Browsing by Publisher "Cukurova Univ Tip Fakultesi Psikiyatri Anabilim Dali"

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    Serum brain-derived neurotrophic factor levels in pain syndromes: A comparative study with major depression
    (Cukurova Univ Tip Fakultesi Psikiyatri Anabilim Dali, 2008) Taşkin E.O.; Aydemir Ö.; Deveci A.; Taneli F.; Selçuki D.; Cerrahoǧlu L.; Danaci A.E.
    Objective: In this study, it is aimed to compare the level of Brain-Derived Neurotrophic Factor (BDNF) of patients with migraine and fibromyalgia to that of depressive patients and healthy subjects in order to answer the question whether stress is related to pain syndromes. Methods: In the migraine group 27 patients and in the fibromyalgia group 19 patients without any previous antidepressant treatment and psychiatric diagnosis were included. In the depression group, 24 patients with at least eight weeks of antidepressant-free period were invited to the study. In the depression group no co-morbid diagnosis in the first axis was made. Twenty-six subjects without any previous psychiatric diagnosis and psychiatric treatment consisted the control group. For making diagnosis of depression and other first axis disorders Structured Clinical Interview for DSM- IV (SCID-I) was used in all study groups. For the assessment of the severity of depression Hamilton Depression Rating Scale (HAM-D) was applied. The diagnosis of migraine was made according to the criteria of International Headache Society. For the diagnosis of the fibromyalgia the criteria of American College of Rheumatology was used. The severity of pain was assessed with visual analogue scale (VAS) in the migraine and fibromyalgia groups. Serum BDNF was kept at -70°C before testing, and assayed with an ELISA Kit (Promega; Madison, WI, USA), after dilution with the Block and Sample solution provided with the kit. The data were subjected to Kruskal Wallis Test in the comparison of serum BDNF levels. Results: The serum BDNF level of the depression group (21.2±11.3 ng/ml) was statistically lower (p<0.0001) than the level of the migraine group (32.2±10.1 ng/ml), fibromyalgia group (30.7±8.9 ng/ml) and the control group (31.4±8.8 ng/ml). The level of BDNF was not significantly different in the migraine, fibromyalgia and control groups. There was no significant correlation between serum BDNF levels, and age and gender. In pain syndromes there was no signification correlation between serum BDNF levels, and mean scores of HAM-D and VAS (r= 0.085; p= 0.579 and r= 0.191; p= 0.204 respectively). Similarly there was no significant correlation between serum BDNF levels and HAM-D scores in the depression group (r=0.122; p= 0.579). Conclusions: Even though the pain syndromes were suggested to be associated with stress, in this present work, serum BDNF level as one of the markers of stress does not support this hypothesis. This might be related to the factor that in pain syndromes such as fibromyalgia or migraine, serum BDNF level may be affected by the alteration in peripheral platelet functions. Furthermore in a limited chronic stress serum BDNF levels tend to be not affected and this may play a significant role in our results.
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    Therapeutic goals, clinical indicators and follow up in major depressive disorder; [Major depresif bozuklukta tedavi hedefleri ve tedavinin izlenmesi]
    (Cukurova Univ Tip Fakultesi Psikiyatri Anabilim Dali, 2011) Aydemir O.
    Major depressive disorder constitutes a very important health problem because of its associated disability. The treatment plan for depression should included targets, since the better the goals are described, the more likely the treatment will be followed up and monitored. For this purpose, clinical psychiatric scales are useful. Psychiatric rating scales are instruments to monitor depression and its treatment in a useful and operational way. Response may be the most important criterion to be monitored and is defined as a 50% reduction in the index scale score. Inadequate response to the treatment is defined as a 25-50% reduction and no response to treatment is defined as a reduction below 25%. Remission is defined as the improvement of most symptoms and during the monitoring of remission the target response is a score below the cutoff score, e.g. reduction of the Hamilton Depression Rating Scale below 7 and reduction of the Montgomery Asberg Scale below 10. While these two scales are the most used instruments in monitoring the treatment of depression, self-rated scales, while less preferred, may also be used. In the global assessment of patients, the Clinical Global Impression scale may be used. The achievement of remission in depression lowers healthcare costs significantly, reduces disease burden, improves quality of life, and reduces medical and psychiatric morbidity and mortality. Even though the functionality of patients improves,when assessed subjectively, it is not possible to suggest that it reaches premorbid levels; thus, in the follow-up of patients, functionality should be monitored, as well as response and remission.
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    Comparative validity and reliability study of the QIDS-SR16 in Turkish and American college student samples; [Türk ve amerikalı üniversite öǧrencilerinde hızlı depresif belirti envanteri-özbildirim formu'nun (HDBE16-ÖF) karşılaştırmalı olarak geçerlik ve güvenirliǧi]
    (Cukurova Univ Tip Fakultesi Psikiyatri Anabilim Dali, 2011) Mergen H.; Bernstein I.H.; Tavli V.; Ongel K.; Tavli T.; Tan S.
    Comparative validity and reliability study of the QIDS-SR16 in Turkish and American college student samples Objective: To evaluate the validity and reliability of the Quick Inventory of Depressive Symptomatology, selfreported version, in a Turkish student sample (QIDS-SR16-T) by comparing it to (a) the American version (QIDS-SR16- US) and (b) the Turkish version of the Beck Depression Inventory (BDI-II-T). Materials and Methods: Slightly modified versions of the QIDS-SR16-T, and the BDI-II-T were administered to 626 outpatients at the Uludaǧ University campus-based family health center. The QIDS-SR16-US was administered to 584 respondents at an American university. SAS and MPlus were used to provide descriptive statistics, classical exploratory factor analysis, and item response theory analyses (in the form of a multiple group confirmatory factor analysis). Results: The internal consistency (Cronbach α) of the QIDS-SR16-T was 0.77. Both QIDS-SR16 versions were unidimensional, but the BDI-II-T was not. The mean QIDSSR16- T and QIDS-SR16-US item-total correlations were similar. The correlation between the QIDS-SR16-T and BDIII- T was 0.72 (.90 when disattenuated). Multiple-group confirmatory factor analysis suggested that the QIDSSR16- T and QIDS-SR16-US had the same factor loadings but different intercepts. This reflects group differences in level of depression, perhaps because the Turkish respondents, unlike their US counterparts, were seen in a medical context where illness-related depression is more prevalent. Scores on the QIDS-SR16-T and the BDI-II-T were also equated. Discussion: The QIDS-SR16-T has good psychometric properties and convergent validity with the BDI-II-T. Its use is recommended when a self-reported instrument is appropriate.
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    Reliability and validity of subjective well-being under neuroleptics scale-short form-Turkish version; [Antipsikotik tedavisi altındaki hastalar için öznel iyilik hali ölçeǧinin Türkçe versiyonunun geçerlik ve güvenirliǧi]
    (Cukurova Univ Tip Fakultesi Psikiyatri Anabilim Dali, 2012) Pazvantoglu O.; Simsek O.F.; Aydemir O.; Sarisoy G.; Korkmaz I.Z.; Mor S.; Boke O.; Ucok A.
    Objective: The Subjective Well-Being Under Neuroleptics Scale (SWNS) is a self-reported measure that evaluates the state of well-being of schizophrenis patients using antipsychotic drugs independently of psychotic symptoms. This study was intended to establish the validity and reliability of the Turkish version of the scale. Methods: The Cronbach alpha coefficient was calculated for reliability analysis of the scale, which was translated into Turkish and applied to 103 schizophrenia patients. The criterion validity was examined by correlation with reference scales (Turkish Version of the Functional Remission of General Schizophrenia, The Short Form of the World Health Organization Quality of Life) concurrently in use. The construct validity of the scale was assured using both exploratory and confirmatory factor analyses. Findings: The Turkish version of the scale was found to have a high reliability co-efficient (0.881). In terms of total scores, the correlation with other scales is mediumgood. However, the results of the Turkish version factor analysis were incompatible with the sub-dimensions of the original scale. Conclusions: Our findings show that the Turkish version of this scale is a valid and reliable tool in the evaluation of states of subjective well-being of schizophrenic patients using antipsychotic drugs. On the other hand, we recommend that studies to be conducted in Turkey use only the scale total score.
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    The impact of psychotropic drugs on psychosocial functioning in bipolar disorder; [İki uçlu bozuklukta kullani{dotless}lan ilaçlari{dotless}n psikososyal işlevsellik üzerine etkisi]
    (Cukurova Univ Tip Fakultesi Psikiyatri Anabilim Dali, 2014) Aydemir O.; Cetinay Aydin P.; Gulec Oyeckin D.; Gulseren S.; Putgul Koybasi G.; Sahin H.
    Objective: Even though bipolar patients achieve remission, they do not reach premorbid psychosocial functioning. Factors such as residual depressive symptoms and number of episodes may cause this effect. The impact of treatment modalities has not been adequately studied. The aim of this study was to evaluate the impact of treatment modalities on psychosocial functioning in remitted bipolar patients. Methods: The study was carried out with 108 patients diagnosed as having bipolar disorder. All patients were in remission and the remission state was confirmed by rating scales. In the assessment of functioning, the Functioning Assessment Short Test (FAST) covering domains such as autonomy, occupational functioning, cognitive functioning, financial issues, interpersonal relations, and leisure time activities was applied. The treatment modalities were mood stabilizers (MS) versus mood stabilizers plus second-generation antipsychotics (MS+SGA). While 38% (n=41) of the patients were on MS only, 67 patients (62%) were on MS+SGA. In the statistical analysis, multiple linear regression analysis was performed. Results: In multiple linear regression analyses, the models concerning autonomy, interpersonal relations, and leisure time were statistically significant. In patients on MS+SGA, autonomy (Beta=3.086, p<0.01), interpersonal relations (Beta=2.807, p<0.01) and leisure time activities (Beta=3.293, p<0.01) were affected negatively. Similarly, total HAM-D score had negative effects on the same domains. Conclusion: Beside residual depressive symptoms, second-generation antipsychotics used in the treatment seem to affect psychosocial functioning negatively.
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    Body mass index and sexual dysfunction in males and females in a population study; [Bir populasyon çali{dotless}şmasi{dotless}nda kadi{dotless}n ve erkeklerde vücut kitle indeksi ve cinsel işlev bozukluklari{dotless}]
    (Cukurova Univ Tip Fakultesi Psikiyatri Anabilim Dali, 2014) Karadag H.; Oner O.; Karaoglan A.; Orsel S.; Demir A.U.; Firat H.; Karadeniz D.; Aksu M.; Ardic S.; Ucar Z.Z.; Sevim S.; Yilmaz H.; Itil O.
    The association of obesity with sexual dysfunctions is complex and far from clear. Most former studies consisted of small samples and did not control several possible confounding factors. Our aim was to investigate the association of BMI with current sexual dysfunction in males and females in a nationally representative population sample after controlling for age, the presence of cardiovascular disorders, diabetes, hypertension, thyroid diseases, anxiety and depression and also menopause in women. The sample included a total of 4162 subjects (2081 females and 2081males). The most frequent sexual problem was premature ejaculation (8.8%) in males and hypoactive sexual desire disorder (13.9%) in females. Univariate analysis showed that hypoactive sexual desire and erectile dysfunction in males and hypoactive sexual desire, lack of pleasure from sexuality and sexual pain in females were associated with obesity. Multivariate analysis indicated that age was significantly associated with almost all types of sexual problems in both sexes. The risks of having no active sexual life, hypoactive sexual desire, lack of pleasure from sexuality and erectile dysfunction were higher in males with diabetes mellitus. Depression and anxiety were associated with all types of sexual problems in females and with no active sexual life, hypoactive sexual desire, erectile dysfunction and premature ejaculation in men. In both sexes BMI was not associated with sexual problems after the confounding factors were controlled. The association of obesity with sexual dysfunction might be mediated by other factors.
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    The associations between endogenous oxytocin levels and emotion recognition in bipolar disorder
    (Cukurova Univ Tip Fakultesi Psikiyatri Anabilim Dali, 2015) Tas C.; Brown E.C.; Onur E.; Aydemir O.; Brune M.
    Objective: Recent studies in patients with Bipolar Disorder (BD) have revealed problems in emotion recognition, specifically for negative emotions, which have been subsequently related to amygdala activity. Previously, the prosocial neuropeptide oxytocin has been shown to be one hormone that alters emotion perception capacities and modulates amygdala response. Accordingly, the aim of this study was to see if plasma oxytocin levels have specific effects on predicting emotion recognition patterns in BD. Methods: Twenty-eight remitted BD patients were recruited for this study and the Vienna Emotion Recognition Task was given. In addition, blood samples were collected for plasma oxytocin analysis. Results: Strong associations were found between fearful emotions and basal oxytocin levels, which were supported by a stepwise regression analysis. Patients with higher levels of basal oxytocin also exhibited greater recognition of fearful emotions. Conclusions: The relationship between recognition of fearful faces and individual endogenous oxytocin levels may contribute to explaining individual differences in social functioning and amygdala dysfunction in BD. © 2015, Cukurova Univ Tip Fakultesi Psikiyatri Anabilim Dali. All rights reserved.
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    Safety of psychotropic medications in pregnancy: An observational cohort study
    (Cukurova Univ Tip Fakultesi Psikiyatri Anabilim Dali, 2016) Öztürk Z.; Olmez E.; Gurpinar T.; Gok S.; Vural K.
    Objective: The question of harmfulness of the psychiatric drugs creates a major dilemma for pregnant women. The risks associated with prenatal psychotropic drug exposure are often overestimated. It is unclear that psychotropic medication or disorders themselves increase the risk of adverse pregnancy outcomes. The purpose of this study is to generate data about the safety of psychotropic drugs in pregnancy and maternal characteristics of the pregnant women exposed to these drugs. Method: An observational cohort study was performed. Pregnancy outcomes of 135 pregnancies after psychotropic drug exposure are compared to a control group of 275 pregnancies. Results: There were no statistically significant differences in rates of major malformations, miscarriages, and preterm deliveries between the two groups. However, the rate of elective abortions was higher in the exposed group compared to the control group (11.1% vs. 5.1%, respectively; RR 2.18; 95% CI: 1.09-4.39), and most of them were nulliparous (45.2%). The majority of the pregnant women did not smoke cigarettes and no alcohol consumption was reported in both groups. Conclusion: Our study showed that there was a tendency to terminate pregnancy among women exposed to psychotropic drugs. An accurate risk assessment about drug safety and informing pregnant women would help to prevent unnecessary terminations of pregnancies. © 2016, Cukurova Univ Tip Fakultesi Psikiyatri Anabilim Dali. All rights reserved.
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    Psychometric properties of the turkish PTSD-short scale in a sample of undergraduate students
    (Cukurova Univ Tip Fakultesi Psikiyatri Anabilim Dali, 2016) Evren C.; Dalbudak E.; Aydemir O.; Koroglu E.; Evren B.; Ozen S.; Coskun K.S.
    Objective: The National Stressful Events Survey for Posttraumatic Stress Disorder (PTSD)-Short Scale (NSESSS-PTSD) allows dimensional self-rating assessment of PTSD according to the DSM-5. The aim of the present study was to evaluate psychometric properties of this scale as Turkish PTSD-Short Scale (PTSD-SS) in a sample of undergraduate students in Turkey. Method: Participants included 415 university students, among which 351 (84.8%) reported trauma and thus were included in the analysis. Participants were evaluated with the PTSD-SS and the PTSD Checklist Civilian (PCL-C) version. Results: Turkish version of the PTSD-SS was found to be psychometrically sound PTSD screening measure with high convergent validity when compared with PCL-C (r=0.79) and having a Cronbach’s α of 0.87. In addition, a single component accounted for 49.94% of total variance for PTSD-SS. The PTSD-SS had sensitivity and specificity scores of 0.91 and 0.77, respectively, when using the optimal cut-off score of 24. Additionally, the PTSD-SS showed good discriminant validity as it significantly differentiated students with high risk of PTSD from those with low risk of PTSD. Conclusion: These findings supported the Turkish PTSD-SS as reliable and valid PTSD screening instrument with a unidimensional scale construct. © 2016, Cukurova Univ Tip Fakultesi Psikiyatri Anabilim Dali. All rights reserved.