Browsing by Publisher "E-Century Publishing Corporation"

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    Outcomes of coronary artery bypass surgery in syrian refugees
    (E-Century Publishing Corporation, 2016) Demir D.; Abanoz M.; Tulay C.M.; Aydın M.S.; Kasapoğlu B.Ö.; Merdanoğlu M.; Altıparmak İ.H.; Gücü A.
    Background: In recent years, an increasing number of individuals have become refugees as a result of wars and domestic disturbance in their countries. The struggle for life of refugees under difficult conditions, increasing health problems, and insufficient Access to health services result in the loss of human lives. The aim of the present study was to present the outcomes of coronary artery bypass surgery in Syrian refugees. Methods: We performed emergency or elective bypass surgery to 53 Syrian refugees who ran away from civil war in Syria, between 2012 and 2014. The preoperative, intraoperative, and postoperative data of the patients were evaluated. Results: Of the patients, 18.9% sustained myocardial infarction, 34% had diabetes, 28.3% had COPD, and 52.8% were smokers. Two patients had emergency surgery and 51 patients had elective surgery. In the postoperative period, five patients (9.4%) were found to have atrial fibrillation. Cerebrovascular disease was observed at three patients (5.7%) in the postoperative period, and one patient had wound infection. A total of three patients (5.7%) died. Conclusion: The authors believe that under appropriate conditions, refugee patients should also receive therapy for chronic disorders in addition to emergency interventions. © 2016, E-Century Publishing Corporation. All rights reserved.
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    Do Wortmannin and Thalidomide induce apoptosis by autophagy inhibition in 4T1 breast cancer cells in vitro and in vivo?
    (E-Century Publishing Corporation, 2021) Uluer E.T.; Sonmez P.K.; Akogullari D.; Onal M.; Tanriover G.; Inan S.
    The aim of this study was to show the effects of autophagy inhibitor Wortmannin and antiangiogenic-proapoptotic Thalidomide on autophagy and apoptosis markers in 4T1 breast cancer cells in vitro and in vivo. The half-maximal inhibitory concentration (IC50) values of 4T1 cells for Wortmannin and Thalidomide were evaluated by Methylthiazolyldiphenyl-tetrazolium bromide (MTT) assay. After cancer formation in 28 BALB/C female mice, drugs were administered for seven days. Cells and tissue sections were evaluated for anti-phosphoinositide 3-kinase (PI3K), anti- the microtubule-associated protein 1 light chain3 (MAPLC3β), anti-caspase 8, anti-caspase 9, and anti-caspase 3 immunoreactivities by immunohistochemical staining and apoptosis by Terminal Transferase dUTP Nick End Labeling (TUNEL) assay. Both PI3K and MAPLC3β immunoreactivities decreased in all treatments when compared to control group except Thalidomide treatment in primary cancer tissue. The caspase 3, 8, and 9 immunoreactivities were increased in all treatment groups and TUNEL positive cells were the highest in the Wortmannin and Thalidomide group. Our findings suggest that autophagy is an important mechanism for 4T1 cells and both Wortmannin and Thalidomide treatments inhibit autophagy and induce apoptosis. In primary cancer tissues, autophagy was not effective as in vitro. The treatment of Wortmannin and Thalidomide increased the apoptotic cells in vivo independent from autophagy inhibition. Different results may be because of microenvironment. Further studies must be done to elucidate the effect of microenvironment. © 2021 E-Century Publishing Corporation. All rights reserved.