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Item Evaluation of sleep quality in mothers of children with bronchiolitis obliterans; [Bronşiyolitis obliteransli çocuklarin annelerinde uyku niteliǧinin deǧerlendirilmesi](Kare Publishing, 2009) Yüksel H.; Çiftdoǧan D.Y.; Yilmaz Ö.; Söǧüt A.Aim: The aim of this study was to evaluate the quality of sleep in mothers of children with bronchiolitis obliterans. Material and Method: The study group consisted of 36 mothers with a child who had bronchiolitis obliterans and 62 mothers with healthy children. All mothers enrolled in the study filled in the Pittsburgh Sleep Quality Index (PSQI). Results: The mean ages of the children of the mothers enrolled in the study were statistically similar (3.57±2.58 vs 3.85±1.46 years, p>0.05). Total Pittsburgh Sleep Quality Index scores and subjective sleep quality scores in the mothers of children with bronchiolitis obliterans were significantly higher than those in the mothers of healthy children (both p=0.015). Conclusions: In this study, it was found that mothers of children with bronchiolitis obliterans have poor sleep quality. Therefore, assessment may be needed for the requirement of support regarding sleep quality in them.Item Knowledge and practice of general pediatricians about childhood asthma and its treatment; [Genel çocuk uzmanlarinin çocukluk çaǧi astimi ve tedavisi konusundaki bilgi durumu ve uygulamalari](Kare Publishing, 2009) Yilmaz Ö.; Söǧüt A.; Alkan S.; Yüksel H.Aim:It is essential educate general pediatricians about childhood asthma and its treatment to standardize care. The aim of this study was to evaluate knowledge and practice of pediatricians about childhood asthma and its treatment. Material and Method:The study included 52 pediatricians who attended one of the seven meetings about asthma treatment. A questionnaire of 42 questions, 23 about asthma and its treatment and 19 about their practice were given before meeting. Results:Hospital of residency did not change answers to the questions, but presence of private office and duration of practice did. Among pediatricians who owned private office, 82.4% said the sentence:"systemic steroids have a role in acute asthma exacerbation treatment" was true, compared to the 47.1% of the ones without private office (p= 0.014). Referral to pediatric allergy center during or after acute asthma exacerbation was significantly lower among the pediatricians who owned private Office (p= 0.002 and p= 0.016 respectively). Duration of practice as a pediatrician influenced knowledge about use of inhaled steroids in asthma (p=.005). Conclusions:In conclusion, duration of practice and presence of private office influence knowledge and practice of general pediatricians about asthma and its treatment. The essence of postgraduate education to provide children more standardized treatment was emphasized with these results.Item Acute generalized exanthematous pustulosis due to amoxicilline-clavulanate; [Amoksisilin-klavulanata baǧli akut yaygin ekzantematöz püstüloz](Kare Publishing, 2010) Söǧüt A.; Yilmaz Ö.; Yildirim Ş.; Özen S.; Temiz P.; Yüksel H.Acute generalized exanthematous pustulosis is an uncommon clinical condition characterized by an acute onset of pustular eruptions. A case of acute generalized exanthematous pustulosis after the use of amoxicilline-clavulanate is presented. The patient presented with pustular and pruritic eruptions after use of drug. The diagnosis was confirmed with pathological data. This condition leading to various clinical manifestations should be thought in the differential diagnosis of pustular dermatosis.Item Attention deficit and hyperactivity symptoms in children with monosymptomatic nocturnal enuresis; [Monosemptomatik nokturnal enürezisi olan çocuklarda dikkat eksikliǧi ve hiperaktivite bulgulari](Kare Publishing, 2010) Ertan P.; Gönülal D.; Söǧüt A.; Yilmaz Ö.; Bozgül A.; Dinç G.; Aydemir Ö.; Yüksel H.Aim: Monosymptomatic nocturnal enuresis in children may cause psychological and behavioral problems. The aim of this study was to assess symptoms of attention deficit and hyperactivity in children with monosymptomatic nocturnal enuresis. Material and Method: Fifty-seven children (23 male, 34 female) with monosymptomatic nocturnal enuresis and 57 healthy controls (25 male, 32 female) aged 6 to 12 years participated in the study. Conners' Parent Rating Scale-48 (CPRS), a 48-item multiple-choice questionnaire, was completed by the mothers to identify the attention deficit and hyperactivity symptoms in children. Results: Mean age of the children with enuresis was 8.54±2.18 years and that of the control group 9.12±2.13 years. Attention deficit score in the enuretic group was significantly higher than that in the control group (p=0.02). Hyperactivity scores were not significantly different between the groups (p=0.36). Bedwetting frequencies were not different between enuretic children with and without attention deficit or hyperactivity symptoms (p=0.06). Conclusions: Psychological and behavioral assessment may be indicated in children with monosymptomatic nocturnal enuresis since the results of this study demonstrate increased attention deficit symptomatology.Item The prevalence of habitual snoring in Aegean region of Turkey and associated risk factors; [Türkiye'nin Ege bölgesinde alişkanlik haline gelmiş horlama sikliǧi ve ilişkili risk etkenleri](Kare Publishing, 2010) Yilmaz Ö.; Dinç G.; Söǧu A.; Aktulun Ş.; Arslan B.; Kocacan M.; Özdel B.; Özen S.; Yasli G.; Yüksel H.Aim: The aim of this study was to determine prevalence of snoring in children younger than 18 years of age and to identify associated risk factors and complications in a population based study. Material and Method: This cross sectional study was conducted in Manisa, Turkey. Questionnaires about snoring and associated risk factors were applied to 650 children who were determined using cluster sampling method (339 females, 311 males). Results: Prevalence of habitual snoring was 4.9%. Current history of wheezing or allergic rhinitis increased the odds of habitual snoring 3.1 times when compared to children without current wheezing (p=0.006; OR: 3.11, 95%CI: 1.3-7.3 and p=0.002; OR: 3.11, 95%CI: 1.5-6.6 respectively). Grade 3 tonsil hypertrophy increased odds of habitual snoring 22.5 times compared to no tonsil hypertrophy (p<0.001; OR: 22.4, 95%CI: 6.0-83.9). Nighttime symptoms like apnea were more frequent in habitual snorers when compared to non-snorers (28.1% vs 3.6%; p<0.001; OR: 10.5, 95%CI: 4.3-25.6). Conclusions: Current wheezing, allergic rhinitis and tonsil hypertrophy are significant risk factors for habitual snoring. Therefore, children with these disorders need to be assessed for snoring that may influence their development.Item Bronchiolitis in childhood: Updates on etiopathogenesis and immunologic lung injury; [Çocukluk çaǧinda bronşiyolitler: Etiopatojenez ve immünolojik akciǧer hasarindaki yenilikler](Kare Publishing, 2010) Yüksel H.; Türkeli A.; Yilmaz Ö.; Güler S.Acute bronchiolitis is a disease characterized with bronchiolar inflammation due to viral infections in children younger than two years that is associated with wheezing, cough, tachypnea, retractions and prolonged expiration. Many pathogens, among which respiratory syncytial virus is the most common, play role in the etiology. Cellular damage due to viral pathogens and anatomic and immunological factors of the host play a role in the development of lower respiratory tract infections only in some children exposed to respiratory syncytial virus and other viruses. Viral infections in children may change Th1/Th2 immune response pattern. Severity of disease changes with the degree of inflammation due to the immune response. Moreover, an increase in disease severity may be observed due to the activation of the non-adrenergic non-cholinergic neurogenic system. Severe RSV infections may develop in children with genetic predisposition. We explained the role of environmental factors, genetic and structural susceptibility of the host, and contribution of immunologic response in this susceptibility, in addition to the role of responsible infectious agents, in the development and severe progression of bronchiolitis.Item The child who pulls his little brothers' hair: A different trichotillomania case(Kare Publishing, 2012) Öyekçin D.G.; Şahin E.M.; Demet M.M.The child who pulls his little brothers' hair: a different trichotillomania case Trichotillomania (TTM) is a relatively common cause of childhood alopecia. We report our observations of 8 year old boy referred for consultation for a 4 year history of hair pulling, nail-biting, nose picking, nail picking and scalp-picking. The most commonly affected sites on the scalp were frontal region and vertex. He had started pulling his hair when he was an infant and had a very chronic, unremitting course. During the last two years, he began to pull his two little brothers' hair when they were playing together or when they were sleeping. Both of his both brothers had alopecia on their scalp. It was discovered that there were frequent arguments, violence and negative behaviors at home. Few cases are reported in the literature about children who pull their siblings' hair. We considered that impaired affective interpersonal communication between mother and child, physical and emotional neglect and childhood trauma might have played a role in the development of TTM for this case. In childhood trichotillomania cases, it is important to investigate whether the siblings have hair loss.Item Frequency of respiratory viruses in children with lower respiratory tract infection; [Alt solunum yolu enfeksiyonu olan çocuklarda solunum yolu viral etkenlerinin sıklıǧı](Kare Publishing, 2013) Akçali S.; Yilmaz N.; Güler Ö.; Şanlidaǧ T.; Anil M.Aim: Lower respiratory tract infections (LRTI) have high morbidity rates in children. In this study, it was aimed to investigate the prevalence of respiratory viruses in children with LRTI symptoms. Material and Method: A total of 160 children who were diagnosed with LRTI between October 2009 and March 2010 were included into the study. The presence of respiratory syncytial virus (RSV) (A+B), influenza virus (A+B), parainfluenza virus (PIV) (1, 2, 3, 4), human metapneumovirus, rhinovirus and coronavirus (OC43+229E) in throat swab samples were investigated by real-time PCR The RealAccurateTM Respiratory RT PCR Kit (PathoFinder B.V., Netherlands). Results: In 67 samples (41.8%), at least one virus which could cause acute respiratory tract infection was found. Overall, RSV was the most frequently identified virus (52.2%), followed by rhinovirus (26.8%), coronavirus (5%), metapneumovirus (2.9%) and PIV 1 (1.4%). As the other viral agents, coronavirus was detected in 4 samples (5%), hMPV was detected in 2 samples (2.9%) and PIV was detected in 1 sample (1.4%). When the frequency of coinfections was evaluated, RSV- rhinovirus association was found in 4 samples, RSV-coronavirus association was found in 1 sample, rhinovirus-coronavirus association was found in 1 sample and RSV-rhinovirus- Coronavirus association was found in 1 sample. Conclusions: In 41.8% of the study group, a viral factor responsible for the clinical signs was detected. For that reason, rapid and sensitive diagnosis of viruses which lead to respiratory infections will guide the clinician for avoidance of redundant antibiotic therapy and preventing viral hospital infections.Item Micturition syncope: Report of two cases(Kare Publishing, 2013) Sari U.S.; Kisabay A.; Selcuki D.Micturition syncope: report of two cases Syncope is a symptom which is a transient loss of consciousness and very common in society and is one of the most important referral causes to emergency services. Micturition syncope (MS) appears as a rare cause of neurally-mediated syncope. MS is caused by reflex which results with vasodilatation and bradycardia, like defecation syncope. In the clinical setting, the MS is presented with transient loss of consciousness during supine position or micturition following after a sleep period mostly in otherwise healthy men. It is a reflex state in which standing triggers vasodilatation and bradicardia. MS covers 2-8% of all syncopes. There is still no consensus about treatment and outcome of MS. In this article two male patients with MS are presented. With these two cases, we aimed to give detailed information about micturition syncope which is a rare type of syncope.Item Primary polydipsia case presenting with severe malnutrition; [Aǧır beslenme bozukluǧu ile başvuran birincil polidipsi olgusu](Kare Publishing, 2013) Şahin G.E.; Zorlu P.; Çaylan N.D.; Uçar Ş.; Açoǧlu E.A.; Şahin G.Primary polydipsia is a clinical status with excessive fluid consumption without any physiological need. A seventeen-month-old male infant with severe malnutrition and developmental retardation was found to have polyuria and polydipsia in the follow-up. The urine density was found to be 1001, Na was found to be 124 mEq/L and the serum and urine osmolarity was found to be low. The patient was diagnosed with primary polydipsia and was treated by gradually water restriction. This case is presented to emphasize that primary polydipsia changes nutritional habits which may lead to malnutrition and developmental retardation.Item Visfatin: A potential biomarker for the early diagnosis and monitoring of acute coronary syndrome(Kare Publishing, 2019) Guvenc Y.; Cuhadar S.; Bayturan O.; Ulman C.; Horasan G.D.; Utuk O.; Acar M.Objectives: Acute coronary syndrome (ACS) is a major cause of mortality and morbidity worldwide; thus, early diagnosis is very important. The most common cause of ACS is the rupture of a vulnerable atherosclerotic plaque in the coronary artery, an occurrence in which inflammation plays a key role. The aim of the present study was to investigate visfatin as a proinflammatory biomarker in the early diagnosis and monitoring of ACS and to compare visfatin’s relationship with troponin T, tumor necrosis factor-alpha (TNF-α), and creatine kinase-MB (CK-MB). Methods: Sixty ACS patients and 30 healthy control subjects were enrolled in this study. One blood sample was drawn from the control participants, and 3 were obtained from the ACS patients at intervals 0-6 hours (T0), 6-12 hours (T1), and 12-24 (T2) hours from the start of chest pain. Serum visfatin, TNF-α, troponin T, and CK-MB levels were assessed. Visfatin and TNF-α levels were assessed using enzyme-linked immunosorbent assay testing, troponin T was evaluated using chemiluminescence, and CK-MB by enzymatic methods. Results: Serum TNF-α, troponin T, and CK-MB levels in the T0 blood samples were statistically significantly higher in the ACS patients compared with the controls (p=0.004, p<0.001, p<0.001, respectively). A significant positive correlation was observed between visfatin and troponin T (r=0.290, p=0.007) in the T0 samples. Visfatin concentrations were lower in the ACS group in the T0, T1 and T2 samples [4.01±6.23ng/mL, 1.80±3.47 ng/mL, and 1.72±2.67ng/mL, respectively; p=0.005; T0 >(T1=T2)]. Conclusion: Visfatin had a significant positive correlation with troponin T. Visfatin did not demonstrate a rise and fall pattern like the standard biomarkers in terms of monitoring the progress of ACS patients, as there was a significant decrease after the first 6 hours. Although visfatin did not demonstrate superiority to troponin, its efficiency in a multimarker panel merits further evaluation. The role of visfatin in the early phase of pathophysiological mechanisms requires additional investigation. © 2018 by International Journal of Medical Biochemistry.Item An in Vitro Study in Which New Boron Derivatives Maybe an Option for Breast Cancer Treatment(Kare Publishing, 2019) Simsek F.; Inan S.; Korkmaz M.Objectives: We aimed to investigate the distribution of immunoreactivities of vascular endothelial growth factor (VEGF), endothelial nitric oxide synthase (eNOS), and inducible NOS (iNOS) on breast cancer cells in response to treatment with boron derivatives. Methods: We initially analyzed the cytotoxic effect and IC50 value of boron by MTT assay. For the evaluation of the angiogenesis, expression level of antibodies was detected to following boron derivatives such as boric acid, boron penta (BP), and T-Boron (DPD) in the absence of boron treatment using the indirect immunohistochemical method. The evaluation of these staining was done using the H-scoring system. Results: It was found that immunoreactivities of VEGF, eNOS, and iNOS increased on control compared to those of the cells of MDA-MB231 human breast cancer cell line. Following boron derivatives treatment, it was observed that they were inhibited the VEGF/NOS labeling in MDA-MB-231 breast cancer cells. Conclusion: The present data suggest that BP, especially DPD, inhibits the angiogenesis of breast cancer cells through VEGF pathway. From this point, these boron derivatives may provide a novel therapeutic approach for breast cancer treatment. © 2019, by Eurasian Journal of Medicine and Oncology.Item The investigation of the effects of the very and mild preterm birth on the musculoskeletal system(Kare Publishing, 2020) Karaali H.K.; Savci S.; Özden A.; Gencoglu C.; Duman N.Objectives: The aim of study was to examine the musculoskeletal system of the very preterm (VP) and mild preterm (MP) born children and to compare them with their term born peers. Methods: Children born with VP and MP between January 1998 and April 2003, whose contact information was available from patient records, were included in our study. The control group consisted of volunteers who were admitted to the Department of Child Health and Diseases during the study. Skeletal muscle mass, fat free mass, posture and physical fitness of all participants were assessed. Results: Eighteen (28.2%) VP, 23 (35.9%) MP and 23 (35.9%) term born children were included in this study. Total posture score was 6.0 [3.5] in the VP group, 5.0 [5.0] in the MP group and 4.0 [2.0] in the term group and the difference between VP and term group was significant (p=0.004). Munich Physical Fitness Test score was 44.0±6.3 in the VP group, 45.6±4.8 in the MP group and 51.9±3.8 in the term group and the difference between VP and term groups and between MP and term groups was significant (p=0.001 and p=0.001, respectively). Conclusion: The musculoskeletal system of the VP and MP born school age children is affected negatively in comparison to their term peers. This situation suggests that very and MP born children later on may have potential health problems originated from musculoskeletal system. © 2020 by Anatolian Journal of Family Medicine.Item Disease burden and associated factors in caregivers of patients with obsessive-compulsive disorder(Kare Publishing, 2020) Suculluoglu-Dikici D.; Cokmus F.P.; Akin F.; Eser E.; Demet M.M.Objective: Obsessive-compulsive disorder (OCD) is one of the leading causes of disability and poor quality of life, with impairment in many areas. It can also adversely affect family members and friends that the person lives with, and this results in a burden. We aimed to evaluate the disease burden in caregivers of patients with OCD and the factors that negatively affect caregiver burden. Method: The study population consisted of 94 patients with OCD and their caregivers. The Yale-Brown Obsessive-Compulsive Scale (YBOCS), the Hamilton Depression Rating Scale, and the World Health Organization Quality of Life Questionnaire Brief Form were filled out by the patients, and the Burden Assessment Scale (BAS) by the caregivers. Results: Longer duration of treatment, higher YBOCS obsession and compulsion scores of the patients, and lower environmental quality of life dimension scores of the patients were found to increase the BAS scores of the caregivers. Additionally, these variables were found to be significant predictors for disease burden (BAS score) (p<0.05). Conclusion: Our study revealed that many variables affect burden, even in caregivers who have no extra burden (who has no disease to cause a burden). Caregivers of patients with OCD should be included in the behavioral and pharmacologic treatment process for the benefit of both the OCD treatment management and the protection of family health. © 2020 Yerkure Tanitim ve Yayincilik Hizmetleri A.S.. All rights reserved.Item Behavioral characteristics of children with type-1 diabetes and the effect of family attitudes on dietary adherence problems(Kare Publishing, 2021) Onen O.; Nalbantoglu O.; Erkuran H.O.; Sapmaz S.Y.; Erbas M.; Arslan G.; Ozkan B.Objective: Assessing the behavioral characteristics and family attitudes of children and adolescents in diabetes is linked to determining the reasons for difficulties in dietary adherence. Our aim was to assess the relationship between behavioral characteristics, family attitudes in children diagnosed with type 1 diabetes mellitus (T1DM), and the dietary adherence and glycemic control. Method: Fifty-four patients T1DM patients and 47 controls aged 7-18 years were included in the study together with their parents. Among the patients diagnosed with T1DM followed in the Pediatric Endocrinology Outpatient Clinic, those with high HbA1c levels (with poor dietary compliance) and those with a HbA1c level below 7.5 (with good dietary compliance) were included in the study as the patient and control group, respectively. A psychiatric assessment interview was conducted with both groups. Sociodemographic data and information on diabetes-related variables, Strengths and Difficulties Questionnaire and Parental Attitude Scale scores were recorded. Results: We have found higher standard diet application rates in patients compared to regular carbohydrate count. The patient group had higher odds of neglecting blood glucose measurement, insulin doses, and a history of stress before decompensation. The rate of psychiatric diagnosis was 26.2%, similar to the general literature, and combined diagnoses were less frequent. Hospital admissions and hypoglycemic episodes were observed at a higher rate in the group that had problems in dietary adherence. Compared to those with good dietary compliance, patients in the dietary non-adherence group had a higher level of parental control and poorer parental perception of their children’s peer relationships. Conclusion: To reduce the risk of acute complications of the disease and to prevent long-term chronic sequelae, it is important to identify positive and some negative behavioral characteristics of child and parental attitudes. Parental role is among the key factors in supporting the autonomy of the child in ensuring dietary compliance. © 2021 Yerkure Tanitim ve Yayincilik Hizmetleri A.S.. All rights reserved.Item The effects of preconditioning with IFN-γ, IL-4, and IL-10 on costimulatory ligand expressions of mesenchymal stem cells(Kare Publishing, 2021) Ozdemir A.T.; Oztatlici M.; Ozdemir R.B.O.; Cakir B.; Ozbilgin K.; Dariverenli E.; Kirmaz C.Objectives: Mesenchymal stem cells (MSCs) are strong immunomodulatory cells, and co-stimulation may play an important role in increasing the effects of MSCs on adaptive immune cells. Preconditioning may add to the effectiveness of MSCs. The aim of this study was to investigate alterations in the costimulatory ligand expressions of MSCs preconditioned with inflammatory cytokines. Methods: MSCs were preconditioned with interferon gamma (IFN-γ), interleukin (IL) 4 (IL-4), and IL-10, and changes in CD80, CD86, CD137L, CD252, CD274, CD275, and human leukocyte antigen (HLA) class I and II expressions were analyzed using flow cytometry and quantitative polymerase chain reaction methods. Human acute monocytic leukemia cell line (THP-1) macrophages preconditioned under the same conditions served as a control for comparison. Results: The frequencies of CD80 (p=0.0003), CD86 (p<0.0001), CD137L (p<0.0001), CD252 (p=0.0003), CD274 (p=0.0077), CD275 (p<0.0001), and HLA-II (p<0.0001)-positive MSCs was significantly lower than that of the THP-1 macrophages with either method, but there was no significant difference in the HLA-I (p=0.1506) cells. Comparison of the expression of the costimulatory ligands revealed that the expression of MSCs was significantly lower than that of THP-1 cells, and was not affected by cytokine stimuli. Conclusion: The study data indicated that although MSCs are strong immunomodulatory cells, the costimulatory li-gand expression required for an effective antigen presentation was extremely low compared with that of professional antigen presenting cells. In addition, preconditioning with IFN-γ, IL-4, and IL-10 failed to increase the expression of important costimulatory ligands, such as CD80 and CD86, in MSCs. The stability of costimulatory ligand expression suggests that MSCs may be an effective source for HLA-I-mediated peripheral tolerance. © 2021 by International Journal of Medical Biochemistry.Item In-vitro evaluation of effects of mesenchymal stem cells on tlr3, tlr7/8 and tlr9-activated natural killer cells(Kare Publishing, 2021) Ozdemir A.T.; Kirmaz C.; Ozdemir R.B.O.; Degirmenci P.; Oztatlici M.; Degirmenci M.Objectives: In this study, it was aimed to investigate the immunomodulatory effects of Mesenchymal stem cells (MSCs) on Natural Killer (NK) cells activated by Toll-like receptor (TLR) agonists. Methods: MDA-MB-231, MCF-7 and NK-92 cells were induced with TLR3, TLR7/8 and TLR9 agonists and co-cultured with MSCs. Alterations in IFN-γ, TNF-α, Granzyme-b and Perforin expressions were determined by qPCR method, CD69 and CD107a expressions were determined by flow cytometry, and cytotoxicity was determined by MTT-assay. Results: All TLR agonists significantly increased the expressions of the IFN-γ, TNF-α, Granzyme-b, Perforin, CD69 and CD107a in-vitro. We determined that the cytokine, cytotoxic molecules, and activation markers of NK-92 cells interact-ing with breast tumor cells significantly increased by TLR3 and TLR9 agonists. However, suppression rather than activation occurred on the NK-92 cells due to the simultaneous induction of the immunosuppressive effects of MSCs by these agonists. On the other hand, the TLR7/8 agonists provided a low NK-92 induction, however, the inhibitory effects of MSCs were not triggered. Therefore, it provided a more significant activation than TLR3 and TLR9 agonists. Conclusion: Our findings suggested that TLR7/8 agonists may be a better choice to induce antitumor effects of NK cells in a tumor tissue rich in MSCs. © 2021 by Eurasian Journal of Medicine and Oncology.Item Nonsuicidal self-injury in adolescents: Role of sociodemographic and clinical factors, emotion regulation, and maladaptive personality traits(Kare Publishing, 2022) Canol T.; Sapmaz S.Y.; Barut E.A.; Cakir A.D.U.; Bilac O.; Kandemir H.Objective: This study aims to assess the individual and psychosocial factors related to nonsuicidal self-injury (NSSI). Method: This study included patients with NSSI (n=44), non-NSSI patients (n=37), and a healthy control group (n=38) between 12 and 18 years of age. The clinical interviews were conducted with all participants. The participants completed an information form, the Difficulties in Emotion Regulation Scale (DERS), and the Personality Inventory for DSM-5-Brief Form. Results: In our findings, NSSI was associated with difficulties in peer relationships, disruption in family unity, domestic violence, smoking, sexual abuse, physical abuse, and suicidal ideation history. Patients in the NSSI group showed higher scores on the DERS than those in other groups. They also showed a higher level of maladaptive personality traits compared with adolescents in other groups. Our findings showed that NSSI was associated with suicidal ideation history and maladaptive personality traits. Conclusion: The existing literature and our findings indicate that previous suicidal ideation and maladaptive personality traits might be suggestive of NSSI. Considering these potential risk factors would allow clinicians to develop more suitable early intervention, follow-up, and treatment strategies for NSSI in the adolescent population. © 2022 Yerkure Tanitim ve Yayincilik Hizmetleri A.S.. All rights reserved.Item Mean platelet volume can indicate dietary adherence and disease severity of celiac disease; [Ortalama trombosit hacmi, çölyak hastalarında diyete uyumu ve hastalık şiddetini gösterebilir](Kare Publishing, 2022) Gerceker E.; Baykan A.R.; Cerrah S.; Yuceyar H.OBJECTIVE: At present, there is no reliable indicator for dietary compliance and disease severity in patients with celiac disease (CD). The aim of this study is to evaluate mean platelet volume (MPV) level as a biomarker for detection of disease activation, dietary adherence, and assessment of disease severity. METHODS: Eighty-one patients with CD and 50 healthy subjects were enrolled in this study. The diagnosis of CD was estab-lished by both positive antibodies against endomysium or gliadin and histopathological criteria (lymphocytic infiltration and total villous atrophy in duodenal biopsies). RESULTS: MPV was observed to be significantly higher among CD patients when compared to healthy controls (8.14±0.26 fL vs. 7.82±0.29 fL and p=0.001). Overall dietary adherence rate was 72.8% (58/81 CD patients). After induction of a gluten-free diet, the MPV was significantly lower in the dietary adherent group than non-adherent patients (7.86±0.17 fL vs. 8.07±0.30 fL and p=0.001). The increase of MPV was correlated with Marsh classification (Marsh 3 active CD vs. Marsh 2 active CD vs. Marsh 1 active CD; 8.32±0.27 fL vs. 8.12±0.19 fL vs. 7.98±0.19 fL; p=0.004 and p=0.009). CONCLUSION: Based on these data, we believe that increased MPV can provide additional benefit to screening in patients with CD. It can indicate the activation of the disease and adherence to the diet. © 2022 by Istanbul Provincial Directorate of Health.Item Digital Evaluation of the Changes in Eyelid and Ocular Surface Measurements and the Correlation of These Parameters with Visual Field Parameters After Upper Eyelid Blepharoplasty(Kare Publishing, 2023) Gumus G.; Karabulut G.O.; Fazil K.; Gunaydin Z.K.; Cabuk K.S.; Akman D.Objectives: We aimed to evaluate the change in eyelid and ocular surface parameters that were measured using a digital measurement program, the change in the visual field (VF), and the correlation between ocular surface area (OSA) and VF parameters in patients who underwent upper eyelid blepharoplasty for involutional dermatochalasis. Methods: Patients who underwent upper eyelid blepharoplasty for involutional dermatochalasis between August 2015 and August 2019 were included in the study. The difference between preoperative and postoperative 3rd month values of manually measured margin reflex distance 1 (MRD1), digitally measured eyelid and ocular surface parameters (MRD1, MRD 2 [MRD2], upper eyelid crease height [ECH], pretarsal show height [PTH], eyebrow line-height [EBH] and OSA), and VF parameters were evaluated. The correlation between preoperative and postoperative values of manually and digitally measured MRD1 and also preoperative and postoperative values of OSA and VF parameters were analyzed. Results: Thirty-six eyes from 36 patients were included in this study and the mean age of patients was 57.93±7.64 years. There were statistically significant changes between preoperative and postoperative values in means of the manually measured MRD1 and the digitally measured MRD1, PTH, OSA, and ECH (p<0.001). However, the postoperative changes in the mean MRD2 and EBH were not statistically significant (p=0.664 and p=0.983). There were moderate positive correlations between pre- and post-operative OSA values and pre- and postoperative values of manual and digital MRD1. A statistically significant agreement was observed between the change in OSA and the change in all VF parameters (Bland-Altman analysis test). Conclusion: Digital measurements can be used to evaluate the changes in eyelid and ocular surface parameters in patients who underwent upper eyelid blepharoplasty surgery. OSA provides fast results in accordance with linear measurements and is compatible with the change in the VF. © 2023 Israel Medical Association Journal.