Browsing by Publisher "E M H SWISS MEDICAL PUBLISHERS LTD"

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    Vasodilator effects of cromakalim and HA 1077 in diabetic rat aorta
    (E M H SWISS MEDICAL PUBLISHERS LTD) Gurpinar, T; Gok, S
    BACKGROUND: Impairment of the vasorelaxant responses have been reported in diabetes mellitus. In this study, the roles of the K-ATP channel and rho kinase pathway were evaluated by using the K-ATP channel opener cromakalim and Rho-kinase inhibitor HA 1077 in diabetic rat aorta. METHODS: Adult male Wistar rats weighing (250-300 g) were divided into diabetic and control groups. Diabetes was induced by a single intraperitoneal injection of streptozotocin (STZ, 55 mg/kg/i.p). RESULTS: Vasodilator responses induced by cromakalim ;(10(-7) to 10(-3)M) and HA 1077 (10(-6) to 10(-4)M) were significantly less in diabetic rings compared with control rings (p<0.01). The decrease in the relaxant effect of cromakalim was more in endothelium-denuded rings compared to the endothelium-intact rings (p<0.05). There were no significant differences between endothelium intact and non-intact rings in the presence of HA 1077. When two drugs were administered together, relaxation was significantly less than with seperate administration of each drug in the diabetic group (p<0.01). Pre-treatment with N omega-nitro-L-arginine methylester (L-NAME) (10(-6) to 10(-4) M), an NO synthase inhibitor, significantly decreased the relaxant response to cromakalime and HA 1077 in both the control and diabetic groups (p<0.05). CONCLUSIONS: These results suggest that the impaired relaxant effects were further decreased depending on KATP channel activity but the effects of Rho-kinase enzyme inhibitors on relaxation responses were not significantly changed in diabetes mellitus.
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    Hand function assessment in patients receiving haemodialysis
    (E M H SWISS MEDICAL PUBLISHERS LTD) Duruöz, MT; Cerrahoglu, L; Dincer-Turan, Y; Kürsat, S
    Objective: To assess the usefulness of Duruozs Hand Index (DHI) in patients undergoing haemodialysis. Methods: Patients receiving haemodialysis for more than 2 months were recruited randomly. Demographic, clinical and functional characteristics of patients were evaluated. Functional assessment was performed with DHI, Hand Functional Index (HFI), Health Assessment Questionnaire (HAQ), Purdue Pegboard, grip strength and 3 kinds of pinch strengths. DHI was correlated (Spearman's) with the other functional parameters in assessing the convergent validity and with non-functional parameters in assessing the divergent validity Results: Sixty patients with a mean age of 50.05 were recruited. The average duration of haemodialysis was 55.02 months. DHI is significantly correlated with HAQ, HFI, Purdue Pegboard scores, grip strength and 3 types of pinch strengths while no significant correlation was found with non-functional parameters. Conclusions: DHI is a practical scale which is efficient in assessing accurately the functional disability of the hand in patients receiving haemodialysis.