Browsing by Publisher "Koninklijke Belgische Vereniging voor ORL Gelaat en Halschirugie"

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    Impact of graft type on anatomical and functional outcome in type-I tympanoplasty
    (Koninklijke Belgische Vereniging voor ORL Gelaat en Halschirugie, 2018) Celik O.; Eskiizmir G.; Karaca G.; Ulkumen B.
    Impact of graft type on anatomical and functional outcome in type-I tympanoplasty. Objective: There is a general opinion that cartilage grafting in type-1 tympanoplasty has better anatomical outcomes when compared with fascia and perichondrium. But, regarding functional outcomes, however, although the literature is mainly in agreement about acceptable hearing gains, there is an on-going dispute on this matter. The aim of this study was to evaluate anatomical and functional outcomes in type-I tympanoplasty according to grafting materials. Methods: In this study, 154 cases who had undergone type-I tympanoplasty over a period of nine years were enrolled and divided into three groups according to graft type: i.e., fascia, perichondrium and cartilage. Pure tone audiometry was reviewed pre- and post-operatively (one year after surgery) for functional outcomes. The average air-bone gap (ABG) and air-conduction gain (ACG) were also determined pre- and post-operatively for each case. Tympanic membrane perforation was documented in terms of involved percentage and site. Results: A significant difference in air conduction gain between cartilage and other grafts (perichondrium (p<0.001), fascia (p<0.001)) was found, while no difference was found between fascia and perichondrium (p=0.720). There was no significant difference between groups in terms of anatomical outcomes (p=0.615). Conclusions: The majority of relevant studies are retrospectively designed, leading to a graft selection bias, while the impact of the site and size of perforation, which may have a confounding effect, is not taken into account. In this study, graft selection bias was eliminated by determining the distribution of the perforation site and size on a group basis. A comparable anatomical, but decreased functional, outcome for cartilage grafting when compared with TMF and perichondrium was revealed. © 2018 Koninklijke Belgische Vereniging voor ORL Gelaat en Halschirugie. All rights reserved.
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    Protective Effect of Spirulina on Cisplatin-Induced Ototoxicity: A Functional and Histopathological Study
    (Koninklijke Belgische Vereniging voor ORL Gelaat en Halschirugie, 2022) Tahir E.; Büyüklü A.F.; Öçal F.C.A.; Gürgen S.G.; Sarsmaz H.Y.
    Objective: The purpose of this study was to evaluate the protective effect of an antioxidant and anti-inflammatory agent, “spirulina,” against cisplatin-induced ototoxicity in rats. Methods: Twenty-eight adult Sprague–Dawley rats were divided into 4 groups. Before drug administration, distortion product otoacoustic emission and auditory brainstem response tests were performed. Group 1 (n = 7) received 1 mg of intraperitoneal saline. Group 2 (n = 7) received a single dose of intraperitoneal cisplatin at 15 mg/kg/day. Group 3 (n = 7) received oral spirulina at 1000 mg/kg/day for 10 days. Group 4 (n = 7) received a single i.p. dose of cisplatin at 15 mg/kg/day, followed by 10 days of oral spirulina at 1000 mg/kg/day. The final distortion product otoacoustic emission and auditory brainstem response measurements were provided 10 days after the initial drug administration. Cochleas were removed, the histochemical examination was performed by caspase-3, caspase-9, and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling methods. Results: Initially, there were no significant differences in distortion product otoacoustic emission and auditory brainstem response measurements between groups. Following cisplatin treatment, the mean difference in signal to noise ratio values was lower in the cisplatin + spirulina group compared to the cisplatin-only group. The increase in auditory brainstem response thresholds was more significant in the cisplatin-only group than in the cisplatin + spirulina group. Posttreatment auditory brainstem response latencies were prolonged in cisplatin and cisplatin + spirulina groups; however, a significant difference was obtained between these 2 groups. The cisplatin + spirulina group had a lower density of apoptotic cells than the cisplatin-only group. Conclusion: Spirulina has no adverse effects on cochlear functions and may provide some protection against cisplatin-induced ototoxicity. © 2022 Koninklijke Belgische Vereniging voor ORL Gelaat en Halschirugie. All rights reserved.