Browsing by Publisher "CELL PRESS"

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    Identification of susceptibility loci for Takayasu arteritis through a large multi-ancestral genome-wide association study
    (CELL PRESS) Ortiz-Fernández, L; Saruhan-Direskeneli, G; Alibaz-Oner, F; Kaymaz-Tahra, S; Coit, P; Kong, XF; Kiprianos, AP; Maughan, RT; Aydin, SZ; Aksu, K; Keser, G; Kamali, S; Inanc, M; Springer, J; Akar, S; Onen, F; Akkoc, N; Khalidi, NA; Koening, C; Karadag, O; Kiraz, S; Forbess, L; Langford, CA; McAlear, CA; Ozbalkan, Z; Yavuz, S; Çetin, GY; Alpay-Kanitez, N; Chung, S; Ates, A; Karaaslan, Y; McKinnon-Maksimowicz, K; Monach, PA; Ozer, HTE; Seyahi, E; Fresko, I; Cefle, A; Seo, P; Warrington, KJ; Ozturk, MA; Ytterberg, SR; Cobankara, V; Onat, AM; Duzgun, N; Bicakcigil, M; Yentür, SP; Lally, L; Manfredi, AA; Baldissera, E; Erken, E; Yazici, A; Kisacik, B; Kasifoglu, T; Dalkilic, E; Cuthbertson, D; Pagnoux, C; Sreih, A; Reales, G; Wallace, C; Wren, JD; Cunninghame-Graham, DS; Vyse, TJ; Sun, Y; Chen, HY; Grayson, PC; Tombetti, E; Jiang, LD; Mason, JC; Merkel, PA; Direskeneli, H; Sawalha, AH
    Takayasu arteritis is a rare inflammatory disease of large arteries. We performed a genetic study in Takayasu arteritis comprising 6,670 individuals (1,226 affected individuals) from five different populations. We discovered HLA risk factors and four non-HLA susceptibility loci in VPS8, SVEP1, CFL2, and chr13q21 and reinforced IL12B, PTK2B, and chr21q22 as robust susceptibility loci shared across ancestries. Functional analysis proposed plausible underlying disease mechanisms and pinpointed ETS2 as a potential causal gene for chr21q22 association. We also identified >60 candidate loci with suggestive association (p < 5 x 10(-s)) and devised a genetic risk score for Takayasu arteritis. Takayasu arteritis was compared to hundreds of other traits, revealing the closest genetic relatedness to inflammatory bowel disease. Epigenetic patterns within risk loci suggest roles for monocytes and B cells in Takayasu arteritis. This work enhances understanding of the genetic basis and pathophysiology of Takayasu arteritis and provides clues for potential new therapeutic targets.
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    Functional outcome in late adolescence/early adulthood of patients with autism spectrum disorderresand its relationships with parental burnout and depression: A preliminary multi-center, cross-sectional study
    (CELL PRESS) Kutuk, MO; Tufan, AE; Kilicaslan, F; Vural, P; Gokcen, C; Guney, SA; Kutuk, B; Ozyurt, G; Inal, N; Multer, T; Acikalin, EY; Ozer, FH; Pamuk, EN; Yesilmese, SC; Karadag, M; Hangul, Z; Bilginer, C; Sahin, N; Bilac, O; Kandemir, H; Ercan, ES; Soylemez, TE; Acikel, SB; Aksu, GG; Dag, P; Toros, F; Mutlu, C; Kardas, O; Kardas, B; Kizildag, S; Demirci, E; Ozmen, S; Sevicin, L; Karagoz, YS; Isik, U; Aktepe, E; Altun, H; Yektas, Ç; Tuysuz, BP; Buber, A; Cansiz, MA; Ogutlu, H; Eray, S; Taner, HA; Altintas, E; Kutuk, O
    The aim of this study is to determine the functioning of adults with autism spectrum disorders (ASDs) diagnosed in childhood and depression and burnout levels among their parents. A total of 261 adults with ASDs and their parents were recruited for the study. Both parents completed the Beck Depression and Maslach Burnout Inventories and reported the functioning of their adult offspring with ASDs. Only 5.4 % of our sample reported good or very good outcomes. The most common psychiatric comorbidities were intellectual disabilities and attention-deficit/ hyperactivity disorder. Maternal burnout and depression scores were significantly elevated compared to those of fathers. There is an undeniable urgent need for more research to identify the needs of adults and families suffering from ASD. Modifications for those with ASD may have to be made for support in workplaces, achieving driving licenses, using public transportation and attendance at tertiary education.
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    Solving the laminar boundary layer problem in heat transfer with heuristic optimization techniques
    (CELL PRESS) Günal, O; Akpinar, M
    Heat transfer takes place in every aspect of our daily life. Many situations, such as energy conversion plants, heating devices, and cooling systems, focus on heat transfer. One of the subjects in heat transfer is the boundary layer of the laminar flow problem. Well-known exploratory algorithms are used to solve for the flow on a flat plate in this study. The algorithms used are genetic algorithm (GA), particle swarm optimization (PSO), simulated annealing (SA), ant colony optimization for continuous domains (ACOR), artificial bee colony (ABC), and firefly algorithm (FA). The three properties, the layer thickness of the laminar boundary, heat flux, and the distance of the leading edge, are optimized. Each property is determined in three conditions; minimum, maximum, and target. The results showed that PSO, SA, ABC, and FA algorithms were more suitable than GA and ACOR algorithms. It has also been determined that the processing times are long in the FA and SA algorithms. The findings show that heuristic algorithms can find global results or results close to global results in heat transfer problems.
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    Magneto-convection of nanofluid flow over multiple rotating cylinders in a confined space with elastic walls and ventilated ports
    (CELL PRESS) Selimefendigil, F; Ghachem, K; Albalawi, H; Alshammari, BM; Labidi, T; Kolsi, L
    In this study, convective heat transfer for nanofluid flow over multiple rotating cylinder in a confined space is analyzed under magnetic field while enclosure has one inlet and one outlet port. Three identical circular cylinder are used and the two walls of the cavity are considered to be elastic. The coupled fluid -structure interaction and magneto -convection problem is solved by finite element method. Impacts of rotational Reynolds number (Rew between -100 and 100), Hartmann number (Ha between 0 and 50), cylinder size (R between 0.001H and 0.11H) and Cauchy number (Ca between 10-8 and 10-3) on the flow and thermal performance features are explored. The flow field and recirculation inside the cavity are significantly affected by the activation of rotation and magnetic field. The vortices are suppressed by increasing the strength of magnetic field and thermal performance is improved. Thermal performance of 56.6% is achieved by activation of magnetic field at the highest strength with rotations of the circular cylinders. When rotations are active, heat transfer rate is reduced while up to 40% reduction is obtained without magnetic field. Cylinder size has the highest impact on the overall thermal performance improvement while up to 132% enhancements are achieved. The contribution of elastic walls on the thermal performance is slight while less than 5% improvements in the average heat transfer is obtained. An optimization study leads to 12.7% higher thermal performance improvements as compared to best case of parametric computational fluid dynamics simulation results while the optimum values of (Rew, Ha, R) is obtained as (-80.66, 50, 0.11H).