Browsing by Publisher "Edizioni Minerva Medica"

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    The role of stem/progenitor cells and wnt/β-catenin signaling pathway in the patients with prostate cancer
    (Edizioni Minerva Medica, 2014) Vatansever H.S.; Gumus B.; Aydogdu O.; Sivrikoz O.N.; Türkôz-Uluer E.; Kivanç M.; Ateşçi Y.Z.; Bugdayci H.
    Aim: The aim of this paper was to investigate the possible effect of cancer stem cells (CSCs) and relationship with Wnt/β-catenin signaling pathway progressing of prostate cancer. Methods: Thirty men with a pathological diagnosis of benign prostate hyperplasia (BPH) (group 1, N.=10), prostate cancer with a gleason score of ≤6 (group 2, N.=10), and prostate cancer with a gleason score of >6 (group 3, N.=10) were included in the study. The patients' groups were compared in terms of immunoreactivity strength of prostatic stem/progenitor cell surface markers including CD133 and CD117. We also compared the immunoreactivity of Wnt7a, a part of Wnt signaling pathway which has a potential role in the progression of several cancers including prostate cancer. The immunoreactivity of Frizzled 6 (Fzd 6) which is the receptor of Wnt family was also evaluated in all groups. Results: Immunohistochemical analyses demonstrated that although CD 133 immunoreactivity was positive in all groups, immunoreactivity was significantly stronger in group 3 when compared to other groups. While CD117 immunoreactivity was negative in group 1 and 2, it was positive in group 3. Wnt7a immunoreactivity was weak in all groups and Fzd 6 immunoreactivity was stronger in group 1 and 3 when compared to group 2. Conclusion: Our findings demonstrated that CSCs and Wnt signaling pathway have a potential role in the development and progression of prostate cancer.
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    Creatine supplementation alters homocysteine level in resistance trained men
    (Edizioni Minerva Medica, 2015) Bereket-Yücel S.
    Aim: This study was conducted to investigate the effects of creatine loading and resistance training on the homocysteine and lipid profiles of young males. Method: Sixty male University students (22.34±2.19 years, 1.79±0.08 m, 77.18±12.57 kg, 15.48±4.57% body fat) were randomly divided in to three groups; control (CG=20), creatine supplement (CEG=20) and placebo (PEG=20). Both CEG and PEG participated in a same resistance-training regimen and either taking a creatine supplement (25 g/d for the first 5 days followed 5 g/d thereafter) or the same amount of placebo for 8 weeks. Participants in CG did not take any creatine supplementation and not engage any exercise program. After the body composition were assessed, the homocysteine (Hcy) concentrations, blood lipids, folic acid and vitamin B12 levels of all the participants were measured at the beginning and end of the eight weeks of resistance training. Results: The analysis of the data indicated that the Hcy levels of the CEG after resistance training and receiving the creatine supplement (9.33±4.60) was significantly lower than that of baseline (12.66±5.89) measurements, F(1,18)=12.28, P=0.00. No significant differences were seen in the Hcy levels of the PEG (15.01±10.87) after 8 weeks of training and receiving a placebo (12.46±12.50), F(1,16)=4.65, P=0.05. Furthermore, there were no significant differences among groups in terms of Hcy levels, F(2,52)=1.72, P=0.19. Conclusion: The present study suggests that as well as strength gain; creatine supplementation with resistance training may afford some protection against emerging cardiovascular risk factors.
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    Aerobic exercise without multivitamin supplementation increased Serum homocysteine levels
    (Edizioni Minerva Medica, 2015) Dinç N.; Bereket-Yücel S.; Taneli F.; Ulman C.; Tikiz H.
    Aim: Aim of the study was to investigate the effects of aerobic exercise on cardiovascular risk factors such as Serum total cholesterol (TC), HDL cholesterol (HDL-C), LDL cholesterol (LDL), triglyceride (TG), lipoprotein (a) Lp(a), apolipoprotein A (Apo A), apolipoprotein B (Apo B), and homocysteine (Hcy) levels and to evaluate the impact of additional multivitamin supplementation on these parameters. Methods: Sixty volunteers (23.01±3.71 yrs, 173.20±9.88 cm, 6932±12.52 kg, 22.92±2.64 kg/m2) were enrolled in the study and randomized into the following 3 groups; multivitamin (MVG), placebo (PG) and control (CG). The volunteers in the MVG and PG attended 8 weeks of aerobic training program which was prescribed individually according to 60% of their maximum VO2. MVG were given a multivitamin supplement while PG were taken a placebo once daily for 8 weeks. Results: The analysis of the data indicated that the Hcy level of PG was significantly higher after 8 weeks of aerobic training, F(1 16) = 17.70, p=0.00. The increase in the MVG was not statistically significant after the multivitamin supplementation and aerobic training, p≥0.05. Unexpectedly, the simple effect analysis showed that there was a statistically significant decrease in HDL levels of both MVG and PG after eight weeks of aerobic training, F(1,17) = 7.67, p=0.01, F(1,16) = 16.00, p=0.02, respectively. Conclusion: Without multivitamin supplementation, aerobic exercise could lead to a significant increase in Hcy levels which has been considered an important cardiovascular risk factor. It is also possible that the baseline HDL levels of the participants could be another physiological variable that cause changes in the Hcy metabolism.
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    Ultrasound-guided catheter-directed foam sclerotherapy for great saphenous vein
    (Edizioni Minerva Medica, 2015) Kurdal A.T.; Yildirim F.; Ozbakkaloglu A.; Iskesen I.; Tetik O.
    Aim: The problem of varicose veins in the lower leg is a common disease and associated with long-term morbidity. It has usually been treated using high ligation with stripping and endovenous ablation surgery of the great saphenous vein. The aim of this paper is to report our own series of patients treated by ultrasound guided catheter directed foam sclerotherapy for the chemical ablation of great saphenous vein. Methods. The study involved 108 legs with symptomatic varicose veins (C2-4) secondary to great saphenous vein insufficiency. The great saphenous vein was accessed at knee level. With the method of Tessari sclerosant foam was made (2 mL 3% polidocanol and 8 mL air) and delivered along the great saphenous vein while the catheter was withdrawn. At two and fifty two weeks after treatment the patients were evaluated. Results. Catheter-directed foam sclerotheraphy was successfully performed in all of the patients. Venous Clinic Severity Score was reduced significantly (P<0.05). Eighty nine percent of the GSV were completely occluded, 4% were partly occluded and 7% were recanalized. No serious side-effects occurred. Conclusion. Catheter-directed foam sclerotheraphy is a safe, simple and minimally invasive procedure. Patient satisfaction was good and the occlusion rate is promising after a single treatment.
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    Predictive value of cyclooxygenase-2 over expression for identifying prostate cancer from benign prostatic hyperplasia in prostate biopsy specimens
    (Edizioni Minerva Medica, 2016) Ceylan Y.; Lekili M.; Muezzinoglu T.; Nese N.; Isisag A.
    BACKGROUND: We studied cyclooxygenase-2 (COX-2) immunohistochemical staining intensity both in prostatic biopsy and surgical samples of patients with prostate cancer to determine if it might provide prognostic information for the decision of re-biopsy indication. METHODS: Twenty-eight patients undergone radical prostatectomy whose final pathologic examination revealed prostatic adenocarcinoma were included in the study. Twelve patients with BPH in their pathological examination of both prostatic biopsy and open prostatectomy were considered as a control group. Intensity of COX-2 receptor was examined with immunohistochemical staining according to standard techniques. RESULTS: Positive COX-2 receptor staining was obtained 89.3% of biopsy samples and 93% of surgical samples in all cancer patients. The rate of agreement in COX-2 receptor staining of biopsy samples and radical prostatectomy samples was 76% in same patients (P=0.54). Similarly, the COX-2 receptor levels in biopsy specimens of patients with BPH open surgery compared with samples of the agreement still rate was 41% (P=0.41). Prostate cancer exchanging COX-2 receptor levels in patients with biopsy specimens in patients with BPH were found significantly more (P=0.008). CONCLUSIONS: In this study the feasibility of presence of COX-2 receptor staining in biopsy samples was shown. We have also demonstrated that COX-2 staining intensity was higher in prostatic biopsy samples of patients with prostatic cancer than patients with BPH. This leads a conclusion that, higher COX-2 expression levels in biopsy specimens may be used to decide re-biopsy in borderline preoperative PSA levels as well as in the cases with suspicious pathological findings for cancer. © 2014 EDIZIONI MINERVA MEDICA.
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    Effects of local cold applications to leg muscles and knee joint on 30-m sprint performance
    (Edizioni Minerva Medica, 2017) Altun M.
    BACKGROUND: Purpose of this study was to investigate the effects of local cold application (LCA) to leg muscles and knee joint on 30-m sprint performance. Differently from other studies, we applied local cold by isolating the muscles of gastrocnemius, quadriceps, hamstring and joint of knee. METHODS: Participants who are male and female with no joint or muscle disease volunteered for the study. Sprint tests without a pre-cooling and with LCA of four anatomical regions were performed in random order for each region in different days. In each test session, participants performed a 30-m sprint test without pre-cooling initially. Then after fifteen minutes of LCA the sprint test was repeated. 161 participants joined the 1st test with LCA to gastrocnemius muscles. 129 participants joined the 2nd test with LCA to quadriceps muscles. 122 participants joined the 3rd test with LCA to hamstring muscles. 129 participants joined the 4th test with LCA to knee joints. 73 participants joined all of the four test. RESULTS: 30-m sprint times were significantly increased according to applied LCA in all test (P<0,01), which means 30-m sprint performances decreased. After LCA to gastrocnemius, hamstring, quadriceps muscles and knee joint, 30-m sprint performances significantly deteriorated (P<0,01) by 0,150ss (3,3%), 0,154ss (3,4%), 0,163ss (3,6%) and 0,182ss (4,1%) respectively. CONCLUSIONS: Our results show that LCA decreased sprint performance at different rates. During sporting events, injured athletes often return to competition after LCA because of the reduction in pain. In this case should it be noted that sprint performance may decrease according to the applied regions of cold at different rates. © 2016 Edizioni Minerva Medica.
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    Acute effects of different warm-up methods on free kick performance in amputee soccer players; [Effetti acuti dei diversi metodi di riscaldamento sul rendimento dei giocatori amputati nel battere i calci di punizione]
    (Edizioni Minerva Medica, 2018) Yildiz S.; Kayihan G.; Gelen E.; Çilli M.; Özkan A.
    BACKGROUND: There are studies documenting the detrimental effects of static stretching and useful effects of dynamic exercises. However, there is no study which has researched the acute effects of different warm-up exercises on free kick performances in amputee soccer. The purpose of this study was to compare the acute effects of static stretching and dynamic warm-up exercise on free kick performance in amputee soccer players. METHODS: Twelve amputee soccer players playing for the national team (mean age 28±7 years) were investigated in our study. This study was designed to determine the acute effects of 3 different warm-up (WU) methods static stretching (SS), dynamic exercises (DYN) and control (NS) on anaerobic performance (free kick speed performance) RESULTS: Although significant differences (P<0.001) were found for DYN and NS when the free kick speed levels of the soccer players were compared pre and post-test; no obvious difference (P>0.05) was found for SS. The data shows that there is a significant increase in free kick speed for DYN and NS according to pre and post-tests results. CONCLUSIONS: The results of this study suggest that it may be desirable for amputee soccer players to perform dynamic exercises before performing activities that require a high power output. © 2018 Edizioni Minerva Medica. All Rights Reserved.
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    Effect of hot and cold applications on elbow proprioception
    (Edizioni Minerva Medica, 2019) Kaynak H.; Altun M.; Özer M.; Akseki D.
    BACKGROUND: Purpose of this study was to investigate the effects of cold application (CA) and hot application (HA) on elbow proprioception in healthy volunteers. CA and HA were applied locally during 15 minutes on the elbow joint and the effect was measured after that. METHODS: A repeated-measure design with 6 (2x3) randomly assigned test conditions: 1) no application on 30° angle; 2) after HA on 30° angle; 3) after CA on 30° angle; 4) no application on 60° angle; 5) after HA on 60o angle and 6) after CA on 60o angle. A total of 82 healthy volunteers (35 women, 47 men) whose ages ranged between 18 and 28 years (20.93±2.13) were included in the study. Proprioception of the elbow was measured by using a digital goniometer with the technique of active joint position sense at the beginning of the study. The tests were repeated at weekly intervals after applying cold or hot in mixed order. Two target angles were defined 30 and 60 degrees of elbow flexion. RESULTS: Reproduction errors were significantly decreased following HA in both target angles (P<0.017). Following CA, significantly increased reproduction error was found only in 30-degree target angle (P<0.017). CONCLUSIONS: We obtained increased elbow proprioception following HA, which means increased proprioceptive acuity of the elbow but a decrease following CA in healthy volunteers. These findings may be useful in prevention and treatment of sports injuries, if supported by future studies. © 2018 EDIZIONI MINERVA MEDICA.
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    The effect of personal, familial, and environmental characteristics on acne vulgaris: A prospective, multicenter, case controlled study
    (Edizioni Minerva Medica, 2019) Karadag A.S.; Balta I.; Saricaoglu H.; Kiliç S.; Kelekçi K.H.; Yildirim M.; Arica D.A.; Ozturk S.; Karaman G.; Çerman A.A.; Bilgili S.G.; Turan E.; Demirci M.M.; Uzunçakmak T.K.; Guvenç S.C.; Ataseven A.; Ferahbaş A.; Aksoy B.; Çolgeçen E.; Ekiz O.; Demir F.T.; Bilgiç O.; Çakmak S.; Uçmak D.; Ozuguz P.; Konkuralp Y.K.; Ermertcan A.T.; Gokdemir G.; Başkan E.B.; Alyamaç G.; Şanli H.
    BACKGROUND: There are only a few studies about epidemiological features of acne vulgaris in the literature. The aim of this study was to analyze demographic, clinical, familial and environmental characteristics of acne, the role of diet and aggravating factors and association of these factors with acne severity. METHODS: Patients with a diagnosis of mild-moderate to severe acne were consecutively interviewed at the participating centers during the study period. RESULTS: A total of 3826 patients and 759 control patients were involved in this study. Mild acne was the most common type of acne, and most of the lesions were localized on face followed by the trunk. The severity of acne was worse in patients who had a positive family history of acne. The most common triggering factor was psychological stress. We found a positive correlation with chocolate, bread, green tea, milk, white sugar, ripe banana, ice cream, apple, orange, and red meat consumption. As we compare the acne severity according to geographical features we detected mild- moderate acne was more common in Mediterranean region and severe acne was more common in East Anatolian region. Family history positivity was more common in Aegean region and least common in Central Anatolian region. There was statistically significant relationship as we compare acne severity and dietary factors such as chocolate, dairy products such as milk, sunflower seed consumption within the geographical regions. CONCLUSIONS: This study presents the demographic and clinical characteristics of acne patients in Asian and the European parts of Turkey. We believe that this study will provide a useful overview of acne in Turkey. © 2017 EDIZIONI MINERVA MEDICA.
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    The relationship of the foot and ankle structure with overuse injuries in licensed footballers: a prospective cohort study
    (Edizioni Minerva Medica, 2021) Sahillioglu A.; Cerrahoglu L.
    BacKGrouNd: foot and ankle are some of the most frequently injured places in football players’ bodies. overuse injuries have an insidious onset and can restrain athletes from sports temporary or even permanently. This study aimed to investigate the relationship between the clinical evaluation of the foot and ankle and findings obtained from foot plantar pressure measurements with the development of overuse injury, during the one-year follow-up. MeThodS: one hundred licensed football players were included in the study. presence of joint hypermobility, foot posture assessment, ankle and first metatarsophalangeal joint range of motion measurements, pedobarographic plantar pressure assessment of foot was carried out. Then, the footballers were followed for 12 months for the development of new foot and ankle overuse injuries, and the clinical and pedobarographic data of the footballers with at least one injury were compared with the group without injury. reSulTS: We found asymmetric pressure distribution between the preferred and non-preferred foot in the group who had an injury in the pedobarographic static foot plantar pressure measurements (P=0.040). A statistically significant limitation was found in the ankle eversion, first metatarsophalangeal joint dorsiflexion and ankle plantar flexion degrees in the injured group compared to the uninjured group (P=0.029, p=0.023, p=0.044, respectively). CONCLUSIONS: These findings suggest that impairments in foot plantar pressure distribution and limitations in ankle and foot joint range of motion may be risk factors for the development of foot and ankle overuse injury. © 2020 Edizioni Minerva Medica.
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    A view on pediatric airway management: a cross sectional survey study
    (Edizioni Minerva Medica, 2022) Saracoglu A.; Saracoglu K.T.; Sorbello M.; Kurdi R.; Greif R.; Abitagaoglu S.; Akin M.; Aksu A.; Aladag E.; Alagoz A.; Alanoglu Z.; Alicikus Tuncel Z.; Altinisik H.B.; Ambrosoli A.L.; Amella S.; Andrašovský A.; Andreotti A.; Arici A.G.; Armstrong J.; Arslan B.; Ávila E.; Aydogmus I.; Ayhan A.; Ayoglu H.; Ayvat P.; Bakis M.; Basaran B.; Baytar C.; Begec Z.; Belete A.; Belludi R.; Bianco M.C.; Bilgin M.U.; Biricik E.; Brueggeney M.K.; Bunjaku D.; Buyukkocak U.; Catineau J.; Cebrián C.G.; Chinnappa S.M.; Cicekci A.; Corte-Ballester J.; Cuéllar Martínez A.B.; Caglar T.; Calisir F.; Cokay Abut Y.; Delen L.A.; Deligoz O.; Demirgan S.; Distefano R.; Dmytriiev D.; Duarte L.; Ece C.; El-Tahan M.; El-Hatib M.; Erdogan Ari D.; Erkalp K.; Erol D.; Erturk E.; Frada R.; Fuchs A.; Garini E.; Gecici M.E.; Giallongo M.; Gomes C.; Gurbuz H.; Has Selmi N.; Hasani A.; Hernandez Cera C.; Hilker T.; Horatanaruang D.; Huitink J.; Karaaslan P.; Karaveli A.; Karisik M.; Kavas A.D.; Kaya A.; Kendigelen P.; Kilinc G.; Koc S.; Dilmen O.; Kozanhan B.; Kupeli I.; Kuyrukluyildiz U.; Lleshi A.; Loizou M.; Luanpholcharoenchai J.; Martinez V.; Matoshi D.; Maurya I.; Meco B.C.; Michalek P.; Milic M.; Mitre I.; Montealegre F.; Nair A.; Nallbani R.; Ng A.; Oc B.; Ok G.; Olguner C.; Ozkan D.; Oksuz G.; Ozcan M.S.; Ozden E.S.; Ozden Omaygenc D.; Ozer Y.; Ozmenoglu Turker H.; Ozmert S.; Rai E.; Rangappa D.; Roca De Togores A.; Salgado H.; Santos P.; Sari S.; Saritas A.; Saygi Emir N.; Sen B.; Shallik N.; Shamim F.; Shirgoska B.; Silay E.; Sinha T.; Srimueang T.; Sudarshan P.; Sugur T.; Sumer I.; Szucs Z.; Sahin T.; Sanal Bas S.; Tan J.; Tawfik L.; Topal S.; Toy E.; Turan Civraz A.Z.; Unal D.; Ural S.G.; Ustalar Ozgen S.Z.; Uysal H.; Yesildal H.; Yilmaz C.; Yuen V.; Yurt E.; Yuzkat N.; Zdravkovic M.; Isohanni M.
    BACKGROUND: This survey aimed to investigate routine practices and approaches of clinicians on pediatric airway in anesthesia and intensive care medicine. METHODS: A 20-question multiple-choice questionnaire with the possibility to provide open text answers was developed and sent. The survey was sent to the members of European Airway Management Society via a web-based platform. Responses were analyzed thematically. Only the answers from one representative of the pediatric service of each hospital was included into the analysis. RESULTS: Among the members, 143 physicians responded the survey, being anesthesiologists (83.2%), intensivists (11.9%), emergency medicine physicians (2.1%), and (2.8%) pain medicine practitioners. Astraight blade was preferred by 115 participants (80.4%) in newborns, whereas in infants 86 (60.1%) indicated a curved blade and 55 (38.5%) a straight blade. Uncuffed tracheal tube were preferred by 115 participants (80.4%) in newborns, whereas 24 (16.8%) used cuffed tubes. Approximately 2/3 of the participants (89, 62.2%) reported not to use routinely a cuff manometer in their clinical practice, whereas 54 participants (37.8%) use it routinely in pediatric patients. Direct laryngoscopy for routine pediatric tracheal intubation was reported by 127 participants (88.8%), while 16 (11.2%) reported using videolaryngoscopes routinely. Interestingly, 39 (27.3%) had never performed neither videolaryngoscopy nor flexible bronchoscopy in children. These results were significantly less in hospitals with a dedicated pediatric anesthesiologist. CONCLUSIONS: This survey on airway management in pediatric anesthesia revealed that the use of cuffed tubes and the routine monitoring of cuff pressure are rare. In addition, the rate of videolaryngoscopy or flexible optical intubation was low for expected difficult intubation. Our survey highlights the need for properly trained pediatric anesthesiologists working in-line with updated scientific evidence. © 2022 Edizioni Minerva Medica. All rights reserved.
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    Evaluation of the effect of gestational diabetes mellitus on fetal cardiac functions with Myocardial Performance Index
    (Edizioni Minerva Medica, 2023) Alkan F.; Oncel Alanyali M.; Artunc Ulkumen B.; Coskun S.
    BACKGROUND: We aimed to evaluate the fetal cardiac functions with Myocardial Performance Index (MPI) in gestational diabetes mellitus (GDM). METHODS: In this study, 35 patients who were diagnosed with GDM, and 35 pregnant without glucose intolerance and their babies were evaluated. Fetal echocardiographic, biometric measurements, umbilical artery pulsatility indices (UAPI) and ductus venosus pulsatility indices (DVPI) measurements were performed to evaluate fetal well-being between the groups. RESULTS: There was no statistically significant difference between the groups in terms of UAPI, DVPI, systolic functions, the mode of delivery and 5-minute APGAR scores (P=0.849, P=0.485, P=0.770, P=0.060, P=0.587). There was statistically significant difference between the isovolumetric relaxation time and isovolumetric contraction time of groups (P=0.006, P=0.03). The MPI results were statistically different between the groups (P=0.000). Postpartum need for hospitalization was more frequently observed in GDM than the control group (P=0.014). CONCLUSIONS: MPI, which is independent of the ventricular anatomy and fetal heart rate, showing both diastolic and systolic functions, was found significantly higher in GDM. We recommend performing MPI measurement routinely to fetal cardiac functions in GDM. Copyright © 2023 Edizioni Minerva Medica.
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    Effects Of 16-week circuit training on physical fitness parameters, pulmonary function, and quality of life in healthy women
    (Edizioni Minerva Medica, 2024) Toprak Celenay S.; Secer E.; Ozer Kaya D.
    BACKGROUND: Circuit training (CT) is an important type of training that can combine different types of exercises in a single form of training. This study aimed to investigate the effects of 16-week CT on physical fitness parameters, pulmonary function, and quality of life in healthy women. METHODS: Twenty-nine healthy women (median age: 37.00 [31.50/39.50] years) were included in the study. CT was applied to the participants for a total of 16 weeks. Participants’ body composition with the Bioelectrical Impedance Analysis System, knee flexor and extensor muscle strength with the Biodex System-4 Pro, flexibility with the sit-and-reach test, pulmonary function with a spirometer device, and quality of life with Short Form-36 were assessed. RESULTS: A significant difference was found between the participants’ pretest and posttest median and interquartile range values of waist-hip ratio, body mass index, right/left knee flexor/extensor mean peak torque (60°/s,180°/s), right hamstring/quadriceps (H/Q) ratio (60°/s), flexibility, and SF-36 Mental Health Score (P<0.050). There was no significant difference between the participants’ pretest and posttest median and interquartile range values of total body fat, fat percentage, right H/Q ratio (180°/s), left H/Q ratio (60°/s,180°/s), pulmonary function, and Short Form-36 Physical Function Score (P>0.050). CONCLUSIONS: CT decreased waist-hip ratio and body mass index, increased knee flexor/extensor strength and flexibility, and improved mental health. The 16-week CT may be an alternative approach to improve physical fitness parameters and mental health without any positive effects on body fat and pulmonary functions in healthy women. © 2024 EDIZIONI MINERVA MEDICA.