Browsing by Publisher "ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER"
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Item QUALITY OF LIFE AND PSYCHIATRIC CONSULTATION IN ELDERLY(ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER) Icelli, IItem Design, synthesis, in vitro- In vivo biological evaluation of novel thiazolopyrimidine compounds as antileishmanial agent with PTR1 inhibition(ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER) Istanbullu, H; Bayraktar, G; Karakaya, G; Akbaba, H; Perk, NE; Cavus, I; Podlipnik, C; Yereli, K; Ozbilgin, A; Butuner, BD; Alptuzun, VThe leishmaniasis are a group of vector-borne diseases caused by a protozoan parasite from the genus Leish-mania. In this study, a series of thiazolopyrimidine derivatives were designed and synthesized as novel anti-leishmanial agents with LmPTR1 inhibitory activity. The final compounds were evaluated for their in vitro antipromastigote activity, LmPTR1 and hDHFR enzyme inhibitory activities, and cytotoxicity on RAW264.7 and L929 cell lines. Based on the bioactivity results, three compounds, namely L24f, L24h and L25c, were selected for evaluation of their in vivo efficacy on CL and VL models in BALB/c mice. Among them, two promising compounds, L24h and L25c, showed in vitro antipromastigote activity against L. tropica with the IC50 values of 0.04 mu g/ml and 6.68 mu g/ml; against L. infantum with the IC50 values of 0.042 mu g/ml and 6.77 mu g/ml, respec-tively. Moreover, the title compounds were found to have low in vitro cytotoxicity on L929 and RAW264.7 cell lines with the IC50 14.08 mu g/ml and 21.03 mu g/ml, and IC50 15.02 mu g/ml and 8.75 mu g/ml, respectively. LmPTR1 enzyme inhibitory activity of these compounds was determined as 257.40 mu g/ml and 59.12 mu g/ml and their selectivity index (SI) over hDHFR was reported as 42.62 and 7.02, respectively. In vivo studies presented that L24h and L25c have a significant antileishmanial activity against footpad lesion development of CL and at weight measurement of VL group in comparison to the reference compound, Glucantime (R). Also, docking studies were carried out with selected compounds and other potential Leishmania targets to detect the putative targets of the title compounds. Taken together, all these findings provide an important novel lead structure for the anti-leishmanial drug development.Item Digital homotopy fixed point theory(ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER) Ege, O; Karaca, IIn this paper, we construct a framework which is called the digital homotopy fixed point theory. We get new results associating digital homotopy and fixed point theory. We also give an application on this theory. (C) 2015 Academie des sciences. Published by Elsevier Masson SAS. All rights reserved.Item The effects of eight-week walking programs of two different intensities on serum lipids and circulating markers of collagen remodelling in humans(ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER) Buyukyazi, GAim. - This study examined the effects of eight weeks of walking programs on serum lipids, circulation matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metal loproteinase-1 (TIMP-1). Methods. - Thirty-seven premenopausal women (30-55 years) completed eight weeks of walking programs either at moderate (similar to 5.25 +/- 0.28 km/h; similar to 53% maximum heart rate reserve (HRRmax) or high-intensity (similar to 7.33 +/- 0.24 km/h; similar to 73% HRRmax). Non-walking, sedentary women served as controls. Estimated Vo(2max) was assessed with a 2 km walking test; body composition was measured using body composition analyzer; lipid, MMP-9, and TIMP-1 concentrations were measured in serum. Results. - After eight weeks, estimated Vo(2max) improved in high-intensity walking group (HIWG; p < 0.01) and in moderate-intensity walking group (MIWG; p < 0.05); BMI, and percent body fat decreased (p < 0.05) in both exercise groups. Only HIW caused significant reductions in total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), and MMP-9 levels (p<0.05); we found no significant changes in high-density lipoprotein-cholesterol and triglyceride levels in any of the groups. Exercise did not cause any significant changes in TIMP-1 levels apart from a nearly significant reduction in HIWG (p = 0.084). Conclusion. - Walking programs with different intensity bring about favorable changes; but significant improvements for protective effects against cardiovascular diseases may be attained only with high-intensity walking programs due to the reduction in TC, LDL-C and MMP-9 levels. (C) 2008 Elsevier Masson SAS. All rights reserved.Item Forced convection of ferrofluids in a vented cavity with a rotating cylinder(ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER) Selimefendigil, F; Öztop, HFIn this study, numerical investigation of the forced convection of ferrofluid in a square cavity with ventilation ports in the presence of an adiabatic rotating cylinder is carried out. The governing equations are solved with a finite element based solver. The effects of Reynolds number (20 <= Re <= 400), angular rotational speed of the cylinder (-500 <= Omega <= 500), strength and location of the magnetic dipole (0 <= gamma <= 250), (0.2 <= a <= 0.8, -0.8 <= b <= -0.2) on the flow and thermal fields are numerically studied. It is observed that the length and size of the recirculation zones can be condtrolled with magnetic dipole strength and angular rotational speed of the cylinder. When the magnetic dipole is closer to the bottom wall of the cavity, flow is accelerated towards the bottom wall with larger influence area. The increasing values of the angular rotational speed of the cylinder in the clockwise direction enhance the heat transfer. (C) 2014 Elsevier Masson SAS. All rights reserved.Item Evaluation of serum microRNA expression profile in panic disorder patients(ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER) Çökmüs, FP; Özmen, E; Alkin, T; Batir, MB; Çam, FSItem Primary pleural synovial sarcoma with diffuse pleural involvement: A case report(ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER) Mutevelizade, G; Sayit, ESynovial sarcoma (SS) is a mesenchymal tumor which generally affects the soft tissues of the extremities. Primary pleural synovial sarcoma (PPSS) is a very rare and aggressive subtype of SS. A 73-year-old male patient presented with chest-back pain and dyspnea. Hypermetabolic diffuse pleural lesions were detected in 18F-FDG PET/CT performed after pleural nodular thickenings were observed on CT. As the result of the molecular analysis performed in the excisional biopsy, SYT-SSX mutation was detected and the patient was diagnosed as SS. Pazopanib treatment was commenced. We are reporting a very rare case of PPSS with diffuse pleural involvement. @ 2023 Elsevier Masson SAS. All rights reserved.Item Splenosis imaging with 99mTc nano-colloid as a different mimicker in a lymphoma patient on 18F-FDG PET/CT(ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER) Sezgin, C; Parlak, Y; Mutevelizade, G; Gumuser, G; Sayit, EFluorodeoxyglucose (FDG) 18F-FDG PET/CT plays an important role in lymphoma staging and evaluation of treatment response. Mimics should be considered when evaluating 18F-FDG PET/CT images to perform correct staging and correct treatment response evaluation. Splenosis is one of the causes that may cause misinterpretation by mixing with lymph nodes in lymphoma patients. In our case report, we visualized splenosis mimicking lymph node in a 50-year-old lymphoma patient with 99mTc nano-colloid scintigraphy.Item INTEREPISODE FUNCTIONING OF BIPOLAR DISORDER(ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER) Aydemir, OItem Thermal management for conjugate heat transfer of curved solid conductive panel coupled with different cooling systems using non-Newtonian power law nanofluid applicable to photovoltaic panel systems(ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER) Selimefendigil, F; Öztop, HFThermal performance features for a coupled conjugate thermo-fluid system with different cooling configurations (flat channel (F-C), grooved channel (G-C) and impinging jets (I-J)) are explored numerically by using non-Newtonian nanofluid. The numerical work is performed for different Reynolds numbers (100 <= Re <= 300), index of power law (0.8 <= n <= 1.2), height (0.1H <= b <= 0.6..) and number (2 <= N <= 9) of corrugation in the G-C system, number (2 <= N-j <= 9) and distance (5 omega <= sx <= 25 omega) between jets in the I-J flow system. Different volume fractions (0 <= phi <= 0.04) and particle sizes (20 nm <= dp <= 80 nm) of nanoparticles are used. When systems operating at the highest and lowest Re are compared, 9 K, 11 K and 8 K temperature reduction are achieved for F-C, G-C and I-J cooling systems. However, I-J flow system at higher Re is very effective on the thermal performance improvement when shear thickening fluid is used. For the G-C flow system, increasing the height and number of the corrugation waves resulted in improvement in the thermal performance. Up to 46% increment in the Nu number (average) and reduction of 6.5 K in the average surface temperature are achieved with varying the height of the corrugation while these values are 17% and 1.6 K when wave number is increased. The average Nu number rises by about 32% and temperature drops by about 6.5 K when jet number is varied from 3 to 11, while these values are obtained as 8% and 4 K for when distance between jets are varied from sx = 5 omega to sx = 25 omega. For F-C, G-C and I-J flow systems, average Nu rises by about 15.5% and 14.5% and 16.3% for shear thinning fluid while they become 16.6%, 9.94% and 12.8% for shear thickening fluid at the highest solid volume fraction. As the nanoparticle size is increasing, there is 6% and 7% reduction in the average Nu number. Thermal performance estimations are made with four inputs and four outputs system by using artificial neural networks.Item Analytical solution for non-equilibrium energy transfer in gold: Influence of ballistic contribution of electrons on energy transfer(ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER) Yilbas, BS; Dolapçi, IT; Pakdemirli, MThe analytical solution for non-equilibrium energy transfers in gold substrate and ballistic contribution of electrons to the energy transfer mechanism is examined. The non-equilibrium energy equation including the ballistic contribution of electrons is obtained using the electron kinetic theory approach. The analytical solution using the perturbation method is introduced to formulate lattice and electron temperature distributions in the film. A numerical method using the finite difference scheme is employed to predict and compare electron and lattice site temperatures to those obtained from the analytical solution. It is found that temperature remains high in the surface region of the gold film due to the cases: (i) accounting for the ballistic contribution of electrons to non-equilibrium energy transfer, and (ii) excluding the ballistic contribution to the non-equilibrium energy transfer. This is true for electron and lattice temperatures. Crown Copyright (C) 2008 Published by Elsevier Masson SAS. All rights reserved.Item Artificial neural network models for predicting soil thermal resistivity(ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER) Erzin, Y; Rao, BH; Singh, DNThermal properties of soils are of great importance in view of the modern trends of utilizing the subsurface for transmission of either heated fluids or high power currents. For these situations, it is essential to estimate the resistance offered by the soil mass in dissipating the heat generated through it. Several investigators have tried to develop mathematical and theoretical models to estimate soil thermal resistivity. However, it is evident that these models are not efficient enough to predict accurate thermal resistivity of soils. This is mainly due to the fact that thermal resistivity of soils is a complex phenomenon that depends upon various parameters viz., type of the soil, particle size distribution and its compaction characteristics (i.e., dry density and moisture content). To overcome this, Artificial Neural Network (ANN) models, which are based on experimentally obtained thermal resistivity values for clay, silt, silty-sand, fine- and coarse-sands, have been developed. Incidentally, these soils are the most commonly encountered soils in nature and exhibit entirely different characteristics. The thermal resistivity of these soils, corresponding to their different compaction states, was obtained with the help of a laboratory thermal probe and compared vis-a-vis those obtained from the ANN model. The thermal resistivity of these soils obtained from ANN models and experimental investigations are found to snatch extremely well. The performance indices such as coefficient of determination, root mean square error, mean absolute error, and variance account for were used to control the performance of the prediction capacity of the models developed in this study. In addition to this, thermal resistivity of these soils obtained from ANN models were compared with those computed from the empirical relationships reported in the literature and were found to be superior. The study demonstrates the utility and efficiency of the ANN model for estimating thermal resistivity of soils. (c) 2007 Elsevier Masson SAS. All rights reserved.Item The effects of input power and ambient temperature on the thermal performance of conical pin fin heat sink in natural convection(ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER) Çorumlu, VIn the present study, thermal performance tests of horizontally oriented HSconical, HScross-cut, and HSflat with a base plate dimensions of 80*80*5 mm3 were performed in natural convection. The effects of ambient temper-ature (30 and 40 degrees C), input power (16.5 and 33 W), and conical pin fin geometry on the thermal performance of the HSs were investigated. The thermal resistance of the heat sinks decreases while the convective heat transfer coefficient, average surface temperature, and average junction temperature increase with increasing ambient temperature and input power. However, the Nusselt number increases with increasing ambient temperature for all HSs at 16.5 W, while the Nusselt number decreases with increasing ambient temperature at 33 W. The highest convective heat transfer coefficients are 32.17, 30.68, and 19.61 W/m2K for HSconical, HSflat, and HScross-cut at 33 W and 40 degrees C, respectively. The lowest thermal resistances are 2.75, 2.80, and 3.81 K/W for HSconical, HScross-cut, and HSflat at 33 W and 40 degrees C, respectively. Thermal resistances of HSconical and HScross-cut decreased by 27.78 % and 26.44 % at maximum and 27.06 % and 24.58 at minimum, respectively, compared to HSflat. The results show that the conical fins have better thermal performance in natural convection.Item Numerical study and identification of cooling of heated blocks in pulsating channel flow with a rotating cylinder(ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER) Selimefendigil, F; Öztop, HFA numerical study of pulsating channel flow with heated blocks in the presence of an adiabatic rotating cylinder is performed. The governing equations are solved with a finite volume based commercial solver. The effects of pulsating frequency, Reynolds number and cylinder rotation angle on the fluid flow and heat transfer characteristics from the surface of the heated blocks are numerically studied. It is observed that the flow field and heat transfer rate are influenced by the variations of these parameters. Furthermore, nonlinear models are created to identify the dynamics of the heat transfer for each of the surface of the blocks using system identification. (C) 2014 Elsevier Masson SAS. All rights reserved.Item Effects of couple stresses on the heat transfer and entropy generation rates for a flow between parallel plates with constant heat flux(ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER) Aksoy, YIn this study, the flow and heat transfer of a fluid with couple stresses is investigated. The flow caused by the pressure gradient between parallel plates is considered as incompressible, steady and fully developed while the bottom plate is adiabatic and the upper plate is exposed to a constant heat flux. Governing equations, i.e. momentum and energy, are derived and solved analytically. Using the analytical results, effects of couple stresses on the Nusselt number as a heat transfer performance parameter and entropy generation rates in the channel are presented via graphs and tables. In addition, second law analysis is performed by calculating mean entropy generation rates and Bejan number along the channel height. (C) 2016 Elsevier Masson SAS. All rights reserved.Item ELDERLY ABUSE IN TURKEY(ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER) Icelli, IItem A pediatric case of pyomyositis presenting with septic pulmonary emboli(ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER) Yuksel, H; Yimaz, O; Orguc, S; Yercan, HS; Aydogan, DPyomyositis is a suppurative infection of skeletal muscle most commonly caused by Staphylococcus aureus. It is mainly encountered in children and immunocompromised. Eight year old previously healthy girl presented with confusion, fever and swelling of the right knee two days after a trauma. Abdominal ultrasonography and computerized tomography taken upon development of hematemesis revealed no pathology in the abdomen, but potential bleeding sites in lung sections. Thorax CT images were interpreted in favor of septic pulmonary emboli due to the presence of peripheral nodular consolidation areas with central cavitation, mostly pathchy in medial areas. S. aureus was isolated in the blood culture. At the end of third week of hospitalization, gadolinium enhanced contrast MRI of right extremity was taken to evaluate right extremity swelling and revealed abcess formation as expected in the clinical progress of pyomyositis. Pyomyositis and septic pulmonary emboli are a rare association. This case demonstrates that the high index of suspicion in pediatric cases with muscle findings and septic pulmonary findings and early institution of therapy may improve the prognosis. (c) 2007 Elsevier Masson SAS. All rights reserved.Item Optimization of convective drying performance of multiple porous moist objects in a 3D channel(ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER) Selimefendigil, F; Coban, SO; Öztop, HFIn this study, a procedure for optimizing the convective drying performance of multi porous moist objects in a three dimensional channel is proposed. The numerical simulation is performed by using the finite element method and COBYLA optimization algorithm is used to find the optimum spacing between the objects without mass transfer in the first stage. Then, heat and mass transfer equations for the porous moist objects are coupled with the channel flow equations at the optimum spacing which delivers the best convective drying performance. It is observed that the flow recirculation and flow reversal in the inter-spacing with various distances between the objects resulted in thermal gradient variations along the multi object surfaces. The average Nusselt number rises for second block while it shows non-monotonic behavior for the first block when the distance between the first and second group objects are varied. Distance between the second and third objects also affected the average Nu variation for all of the objects. The lateral distance between first and second group objects resulted in up to 50% variation in the average Nu for the second block. The optimum spacing between the objects for the maximum Nusselt number of the objects are obtained as d(1)=5.93h(c), d(2)=7h(c). and d(3)=0.584h(c). The moisture reduction amounts for each of the object at the optimums spacing are found higher as compared to parametric variation of unsteady simulation results. The computational cost for the parametric unsteady coupled heat and mass transport equations in the channel and in the porous moist objects is 75 h 12 min while the optimization assisted simulation results reduced the computational cost to 2 h 33 minutes. Also, artificial neural networks are utilized to obtain the dynamic feature of convective drying at the optimum spacing considering various values of hot dry air temperature which delivers fast and accurate prediction results when compared to high fidelity computational fluid dynamics simulation results.Item Brain hemodynamic changes during sprint interval cycling exercise and recovery periods(ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER) Manci, E; Günay, E; Güdücü, C; Özgören, M; Bediz, CSObjectives. - The prefrontal cortex (PFC) is one of the most investigated brain regions on exercise due to its relationship with maintaining exercise. This study aims to demonstrate the effects of a high-intensity exercise on cerebral hemodynamic parameters in the PFC and how physical load reflects on PFC. Methods. - Twelve male (mean +/- SD: age = 20 +/- 1.56 years) performed the Wingate Anaerobic Test (WAnT; 30-s all-out) for three repetitions as a Sprint Interval Training (SIT) exercise model via a cycling ergometer with 4 min of active recovery (50 W, 50 rpm) between the repetitions. A functional Near-infrared Spectroscopy (fNIRS) device was used to record hemodynamic changes of the prefrontal cortex throughout the entire protocol. Results. - The oxy-hemoglobin (oxy-Hb) and total-hemoglobin (total-Hb) levels in the PFC were increased significantly (P < 0.001), while the power outputs were decreased in repetitive WAnT's (P < 0.05). The oxy-Hb values were higher than the pre-exercise values even in the recovery periods between WAnT's (P < 0.001). Conclusions. - In conclusion, repeated load with the active recovery periods might be an optimal approach for increasing the PFC oxygenation to its peak values. These results suggest that a repeated Wingate test could be used as a test to improve the metabolic condition of the athlete's brain. (c) 2022 Elsevier Masson SAS. All rights reserved.Item Effects of a statin group drug, pravastatin, on the insulin resistance in patients with metabolic syndrome(ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER) Güçlü, F; Özmen, B; Hekimsoy, Z; Kirmaz, CBackground. - In West of Scotland Coronary Prevention Study (WOSCOPS), development of type 2 diabetes mellitus (DM) was found to decrease by 30% in pravastatin-treated patients. In the study, it is suggested that pleiotropic effects of pravastatin may be responsible too as well as its lipid lowering effect. Objective. - The aim of this study was to assess the effects of pravastatin treatment on the insulin resistance in patients with metabolic syndrome with impaired glucose tolerance (IGT), by Homeostasis Model Assessment (HOMA) test, insulin sensitivity indices and glucose half activation time (glucose t1/2). Methods. - Study population consisted of 25 women who were diagnosed with metabolic syndrome. At baseline and 10 weeks after the 20 mg/daily tablet pravastatin treatment, waist/hip circumference, body weight and arterial blood pressure measurements, plasma glucose, total cholesterol, triglyceride, high density lipoprotein (HDL)-cholesterol, transaminases, glycosylated haemoglobin (A1C) and insulin level measurements were obtained along with HOMA test and insulin tolerance test after 12 h of fasting. Insulin sensitivity indices and glucose t1/2 were assessed. Results. - After the treatment, a statistically significant decrease was observed in arterial blood pressure values (P < 0.0001). While plasma total cholesterol, low density lipoprotein (LDL)-cholesterol, and triglyceride levels were found to decrease significantly and HDL-cholesterol levels increased significantly, a decrease in baseline insulin levels, an increase in insulin sensitivity levels were observed along with an decrease in glucose t1/2. Related to the improvement in aforementioned parameters, statistically significant decreases were noted in HOMA, postprandial and fasting glucose levels and A1C values (P < 0.0001). Conclusion. - Our study suggests that using pravastatin in the dyslipidemia treatment of metabolic syndrome with IGT may be an effective approach by its advantageous effects on insulin resistance. Based on this result, it is possible to say that this can be a risk lowering treatment approach for the development of type 2 DM. (C) 2004 Elsevier SAS. 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