Browsing by Publisher "Elsevier Masson s.r.l."
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Item Digital homotopy fixed point theory(Elsevier Masson s.r.l., 2015) Ege O.; Karaca I.In this paper, we construct a framework which is called the digital homotopy fixed point theory. We get new results associating digital homotopy and fixed point theory. We also give an application on this theory. © 2015 Académie des sciences.Item Investigation of time dependent heat and mass transportation for drying of 3D porous moist objects in convective conditions(Elsevier Masson s.r.l., 2021) Selimefendigil F.; Çoban S.Ö.; Öztop H.F.Three-dimensional numerical study of convective drying process was investigated for two porous moist blocks in a channel under turbulent flow conditions by considering different parameters which are effective on heat and moisture transfer phenomena. The 3D unsteady flow and heat and mass transfer equations were solved with Galerkin weighted residual finite element method. Drying objects were rectangular shaped porous objects and effects of size and distance between the objects, velocity and temperature of inlet drying air were investigated with varying values. Transport of heat and moisture for the problem was evaluated. Obtained results showed that all of the changing parameters had significant effects on flow properties, heat and mass transfer phenomena in 3D. As the interspacing between the blocks increases, it has a positive impact on the drying process especially for second porous block even though it is not as effective as the velocity or the size. As the height of the porous block increases, due to the blockage effect it has adverse effects on the transportation phenomena. © 2020 Elsevier Masson SASItem Thermal management for conjugate heat transfer of curved solid conductive panel coupled with different cooling systems using non-Newtonian power law nanofluid applicable to photovoltaic panel systems(Elsevier Masson s.r.l., 2022) Selimefendigil F.; Öztop H.F.Thermal performance features for a coupled conjugate thermo-fluid system with different cooling configurations (flat channel (F-C), grooved channel (G-C) and impinging jets (I-J)) are explored numerically by using non-Newtonian nanofluid. The numerical work is performed for different Reynolds numbers (100≤Re≤300), index of power law (0.8≤n≤1.2), height (0.1H≤b≤0.6H) and number (2≤N≤9) of corrugation in the G-C system, number (2≤Nj≤9) and distance (5w≤sx≤25w) between jets in the I-J flow system. Different volume fractions (0≤ϕ≤0.04) and particle sizes (20nm≤dp≤80nm) of nanoparticles are used. When systems operating at the highest and lowest Re are compared, 9 K, 11 K and 8 K temperature reduction are achieved for F-C, G-C and I-J cooling systems. However, I-J flow system at higher Re is very effective on the thermal performance improvement when shear thickening fluid is used. For the G-C flow system, increasing the height and number of the corrugation waves resulted in improvement in the thermal performance. Up to 46% increment in the Nu number (average) and reduction of 6.5 K in the average surface temperature are achieved with varying the height of the corrugation while these values are 17% and 1.6 K when wave number is increased. The average Nu number rises by about 32% and temperature drops by about 6.5 K when jet number is varied from 3 to 11, while these values are obtained as 8% and 4 K for when distance between jets are varied from sx=5w to sx=25w. For F-C, G-C and I-J flow systems, average Nu rises by about 15.5% and 14.5% and 16.3% for shear thinning fluid while they become 16.6%, 9.94% and 12.8% for shear thickening fluid at the highest solid volume fraction. As the nanoparticle size is increasing, there is 6% and 7% reduction in the average Nu number. Thermal performance estimations are made with four inputs and four outputs system by using artificial neural networks. © 2021Item Optimization of convective drying performance of multiple porous moist objects in a 3D channel(Elsevier Masson s.r.l., 2022) Selimefendigil F.; Coban S.O.; Öztop H.F.In this study, a procedure for optimizing the convective drying performance of multi porous moist objects in a three dimensional channel is proposed. The numerical simulation is performed by using the finite element method and COBYLA optimization algorithm is used to find the optimum spacing between the objects without mass transfer in the first stage. Then, heat and mass transfer equations for the porous moist objects are coupled with the channel flow equations at the optimum spacing which delivers the best convective drying performance. It is observed that the flow recirculation and flow reversal in the inter-spacing with various distances between the objects resulted in thermal gradient variations along the multi object surfaces. The average Nusselt number rises for second block while it shows non-monotonic behavior for the first block when the distance between the first and second group objects are varied. Distance between the second and third objects also affected the average Nu variation for all of the objects. The lateral distance between first and second group objects resulted in up to 50% variation in the average Nu for the second block. The optimum spacing between the objects for the maximum Nusselt number of the objects are obtained as d1=5.93hc, d2=7hc and d3=0.584hc. The moisture reduction amounts for each of the object at the optimums spacing are found higher as compared to parametric variation of unsteady simulation results. The computational cost for the parametric unsteady coupled heat and mass transport equations in the channel and in the porous moist objects is 75 h 12 min while the optimization assisted simulation results reduced the computational cost to 2 h 33 minutes. Also, artificial neural networks are utilized to obtain the dynamic feature of convective drying at the optimum spacing considering various values of hot dry air temperature which delivers fast and accurate prediction results when compared to high fidelity computational fluid dynamics simulation results. © 2021 Elsevier Masson SASItem Optimization of bifurcating channel cooling system for double inclined conductive panel system under inclined magnetic field(Elsevier Masson s.r.l., 2023) Selimefendigil F.; El-Sinawi A.H.; Oztop H.F.A novel cooling system with wavy branching channels is proposed considering nano-enhanced magnetic field effects for thermal management of double inclined conductive panels. Thermal performance assessment is conducted by varying Reynolds number (250≤Re≤1000), Hartmann number (0≤Ha≤400), magnetic field inclination (250≤γ≤1000), amplitude (0≤Af≤0.4) and wave number (1≤Nf≤12). As the cooling fluid, water with Ag–MgO hybrid nanoparticles is considered. Temperature drops of 4.5 °C and 2.6 °C are obtained with the highest Re for left inclined panel (p1) and right inclined panel (p2). As the vortex distribution is highly affected for the wavy branching channels by the magnetic field strength, its impact on the cooling performance for p1 and p2 are different. It shows a favorable impact for panel p2 while average Nusselt number (Nu) increments become 10% and 6.3% when using flat and wavy branching channels at the highest magnetic field strength. For panel p1, varying inclination of magnetic field results in average surface temperature drop of 1.6 °C for wavy channel. The optimum value of wave number in the corrugated branching channel is Nf=2 for achieving the highest cooling performance while higher amplitudes of corrugation has favorable impacts on the cooling for each of the panels. As compared to un-cooled panel configuration, utilization of flat branching channel with nano-enhanced magnetic field results in 47.4 °C and 48.9 °C surface temperature drops for panels p1 and p2. Optimization based on COBYLA is utilized to achieve additional temperature drops as compared to parametric computational fluid dynamics. The optimum values of (Ha, γ, Af) are obtained as (40, 89, 0.04) at Re=100 and (40, 60.8, 0.0038) at Re=1000. The proposed single cooling method with wavy branching channel under nano-enhanced magnetic field can be used and further developed for effectively cooling of photo-voltaics with inclined arrangement, electronic cooling and many other heat transfer devices. © 2023 Elsevier Masson SASItem Primary pleural synovial sarcoma with diffuse pleural involvement: A case report; [Sarcome synovial pleural primitif avec atteinte pleurale diffuse : un rapport de cas](Elsevier Masson s.r.l., 2023) Mutevelizade G.; Sayit E.Synovial sarcoma (SS) is a mesenchymal tumor which generally affects the soft tissues of the extremities. Primary pleural synovial sarcoma (PPSS) is a very rare and aggressive subtype of SS. A 73-year-old male patient presented with chest-back pain and dyspnea. Hypermetabolic diffuse pleural lesions were detected in 18F-FDG PET/CT performed after pleural nodular thickenings were observed on CT. As the result of the molecular analysis performed in the excisional biopsy, SYT-SSX mutation was detected and the patient was diagnosed as SS. Pazopanib treatment was commenced. We are reporting a very rare case of PPSS with diffuse pleural involvement. © 2023 Elsevier Masson SASItem Two case reports and a literature review of typical GBS and rare GBS variants associated with COVID-19(Elsevier Masson s.r.l., 2023) Orak S.A.; Kubur Ç.Ç.; Atasever A.K.; Polat M.Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in late 2019, and is the infectious agent that caused the coronavirus disease 2019 (COVID-19) pandemic. Although respiratory and gastrointestinal manifestations of SARS-CoV-2 are well defined, the spectrum of neurological involvement is less defined. The classic type of Guillain–Barré syndrome (GBS) progresses over days to weeks and has a monophasic course. Areflexia/hyporeflexia and ascending and symmetrical paralysis are observed clinically in patients. It is an autoimmune process that typically leads to the destruction of myelin after infection. There have been numerous reports of adult patients with the coexistence of GBS disease and active COVID-19 illness, but this number is lacking for children. In this study, we present a literature review of the etiological correlation between SARS-CoV-2 and GBS and describe the cases of two pediatric patients with acute monophasic Guillain–Barré syndrome (GBS) during active COVID-19 infection. © 2023 French Society of PediatricsItem The effect of COVID-19 on patients recieving omalizumab treatment; [L'effet du COVID-19 sur les patients recevant un traitement par omalizumab](Elsevier Masson s.r.l., 2023) Sayaca N.; Cansız K.A.; Yıldırım E.; Öztürk B.; Kırmaz C.Background and aim: Although exposure during drug administration and susceptibility to coronavirus disease-19 (COVID-19) infection secondary to immunomodulatory effects constitute potential risks for patients with chronic spontaneous urticaria (CSU) or asthma on omalizumab (OMZ), there is a risk of loss of response following discontinuation of OMZ. There are few studies describing the clinical course of COVID-19 in patients receiving OMZ. Materials and methods: A total of 103 patients on OMZ were included in the study between February 2021 and January 2022. Results: Fourteen (13.6%) of the patients participating in the study had SARS-CoV-2 infection, of whom 3 (21.4%) required hospitalization and 11 (78.6%) were treated in an outpatient clinic. During the pandemic, 17 (16.5%) of the patients interrupted their OMZ treatment. Patients on OMZ for six months or less had a lower rate of interruption (2.5%) than those on OMZ for more than 6 months (25.4%). Patients interrupted treatment for the following reasons: 3 (17.6%) had COVID-19, 10 (58.9%) did not attend the hospital visit due to concern about contamination with SARS-CoV-2, and 4 (23.5%) thought that OMZ treatment would facilitate contamination with SARS-CoV-2. After interrupting OMZ, 3 (25%) female patients and 5 (100%) male patients presented no worsening of their symptoms. Three (13%) of the patients on OMZ for asthma and 11 (13.8%) of those on the drug for urticaria had COVID-19 infection. Patients presenting CSU and severe asthma are completely different, with different potential consequences of OMZ interruption. Nine (52.9%) patients had aggravated symptoms following interruption of OMZ treatment. Three of them described worsening of asthma symptoms and a need to increment their maintenance therapy due to asthma exacerbation after nearly three weeks of interruption, and 6 of them had hives and pruritus as urticaria exacerbation nearly four weeks after interruption of OMZ. The asthma patients did not stop their other treatments, including inhaled corticosteroids. Conclusion: Use of OMZ does not increase the risk of SARS-CoV-2 infection, COVID-19-related pneumonia, or COVID-19-related hospitalization. We advise patients not to interrupt OMZ treatment during the COVID-19 pandemic unless advised to do so by their doctors, and we recommend that they receive instruction concerning self-administration of OMZ to avoid visiting hospitals in the event of a pandemic. © 2023 Elsevier Masson SASItem Design, synthesis, in vitro – In vivo biological evaluation of novel thiazolopyrimidine compounds as antileishmanial agent with PTR1 inhibition(Elsevier Masson s.r.l., 2023) Istanbullu H.; Bayraktar G.; Karakaya G.; Akbaba H.; Perk N.E.; Cavus I.; Podlipnik C.; Yereli K.; Ozbilgin A.; Debelec Butuner B.; Alptuzun V.The leishmaniasis are a group of vector-borne diseases caused by a protozoan parasite from the genus Leishmania. In this study, a series of thiazolopyrimidine derivatives were designed and synthesized as novel antileishmanial agents with LmPTR1 inhibitory activity. The final compounds were evaluated for their in vitro antipromastigote activity, LmPTR1 and hDHFR enzyme inhibitory activities, and cytotoxicity on RAW264.7 and L929 cell lines. Based on the bioactivity results, three compounds, namely L24f, L24h and L25c, were selected for evaluation of their in vivo efficacy on CL and VL models in BALB/c mice. Among them, two promising compounds, L24h and L25c, showed in vitro antipromastigote activity against L. tropica with the IC50 values of 0.04 μg/ml and 6.68 μg/ml; against L. infantum with the IC50 values of 0.042 μg/ml and 6.77 μg/ml, respectively. Moreover, the title compounds were found to have low in vitro cytotoxicity on L929 and RAW264.7 cell lines with the IC50 14.08 μg/ml and 21.03 μg/ml, and IC50 15.02 μg/ml and 8.75 μg/ml, respectively. LmPTR1 enzyme inhibitory activity of these compounds was determined as 257.40 μg/ml and 59.12 μg/ml and their selectivity index (SI) over hDHFR was reported as 42.62 and 7.02, respectively. In vivo studies presented that L24h and L25c have a significant antileishmanial activity against footpad lesion development of CL and at weight measurement of VL group in comparison to the reference compound, Glucantime®. Also, docking studies were carried out with selected compounds and other potential Leishmania targets to detect the putative targets of the title compounds. Taken together, all these findings provide an important novel lead structure for the antileishmanial drug development. © 2022 Elsevier Masson SASItem Brain hemodynamic changes during sprint interval cycling exercise and recovery periods; [Modifications hémodynamiques au niveau du cerveau pendant des intervalles de sprint et de récupération sur ergocycle](Elsevier Masson s.r.l., 2023) Manci E.; Günay E.; Güdücü C.; Özgören M.; Bediz C.S.Objectives: The prefrontal cortex (PFC) is one of the most investigated brain regions on exercise due to its relationship with maintaining exercise. This study aims to demonstrate the effects of a high-intensity exercise on cerebral hemodynamic parameters in the PFC and how physical load reflects on PFC. Methods: Twelve male (mean ± SD: age = 20 ± 1.56 years) performed the Wingate Anaerobic Test (WAnT; 30-s all-out) for three repetitions as a Sprint Interval Training (SIT) exercise model via a cycling ergometer with 4 min of active recovery (50 W, 50 rpm) between the repetitions. A functional Near-infrared Spectroscopy (fNIRS) device was used to record hemodynamic changes of the prefrontal cortex throughout the entire protocol. Results: The oxy-hemoglobin (oxy-Hb) and total-hemoglobin (total-Hb) levels in the PFC were increased significantly (P < 0.001), while the power outputs were decreased in repetitive WAnT's (P < 0.05). The oxy-Hb values were higher than the pre-exercise values even in the recovery periods between WAnT's (P < 0.001). Conclusions: In conclusion, repeated load with the active recovery periods might be an optimal approach for increasing the PFC oxygenation to its peak values. These results suggest that a repeated Wingate test could be used as a test to improve the metabolic condition of the athlete's brain. © 2022 Elsevier Masson SASItem The percentage of hesitation and factors associated with acceptance or refusal for COVID-19 vaccine: Does training about vaccines by allergist affect personal decision?; [Hésitations et facteurs associés à l'acceptation ou au refus de la vaccination contre la COVID-19: l’éducation thérapeutique sur les vaccins affecte-t-elle la décision personnelle ?](Elsevier Masson s.r.l., 2023) Sayaca N.; Aşık Cansız K.; Yıldırım E.; Öztürk B.; Kırmaz C.Background and aim: As the impact of coronavirus disease (COVID)-19 arises worldwide, the effect of vaccines is protecting its importance. The aim of this study was to investigate the vaccination perspectives of patients and learn how many patients were persuaded to get vaccinated with the effect of the education provided by allergists. Materials and methods: A cross-sectional study was carried out among 200 adult patients in the outpatient clinic between February 2021 and January 2022. Patients filled out the anti-vaccination scale form and a questionnaire form developed by allergists. The training about COVID-19 vaccines has been given to the patients who did not consider getting vaccinated. The patients were called by phone and questioned whether they have been vaccinated or not, after 22 weeks. Results: Out of 200 patients participants, 60.5% were considering getting vaccinated. Patients who did not consider getting vaccinated comprised 45.7% of women and 31% of men. While 52.4% of primary school graduates considered getting vaccinated, 75% of high school graduates and 60.8% of higher education graduates were considering getting vaccinated. Major reasons for rejecting vaccination were concerns about side effects and allergy. While the majority of women (47.2%) who did not want to get vaccinated were concerned about vaccine side effects, the majority of men (34.6%) did not want to get vaccinated because they did not trust the efficacy of the vaccine. Vaccination rates have been increased with the training we provided to our patients who did not consider getting the vaccine. 76 patients could be reached by phone and 81.6% of them were vaccinated, and 18.4% were not. Conclusion: The vaccination rates of allergy patients who did not consider getting vaccinated were increased with the information provided by allergists. So, the allergists should give more attention for giving information and increasing the vaccination rates of covid-19. © 2022 Elsevier Masson SASItem Efficient synthesis of novel 1,10 phenanthroline-substituted imidazolium salts: Exploring their anticancer applications(Elsevier Masson s.r.l., 2024) Çakır S.; Ilhan S.; Atmaca H.; Türkmen H.This study reports a new series of 1,10-phenanthroline-substituted imidazolium salts (1a–f), examining their design, synthesis, structure and anticancer activities. The structures of these salts (1a–f) were characterized using 1H, 13C NMR, elemental analysis, mass spectrometry and Fourier transform infrared (FT-IR) spectroscopies. The salts' cytotoxic activities were tested against cancer cell lines, specifically MCF-7, MDA-MB-231 and non-tumorigenic MCF-10A mammary cells. The study compared the impact of aliphatic and benzylic groups in the salts’ structure on their anticancer activity. Screening results revealed that compound 1c, in particular, showed promising inhibitory activity against the growth of MDA-MB-231 breast cancer cells, with an IC50 value of 12.8 ± 1.2 μM, indicating its potential as a chemotherapeutic agent. Cell apoptosis analysis demonstrated a tendency for compound 1c to induce early apoptosis in breast cancer cells. The stability/aquation of compound 1c was investigated using 1H NMR spectroscopy and its binding modes with DNA were explored via UV–Vis spectroscopy. Additionally, the study investigated the interaction residues and docking scores of compound 1c and the reference drug doxorubicin against Bax and Bcl-2 proteins using molecular docking. © Elsevier Masson SASItem The effects of input power and ambient temperature on the thermal performance of conical pin fin heat sink in natural convection(Elsevier Masson s.r.l., 2024) Çorumlu V.In the present study, thermal performance tests of horizontally oriented HSconical, HScross-cut, and HSflat with a base plate dimensions of 80*80*5 mm3 were performed in natural convection. The effects of ambient temperature (30 and 40 °C), input power (16.5 and 33 W), and conical pin fin geometry on the thermal performance of the HSs were investigated. The thermal resistance of the heat sinks decreases while the convective heat transfer coefficient, average surface temperature, and average junction temperature increase with increasing ambient temperature and input power. However, the Nusselt number increases with increasing ambient temperature for all HSs at 16.5 W, while the Nusselt number decreases with increasing ambient temperature at 33 W. The highest convective heat transfer coefficients are 32.17, 30.68, and 19.61 W/m2K for HSconical, HSflat, and HScross-cut at 33 W and 40 °C, respectively. The lowest thermal resistances are 2.75, 2.80, and 3.81 K/W for HSconical, HScross-cut, and HSflat at 33 W and 40 °C, respectively. Thermal resistances of HSconical and HScross-cut decreased by 27.78 % and 26.44 % at maximum and 27.06 % and 24.58 at minimum, respectively, compared to HSflat. The results show that the conical fins have better thermal performance in natural convection. © 2023 Elsevier Masson SASItem Predicting thyroid cancer ablation success: Pre-ablative 99mTc-Pertechnetate and post-ablative 131I scan comparison; [Prédiction du succès de l'ablation dans le cancer de la thyroïde : une comparaison de la scintigraphie pré-ablative à la 99mTc-pertechnétate et de la scintigraphie post-ablative au 131I](Elsevier Masson s.r.l., 2024) Mutevelizade G.; Parlak Y.; Bozdemir B.C.; Sezgin C.; Gumuser G.; Sayit E.Introduction: The purpose of this study was to evaluate the relationship between pre-ablative 99mTc-pertechnetate scintigraphy, and therapeutic iodine-131 (131I) whole-body scan (TxWBS), with ablation status and to investigate the possible predictive factors for successful ablation in differentiated thyroid carcinoma (DTC) patients. Materials and methods: A total of 330 DTC patients underwent 99mTc-pertechnetate scintigraphy after thyroidectomy. Uptake values were determined using the region-of-interest technique. All patients had neck ultrasonography and TxWBS. Both scintigraphic scans were interpreted visually and qualitatively. The ablation status was evaluated with a diagnostic 131I whole-body scan. Results: The success rate for residual thyroid ablation was 88.8%. The sensitivity, specificity, accuracy, PPV, and NPV of 99mTc-Pertechnetate scintigraphy were 82.4%, 87.5%, 82.7%, 99.2%, and 20.2%, respectively. Pre-ablative TG values and 99mTc uptake (%) were significantly lower in successfully ablated patients. The 99mTc uptake was determined as a significant predictive factor for ablation success (P = 0.000). The optimal 99mTc uptake cut-off value of 0.75% was demonstrated for successful ablation. There were significant positive correlations between the visual and the calculated uptake (%) of residual tissues on both scintigraphic scans, Considering the number of remnant tissue foci, significant positive correlations were found between 99mTc-Pertechnetate scintigraphy, TxWBS, and USG. Conclusion: Pre-ablative 99mTc-Pertechnetate uptake (%) value of the remnant tissue can predict the ablation status in DTC patients. 99mTc-Pertechnetate scintigraphy, which is an easily applicable and accessible imaging method, has maintained its place in the postoperative and pre-ablative period in DTC patients over the years and has not lost any of its value. © 2024 Elsevier Masson SASItem Splenosis imaging with 99mTc nano-colloid as a different mimicker in a lymphoma patient on 18F- FDG PET/CT; [Scintigraphie aux nanocolloïdes-33mTc pour différencier une splénose d'un ganglion lymphatique fixant le 18F-FDG](Elsevier Masson s.r.l., 2024) Sezgin C.; Parlak Y.; Mutevelizade G.; Gumuser G.; Sayit E.Fluorodeoxyglucose (FDG) 18F-FDG PET/CT plays an important role in lymphoma staging and evaluation of treatment response. Mimics should be considered when evaluating 18F-FDG PET/CT images to perform correct staging and correct treatment response evaluation. Splenosis is one of the causes that may cause misinterpretation by mixing with lymph nodes in lymphoma patients. In our case report, we visualized splenosis mimicking lymph node in a 50-year-old lymphoma patient with 99mTc nano-colloid scintigraphy. © 2024 Elsevier Masson SASItem Influence of gender on Behçet's disease phenotype and irreversible organ damage: Data from the International AIDA Network Behçet's Disease Registry(Elsevier Masson s.r.l., 2025) Sota J.; Ragab G.; AlMaglouth I.; Lopalco G.; Tufan A.; Direskeneli H.; Hinojosa-Azaola A.; Mayrink Giardini H.A.; Guerriero S.; Triggianese P.; Sfikakis P.P.; Piga M.; Ruscitti P.; Govoni M.; Iagnocco A.; Carubbi F.; Hernández-Rodríguez J.; Laymouna A.H.; Mahmoud A.A.-M.A.; Ghanema M.; Aboabat A.A.; Asfina K.N.; Alanazi F.; Morrone M.; Spedicato V.; Kucuk H.; Kardas R.; Alibaz Öner F.; Sevik G.; Torres-Ruiz J.; Kawakami-Campos P.A.; Parente de Brito Antonelli I.; Dammacco R.; Chimenti M.S.; Arida K.; Floris A.; Gentile M.; Ruffilli F.; Bellis E.; Alunno A.; Espinosa G.; Gentileschi S.; Gaggiano C.; Vitale A.; Caggiano V.; Lopez R.; Tarsia M.; Monti S.; Hatemi G.; Karakoç A.; Frassi M.; Giacomelli R.; Tharwat S.; Thabet M.; Ciccia F.; Emmi G.; Viapiana O.; Şahin A.; Sebastiani G.D.; Batu E.D.; Ozen S.; Sener S.; Opris-Belinski D.; Costi S.; Conforti A.; Cattalini M.; Bartoloni E.; Akkoç N.; Gunduz O.S.; Conti G.; Maier A.; Giardina A.; Li Gobbi F.; Parronchi P.; Sarzi Puttini P.; Breda L.; De Paulis A.; Carreño E.; La Torre F.; Więsik-Scewczyk E.; de-la Torre A.; Mejía-Salgado G.; Shahram F.; Guiducci S.; Maggio M.C.; Aragona E.; Rigante D.; Ciavarro A.; Önen F.; Erten; Insalaco A.; Del Giudice E.; Barone P.; Gicchino F.; Brucato A.; Lo Gullo A.; Mauro A.; Karamanakos A.; Balistreri A.; Mazzei M.A.; Frediani B.; Fabiani C.; Cantarini L.Objectives: Gender impact on phenotypical expression of Behçet's disease (BD) has been specifically investigated only in a few large-scale studies. The main goal of the study was to examine gender differences in a large cohort of patients affected by BD. Methods: Data were retrieved from the International AIDA Network Registry for BD. We assessed differences between males and females in terms of Behçet's syndrome Overall Damage Index (BODI), differences in the disease manifestations at onset and in the cumulative manifestations throughout disease course, as well as differences in the cardiovascular risk. Finally, predictive factors leading to major organ involvement were investigated. Results: In total, 1024 BD patients (567 males, 457 females) were enrolled in the study, with a male-to-female ratio of 1.24/1. Males displayed a significantly higher mean ± SD BODI (1.92 ± 2.09) at the last follow-up, compared to female patients (1.25 ± 1.87) (P < 0.0001). Uveitis (P < 0.0001) and vascular involvement (P = 0.0076) were significantly more frequent among males whereas female patients were significantly over-represented in arthralgia (P < 0.0001), arthritis (P = 0.00025), isolated headache (P < 0.0001), central nervous system (CNS) involvement (P = 0.040), and gastrointestinal involvement (P = 0.00046). Regarding cardiovascular risk, no differences between the two groups emerged (P = 0.617). Four variables were associated with the development of major organ involvement: male gender (OR = 2.104, P = 0.001), current treatment with biologic agents (OR = 2.257, P = 0.0003), origin from endemic countries (OR = 2.661, P = 0.0009), and disease duration (OR = 1.002, P = 0.024). Conclusion: BD displays a more severe course among males. This subgroup develops more irreversible damage and presents more frequently ocular and vascular involvement during disease course. On the other hand, female patients are prone to experience articular involvement, headache, CNS and gastrointestinal involvement. These data suggest the existence of a gender-driven disease expression. © 2024 The Author(s)