Browsing by Publisher "Ege University Press"

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    Seroprevalance of chlamydophila pneumoniae in patients with alzheimer's disease and vascular dementia; [Alzheimer ve vasküler demanslı hastalarda chlamydophila pneumonaie seroprevalansı]
    (Ege University Press, 2010) Ecemiş T.; Mavioǧlu H.; Özkütük N.; Akçali S.; Karaçam M.; Şanlidaǧ T.
    In recent years, it was been argued that Chlamydophila pneumoniae, which is an intracellular pathogen capable of causing chronic infection, might be effective in some forms of dementia, an argument confirmed or rejected by some studies. The objective of this study was to determine if there was an association between C. pneumoniae infection and Alzheimer's disease and vascular dementia. We tested 54 patients with Alzheimer and 29 patients with vascular dementia and 50 controls for C. pneumoniae IgG and IgA antibodies and analyzed the results statistically. C. pneumoniae IgG antibodies were found in 25 patients (49.2%) with Alzheimer's disease, 15 patients (51.8%) with vascular dementia and 22 controls (44%) whereas 6 patients (11.1%), 2 patients (6.9%) and 3 controls (6%), respectively, tested positive for IgA. It was found no serological evidence for a significant association between C. pneumoniae and Alzheimer's disease as well as vascular dementia.
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    Prognostic factors in metastatic brain tumors: Study of 62 patients; [Metastatik beyin tümörlerinde prognostik faktörler: 62 hastalık çalışma]
    (Ege University Press, 2012) Duransoy Y.K.; Selçuki M.; Gökçe T.; Duransoy A.
    Background: Brain metastases are the major cause of morbidity and mortality in patients with cancer. Variety of clinical and autopsy studies showed that brain metastases develop at 15%-45% of all cancer patients during the course of the disease and 1/2-2/3 of them were symptomatic. Average life expectancy of cancer patients with untreated metastatic brain tumors are approximately 1-2 months. Methods: We investigated the prognostic factors of removal of metastatic brain tumors in patients who admitted to neurosurgery department. Eighteen of 80 patients in the program excluded for various reasons and this study was completed with the remaining 62 cases. Results: Our study showed that neurological and general status, the extension of surgical resection, presence of the extra-cranial metastases at diagnosis and localization of the primary focus affect the prognosis. Conclusion: In the planning of treatment of patients with metastatic brain tumors, colleagues have to keep in mind level of neurological and general status, the extension of surgical resection, presence of the extra-cranial metastases at diagnosis and localization of the primary focus affect the prognosis. Surgical resection is beneficial for improving neurological status and survival of patients in brain metastases. Local control is essential and can be achieved with one of the adjunct therapies following the surgery.
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    Edaravone leads to increased internal luminal vascular circumference following subarachnoid hemorrhage in an animal model of vasospasm; [Edaravone hayvan vazospazm modelinde subaraknoid kanama sonrası damar i̇ç lümen çevresinde genişlemeye yol açmaktadır]
    (Ege University Press, 2012) Mete M.; Özer F.D.; Duransoy Y.K.; Kocaman U.; Oran I.; Demirtaş E.; Selçuki M.
    Purpose: Cerebral vasospasm is the leading cause of morbidity and mortality following subarachnoid hemorrhage. Although a number of factors have been examined in clinical and experimental studies, the agent(s) responsible for developing and diminishing vasospasm remain poorly understood. Here, the role of edaravone, an antioxidant agent, was evaluated for its ability to diminish vasospasm in an animal model of subarachnoid hemorrhage. Materials and Methods: A rat basilar artery subarachnoid hemorrhage model was used. Rats were divided into three groups: sham (n=7; Group 1), subarachnoid hemorrhage (n=7 Group 2), and subarachnoid hemorrhage plus edaravone (4 mg/kg intraperitoneally, n=7; Group 3). At the end of the seventh day, the rats were sacrificed, their brains were removed, and sections were taken from the basilar artery. These were examined using a light microscope, comparing the internal luminal circumference of the basilar artery of each group. Results: The circumference was largest in Group 1, followed by Group 3 and then Group 2. That of Group 3 was 2% higher than that of Group 2, but this difference was not statistically significant. Conclusion: This animal model for vasospasm suggests that edaravone helps enlarge internal luminal circumference following vasospasm caused by subarachnoid hemorrhage. It may do this by blocking lipid peroxidation and thereby reducing the effects of oxyhemoglobin and reactive oxygen species.
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    Comparison of the histopathologic outcome of three different allograft used for the repair of spinal dural defect in rats; [Ratlarda spinal dura defekt tamirinde kullanılan üç farklı allogreftin histopatolojik sonuçlarının karşılaştırılması]
    (Ege University Press, 2013) Atci I.B.; Demirçivi Özer F.; Mete M.; Çamlar M.; Kocaman Ü.; Akçay E.; Erşahin y.; Öner Ö.; Küpelioǧlu A.
    Purpose: Repairing of the duramater is one of the major factor that effects the mortality and morbidity of patients after neurosurgical approaches. The gold standard for repairing of duramater is watertight suture or duraplasty with autografts such as pericranium and/or temporal fascia. Sometimes edges of the dura mater generally are shrunken and the watertight suture of the dura becomes impossible especially in emergency conditions. In the present study, we aimed to determine the most effective artificial dural graft in experimental dural defect in rats. Materials and Methods: Twenty eights wistar albino rats weight ranging from 280-320 grams and equal numbers of male and female were used. The animals were divided into four groups. Control (n=7 Group-1), collagen matrix graft (n=7 Group-2), cellulose graft (n=7 Group-3) and teflon graft (n=7 Group-4). Rats were sacrificed after 30 days and their damaged dura were removed and sections were taken. All histological preparations examined using light microscope. Histological analysis focused on fibroblastic activation, new capillary formation, inflammatory reaction, foreign body reaction and capsule formation and results were compared. Results: While fibroblastic activation was observed most frequently in teflon graft group, new capillary formation, inflammatory reactions and capsule formation were most frequently seen in cellulose grafts group. Conclusion: This animal model for artificial dural grafts suggest that cellulose was the most effective dural substitute for repairing of defective dura.
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    Double dorsal lipoma; Fibrous septum; lipomyelomeningocele; split cord malformation; [Aynı seviyede ayrık omurilik anomalisi tip ii ve çift lipom birlikteliği: Nadir bir olgunun sunumu]
    (Ege University Press, 2014) Mete M.; Gursoy G.; Umur A.Ş.; Selçukİ M.
    Split cord malformations are classified as type I and type II and can be associated with lipomyelomeningocele. Although multiple lipoma in different levels at the same patient has been described, combination of SCM with double lipoma at the same level in literature is only once described previously. Herein, authors presented a 12 years old girl who had SCM type II associated with double lipoma at the same level. © 2014, Ege University Press. All rights reserved.
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    The effects of fibroblast growth factor-2 blocking on development of chick cervical vertebra and relationship with oxidative stress and apoptosis; [Fibroblast growth faktör-2 bloklamasi{dotless}ni{dotless}n tavuk servikal omurlari{dotless} üzerindeki etkisi ve oksidatif stres ve apoptozis ile i̇lişkisi]
    (Ege University Press, 2014) Duransoy Y.K.; Şimşek T.; Öztürk F.; Mete M.; Tuǧlu M.I.; Selçuki M.
    Fibroblast growth factor (FGF) plays a role in the development of bone and cartilage. FGF-2 is a member of this family and blocking of FGF-2 affects the bone development. In this study, effects of FGF-2 blocking on the formation of vertebrae in chick embryos before ossifications and orientation of cervical vertebrae were investigated with histological examinations. In this study, anti-FGF-2 was performed to chick embryos at E4th and E10th days. Samples were taken in E15th days and changes in the cervical spine were evaluated as histochemically (with hematoxylin-eosin, Alizarin red, Masson's trichrome staining) and immunohistochemically (with iNOS, eNOS and TUNEL). Also changings were evaluated by morphometric analysis. In macroscopic examination of the cervical vertebrae significant difference was not detected. But in histochemical staining, defects were observed in cartilage and ossification process. Increasing in oxidative stress was demonstrated by iNOS and eNOS. Also apoptosis which was represented by tunnel was found to be increased. FGF-2 blocking affects the ossification process in the cervical spine by inducing oxidative stress and apoptosis which results with cell death.
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    Preoperative and postoperative evaluation of electromyography and magnetic resonance imaging findings in carpal tünnel syndrome; [Karpal Tünel Sendromunda Elektromiyografi ve Manyetik Rezonans Görüntüleme Bulgularının Preoperatif ve Postoperatif Değerlendirilmesi ]
    (Ege University Press, 2014) Özkal B.; Yaldiz C.; Asil K.; Selçuki D.; Selçuki M.
    Introduction: Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy caused by the compression of the median nerve in the carpal tunnel in the wrist. In the diagnosis of CTS, neurological examination and electrophysiological studies (EMG) findings are based primarily. This study was conducted in order to determine how effective magnetic resonance imaging examining in the diagnosis and follow-up of patients diagnosed with carpal tunnel syndrome is.; Material and methods: Our research was performed on 21 patients with 23 wrists diagnosed with CTS with clinical and electrophysiological tests. Magnetic resonance imaging (MRI) was performed preoperatively and postoperatively in 14.2 weeks for the hands of 21 patients in the anatomical prone position by using a wrist coil. The length and width measurements of the sections of the median nerve were proportionalized at three levels (length / width), and flattening ratio of the median nerve, median nerve area, the intensity of the median nerve were evaluated. All patients was operated by the same surgeon, neurolysis was not applied to any patient.; Results: When the results of the EMG before and after surgery of the study group were analyzed, it has been detected that, there was a significant improvement in motor conduction velocity and sensory conduction time compared to preoperative results. Hand / wrist MRI of the study group was compared with the control group, it has been observed that, the arithmetic mean of all measurements, except the ratio of carpal tunnel area / wrist area were greater than the control group. The differences in terms of median nerve flattening ratio in the middle and distal, the distal median nerve area, flexor retinaculum thickness, flexor retinaculum spring, the flexor retinaculum spring ratio were not significant.; Conclusion: Electrophysiological studies are the gold standard in the diagnosis of CTS. MRI is an effective method in the evaluation of patients after surgery. It may be used to reveal the cause of failed surgery. MR imaging is an effective method in the diagnosis of patients and in post-operative follow-up. © 2014 Ege University Press. All rights reserved.
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    Extremely rare cause of ventriculo-peritoneal (V-P) shunt dysfunction: Spontaneous peritoneal catheter knotting; [Ventrikülo-peritoneal(V-P) şant disfonksiyonun nadir sebebi: Spontan peritoneal katater düǧümlenmesi]
    (Ege University Press, 2014) Yaldiz C.; Kurtuluş Duransoy Y.; Mete M.; Ünlü Ünsal U.; Selçuki M.
    Shunt application is one of the most common treatment method for hydrocephalus. Many complications have been reported in literature for ventricular and peritoneal catheters and shunt valve. Spontaneous knotting of peritoneal catheter is an extremely rare condition. Mechanism of knotting is still unclear and peristaltism, elasticity of shunt materials, intraabdominal density, length of the peritoneal catheter and surgical technique may be responsible factors. In this paper, we presented a peritoneal catheter knotting resulted in shunt dysfunction in an 8-year-old girl. During surgery, we removed the peritoneal catheter, untied the knot and placed in the peritoneum again.
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    A giant hypertrophy of C5 spinous process in Klippel-Feil syndrome; [Klippel-Feil sendromunda C5 spinöz proçesinin dev hipertrofisi]
    (Ege University Press, 2015) Mete M.; Ünsal Ü.Ü.; Duransoy Y.K.; Umur A.Ş.; Selçukİ M.
    Congenital cervical spinal anomalies are relatively common and can be seen in upper and lower cervical regions. However, hypertrophy of the lamina and spinous process of cervical vertebra is extremely rare. Here we reported an 11-year-old girl with unilateral hypertrophy of the lamina and spinous process of C5 vertebra coexistence with Klippel-Feil syndrome, occipitalization of atlas and atlantoaxial congenital fusion. Because of cosmetic anomaly patient underwent surgery and spinous process excised. To the best of our knowledge, this coexistence of congenital cervical bony anomalies in a child has not been reported previously in English literature. © 2015, Ege University Press. All rights reserved.
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    Miller Fisher Syndrome/pharyngeal-cervical-brachial variant of GBS overlap and human herpes Virus-6 reinfection: May there BE a relationship?; [MFS/ Faringeal-Servikal-Brakial variant GBS Çakışması ile human herpes Virüs enfeksiyonu arasında bir ilişki var mı?]
    (Ege University Press, 2016) Mavioğlu H.; Kisabay A.; Sari S.; Akçali S.; Oktan B.
    Miller Fisher Syndrome (MFS) is a rare variant of Gulliain Barre syndrome (GBS) characterized by external ophthalmoplegia, ataxia, areflexia, and usually by positive anti GQ1b antibody. It occurs through an autoimmune mechanism most frequently after Campylobacter jejuni, followed by Haemophilus influenzae infection. Although occurrence with other viruses and bacteria has been reported, the concurrence of MFS and Human Herpes Virus-6 (HHV-6) has not been reported so far. There are a few publications reporting association of GBS with HHV-6. In the present study, HHV-6 DNA with PCR was detected in the cerebrospinal fluid (CSF) of a 59 year-old female patient diagnosed with MFS/pharyngeal-cervical-brachial variant of GBS overlap from clinical findings and positive anti-GQ1b antibody in the serum. This article aims to create awareness of a possible relationship between MFS, GBS and HHV-6. © 2016, Ege University Press. All right reserved.
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    Effects of CPAP (Continous positive airway pressure) treatment on oxidative stress and pro-inflammatory process; [CPAP (Continous positive airway pressure) tedavisinin oksidatif stres ve proinflamatuar sürece olan etkisi]
    (Ege University Press, 2016) Kisabay A.; Sari U.S.; Çakiroğlu Aldemir E.; Oktan B.; Korkmaz T.; Dinç Horasan G.; Yilmaz H.
    Introduction: Obstructive sleep apnea syndrome (OSAS) is an independent risk factor for development of atherosclerotic processes because it leads to hypertension, impaired glucose metabolism, obesity and metabolic syndrome, cardiac diseases, elevated blood pressure, and increased level of cholesterol, triglycerides, homocysteine, and coagulation. Materials and Methods: Our aim was to evaluate presence of subclinical atherosclerosis prior to CPAP treatment in the patients with OSAS without any history of previous diseases and any pathological finding in their investigations. After obtaining approval from the Ethics Board, we planned to compare the results of investigations for risk factors for atherosclerosis (fasting blood glucose [FBG], total cholesterol, Triglycerides, HDL- and LDL-cholesterol, thyroid function test, homocysteine, fibrinogen, high sensitivity C-reactive protein [hsCRP]) before and after CPAP treatment and to examine the effect of CPAP treatment on these parameters between July 2013 and July 2015. Findings: Findings obtained before CPAP treatment (homocysteine, hsCRP, HbA1c, subclinical hypothyroidism) suggested subclinical atherosclerosis. In comparative evaluation between the findings before and after CPAP treatment, no statistically significant difference was found in levels of triglycerides, HDL-cholesterol and fT4 (P = 0.346, 0.540, 0.060, respectively) whereas significant differences were found in leukocyte and platelet counts, hemoglobin level, fasting blood glucose, LDL-cholesterol, homocysteine, fibrinogen, fT3, TSH, CRP, and HbA1c (P = 0,003,-0,010,-0,000,-0,001,-0,008-0,004-0,000-0,000-0,025-0,000-0,000-0,000, respectively). Subclinical hypothyroidism was present in 12 (20%) patients before CPAP and in 5 (7%) patients after CPAP treatment. Conclusions: Improvement has been seen even in early markers of atherosclerosis with effective CPAP. © 2016, Ege University Press. All Rights Reserved.