Browsing by Publisher "Pacini Editore S.p.A."

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    In vivo tissue response and durability of five novel synthetic polymers in a rabbit model; [Biocompatibilità e durata in vivo di cinque nuovi polimeri sintetici testati su coniglio]
    (Pacini Editore S.p.A., 2016) Sahin E.; Cingi C.; Eskiizmir G.; Altintoprak N.; Calli A.; Calli C.; Yilgör I.; Yilgör E.
    Alloplastic materials are frequently used in facial plastic surgeries such as rhinoplasty and nasal reconstruction. Unfortunately, the ideal alloplastic material has not been found. This experimental study evaluates the tissue response and durability of five novel polymers developed as an alloplastic material. In this experimental study involving a tertiary university hospital, six subcuticular pockets were formed at the back of 10 rabbits for the implantation of each polymer and sham group. Each pocket was excised with its adjacent tissue after three months, and collected for histopathological examination. Semi-quantitative examination including neovascularisation, inflammation, fibrosis, abscess formation, multinucleated foreign body giant cells was performed, and integrity of polymer was evaluated. A statistical comparison was performed. No statically significant difference was detected in neovascularisation, inflammation, fibrosis, abscess formation and multinucleated foreign body giant cells when a paired comparison between sham and polymer II, III and IV groups was performed individually. Nevertheless, the degree of fibrosis was less than sham group in polymer I (p =. 027) and V (p =. 018), although the other variables were almost similar. The integrity of polymers III (9 intact, 1 fragmented) and IV (8 intact, 2 absent) was better than the other polymers. These novel synthetic polymers could be considered as good candidates for clinical applicability. All polymers provided satisfactory results in terms of tissue response; however, fibrovascular integration was higher in polymers II, III and IV. In addition, the durability of polymer III and IV was better than the others. © 2016, Pacini Editore S.p.A. All rights reserved.
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    Childhood onset limb-girdle muscular dystrophies in the aegean part of Turkey
    (Pacini Editore S.p.A., 2018) Yiş U.; Diniz G.; Hazan F.; Daimagüler H.S.; Baysal B.T.; Baydan F.; Akinci G.; Ünalp A.; Aktan G.; Bayram E.; Hiz S.; Paketçi C.; Okur D.; Özer E.; Danyeli A.E.; Polat M.; Uyanik G.; Çirak S.
    The aim of this study is to analyze the epidemiology of the clinical and genetic features of childhood-onset limb-girdle muscular dystrophies (LGMD) in the Aegean part of Turkey. In total fifty-six pediatric cases with LGMD followed in four different pediatric neurology departments in the Aegean region of Turkey were evaluated. Among them, LGMD2C was the most common followed by LGMD2A, LGMD2D, and LGMD2F with equal frequencies. In twenty-eight patients (50%) the diagnosis could be confirmed by genetic analysis, where SGCG proved to be disease-causing in most of the cases. About half of the patients were diagnosed with whole exome or targeted gene sequencing. A positive correlation between muscle biopsy and genetic findings were observed in 11% of the patients. We report one novel frameshifting mutation in TTN. Knowledge on frequencies of childhood-onset limb-girdle muscular dystrophies and related genes in Turkey will lead to a prompt diagnosis of these neuromuscular disorders. © 2018 Pacini Editore S.p.A. All rights reserved.