Browsing by Publisher "NLM (Medline)"

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    Insulin Resistance as Related to Psychiatric Disorders in Obese Children
    (NLM (Medline), 2018) Özalp Kızılay D.; Yalın Sapmaz Ş.; Şen S.; Özkan Y.; Ersoy B.
    Objective: The current study aimed to investigate psychiatric consequences of obesity and the relationship between componenets of the metabolic syndrome and psychiatric disorders in children. Our second aim was to elucidate which of the anthropometric parameters or metabolic components were most strongly associated with psychiatric disorders. Methods: The study included 88 obese and overweight children with a body mass index (BMI) greater than 85th percentile. The patients were evaluated for psychiatric disorders by a single child and adolescent psychiatrist. Forty patients diagnosed with psychiatric disorders and 48 patients with normal psychiatric evaluation were compared in terms of anthropometric and metabolic parameters. BMI, BMI-standard deviation score and BMI percentile, waist circumference, waist to hip ratio, blood pressure and pubertal stage of all patients were recorded. Fasting serum glucose, insulin, lipid profile and homeostatic model assessments of insulin resistance (HOMA-IR) were measured to evaluate the metabolic parameters. Serum and 24 hour urine cortisol levels were measured. Results: HOMA-IR in the group with psychiatric disorders was found to be significantly higher than in the group without psychiatric disorders (6.59±3.36 vs 5.21±2.67; p=0.035). Other anthropometric measurements and metabolic parameters were not significantly different between the two groups. Conclusion: An understanding of the relationships between obesity related medical comorbidities and psychiatric pathologies is important to encourage patients and their families to make successful healthy lifestyle changes and for weight management in terms of appropriate treatment.
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    GINA 2019: a fundamental change in asthma management: Treatment of asthma with short-acting bronchodilators alone is no longer recommended for adults and adolescents
    (NLM (Medline), 2019) Reddel H.K.; FitzGerald J.M.; Bateman E.D.; Bacharier L.B.; Becker A.; Brusselle G.; Buhl R.; Cruz A.A.; Fleming L.; Inoue H.; Ko F.W.-S.; Krishnan J.A.; Levy M.L.; Lin J.; Pedersen S.E.; Sheikh A.; Yorgancioglu A.; Boulet L.-P.
    [No abstract available]
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    Reliability and validity of the Turkish version of the WHO-5, in adults and older adults for its use in primary care settings
    (NLM (Medline), 2019) Eser E.; Çevik C.; Baydur H.; Güneş S.; Esgin T.A.; Öztekin ÇS.; Eker E.; Gümüşsoy U.; Eser G.B.; Özyurt B.
    BACKGROUND: This study aims to determine the psychometric properties of the World Health Organization Well-Being Index (WHO-5) Turkish version in Turkish adults and older adults. METHODS: This is a multicenter cultural adaptation study carried out with 1752 participants. Internal consistency (by Cronbach's alpha); Construct validity (by known groups and confirmatory factor analysis-CFI) and discriminant validity are evaluated stratified by adults and older adults. Cohen's Effect Size is used in known groups and discriminant validity analyses. RESULTS: Distribution properties of the WHO-5 Turkish version are in acceptable limits. Alpha values are 0.81 for adults and 0.86 for older adults. The variances of the 58.5% of the adults sample and 63.9% of the older adults sample are explained in Exploratory FA. Model fits (CFI) are satisfactory ( > 0.95) in both samples; but RMSEA is poor in the older adults sample (0.166) whereas it is acceptable (0.073) in the adults sample. Known groups validity and discriminant analyses are satisfactory in both adults and older adults. CONCLUSION: The WHO-5 Turkish version has a good measurement capacity, internal consistency and good model fits in both samples. The error values in the older adults group suggest that the results when testing older adults should be interpreted with caution.
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    A nationwide retrospective study in Turkish children with nephrocalcinosis
    (NLM (Medline), 2021) Döven S.S.; Tülpar S.; Baştuğ F.; Yıldırım Z.N.Y.; Yılmaz E.K.; Çiçek N.; Küçük N.; Çomak E.; Yazıcıoğlu B.; Nalçacıoğlu H.; Delibaş A.; Uysal B.; Ağbaş A.; Gemici A.; Günay N.; Ertan P.; Bıyıklı N.; Hacıhamdioğlu D.Ö.; Elmacı A.M.; Atikel Y.Ö.; Delebe E.ÖÇ.; Sever F.L.; Gökçe İ.; Öner N.; Akman S.; Aksu B.; Atmış B.; Yel S.; Yılmaz A.; Çelik B.; Dursun İ.; Alpay H.
    BACKGROUND: Nephrocalcinosis (NC) is defined as calcium deposition in the kidney parenchyma and tubules. This study aims to determine the etiology, risk factors, and follow-up results of patients with NC in Turkey. METHODS: Patients diagnosed with NC in the pediatric nephrology Department Units of 19 centers from all geographical regions of Turkey over a 10-year period (2010-2019) were included in the study. The medical records from the centers were reviewed and demographic data, admission complaints, medical history, systemic and genetic disorders, risk factors for NC, treatment details, and presence of NC after one-year follow-up, were recorded retrospectively. RESULTS: The study sample included 195 patients (88 females, 107 males). The mean age at diagnosis was 39.44 ± 47.25 (0.5-208) months; 82/190 patients (43.2%) were diagnosed incidentally; 46/195 patients (23.6%) had an underlying disease; idiopathic hypercalciuria was detected in 75/195 (38.4%) patients. The most common systemic diseases were distal renal tubular acidosis in 11/46 patients (23.9%), primary hyperoxaluria in 9/46 patients (19.6%) and Bartter syndrome in 7/46 patients (15.3%). After one year of follow-up, NC resolved in 56/159 patients (35.2%) and they all did not have an underlying systemic disease. DISCUSSION: The most common presentation of NC was incidental. Distal renal tubular acidosis and primary hyperoxaluria were the main systemic diseases leading to NC, while hypercalciuria was the most common metabolic risk factor. Nephrocalcinosis was found to remain in most of the patients at a one-year follow-up. It may resolve particularly in patients with no underlying systemic disease.
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    A painless, solitary, yellow-pink colored, vascularized, firm nodule on the forehead
    (NLM (Medline), 2021) Arslan Z.; Çetinarslan T.; Bali Z.U.; Evrenos M.K.; Temiz P.; Ermertcan A.T.
    [No abstract available]
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    RETRACTED ARTICLE: Evaluation of macular thickness and visual pathways using optic coherence tomography and pattern visual evoked potential in different clinical stages of obstructive sleep apnea syndrome
    (NLM (Medline), 2021) Kısabay Ak A.; Batum M.; Göktalay T.; Mayali H.; Kurt E.; Selçuki D.; Yilmaz H.
    AIM: The present study aimed to investigate and compare possible changes in amplitude and latency of pattern visual evoked potentials (PVEP) and thickness of quadrants of the macula (TQM) using optic coherence tomography (OCT). MATERIALS AND METHODS: According to polysomnography examinations, 30 mild, 30 severe, 30 controls were included in the study after approval from the ethics committee. RESULTS: No significant difference was found in age and gender between the groups (p = 0.184 and p = 0.954). Significant difference was found between external and internal superior TQM, mean thickness of ganglion cell layer in comparison of all three groups (p = 0.011, p = 0.047, p = 0.030). In comparison between severe OSAS and control groups, significant difference was found in internal nasal, internal superior and external superior TQM (p = 0.048, p = 0.033, p = 0.014) while no significant difference was found TQM in comparison between the mild OSAS and control groups. In comparison between the group of severe OSAS and controls, significant increase was found in P100 as well as N145 latencies whereas only P100 latency was found to increase when mild OSAS was compared with controls. No significant correlation was found between TQM and PVEP parameters in mild and severe OSAS patients. DISCUSSION: Latency and amplitude of PVEP altered in OSAS because edema and inflammation was remarkable in mild as well as severe stages of the disease. Furthermore, thinning in the macula was observed only in severe stages of the disease, explained with level of atrophy and exposure to extended hypoxia.
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    Can Albumin Bilirubin Ratio and Inflammatory Prognostic Index Be A New Marker Determining Survival in Metastatic Pancreatic Cancer?
    (NLM (Medline), 2021) Ekinci F.; Sarı D.; Çelik C.; Dirican A.; Erdoğan A.P.; Gökse G.
    OBJECTIVE: The main purpose of our study is to analyze the predictive and prognostic value of inflammatory prognostic index (IPI (using albumin, CRP, neutrophils and lymphocytes) and albumin / bilirubin ratio in metastatic pancreatic cancer patients in addition to other markers currently used. MATERIALS AND METHODS: Medical records of patients with pancreatic cancer treated in Celal Bayar University Medical Faculty Hospital Medical Oncology Clinic between February 2012 and April 2020 were retrospectively reviewed. Clinicopathologic variables such as age, gender, performance status (PS), treatments, histopathology type, localization of metastasis, comorbidity were recorded by an electronic medical record system. Patients performance status were recorded according to the Eastern Cooperative Oncology Group (ECOG). A total of 110 pancreatic cancer patients were reviewed. The IPI was calculated as C-reactive protein × NLR (neutrophil/lymphocyte ratio)/serum albumin. Univariate and multivariate analyses were performed to assess the prognostic value of relevant factors. RESULTS: Median OS of all patients was 6 months. The NLR cut off value we calculated was 3,47. The median OS of 47 (49,4%) patients was 8 months (95 % cl. 8,673- 15,383) with NLR < 3,47 and median OS of 48 (50,6%) patients was 4 months (95 % cl. 4,221-7,523) with NLR ≥ 3,47 (P: 0,001). The cut off value calculated for the IPI was 0,79. The median OS of 24 (25,8 %) patients was 8 months (95 % cl. 7,475-18,814) with IPI < 0,79 andmedian OS of 69 (74,2 %) patients was 5 months (95 % cl. 5,774-9,580) with IPI ≥ 0,79 (P: 0,047). The ABR cut off value we calculated was 5,23. The median OS of 45 (47,3 %) patients was 4 months (95 % cl. 8,879- 15,174) with ABR ≥ 5,23 and median OS of 50 (42,7 %) patients was 9 months (95 % cl. 4,015-7,585) with ABR < 5,23 (p< 0.001) (Figure 1). According to this analyses, presenting with jaundice, peritoneum metastasis, CA19.9 and LDH values higher than cut off, high NLR, high IPI and high ABR were also significantly associated with OS. In multivariate analyses, ABR was an independent prognostic factor in PC. Patients with high ABR (> 5,23) had increases in the risk of death compared with those with low ABR (< 5,23) (HR, 0,305; 95 % CI, 0,176-0,531; p: 0.000). Alongside ABR, CA-19.9 (HR, 2,300; 95 % CI, 1,111-4,764; p: 0,025) and LDH (HR, 3,348; 95 % CI, 1,792-6,253; p: 0.000) were an independent prognostic factor in PC. CONCLUSION: In this study, we demonstrated that both IPI and ABR, which were not evaluated in PC before, are non-invasive, cheap, accessible, and easily formulated parameters in determining the prognosis. Especially the fact that ABR is an independent prognostic indicator in multivariate analysis makes it stronger. Although we are aware that our study is retrospective, we hope that the reliability of these scores will increase if it is done with more patient series and if it is done multicenter.
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    Clinical and psychosocial factors affecting treatment adherence in children with rheumatic heart disease
    (NLM (Medline), 2022) Alkan F.; Yigit E.; Sapmaz S.Y.; Coskun S.
    INTRODUCTION: The present study aimed to investigate the outcomes of psychiatric symptoms and family functions on treatment adherence in children, in addition to sociodemographic characteristics and clinical factors related to the disease. MATERIAL AND METHOD: The research sample consisted of 43 children who were followed up with rheumatic heart disease diagnosis during the study. Clinical features were obtained from the patient files. The family assessment device evaluating family functioning and the strengths and difficulties questionnaire scale to screen emotional and behavioural problems in children were used. RESULTS: Considering the regularity of treatment in our patients, there were 31 (72%) patients adherent to secondary prophylaxis regularly, 7 (6.9%) patients were partially adherent, and 5 (11.6%) patients non-adherent. Patients were divided into treatment adherent (Group 1) and non-adherent (Group 2). There was no statistically significant impact on treatment adherence whether the patients receive enough information, lifestyle, fear of developing adverse effects, fear of addiction, lack of health insurance, difficulties in reaching the drug or hospital. However, the fear of syringes on treatment adherence had an effect statistically significantly (p = 0.047). Forgetting to get a prescription and/or take the drug when the time comes was statistically higher in the non-adherent group (p = 0.009). There was no statistically significant effect of psychosocial factors on treatment adherence between groups. DISCUSSION: Providing an effective active recall system, involving primary care workers, providing training on the disease and its management, and a comprehensive pain management programme can improve the process, especially for cases where secondary prophylaxis is missed.
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    Erratum: Publisher Correction: Situational factors shape moral judgements in the trolley dilemma in Eastern, Southern and Western countries in a culturally diverse sample (Nature human behaviour (2022) 6 6 (880-895))
    (NLM (Medline), 2022) Bago B.; Kovacs M.; Protzko J.; Nagy T.; Kekecs Z.; Palfi B.; Adamkovic M.; Adamus S.; Albalooshi S.; Albayrak-Aydemir N.; Alfian I.N.; Alper S.; Alvarez-Solas S.; Alves S.G.; Amaya S.; Andresen P.K.; Anjum G.; Ansari D.; Arriaga P.; Aruta J.J.B.R.; Arvanitis A.; Babincak P.; Barzykowski K.; Bashour B.; Baskin E.; Batalha L.; Batres C.; Bavolar J.; Bayrak F.; Becker B.; Becker M.; Belaus A.; Białek M.; Bilancini E.; Boller D.; Boncinelli L.; Boudesseul J.; Brown B.T.; Buchanan E.M.; Butt M.M.; Calvillo D.P.; Carnes N.C.; Celniker J.B.; Chartier C.R.; Chopik W.J.; Chotikavan P.; Chuan-Peng H.; Clancy R.F.; Çoker O.; Correia R.C.; Adoric V.C.; Cubillas C.P.; Czoschke S.; Daryani Y.; de Grefte J.A.M.; de Vries W.C.; Burak E.G.D.; Dias C.; Dixson B.J.W.; Du X.; Dumančić F.; Dumbravă A.; Dutra N.B.; Enachescu J.; Esteban-Serna C.; Eudave L.; Evans T.R.; Feldman G.; Felisberti F.M.; Fiedler S.; Findor A.; Fleischmann A.; Foroni F.; Francová R.; Frank D.-A.; Fu C.H.Y.; Gao S.; Ghasemi O.; Ghazi-Noori A.-R.; Ghossainy M.E.; Giammusso I.; Gill T.; Gjoneska B.; Gollwitzer M.; Graton A.; Grinberg M.; Groyecka-Bernard A.; Harris E.A.; Hartanto A.; Hassan W.A.N.M.; Hatami J.; Heimark K.R.; Hidding J.J.J.; Hristova E.; Hruška M.; Hudson C.A.; Huskey R.; Ikeda A.; Inbar Y.; Ingram G.P.D.; Isler O.; Isloi C.; Iyer A.; Jaeger B.; Janssen S.M.J.; Jiménez-Leal W.; Jokić B.; Kačmár P.; Kadreva V.; Kaminski G.; Karimi-Malekabadi F.; Kasper A.T.A.; Kendrick K.M.; Kennedy B.J.; Kocalar H.E.; Kodapanakkal R.I.; Kowal M.; Kruse E.; Kučerová L.; Kühberger A.; Kuzminska A.O.; Lalot F.; Lamm C.; Lammers J.; Lange E.B.; Lantian A.; Lau I.Y.-M.; Lazarevic L.B.; Leliveld M.C.; Lenz J.N.; Levitan C.A.; Lewis S.C.; Li M.; Li Y.; Li H.; Lima T.J.S.; Lins S.; Liuzza M.T.; Lopes P.; Lu J.G.; Lynds T.; Máčel M.; Mackinnon S.P.; Maganti M.; Magraw-Mickelson Z.; Magson L.F.; Manley H.; Marcu G.M.; Seršić D.M.; Matibag C.-J.; Mattiassi A.D.A.; Mazidi M.; McFall J.P.; McLatchie N.; Mensink M.C.; Miketta L.; Milfont T.L.; Mirisola A.; Misiak M.; Mitkidis P.; Moeini-Jazani M.; Monajem A.; Moreau D.; Musser E.D.; Narhetali E.; Ochoa D.P.; Olsen J.; Owsley N.C.; Özdoğru A.A.; Panning M.; Papadatou-Pastou M.; Parashar N.; Pärnamets P.; Paruzel-Czachura M.; Parzuchowski M.; Paterlini J.V.; Pavlacic J.M.; Peker M.; Peters K.; Piatnitckaia L.; Pinto I.; Policarpio M.R.; Pop-Jordanova N.; Pratama A.J.; Primbs M.A.; Pronizius E.; Purić D.; Puvia E.; Qamari V.; Qian K.; Quiamzade A.; Ráczová B.; Reinero D.A.; Reips U.-D.; Reyna C.; Reynolds K.; Ribeiro M.F.F.; Röer J.P.; Ross R.M.; Roussos P.; Ruiz-Dodobara F.; Ruiz-Fernandez S.; Rutjens B.T.; Rybus K.; Samekin A.; Santos A.C.; Say N.; Schild C.; Schmidt K.; Ścigała K.A.; Sharifian M.; Shi J.; Shi Y.; Sievers E.; Sirota M.; Slipenkyj M.; Solak Ç.; Sorokowska A.; Sorokowski P.; Söylemez S.; Steffens N.K.; Stephen I.D.; Sternisko A.; Stevens-Wilson L.; Stewart S.L.K.; Stieger S.; Storage D.; Strube J.; Susa K.J.; Szekely-Copîndean R.D.; Szostak N.M.; Takwin B.; Tatachari S.; Thomas A.G.; Tiede K.E.; Tiong L.E.; Tonković M.; Trémolière B.; Tunstead L.V.; Türkan B.N.; Twardawski M.; Vadillo M.A.; Vally Z.; Vaughn L.A.; Verschuere B.; Vlašiček D.; Voracek M.; Vranka M.A.; Wang S.; West S.-L.; Whyte S.; Wilton L.S.; Wlodarczyk A.; Wu X.; Xin F.; Yadanar S.; Yama H.; Yamada Y.; Yilmaz O.; Yoon S.; Young D.M.; Zakharov I.; Zein R.A.; Zettler I.; Žeželj I.L.; Zhang D.C.; Zhang J.; Zheng X.; Hoekstra R.; Aczel B.
    [No abstract available]
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    Evaluation of Ex Vivo Cultivation Potentials of Trypanosoma cruzi, Leishmania tropica ve Toxoplasma gondii Parasites in J774, Vero and HeLa Cell Lines; [Trypanosoma cruzi, Leishmania tropica ve Toxoplasma gondii Parazitlerinin J774, Vero ve HeLa Hücre Hatlarında Ex Vivo Kültivasyon Potansiyellerinin Değerlendirilmesi]
    (NLM (Medline), 2023) Yıldırım A.; Özbilgin A.; Yereli K.
    Three obligate intracellular protozoan parasite species, namely Trypanosoma cruzi, Leishmania tropica and Toxoplasma gondii, causative agents of Chagas disease, Leishmaniasis and toxoplasmosis, respectively, which are responsible for significant morbidity and mortality and reside in macrophage cells, affect more than half of the world's population in connection with socio-economic and geographical factors and also causes neglected parasitic diseases of increasing importance. This study aimed to evaluate the ex vivo cultivation potential of T.cruzi, L.tropica and T.gondii parasites in J774, Vero and HeLa cells and to reproduce in a short time and in large amounts without losing their virulence properties. Ex vivo experimental models were created by infecting J774, Vero and HeLa cell lines confluently produced in cell culture flasks with T.cruzi, L.tropica and T.gondii parasites. In ex vivo cultivation, one passage was applied for seven days and three times in a row. Cells removed from the surface after each passage were plated on eight-well chamber slides. Giemsa stained slides were prepared and infection rates were evaluated by light microscopic examination. At the end of the study, it was observed that all three cell lines could be infected with T.cruzi, L.tropica and T.gondii parasites, and infection rates increased in all cell lines after consecutive passages. As a result of ex vivo cultivation, the best cell lines from which T.cruzi and L.tropica strains grew, were J774, Vero and HeLa, and HeLa, J774 and Vero cell lines for T.gondii strain, respectively (p<0.05). Trypanosoma cruzi, L.tropica and T.gondii parasites were successfully grown in J774, Vero and HeLa cell lines by ex vivo culture method in a short time and in large amounts without losing their virulence properties. Cell lines with the best ex vivo cultivation potential for T.cruzi and L.tropica parasites were J774, Vero and HeLa, respectively, while HeLa, J774 and Vero for T.gondii. It is thought that the data obtained in this regard will contribute to many studies on the development of vaccines, drugs and new diagnostic kits.