Browsing by Publisher "IOS Press BV"
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Item Disodium pentaborate decahydrate (DPD) induced apoptosis by decreasing hTERT enzyme activity and disrupting F-actin organization of prostate cancer cells(IOS Press BV, 2014) Korkmaz M.; Avcı C.B.; Gunduz C.; Aygunes D.; Erbaykent-Tepedelen B.Animal and cell culture studies have showed that boron and its derivativesmay be promising anticancer agents in prostate cancer treatment. Thus, DU145 cells were treated with disodium pentaborate decahydrate (DPD) for 24, 48, and 72 h in order to investigate the inhibitor effect and mechanisms of DPD. Then, cell proliferation, telomerase enzyme activity, actin polymerization, and apoptosis were detected by WST-1 assay, qRT-PCR, immunofluorescence labeling, and flow cytometry, respectively. We found that DPD inhibited the growth of human prostate cancer cell line DU145 at the concentration of 3.5 mM for 24 h. Our results demonstrated that 7 mM of DPD treatment prevented the telomerase enzyme activity at the rate of 38%. Furthermore, DPD has an apoptotic effect on DU145 cells which were examined by labeling DNA breaks. With 7 mM of DPD treatment, 8, 14, and 41% of apoptotic cells were detected for 24, 48, and 72 h, respectively. Additionally, immunofluorescence labeling showed that the normal organization of actin filaments was disrupted in DPD-exposed cells, which is accompanied by the alteration of cell shape and by apoptosis in targeted cells. Taken together, the results indicate that DPD may exert its cytotoxicity at least partly by interfering with the dynamic properties of actin polymerization and decreasing the telomerase activity. Eventually, for the first time, the results of this study showed that DPD suppressed the activity of telomerase in DU145 cells, and therefore, we suggested that DPD could be an important agent for its therapeutic potential in the treatment of prostate cancer. © International Society of Oncology and BioMarkers (ISOBM) 2013.Item Capsaicin inhibits cell proliferation by cytochrome c release in gastric cancer cells(IOS Press BV, 2014) Meral O.; Alpay M.; Kismali G.; Kosova F.; Cakir D.U.; Pekcan M.; Yigit S.; Sel T.Capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide) is the principal pungent component in hot peppers. The role of capsaicin in carcinogenesis is quite controversial. Although some investigators suspect that capsaicin is a carcinogen, co-carcinogen, or tumor promoter, others have reported that it has chemopreventive and chemotherapeutic effects. The present study aimed to evaluate the cytotoxicity and chemosensitizing activities of capsaicin alone and on 5-flourouracil (5-FU)-treated gastric cancer cells. In this study, the gastric cancer cell line HGC-27 was used and capsaicin used as a chemosensitizer and 5-flourouracil (5-FU) was used as chemotherapeutic. Cytotoxicity and chemosensitizing activities were analyzed with MTT assay; supernatant levels of LDH and glucose were detected as biochemical markers of cell viability; cytochrome c and AIF were evaluated with western blot; and additionally, wound-healing assays were employed. Results suggested that capsaicin had significant anticancer abilities; such capsaicin were capable of causing multifold decreases in the half maximal inhibitory concentration IC50 value of 5-FU. The continuing controversy surrounding consumption or topical application of capsaicin clearly suggests that more well-controlled epidemiologic studies are needed to evaluate the safety and efficacy of capsaicin use. In summary, the present study demonstrated that capsaicin has the potential to be used for treating gastric carcinoma with 5-FU in vitro. © 2014 International Society of Oncology and BioMarkers (ISOBM).Item Possible relations between oxidative damage and apoptosis in benign prostate hyperplasia and prostate cancer patients(IOS Press BV, 2014) Kosova F.; Temeltaş G.; Arı Z.; Lekili M.Cancer has been described as the twentieth century plague, and is a very common health problem. It has been reported that ROS and ROS products play a key role in cancer and that oxidative damage is effective in apoptosis initiation. In this study we aimed to evaluate the relationship between MDA (malondialdehyde), DNA damage (8-hydroxyguanine, 8-OH-dG), and caspase-3 in BHP and prostate cancer patients. Twenty male patients with prostate cancer and 20 male patients with benign prostate hyperplasia were included into this study. The MDA (nanomole), DNA damage (nanograms per millilitre), and caspase-3 (nanograms per millilitre) levels were measured in prostate cancer and benign prostate hyperplasia using Elisa kits (Millipore Corporation, Billerica, MA, USA). In the prostate cancer group, serum MDA (30.96± 9.25) and DNA damage (4.42±0.36) levels were significantly raised (p <0.05) when compared to the benign prostate hyperplasia group (24.05±8.06, 3.99±0.54). However, in the prostate cancer group, serum caspase-3 (2.36±0.82) levels were statistically significantly lowered (p <0.05) compared with the benign prostate hyperplasia group (3.15±1.04). We observed that altered prooxidant, DNA damage levels may lead to an increase in oxidative damage and may consequently play an important role in prostate carcinogenesis. These findings indicate that, although the triggering of these changes is unknown, changes in the levels of MDA, DNA damage, and caspase-3 in the blood are related to prostatic carcinoma development. In addition, it would be appropriate to conduct new studies with a large number of patients at different stages. © International Society of Oncology and BioMarkers (ISOBM) 2013.Item Integration of fuzzy analytic hierarchy process and multi-objective fuzzy goal programming for selection problems: An application on roadheader selection(IOS Press BV, 2015) Ozfirat P.M.; Ozfirat M.K.; Malli T.; Kahraman B.In this study a general methodology employing fuzzy analytic hierarchy process and fuzzy goal programming is developed for selection problems. The proposed methodology has two main sub-phases. In the first phase, fuzzy triangular numbers are used in order to represent the comparisons among decision criteria. Then lower and upper bounds as well as mid-values of priorities belonging to each decision criteria are computed. In the second phase these values and fuzzy triangular numbers are entered into the goal programming model and the model is solved to give the final priorities of decision criteria. Then the weighted sum of ratings for each selection alternative are found where the weights are final priorities from goal programming model. The proposed methodology is presented on a real life roadheader selection problem from mining industry. The results revealed that the methodology is easily applicable and provides satisfactory results. © 2015 - IOS Press and the authors. All rights reserved.Item Behavioural Representation of the Aorta by Utilizing Windkessel and Agent-Based Modelling(IOS Press BV, 2021) Emek S.; Bora S.; Evren V.; Çakirlar I.The main objective of the present paper is to report two studies on mathematical and computational techniques used to model the behaviour of the aorta in the human cardiovascular system. In this paper, an account of the design and implementation of two distinct models is presented: a Windkessel model and an agent-based model. Windkessel model represents the left heart and arterial system of the cardiovascular system in the physiological domain. The agent-based model offers a simplified account of arterial behaviour by randomly generating arterial parameter values. This study has described the mechanism how and when the left heart contracts and pumps the blood out of the aorta, and it has taken the Windkessel model one step further. The results of this study show that the dynamics of the aorta can be explored in each modelling approaches as proposed and implemented by our research group. It is thought that this study will contribute to the literature in terms of development of the Windkessel model by considering its timing and redesigning it with digital electronics perspective. © 2021 Vilnius University.Item Tauberian theorems for statistical Cesàro and statistical logarithmic summability of sequences in intuitionistic fuzzy normed spaces(IOS Press BV, 2021) Yavuz E.We define statistical Cesàro and statistical logarithmic summability methods of sequences in intuitionistic fuzzy normed spaces(IFNS) and give slowly oscillating type and Hardy type Tauberian conditions under which statistical Cesàro summability and statistical logarithmic summability imply convergence in IFNS. Besides, we obtain analogous results for the higher order summability methods as corollaries. Also, two theorems concerning the convergence of statistically convergent sequences in IFNS are proved in the paper. © 2021 - IOS Press. All rights reserved.Item A low-cost air quality monitoring system based on Internet of Things for smart homes(IOS Press BV, 2022) Taştan M.Global climate change and COVID-19 have changed our social and business life. People spend most of their daily lives indoors. Low-cost devices can monitor indoor air quality (IAQ) and reduce health problems caused by air pollutants. This study proposes a real-time and low-cost air quality monitoring system for smart homes based on Internet of Things (IoT). The developed IoT-based monitoring system is portable and provides users with real-time data transfer about IAQ. During the COVID-19 period, air quality data were collected from the kitchen, bedroom and balcony of their home, where a family of 5 spend most of their time. As a result of the analyzes, it has been determined that indoor particulate matter is mainly caused by outdoor infiltration and cooking emissions, and the CO2 value can rise well above the permissible health limits in case of insufficient ventilation due to night sleep activity. The obtained results show that the developed measuring devices may be suitable for measurement-based indoor air quality management. In addition, the proposed low-cost measurement system compared to existing systems; It has advantages such as modularity, scalability, low cost, portability, easy installation and open-source technologies. © 2022 - IOS Press. All rights reserved.Item Relationships between nurse managers' person-organization fit, person-job fit, and cultural values in Turkey(IOS Press BV, 2023) Bilgin N.; Kutlu A.While individuals' thoughts and behaviors are shaped according to their environment's cultural characteristics, the managers' values also shape organizational culture. Therefore, the concepts of person-organization fit and person-job fit can also be affected by the managers' culture. OBJECTIVE: This research aimed to examine the relationships between organization, job fit and cultural values of nurse managers working in university hospitals in Turkey. METHODS: This research is a cross-sectional analytical study. The research sample comprised 391 nurse managers working in the 20 university hospitals in Turkey. The research data were collected via an information form, individual cultural values scale, person-organization fit scale (POFS), and person-job fit scale (PJFS). Descriptive statistics were computed to define demographic characteristics. Spearman's correlation coefficient was used to evaluate the relationship between numeric variables. RESULTS: The means of the nurse managers' power distance, uncertainty avoidance, collectivism, masculinity, long-term orientation scores were 3.03, 5.98, 5.34, 3.02, and 5.60, respectively. The means of the nurse managers' POFS and PJFS scores were 3.33 and 4.13, respectively. There was a positive relationship among power distance and long-term orientation dimensions and person-organization fit, while there was a negative relationship between the masculinity dimension and person-job fit (p < 0.05). CONCLUSIONS: This study found that the nurse managers' individual cultural values were related to the organization and job fit. In this context, it is worth considering the individuals' cultural values in nurse recruitment and selection processes. © 2023 - IOS Press. All rights reserved.Item Soft isomorphism for digital images and computational topological applications(IOS Press BV, 2023) Öztunç S.; İhtiyar S.In this paper the concept of soft continuity is focused on for digital images by using soft sets which is defined on κ - adjacent digital images. Also the definitions of digital soft isomorphism and digital soft retraction are given. Some theorems are obtained deal with soft isomorphism and soft retraction for digital images and some numerical examples are presented in dimension 2. Finally digital soft retraction is obtained as a soft topological invariant. © 2023 - IOS Press. All rights reserved.Item Lacunary statistical convergence on d - fuzzy normed space(IOS Press BV, 2024) Yapali R.; Korkmaz E.; Çinar M.; Çoskun H.The idea of lacunary statistical convergence sequences, which is a development of statistical convergence, is examined and expanded in this study on Ⅎ - fuzzy normed spaces, which is a generalization of fuzzy spaces. On Ⅎ - fuzzy normed spaces, the definitions of lacunary statistical Cauchy and completeness, as well as associated theorems, are provided. The link between lacunary statistical Cauchyness and lacunary statistical boundedness with regard to Ⅎ - fuzzy norm is also shown. © 2024 - IOS Press. All rights reserved.Item The effect of pre- and post COVID-19 hazard and risk management of nurses on performance evaluation(IOS Press BV, 2024) Bingöl Ü.; Kutlu A.BACKGROUND: It is important to identify the hazards encountered by nurses before and after COVID-19, assess the potential risks and risk levels, take measures for the identified hazards and risks, and determine the effect of risk management on employee performance evaluation. OBJECTIVE: The aim of this study was to determine the effect of hazard and risk management of nurses before and after COVID-19 on performance evaluation. METHODS: The study consisted of two stages. The first stage had a descriptive design, while the second stage had a one-group pre-test and post-test design. The second stage of the study was conducted during the COVID-19 pandemic. There were 377 nurses who agreed to participate in the study in the first stage and 201 nurses in the second stage. The study data was collected via Information Form, Hazard and Risk Identification Form, and Employee Performance Scale (EPS). In the second stage of the study, training was provided using instruction cards called 'Means of Protection Against Hazards and Risks' for potential moderate- and high-level hazards and risks existing after the pre-test. The post-test stage was conducted two weeks after the training. Mann-Whitney U Test, Kruskal-Wallis Test, and Spearman's correlation coefficients were used for statistical analyses of descriptive statistics. RESULTS: The mean EPS score was found to be pre training 3,85±0,60, after training was found to be 3.92±0.55. Moreover, there was a weak negative correlation between pre- and post-training risk levels during the COVID-19 pandemic. CONCLUSION: Hazard and risk management training had a positive effect on the performance of employees. © 2024 - IOS Press. All rights reserved.