Browsing by Publisher "Har Krishan Bhalla and Sons"

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    Effect of Herbal Essential Oil mixture on Intestinal Mucosal Development, Growth Performance, and Weights of Internal Organs of Quails
    (Har Krishan Bhalla and Sons, 2014) Çabuk M.; Eratak S.; Alçiçek A.; Tuglu I.
    Abstract: The aim of this study was to examine the effects of herbal essential oil mixture on intestinal mucosal development, weights of the internal organs, carcass characteristics, and growth performance of quail (Coturnix coturnix japonica). A total of 276 quails that were 1 day old were studied. The quails were weighed and divided into 3 groups, each with 4 replicates, consisting of a control, antibiotic (avilamycin 10 mg/kg diet), and the essential oil mixture (EOM) at 48 mg/kg diet. Supplementation with EOM and antibiotic significantly increased goblet cell size and goblet cell number on day 38. Villi height, villi width, and crypt depth were not affected by any treatment. Quails receiving the diet containing EOM and antibiotic were significantly heavier than those fed the control diet on days 28 and 38. No significant effects of the dietary treatments on feed intake were observed. Moreover, addition of EOM and antibiotic to the quail diet resulted in a significantly better feed conversion ratio than that of the control on days 28 and 38. No differences were observed for carcass yield or liver, gizzard, and small intestine weights. Beneficial effects of the EOM were observed in goblet cells of the intestinal mucosa. © 2014, © 2014 Har Krishan Bhalla & Sons.
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    Antiproliferative, antioxidant and anti-inflammatory effects of Boswellia Sacra on human pancreatic cancer cells
    (Har Krishan Bhalla and Sons, 2023) Becer E.; Altundag E.M.; Özbilenler C.; Vatansever H.S.; Baser K.H.C.
    Pancreatic cancer is a highly lethal and malignant tumor with high occurrence worldwide. Natural products such as essential oils with a lack of side effects may benefit pancreatic cancer supplementary therapy. Essential oil of BS was prepared by distillation of the gum resin and also has been shown to have anti-cancer and antioxidant activities. The present study aimed to determine the anti-cancer, antioxidant and anti-inflammatory activities in PANC-1 cells. Chemical Functional Moieties of Boswellia sacra essential oil were determined by Fourier transform infrared (FTIR) spectroscopy. The essential oil was simultaneously analyzed by GC/MS and GC-FID. Cell viability was determined by MTT assay. Anti-cancer activity of BS essential oil was investigated by immunocytochemistry using antibodies against STAT-3, IHH, β-catenin, CD133, and Ki-67. The antioxidant activity of BS essential oil was tested by DPPH method. 41 compounds were identified in the essential oil. The IC50 value of BS essential oil was found as 130 μg/mL in PANC-1 cells. Ki-67 immunoreactivity significantly decreased in BS essential oil-treated PANC-1 cells. STAT-3 and β-catenin immunoreactivities significantly increased in BS essential oil-treated PANC-1 cells. Also, BS essential oil showed antioxidant and anti-inflammatory activities. We conclude that BS essential oil may suppress proliferation via the β-catenin activation pathway in PANC-1 cells. © 2023 Har Krishan Bhalla & Sons.