Browsing by Publisher "S.O.G. CANADA Inc."
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Item The effects of the informed consent given for cesarean section on anxiety and knowledge(S.O.G. CANADA Inc., 2014) Yildirim G.; Cetin A.; Aksu M.; Altiparmak S.; Guler N.Purpose: To determine the effects of information given before cesarean section on women's anxiety levels and their knowledge about informed consent regarding it. Materials and Methods: Sixty women who elected to undergo cesarean section were included in the study. The data were collected using the pregnancy-related clinical information form, informed consent form, cesarean information form, and State and Trait Anxiety Inventory. Kruskal-Wallis test, Mann-Whitney U test, chi-square test and Pearson correlation were used as statistical methods. Results: The women's knowledge scores before and after they were informed about cesarean section were 14.8 ± 5.5 and 29.8 ± 2.6, respectively (p < 0.05). Their state anxiety scores before and after they were informed about cesarean section were 28.4 ± 6.6 and 28.0 ± 5.9, respectively (p > 0.05). Conclusion: It was determined that the participants' pre-training knowledge scores about cesarean section increased significantly after they were informed, and that their state and trait anxiety scores decreased very little after they were informed.Item Sexual dysfunction in Turkish women with dispareunia and its impact on the quality of life(S.O.G. CANADA Inc., 2014) Ulkumen B.A.; Erkan M.M.; Pala H.G.; Baytur Y.B.Purpose of Investigation: The authors aimed to determine the prevalence of female sexual dysfunction (FSD) among Turkish dyspareunic women and to establish the associated factors with FSD. Furthermore, they aimed to investigate if dyspareunia and possible ssociated sexual complaints were related to impaired quality of life (QoL). Materials and Methods: The study included 154 women admitted to the present gynecology department at a tertiary center in the west region of Turkey, 67 of which suffered from dyspareunia. The remaining 87 sexually healthy women were included in the control group. FSD was assessed with 19-item validated female sexual function index (FSFI). QoL was assessed using short form 36 (SF-36). The chi-squared test and t-test were used for analysing the group differences. Pearson's correlation test was used to determine the effect of the variables of FSFI on the SF-36. Multivariate analysis and logistic regression was used to determine independent risk factors for FSD and to estimate odds ratio (OR) with 95% confidence interval (CI). Results: The incidence of FSD in dyspareunic group and control group was 86.57% and 36.8%, respectively (p < 0.001). Dyspareunic women had lower scores with regards to sexual desire, arousal, lubrication, orgasm, satisfaction, and pain domains at significant level (p < 0.001). Education level, time period after the last delivery, duration of marriage, parity, and dyspareunia were significantly related to FSD. However, dyspareunia was an independent risk factor for FSD (OR 11.49; 95% CI 4.95-26.67). Regarding the impact on the QoL, dyspareunic women had lower scores with regards to the physical role, social function, bodily pain, and vitality domains. Conclusion: The present results show that dyspareunia has a major impact on women's sexual ftinction and QoL. Clinicians have an important role for encouraging women to report their sexual complaints. Identifying dyspareunia and treating FSD may positively affect women's sexual function and overall QoL.Item A comparison of the molecular distribution of proangiogenic factors in endometrium of missed abortions and of voluntary first trimester termination cases(S.O.G. CANADA Inc., 2015) Özçakir T.; Turan M.A.; Şimşek F.; Atay C.; Vatansever S.; Özbilgin K.Objective: The authors aimed to evaluate the angiogenic changes that occur in the cases with missed abortions compared with the voluntary termination of pregnancy as control group, with this controlled clinical study. Materials and Methods: The study included fifteen healthy volunteer women with unwanted pregnancy less than 10th gestational week in an academic research environment. The patients were 19 women between 6th and 11th gestational weeks diagnosed with missed abortion as the patient group. Immunohistochemistry was utilized to examine temporal and spatial expression of vascular endothelial growth factor (VEGF) and their two receptors: VEGF-R1 (Flt-1) and VEGF-R2 (Flk-l/KDR), and Trombospondin-1, eNOS, iNOS, and HIF-la in the both deciduas and placenta of the both groups. Results: This study discovered the significant difference (p < 0.005) between the groups of controlled and missed abortion in the decidual and placental cell components, and has put forward that thrombospondin and iNOS have an impact on abortion through antiangiogenic effect in cases of missed abortions. Conclusions: The potential role of molecules affecting angiogenesis in the etiology of missed abortion has been evaluated and the authors aimed for this to be a guide for studies on further treatments and on the prevention of the development of missed abortions.Item Outcomes and management strategies in pregnancies with early onset oligohydramnios(S.O.G. CANADA Inc., 2015) Ulkumen B.A.; Pala H.G.; Baytur Y.B.; Koyuncu F.M.Objective: To evaluate the outcomes and management options in pregnancies with early onset oligohydramnios. Materials and Methods: The file datas of all pregnancies diagnosed as oligohydramnios or anhydramnios before 27 gestational weeks between January 2006 and September 2013 were evaluated retrospectively. The underlying pathology and associated anomalies, karyotype analysis, the outcome of the pregnancy (either termination or labour), and gestational week at the time of diagnosis were analyzed. Results: A total of 54 pregnancies were evaluated; mean gestational week at the time of the diagnosis was 19.8 ± 4.6. Mean maternal age was 27.28 ± 6.03. Thirty-seven pregnancies were anhydramniotic, 13 fetuses had associated anomalies, five of them had multicyctic dysplastic kidney, five had bilateral renal agenesis, one had hypoplastic right heart syndrome, one had clubfoot, and one had ventricular septal defect and cleft palate. Karyotyping was normal regarding the fetuses with structural anomalies. Nineteen patients had premature preterm rupture of membranes and 39 patients had termination of pregnancy. Conclusion: The prognosis of early onset oligohydramnios is poor. Main determinant is gestational week at the time of the diagnosis.Item The expression of forkhead transcription factors in decidua and placenta in patients with missed abortion(S.O.G. CANADA Inc., 2015) Ozbilgin K.; Kahraman B.; Turan A.; Atay C.; Vatansever S.; Inan S.; Özçakir T.Background: Forkhead transcription factors 3a (FOX03a) has pleiotropic biological functions in the female reproductive tract. FOX03a has a function in decidualization, in placental development, and also in inhibition of apoptosis. This study aims to investigate a possible role of FOX03a in missed abortion. Materials and Methods: Decidual and placental tissue samples were obtained from the women with unwanted pregnancy as the control group and with missed abortion as the patient group. Immunohistochemistry technique was utilized to compare FOX03a expression of the decidual cells in uterine decidual stroma and cytotrophoblast-syncytiotrophoblast cells in placental villous stroma. Immunohistochemistry was evaluated semi-quantitatively utilizing the H-score technique. Results: It was demonstrated that H-Scores of FOX03a expression in both uterine decidual stroma were increased in the missed abortion group (255.83±12.41) than in the normal pregnancy group (133.33±17.43). It was also shown that there was no difference between non-decidual area of the endometrium of the normal pregnancy and the missed abortion group (30.33±4.32; 39.66±14.30, respectively) and placental villous stroma (13.00±1.89; 13.00±1.67, respectively). However, the immunoreactivity of cytotrophoblast and syncytiotrophoblast cells significantly increased in the missed abortion group (18.83±1.47; 322.00±6.06, respectively) than in the normal pregnancy group (11.00±1.26; 254.00±8.17, respectively) (p < 0.05). Conclusion: These data support the hypothesis that increased FOX03a expression in missed abortion may prevent the discharge of dead fetus to maintain decidualization, prevention of oxidative stress, immunomodulation, and inhibition of apoptosis.Item The relationship between uterine prolapse and premalignant endometrial pathology(S.O.G. CANADA Inc., 2016) Gene M.; Celik E.; Eskicioglu F.; Gur E.B.; Kurtulmus S.; Gulec E.; Guclu S.Objective: The aim of this study was to stress the importance of performing a thorough uterine assessment before selecting an organ- sparing surgery in patients presenting with uterine prolapse and no other complaints. Materials and Methods: This study included a total of 111 participants who presented with pelvic organ prolapse and underwent hysterectomy for grades 3-4 uterine prolapse. The post- hysterectomy histopathology results were classified as benign (atrophic endometrium, proliferative or secretory endometrium) or pathologic (endometrial hyperplasia, endometrial polyp, adenomyosis, myoma uteri, and endometrium carcinoma). Results: Of the 111 patients enrolled in this study, 23 (20.2%) had endometrial hyperplasia, eight (7.2%) had endometrial polyps, 30 (27%) had uterine fibroids, and 20 (18%) had adenomyosis. Conclusion: There may be premalignant lesions of the endometrium in both premenopausal and postmenopausal women presenting with uterine prolapse and no other symptoms. A chronic inflammatory process resulting from the extra-vaginal location of the uterus may play a role in the development of these lesions. Further studies are needed on this subject.Item Evaluation of female athlete triad and gynecological complaints in young Turkish female athletes(S.O.G. CANADA Inc., 2016) Solmaz Hasdemir P.; Oral O.; Calik E.; Ulusoy M.; Varol R.; Tayfun Ozcakir H.Purpose: Female athlete triad (FAT) is a serious healthcare concern in the young female population. The aim of this study was to determine the prevalence and clinical characteristics of FAT and its relationship with gynecologic complaints of young Turkish female athletes. Materials and Methods: This was a cross-sectional survey and included 87 female athletes involved in a variety of sports as a case group and 85 sedentary female university students from Ege and Celal Bayar Universities. All subjects completed a questionnaire consisting of 32 separate questions assessing eating behavior, menstrual status, gynecologic and systemic complaints, psychological problems, and sexual history. SPSS 21.0 was used for statistical analysis. Results: This survey involved 172 females in between to 30 years of age. The age of menarche was found to be significantly lower in the sedentary group (p = 0.00). Late menstruation and oligo-amenorrhea were notable complaints among the athletes, and body mass index (BMI) was found to be statistically lower in the athletic group (p = 0.00). Cold hands and hair loss were seen more often in the sedentary group compared to the athletic group (p < 0.05). According to a logistic regression analysis, independent variables (BMI, menstrual status, and bone fractures) were found to be statistically insignificant (p > 0.05). Conclusions: Excessive sports activity can be hazardous in young female population. Lower BMI might be related to menstrual irregularity. Young female population should be informed about this relationship, especially athletes who are particularly at risk. Certain precautions should be taken into consideration in this population in order to get benefits of sports activity.Item Protective role of adrenomedullin in heterotopic ovarian transplant(S.O.G. CANADA Inc., 2017) Erdemoglu E.; Gürgen S.G.; Kürşat Bozkurt K.; Oz Oyar E.Purpose of investigation: To study adrenomedullin (ADM) in preventing ischemia and morphological changes in heterotopically transplanted ovary. Materials and Methods: Forty female Sprague-Dawley rats were divided into four groups. In groups 1 and 2 each ovary was transplanted to the corresponding inguinal region by heterotopic transplantation. In groups 3 and 4, ovaries were left intact without transplantation. Treatment was injected to left inguinal region. ADM was given in groups 1 and 3 and placebo was given in groups 2 and 4. Left ovaries showing local treatment effect in heterotopic transplantation was designated as A (1A, 2A, 3A, and 4A), right ovaries showing systemic treatment effect were designated as (1B, 2B,3B, and 4B). Main outcome measures were ischemia, follicle count, and CD 31 expression. Results: Ovaries treated with local ADM (group 1A) were in consonance with normal rat ovaries. The ovaries of rats in group 1B and placebo treated transplant group (groups 2A, 2B) exhibited varying effects of ischemia. The mean follicle numbers in groups 1A, 1B, 2A, 2B were 28 ± 3.3, 16.8 ± 2.5, 17.7 ± 2.1, 16.4 ± 2.9, respectively. The mean follicle number in groups 3A, 3B, 4A, and 4B were 27.7 ± 2.0, 28.3 ± 2.2, 28.3 ± 2.2, 27.8 ± 1.9, respectively. Corpus luteum number and CD31 expression was found to be significantly higher in group 1A. Conclusion: Subcutaneous injection of ADM to heterotopic ovarian graft site causes vasodilatation and increases angiogenesis and may protect ovarian graft against hypoxic damage.Item The role of angiogenic factors in first trimester pregnancy losses(S.O.G. CANADA Inc., 2017) Eskicioǧlu F.; Özbilgin K.; Taşkend S.; Önal T.; Gökmen T.Objective: A good blood supply towards the peri-implantation endometrium is an essential requirement for pregnancy. Intermedin (IMD), vascular endothelial growth factor (VEGF), and endothelial nitric oxide synthase (eNOS), are angiogenic and vasoactive agents that play contributory roles in endometrial vascularity. The goal of this study was to immunohistochemically investigate the roles of various vasoactive factors in first trimester pregnancy losses. Materials and Methods: This was a prospective case-controlled study carried out on decidual and placental tissue samples obtained from women with unwanted pregnancies who served as the control group (n=10), and those with missed abortions who were the "missed abortion group"(n = 10). Immunohistochemistry techniques were used to compare IMD, receptor activity modifying protein (RAMP)1, RAMP2, RAMP3, VEGF, and eNOS expression of decidual and placental cells. Immunostaining for these factors was evaluated semiquantitatively by H-score analysis. Results: IMD and RAMPs in decidual cells exhibited higher expression in the control group. However, IMD and RAMP2 had a stronger expression in placental cells in the missed abortion group. In the control group, VEGF and eNOS had a higher expression in decidual cells and on the placental side, especially in syncytiotrophoblasts and cytotrophoblasts. Conclusion: Expressions of vasoactive agents, such as IMD, VEGF, and eNOS, decrease in first trimester pregnancy losses. Additionally, a compensatory mechanism against decreased endometrial and subendometrial vascularity results in the death of the embryo/fetus enhances in missed abortion cases. This mechanism characterized by increased expressions of IMD and RAMP2 initially begins in the syncytiotrophoblasts and cytotrophoblasts.Item Central nervous system metastatic epithelial ovarian cancer. Clinical parameters and prognostic factors: A multicenter study of Anatolian Society of Medical Oncology(S.O.G. CANADA Inc., 2017) Seber S.; Turkmen E.; Harputoǧlu H.; Yeşil H.; Arpaci E.; Menekse S.; Pilanci K.; Oruç Z.; Taskovlu B.Y.; Gumusay O.; Aksoy A.; Karaagac M.; Ozarslan E.; Yetisyigit T.Central nervous system (CNS) metastasis is a rare event in the course of late stage epithelial ovarian cancer (EOC); however its incidence is increasing in parallel with prolonged survival of patients. Objective: The authors assessed the clinical parameters and potential prognostic features in patients with CNS metastatic disease. Materials and Methods: Clinical data of the 33 patients from the participating centers were retrospectively collected and analyzed. Median age at the time of CNS metastasis was 57 years. Median time from the diagnosis of primary EOC until CNS metastatic disease was 22 months. Nearly half (45.5%) of the patients had single CNS metastatic lesions and all patients in the study group except two received radiotherapy as palliative treatment. Median overall survival (OS) from the time of CNS metastasis was 15 months (0-66). At univariate analysis only number of brain metastatic lesions (p = 0.001) and presence of extracranial disease (p = 0.004) were strongly associated with OS whereas multimodal treatment, size of metastatic lesions, platinum sensitivity, age, grade, and disease stage at presentation were not. Development of CNS metastasis carries a poor prognosis, however patients with single metastatic lesions and only intracranial metastatic disease can have prolonged survival after appropriate palliative management of their disease.