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Item Terlemez quartz monzonite of Central Anatolia (Aksaray-Sarikaraman): Age, petrogenesis and geotectonic implications for ophiolite emplacement(John Wiley and Sons Ltd, 1999) Yaliniz K.M.; Aydin N.S.; Göncüoǧlu M.C.; Parlak O.The Terlemez quartz monzonite is one of the Central Anatolian Granitoids and is exposed to the east of one of the main granitoid belts trending in a NW-SE direction and situated at the western end of the Central Anatolian Crystalline Complex. The Terlemez quartz monzonite is medium- to coarse-grained with granoblastic texture. It is essentially composed of quartz, plagioclase, hornblende and K-feldspar and variable contents of biotite. It is mostly compact and massive, but close to the contact with the ophiolitic basic rocks it shows a chilled margin. It characteristically includes K-feldspar megacrysts up to 3 cm in width and 10 cm in length, and contains irregular, angular or sub-rounded micromafic granular enclaves as well as xenoliths and large 'roof-pendants' of gabbroic composition derived from the Sarikaraman Ophiolite, which is the most representative member of the supra-subduction zone type of Central Anatolian Ophiolites. The Terlemez quartz monzonite is a calc-alkaline, metaluminous intrusion. It typically displays moderately developed negative Ba and Nb trace element anomalies and enrichment in light rare earth elements relative to heavy rare earth elements without any significant Eu, Sr and Ti anomalies. On the basis of field, petrographic and geochemical data, the Terlemez quartz monzonite has been classified as H-type (hybrid type), which requires significant input from a mantle-derived mafic magma. The intrusion represents the advanced stage of the post-collisional magmatism of the Central Anatolian Crystalline Complex. Unlike the other Central Anatolian Granitoids, the Terlemez quartz monzonite has a clear intrusive contact with the well studied Middle Turonian-Lower Santonian Sarikaraman Ophiolite. The K-Ar hornblende age obtained from the quartz monzonite (81.5 ± 1.9 Ma) is interpreted as the intrusion age. These data suggest a post-Early Santonian to pre-Early Campanian emplacement age for the supra-subduction zone type of Central Anatolian Ophiolites. The data further suggest that the post-collisional magmatism in Central Anatolia post-dates the emplacement of fore arc-type ophiolites onto the passive margin of the Tauride-Anatolide platform. The very short time interval between the formation and emplacement ages of supra-subduction zone-type ophiolites seems to be a very typical feature of the fore arc-type Eastern Mediterranean Ophiolites.Item Impetigo herpetiformis at the 36th week of gestation(John Wiley and Sons Ltd, 2000) Aka N.; Kuşcu N.K.; Yaziciolu E.[No abstract available]Item Formation and emplacement ages of the SSZ-type Neotethyan ophiolites in Central Anatolia, Turkey: Palaeotectonic implications(John Wiley and Sons Ltd, 2000) Yaliniz M.K.; Göncüoglu M.C.; Özkan-Altiner S.Isolated outcrops of ophiolitic rocks, termed the Central Anatolian Ophiolites, are found as allochthonous bodies in the Central Anatolian Crystalline Complex, that represent the metamorphosed passive northern edge of the Tauride-Anatolide Platform, central Turkey. In terms of pseudostratigraphic relationships of the magmatic units and their chemical designation, the Central Anatolian Ophiolites exhibit a supra-subduction zone (fore-arc) setting within the Vardar-Izmir-Ankara-Erzincan segment of the Neotethys. The epi-ophiolitic sedimentary cover of the Central Anatolian Ophiolites is generally characterized by epiclastic volcanogenic deep-sea sediments and debris flows intercalated with pelagic units. The richest and most significant planktonic foraminiferal association recorded from the lowest pelagic members infer a formation age of early-middle Turonian to early Santonian. K/Ar ages of post-collisional granitoids (81-65 Ma) intruding the basement rocks as well as the Central Anatolian Ophiolites suggest a post-early Santonian to pre-middle Campanian emplacement age. The marked high volume of epiclastic volcanogenic sediments intercalculated with the pelagics of the Central Anatolian Ophiolite is suggestive of rifting in a marginal sea adjacent to a volcanic arc. Penecontemporaneous tectonism is reflected in repetitions in the stratigraphy and in debris flows, which result from major slides and mass-gravity reworking of pre-existing units and of arc-derived volcanics and sediments. Correlating the rock units and formation/obduction ages of the Central Anatolian Ophiolites with further supra-subduction zone type ophiolites in the eastern (Turkey) and western (Greece) parts of the Vardar-Izmir-Ankara-Erzincan segment of Neotethys we conclude that the intraoceanic subduction in the east is definitely younger and the closure history of this segment is more complex than previously suggested. Copyright (C) 2000 John Wiley and Sons, Ltd.Item Collagenase treatment of sore nipples(John Wiley and Sons Ltd, 2002) Kuşcu N.K; Koyuncu F.; Laçin S.[No abstract available]Item Celiac disease and polycystic ovary syndrome(John Wiley and Sons Ltd, 2002) Kuscu N.K; Akcali S.; Kucukmetin N.T.[No abstract available]Item Doppler sonographic assessment of posttraumatic reflex sympathetic dystrophy(John Wiley and Sons Ltd, 2003) Pekindil G.; Pekindil Y.; Sarikaya A.To reveal the arterial Doppler sonographic findings in cases of posttraumatic reflex sympathetic dystrophy. Methods. Eleven patients had hand reflex sympathetic dystrophy, and 9 had foot reflex sympathetic dystrophy. The duration of symptoms ranged from 1 to 28 weeks, and the history of fracture ranged from 6 to 48 weeks. Bilateral brachial or popliteal arteries proximal to injuries were evaluated by Doppler sonography with a 7.5-MHz linear transducer. All patients also had triphasic bone scintigraphy and extremity thermography. Results. Two patients had monophasic waveforms and 4 had low-pulsatility triphasic waveforms on the affected limbs when compared with the asymptomatic limbs. All opposite asymptomatic limbs had normal triphasic waveforms in these 6 cases. Spectral analysis revealed a loss or decrease of a normal reversed flow component with a reduced pulsatility index on the affected limb. Fourteen other patients had symmetric triphasic waveforms. We observed that the patients who had stage 1 reflex sympathetic dystrophy and warm limbs with durations of symptoms of more than 2 weeks had positive Doppler sonographic findings, whereas all patients with stage 2 reflex sympathetic dystrophy and all with normal skin temperature, regardless of stage, had normal waveforms. Conclusions. Doppler sonography revealed loss of normal triphasic arterial waveforms in some of the cases of stage 1 disease, whereas many cases of stage 1 disease and all cases of stage 2 disease had normal findings. Therefore, we think that Doppler sonography cannot be used for the diagnosis of reflex sympathetic dystrophy but may help in assessing hemodynamic stages of the disease.Item Mode of delivery and pelvic floor muscle strength and sexual function after childbirth(John Wiley and Sons Ltd, 2005) Baytur Y.B.; Deveci A.; Uyar Y.; Ozcakir H.T.; Kizilkaya S.; Caglar H.Objective: To investigate the respective roles of the mode of delivery and strength of pelvic floor muscles in the sexual function of women. Method: Thirty-two women who were delivered vaginally and 21 women who underwent cesarean delivery at the Celal Bayar University School of Medicine Obstetrics Department were enrolled in the study, and 15 nulliparas were recruited as controls. Sexual function was assessed in all women by a validated questionnaire (the Female Sexual Function Index). Desire, arousal, lubrication, orgasm, satisfaction, and pain were measured separately, and pelvic floor muscle strength was assessed by a perineometer. Sexual function was compared among the 3 groups. The correlation between pelvic floor muscle strength and sexual function was also investigated. Results: Pelvic floor muscle strength was significantly lower in the group vaginally delivered compared with the group delivered by cesarean section and the nulliparous group (P<0.05). There was no difference between the groups regarding sexual function (P>0.05), and there was also no correlation between sexual function and pelvic muscle strength. Conclusion: Pelvic floor muscle strength and mode of delivery did not affect sexual function in our study participants. The muscular component of female sexual function should be further investigated. © 2005 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.Item Perineometer and digital examination for assessment of pelvic floor strength(John Wiley and Sons Ltd, 2007) Uyar Y.; Baytur Y.B.; Inceboz U.[No abstract available]Item Endometrial fluid in postmenopausal women(John Wiley and Sons Ltd, 2009) Inceboz U.; Uyar Y.; Baytur Y.; Kandiloglu A.R.[No abstract available]Item A Turkish Gynecologic Oncology Group study of fertility-sparing treatment for early-stage endometrial cancer(John Wiley and Sons Ltd, 2012) Dursun P.; Erkanli S.; Güzel A.B.; Gultekin M.; Tarhan N.C.; Altundag O.; Demirkiran F.; Beşe T.; Yildirim Y.; Bozdag G.; Yarali H.; Simsek T.; Ozcelik B.; Ortaç F.; Taskin S.; Guvenal T.; Ozgul N.; Haberal A.; Vardar M.A.; Dede M.; Yenen M.; Altintas A.; Arvas M.; Ayhan A.Objective: To analyze the results of fertility-sparing treatment of early-stage endometrial cancer (EC) in patients treated at Turkish gynecologic oncology centers, and to present a review of the literature. Methods: Thirteen healthcare centers in Turkey were contacted to determine if they were eligible to participate in the study. Centers that were eligible and agreed to participate were sent a database form to record the demographic characteristics, clinicopathologic findings, and follow-up results for their EC patients. Results: Eleven Turkish healthcare centers provided data on 43 EC patients. Mean duration of treatment was 5 months and mean follow-up was 49 months. In total, 35 (81.4%) patients were tumor free following primary progesterone therapy. Mean time from the end of progesterone therapy to pregnancy was 10.6 ± 4.3 months (range, 3-18 months). Two patients had tumor recurrence during follow-up. The pregnancy rate among the 31 women who actively sought pregnancy was 41.9% (n = 13). Conclusion: Conservative management of early-stage EC in women of reproductive age using oral progestins was effective and did not compromise oncological outcome. Pregnancy in the study patients was achieved spontaneously and artificially. © 2012 International Federation of Gynecology and Obstetrics.Item Radiolabeling of new generation magnetic poly(HEMA-MAPA) nanoparticles with 131I and preliminary investigation of its radiopharmaceutical potential using albino Wistar rats(John Wiley and Sons Ltd, 2013) Avcibaşi U.; Demiroǧlu H.; Ediz M.; Akalin H.A.; Özçalişkan E.; Şenay H.; Türkcan C.; Özcan Y.; Akgöl S.; Avcibaşi N.In this study, N-methacryloyl-l-phenylalanine (MAPA) containing poly(2-hydroxyethylmethacrylate) (HEMA)-based magnetic poly(HEMA-MAPA) nanobeads [mag-poly(HEMA-MAPA)] were radiolabeled with 131I [ 131I-mag-poly(HEMA-MAPA)], and the radiopharmaceutical potential of 131I-mag-poly(HEMA-MAPA) was investigated. Quality control studies were carried out by radiochromatographic method to be sure that 131I binded to mag-poly(HEMA-MAPA) efficiently. In this sense, binding yield of 131I-mag-poly(HEMA-MAPA) was found to be about 95-100%. In addition to this, optimum radiodination conditions for 131I-mag-poly(HEMA- MAPA) were determined by thin-layer radiochromatography studies. In addition to thin-layer radiochromatography studies, lipophilicity (partition coefficient) and stability studies for 131I-mag-poly(HEMA-MAPA) were realized. It was determined that lipophilicities of mag-poly(HEMA-MAPA) and 131I-mag-poly(HEMA-MAPA) were 0.12 ± 0.01 and 1.79 ± 0.76 according to ACD/logP algorithm program, respectively. Stability of the radiolabeled compound was investigated in time intervals given as 0, 30, 60, 180, and 1440 min. It was found that 131I-mag-poly(HEMA-MAPA) existed as a stable complex in rat serum within 60 min. After that, biodistribution and scintigraphy studies were carried out by using albino Wistar rats. It was determined that the most important 131I activity uptake was observed in the breast, the ovary, and the pancreas. Scintigraphy studies well supported biodistribution results. Copyright © 2013 John Wiley & Sons, Ltd.Item Bernstein series solution of linear second-order partial differential equations with mixed conditions(John Wiley and Sons Ltd, 2014) Isik O.R.; Sezer M.; Guney Z.The purpose of this study is to present a new collocation method for numerical solution of linear PDEs under the most general conditions. The method is given with a priori error estimate. By using the residual correction procedure, the absolute error can be estimated. Also, one can specify the optimal truncation limit n, which gives better result in any norm. Finally, the effectiveness of the method is illustrated in some numerical experiments. Numerical results are consistent with the theoretical results. Copyright © 2013 John Wiley & Sons, Ltd.Item 99mTc-Doxycycline hyclate: A new radiolabeled antibiotic for bacterial infection imaging(John Wiley and Sons Ltd, 2014) Ilem-Özdemir D.; Asikoglu M.; Ozkilic H.; Yilmaz F.; Hosgor-Limoncu M.; Ayhan S.Radiolabeled antibiotics are promising radiopharmaceuticals for the precise diagnosis and detection of infectious lesions. Doxycycline Hyclate (DOX) was chosen to investigate new 99mTc-labeled antibacterial agent. Ready to use freeze dry kits were formulated with optimum labeling conditions. Human serum stability, sterility, and pyrogenicity of kits were estimated, and gamma scintigraphy, in vivo biodistribution, and histopathological studies with bacterial infected rats were performed. DOX were successfully labeled by 99mTc with high radiochemical purity, and the labeled compound was stable in human serum. Kits were sterile, pyrogen-free, and stable up to 6 months. Static images depicted rapid distribution throughout the body and high uptake in bacterial infected thigh muscle. The uptake ratios of radiopharmaceuticals in infected thigh muscle were found above 2 up to 5 h. Five hours after injection, the rats were sacrificed, and biodistribution was determined. Samples of bacterial infected muscle, healthy muscle, blood, liver, spleen, lung, kidney, stomach, intestine, urine and heart were weighed, and the radioactivity was measured by using a gamma counter. The %ID/g of 99mTc-DOX was found 0.23 ± 0.06 for infected thigh muscle. According to the imaging, biodistribution, and histopathological studies, the promising characteristics of 99mTc-DOX make the new radiopharmaceutical valuable to examine for future studies. Copyright © 2013 John Wiley & Sons, Ltd.Item An anticipated shear design method for reinforced concrete beams strengthened with anchoraged carbon fiber-reinforced polymer by using neural network(John Wiley and Sons Ltd, 2015) Tanarslan H.M.; Kumanlioglu A.; Sakar G.Using externally bonded carbon fiber-reinforced polymer (FRP) for strengthening has been turned into a popular decision owing to its mechanical leads. Consequently, design guidelines and researchers have established several analytical equations to predict the contribution of FRP to ultimate shear capacity. The developed analytical equations projected the influence of FRP reinforcements within certain limits. However, not mentioned parameters such as the shear span-to-depth ratio and anchorage application influence the ultimate behavior of strengthened specimens. Accordingly, distant predictions between test results and code predictions are observed for the specimens in whom anchorage is applied. As an alternative method, artificial neural network (NN) can be used to predict the contribution of anchoraged carbon FRP to shear strength of de ficient reinforced concrete beams. Accordingly, two NN models with backpropagation are developed in this study. Unlike the existing design codes, the model considers the effect of anchorage and the shear span-to-depth ratio at the ultimate state. Artificial NN model is trained, validated and tested using the literature of 79 reinforced concrete beams. Then, NN results are compared with those 'theoretical' predictions calculated directly from International Federation for Structural Concrete, the American guideline (ACI 440.2R) and the Australian guideline. Within all theoretical predictions of design guidelines, fib14 provided the best predictions according to experimental results. Consequently, 25% of fib14 predictions are within ±10% of the experimental results, and also, 65% of the fib14 predictions are within ±25% of the measured values. Besides, executed comparisons indicated that the NN model is more exact than the guideline equations with respect to the experimental results and can be applied effectively within the range of parameters covered in this study. Copyright © 2014 John Wiley & Sons, Ltd.Item Studies on luminescence from a cerium-doped strontium stannate phosphor(John Wiley and Sons Ltd, 2015) Karabulut Y.; Ayvacikli M.; Canimoglu A.; Garcia Guinea J.; Can N.The crystal structure and morphology of Ce3+-doped SrSnO3 materials prepared using the solid-state reaction method were extensively characterized using experimental techniques. X-Ray diffraction results show that the cerium substitution of strontium does not change the structure of the strontium stannate. Raman spectroscopy was used to investigate the microstructures and lattice vibrations. Environmental scanning electron microscopy images showed that phosphors aggregate and their particles form irregular shapes. SrSnO3 exhibits an intense green emission with a broad band originating from the 5d1 → 4f1 transition of cerium. It was observed that, after exposure to beta-irradiation, the glow curve of this material has two broad thermoluminescence peaks, one centered at ∼ 127C and the other at ∼ 245C for a heating rate of 5 K/s. The kinetic parameters, which include the frequency factor and the activation energy of the material, were calculated using Chen's method, after beta-irradiation. The fading and reusability of the phosphor were also studied and it was found that the phosphor is suitable for radiation dosimetry. Copyright © 2014 John Wiley & Sons, Ltd. Copyright © 2014 John Wiley & Sons, Ltd.Item First trimester ultrasound screening for Down syndrome based on maternal age, fetal nuchal translucency and different combinations of the additional markers nasal bone, tricuspid and ductus venosus flow(John Wiley and Sons Ltd, 2015) Abele H.; Wagner P.; Sonek J.; Hoopmann M.; Brucker S.; Artunc-Ulkumen B.; Kagan K.O.Objective: To examine the performance of screening for Down syndrome based on maternal age, fetal nuchal translucency (NT) and different combinations of the additional ultrasound parameters: nasal bone (NB), tricuspid flow (TF) and ductus venosus (DV). Methods: Retrospective study at the University of Tuebingen, Germany including women who underwent chorionic villous sampling between 2008 and 2014. Prior to invasive testing, the crown rump length, NT, NB, TF and DV were measured. In each case, the added value of the additional markers NB, TF and DV were compared with screening for trisomy 21 based on maternal age (MA) and NT thickness alone. Results: A total of 1916 pregnancies met the inclusion criteria, including 1823 fetuses with a normal karyotype and 93 with trisomy 21. Screening based on MA, fetal NT and one, two and three of the additional ultrasound markers resulted in a detection rate of about 80%, 87% and 94%, respectively for a false positive rate of 3%. Conclusion: Detection rates for trisomy 21 in first trimester ultrasound screening are substantially higher if all three additional markers rather than just one are assessed. © 2015 John Wiley & Sons, Ltd.Item Olive leaf extract improves the atherogenic lipid profile in rats fed a high cholesterol diet(John Wiley and Sons Ltd, 2015) Olmez E.; Vural K.; Gok S.; Ozturk Z.; Kayalar H.; Ayhan S.; Var A.Coronary heart disease because of atherosclerosis is still the most common cause of mortality. Elevated levels of low-density lipoprotein and total cholesterol are major risk factors for atherosclerotic cardiovascular disease. The aim of this study was to evaluate the effects of the olive leaf extract on serum lipid profile, early changes of atherosclerosis and endothelium-dependent relaxations in cholesterol-fed rats. For this purpose, rats were fed by 2% cholesterol-enriched or standard chow for 8-weeks. Some rats in each group were also fed orally by olive leaf extract at doses of 50 or 100-mg/kg/day. Atorvastatin at dose of 20-mg/kg of body weight daily was also given as positive control. After 8-weeks, lipid profiles of rat serums were analyzed. Antioxidant enzyme activities (superoxide dismutase and glutathione peroxidase) and degree of lipid peroxidation (malondialdehyde levels) were also measured in the hearts isolated from rats. In addition, expression of adhesion molecules and endothelium-dependent relaxations of isolated thoracic aortas of rats were evaluated. Total cholesterol and LDL-cholesterol levels were found to be increased in cholesterol-fed rats, and both doses of olive leaf extract and atorvastatin significantly decreased those levels. In conclusion, because the olive leaf extract attenuates the increased cholesterol levels, it may have beneficial effects on atherosclerosis. Copyright © 2015 John Wiley & Sons, Ltd.Item Multicenter retrospective analysis regarding the clinical manifestations and treatment results in patients with hairy cell leukemia: Twenty-four year Turkish experience in cladribine therapy(John Wiley and Sons Ltd, 2015) Hacioglu S.; Bilen Y.; Eser A.; Sivgin S.; Gurkan E.; Yildirim R.; Aydogdu I.; Dogu M.H.; Yilmaz M.; Kayikci O.; Tombak A.; Kuku I.; Celebi H.; Akay M.O.; Esen R.; Korkmaz S.; Keskin A.In this multicenter retrospective analysis, we aimed to present clinical, laboratory and treatment results of 94 patients with Hairy cell leukemia diagnosed in 13 centers between 1990 and 2014. Sixty-six of the patients were males and 28 were females, with a median age of 55. Splenomegaly was present in 93.5% of cases at diagnosis. The laboratory findings that came into prominence were pancytopenia with grade 3 bone marrow fibrosis. Most of the patients with an indication for treatment were treated with cladribine as first-line treatment. Total and complete response of cladribine was 97.3% and 80.7%. The relapse rate after cladribine was 16.6%, and treatment related mortality was 2.5%. Most preferred therapy (95%) was again cladribine at second-line, and third line with CR rate of 68.4% and 66.6%, respectively. The 28-month median OS was 91.7% in all patients and 25-month median OS 96% for patients who were given cladribine as first-line therapy. In conclusion, the first multicenter retrospective Turkish study where patients with HCL were followed up for a long period has revealed demographic characteristics of patients with HCL, and confirmed that cladribine treatment might be safe and effective in a relatively large series of the Turkish study population. © 2015 John Wiley & Sons, Ltd.Item Investigation of a historic masonry structure by numerical and operational modal analyses(John Wiley and Sons Ltd, 2015) Nohutcu H.; Demir A.; Ercan E.; Hokelekli E.; Altintas G.This paper presents the results of model calibration conducted on a historical mosque called Hafsa Sultan in Manisa, Turkey. The finite element model of the mosque was calibrated by the use of the results obtained from ambient vibration tests of the structure. In order to develop a solid model of the structure, the dimensions of the structure, defects such as cracks and material degradations in the structure, and the materials used in different parts were identified. For the evaluation of the material properties of the structure, nondestructive and destructive testing methods were used. The numerical and experimental modal parameters of the structure were obtained by finite element method (FEM) and Operational Modal Analysis (OMA), respectively. The natural frequencies and corresponding mode shapes were obtained from both FEM and OMA and compared with each other. While a good compatibility was achieved between mode shapes, some differences between natural frequencies occurred. It was thought that the differences resulted from variations in the Young's modulus of masonry, cracks in elements or boundary conditions. Therefore, the finite element model was calibrated by changing material parameters. Finally, a more realistic numerical model of the mosque was put forward and the results were discussed in detail. Copyright © 2015 John Wiley & Sons, Ltd.Item Thermally stimulated luminescence glow curve structure of β-irradiated CaB4O7:Dy(John Wiley and Sons Ltd, 2015) Akin A.; Ekdal E.; Tuncer Arslanlar Y.; Ayvaci M.; Karali T.; Can N.Thermally stimulated luminescence glow curves of CaB4O7:Dy samples after β-irradiation showed glow peaks at ∼335, 530 and 675 K, with a heating rate of 2 K/s. The main peak at 530 K was analyzed using the Tmax-Tstop method and was found to be composed of at least five overlapping glow peaks. A curve-fitting program was used to perform computerized glow curve deconvolution (CGCD) analysis of the complex peak of the dosimetric material of interest. The kinetic parameters, namely activation energy (E) and frequency factor (s), associated with the main glow peak of CaB4O7:Dy at 520 K were evaluated using peak shape (PS) and isothermal luminescence decay (ILD) methods. In addition, the kinetics was determined to be first order (b =1) by applying the additive dose method. The activation energies and frequency factors obtained using PS and ILD methods are calculated to be 0.72 and 0.72 eV and 8.76 × 105 and 1.44 × 106/s, respectively. Copyright © 2014 John Wiley & Sons, Ltd. Copyright © 2014 John Wiley & Sons, Ltd.