    (Blackwell Publishing Ltd, 2015) Sadílek D.; Nguyen P.; Koç H.L.; Kovařík F.; Yağmur E.A.; Stahlavsky F.
    Recent cytogenetic and genomic studies suggest that morphological and molecular evolution is decoupled in the basal arachnid order Scorpiones. Extraordinary karyotype variation has been observed particularly in the family Buthidae, which is unique among scorpions for its holokinetic chromosomes. We analyzed the karyotypes of four geographically distant species of the genus AndroctonusEhrenberg, 1828 (Androctonus australis, Androctonus bourdoni, Androctonus crassicauda, Androctonus maelfaiti) (Scorpiones: Buthidae) using both classic and molecular cytogenetic methods. The mitotic complement of all species consisted of 2n=24 elements. Fluorescence in situ hybridization with a fragment of the 18S ribosomal RNA gene, a cytogenetic marker well known for its mobility, identified a single interstitial rDNA locus on the largest chromosome pair in all species examined. Our findings thus support the evolutionary stasis of the Androctonus karyotype, which is discussed with respect to current hypotheses on chromosome evolution both within and beyond the family Buthidae. Differences in karyotype dynamics between Androctonus spp. and the other buthids can help us better understand the driving forces behind their chromosome evolution and speciation. © 2015 The Linnean Society of London.
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    MACVIA-ARIA Sentinel NetworK for allergic rhinitis (MASK-rhinitis): The new generation guideline implementation
    (Blackwell Publishing Ltd, 2015) Bousquet J.; Schunemann H.J.; Fonseca J.; Samolinski B.; Bachert C.; Canonica G.W.; Casale T.; Cruz A.A.; Demoly P.; Hellings P.; Valiulis A.; Wickman M.; Zuberbier T.; Bosnic-Anticevitch S.; Bedbrook A.; Bergmann K.C.; Caimmi D.; Dahl R.; Fokkens W.J.; Grisle I.; Lodrup Carlsen K.; Mullol J.; Muraro A.; Palkonen S.; Papadopoulos N.; Passalacqua G.; Ryan D.; Valovirta E.; Yorgancioglu A.; Aberer W.; Agache I.; Adachi M.; Akdis C.A.; Akdis M.; Annesi-Maesano I.; Ansotegui I.J.; Anto J.M.; Arnavielhe S.; Arshad H.; Baiardini I.; Baigenzhin A.K.; Barbara C.; Bateman E.D.; Beghé B.; Bel E.H.; Ben Kheder A.; Bennoor K.S.; Benson M.; Bewick M.; Bieber T.; Bindslev-Jensen C.; Bjermer L.; Blain H.; Boner A.L.; Boulet L.P.; Bonini M.; Bonini S.; Bosse I.; Bourret R.; Bousquet P.J.; Braido F.; Briggs A.H.; Brightling C.E.; Brozek J.; Buhl R.; Burney P.G.; Bush A.; Caballero-Fonseca F.; Calderon M.A.; Camargos P.A.M.; Camuzat T.; Carlsen K.H.; Carr W.; Cepeda Sarabia A.M.; Chavannes N.H.; Chatzi L.; Chen Y.Z.; Chiron R.; Chkhartishvili E.; Chuchalin A.G.; Ciprandi G.; Cirule I.; Correia De Sousa J.; Cox L.; Crooks G.; Costa D.J.; Custovic A.; Dahlen S.E.; Darsow U.; De Carlo G.; De Blay F.; Dedeu T.; Deleanu D.; Denburg J.A.; Devillier P.; Didier A.; Dinh-Xuan A.T.; Dokic D.; Douagui H.; Dray G.; Dubakiene R.; Durham S.R.; Dykewicz M.S.; El-Gamal Y.; Emuzyte R.; Fink Wagner A.; Fletcher M.; Fiocchi A.; Forastiere F.; Gamkrelidze A.; Gemicioʇlu B.; Gereda J.E.; González Diaz S.; Gotua M.; Grouse L.; Guzmán M.A.; Haahtela T.; Hellquist-Dahl B.; Heinrich J.; Horak F.; Hourihane J.O.B.; Howarth P.; Humbert M.; Hyland M.E.; Ivancevich J.C.; Jares E.J.; Johnston S.L.; Joos G.; Jonquet O.; Jung K.S.; Just J.; Kaidashev I.P.; Kalayci O.; Kalyoncu A.F.; Keil T.; Keith P.K.; Khaltaev N.; Klimek L.; Koffi N'Goran B.; Kolek V.; Koppelman G.H.; Kowalski M.L.; Kull I.; Kuna P.; Kvedariene V.; Lambrecht B.; Lau S.; Larenas-Linnemann D.; Laune D.; Le L.T.T.; Lieberman P.; Lipworth B.; Li J.; Louis R.; Magard Y.; Magnan A.; Mahboub B.; Majer I.; Makela M.J.; Manning P.; De Manuel Keenoy E.; Marshall G.D.; Masjedi M.R.; Maurer M.; Mavale-Manuel S.; Melén E.; Melo-Gomes E.; Meltzer E.O.; Merk H.; Miculinic N.; Mihaltan F.; Milenkovic B.; Mohammad Y.; Molimard M.; Momas I.; Montilla-Santana A.; Morais-Almeida M.; Mösges R.; Namazova-Baranova L.; Naclerio R.; Neou A.; Neffen H.; Nekam K.; Niggemann B.; Nyembue T.D.; O'Hehir R.E.; Ohta K.; Okamoto Y.; Okubo K.; Ouedraogo S.; Paggiaro P.; Pali-Schöll I.; Palmer S.; Panzner P.; Papi A.; Park H.S.; Pavord I.; Pawankar R.; Pfaar O.; Picard R.; Pigearias B.; Pin I.; Plavec D.; Pohl W.; Popov T.A.; Portejoie F.; Postma D.; Potter P.; Price D.; Rabe K.F.; Raciborski F.; Radier Pontal F.; Repka-Ramirez S.; Robalo-Cordeiro C.; Rolland C.; Rosado-Pinto J.; Reitamo S.; Rodenas F.; Roman Rodriguez M.; Romano A.; Rosario N.; Rosenwasser L.; Rottem M.; Sanchez-Borges M.; Scadding G.K.; Serrano E.; Schmid-Grendelmeier P.; Sheikh A.; Simons F.E.R.; Sisul J.C.; Skrindo I.; Smit H.A.; Solé D.; Sooronbaev T.; Spranger O.; Stelmach R.; Strandberg T.; Sunyer J.; Thijs C.; Todo-Bom A.; Triggiani M.; Valenta R.; Valero A.L.; Van Hage M.; Vandenplas O.; Vezzani G.; Vichyanond P.; Viegi G.; Wagenmann M.; Walker S.; Wang D.Y.; Wahn U.; Williams D.M.; Wright J.; Yawn B.P.; Yiallouros P.K.; Yusuf O.M.; Zar H.J.; Zernotti M.E.; Zhang L.; Zhong N.; Zidarn M.; Mercier J.
    Several unmet needs have been identified in allergic rhinitis: identification of the time of onset of the pollen season, optimal control of rhinitis and comorbidities, patient stratification, multidisciplinary team for integrated care pathways, innovation in clinical trials and, above all, patient empowerment. MASK-rhinitis (MACVIA-ARIA Sentinel NetworK for allergic rhinitis) is a simple system centred around the patient which was devised to fill many of these gaps using Information and Communications Technology (ICT) tools and a clinical decision support system (CDSS) based on the most widely used guideline in allergic rhinitis and its asthma comorbidity (ARIA 2015 revision). It is one of the implementation systems of Action Plan B3 of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA). Three tools are used for the electronic monitoring of allergic diseases: a cell phone-based daily visual analogue scale (VAS) assessment of disease control, CARAT (Control of Allergic Rhinitis and Asthma Test) and e-Allergy screening (premedical system of early diagnosis of allergy and asthma based on online tools). These tools are combined with a clinical decision support system (CDSS) and are available in many languages. An e-CRF and an e-learning tool complete MASK. MASK is flexible and other tools can be added. It appears to be an advanced, global and integrated ICT answer for many unmet needs in allergic diseases which will improve policies and standards. © 2015 John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.