Browsing by Publisher "Springer-Verlag Italia s.r.l."
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Item Spacelike helices in Minkowski 4-space E 1 4(Springer-Verlag Italia s.r.l., 2010) Önder M.; Kocayiğit H.; Kazaz M.In this paper, we give some characterizations for spacelike helices in Minkowski space-time E 1 4 . We find the differential equations characterizing the spacelike helices and also give the integral characterizations for these curves in Minkowski space-time E 1 4 . © 2010 Università degli Studi di Ferrara.Item Novel combination of docetaxel and thymoquinone induces synergistic cytotoxicity and apoptosis in DU-145 human prostate cancer cells by modulating PI3K–AKT pathway(Springer-Verlag Italia s.r.l., 2015) Dirican A.; Atmaca H.; Bozkurt E.; Erten C.; Karaca B.; Uslu R.Background: The treatment of castrate-resistant prostate cancer (CRPC) still remains as an important challenge of daily oncology practice. Docetaxel significantly prolongs overall survival in men with CRPC. Thymoquinone (TQ), one of the flavonoid compounds isolated from Nigealla sativa, has been shown to possess cytotoxic activity against a variety of cancer cell lines. Materials and Methods: The aim of the study was to investigate the possible synergistic cytotoxic/apoptotic effects of a novel combination, docetaxel and TQ in DU-145 hormone- and drug-refractory prostate cancer cells and their effects on PI3K and ERK signaling pathways Results: We observed that the combination of docetaxel and TQ resulted in a significant synergistic cytotoxicy and apoptosis as compared to any single agent alone, in a dose-dependent manner. It was found that viability of the combination treated cells was not significantly changed in the presence of LY294002 as compared to inhibitor treated cells. However, in the presence of FR180204, viability of combination treated cells was significantly decreased as compared to inhibitor treated cells. In conclusion, cytotoxic effect of the docetaxel and TQ combination is correlated with the block of the PI3K/Akt signaling pathway in DU-145 cells. Conclusion: Therefore, this combination strategy may be an alternative approach for the challenging era of daily oncologic practice. Also, the combination of docetaxel and TQ might allow a reduction in docetaxel doses and diminish adverse effects of docetaxel while maintaining the therapeutic effect in patients with CRPC. © 2014, Federación de Sociedades Españolas de Oncología (FESEO).Item Evaluation of neurodegeneration through visual evoked potentials in restless legs syndrome(Springer-Verlag Italia s.r.l., 2016) Kısabay A.; Sarı U.S.; Korkmaz T.; Dinçhorasan G.; Yılmaz H.; Selçuki D.Restless legs syndrome (RLS) is a disease characterized by some type of dysesthesia, an indescribable abnormal sensation in the extremities. Our objective was to determine whether the visual evoked potentials (VEP) can be used as a quantitative monitoring method to evaluate demyelination-remyelination and neurodegeneration in the patients with RLS. The present study was carried out prospectively. It was planned to determine normal or pathological conditions in the form of increased latency or decreased amplitude of VEP and to evaluate possible pathologies in the visual and retinal pathways at early stages and at months 3 and 6 of follow-up in the patients with RLS (with or without iron deficiency anemia), in those without RLS (at the time of diagnosis prior to any medical therapy) without any visual symptoms. It was observed that latency of VEP improved but didn’t return to normal limits following treatment with dopamin agonists, iron, or combination of both and that there was no significant difference between the post-treatment data and those of the control group. These results in combination with the fact that the latencies and amplitudes didn’t return to normal levels despite the 6-month-treatment but showed a progressive course with partial regeneration suggests that there was incomplete remyelination. It should be kept in mind that this syndrome is likely to be a part of neurodegenerative process. © 2016, Belgian Neurological Society.Item Some fixed point results on complex valued Gb -metric spaces(Springer-Verlag Italia s.r.l., 2018) Ansari A.H.; Ege O.; Radenović S.In this paper, we prove some fixed point theorems for new type generalized contractive mappings involving C-class function in complex valued Gb-metric spaces. The obtained results generalize and improve some fixed point results in the literature. © 2017, Springer-Verlag Italia.Item The increase of neuropathic symptoms in diabetic patients is related with osteopenia(Springer-Verlag Italia s.r.l., 2021) Börekci E.; Kara A.; Kılıç M.; Tanık N.; Ozan Z.T.; Yıldırım T.; Aral Y.Purpose: To investigate the relationship between the intensity of neuropathic pain and the severity of osteopenia in type 2 diabetic patients with painful diabetic peripheral neuropathy (painful DPN). Methods: In 220 patients with type 2 diabetes included in the screening, the presence of neuropathic pain was evaluated using the Douleur Neuropathique 4 Questions (DN4) scoring system. One hundred forty-five patients with painful DPN were identified and included in the study. Socio-demographic and laboratory evaluations were made and bone mineral density (BMD) of these patients was evaluated by the dual-energy x-ray absorptiometry (DEXA) method. Results: There was a significant correlation between the neuropathic pain score and the total T scores of the lumbar spine and femur in patients with painful DPN. According to the regression analysis (standard coefficients), the DN4 score (0.498); the level of vitamin D (− 0.246) and the female sex (0.236) for the lumbar spine region; age (0.387); DN4 score (0.261); and vitamin D level (− 0.155) for the femur region were independently influencing factors on the development of osteoporosis. When osteoporosis (T score ≤ − 2.5) of the lumbar spine was analyzed by binary logistic regression, the risk of osteoporosis in women was 4.4 times higher, and the risk increased with increasing DN4 score. Conclusion: The increase of neuropathic symptoms in patients with DPN is an effective and important factor in the development of diabetic osteopenia. © 2020, Fondazione Società Italiana di Neurologia.Item A new modified semi-analytical technique for a fractional-order Ebola virus disease model(Springer-Verlag Italia s.r.l., 2021) Srivastava H.M.; Deniz S.Ebola virus disease is a fatal hemorrhagic fever of humans and primates caused by viruses. There are many mathematical models to investigate this viral disease. In this paper, the classical form of the Ebola virus disease model has been modified by using new fractional derivatives. The resulting fractional forms of the Ebola virus disease model have then been examined by applying a newly-developed semi-analytical method. The optimal perturbation iteration method has been implemented to obtain new approximate solutions to the system of differential equations which better model the Ebola virus disease. New algorithms are constructed by using three types of operators of fractional derivatives. A real-world problem is also solved in order to prove the efficiency of the proposed algorithms. A good agreement has been found with the real values of the parameters. Finally, several graphical illustrations are presented for different values of the involved biological parameters to show the effects of the new approximate solutions. Obtained results prove that the new method is highly accurate in solving these types of fractional models. © 2021, The Royal Academy of Sciences, Madrid.Item Ischemic chiasmal syndrome associated with posterior communicating artery (PCoA) and tuberothalamic artery (TA) infarction: a case report(Springer-Verlag Italia s.r.l., 2021) Ataç C.; Ak A.K.; Batum M.; Arı S.; Ovalı G.Y.; Çelebisoy N.Lesions affecting the body of the optic chiasm typically produce bitemporal hemianopia. The blood supply comes from the anterior communicating artery, anterior cerebral, posterior communicating, posterior cerebral, and basilar arteries. We herein report a young patient admitted to the emergency department with acute confusion, left-sided hemiparesis, hemihypoesthesia, and dysarthria. Bitemporal hemianopia was detected after resolution of confusion. On cranial magnetic resonance imaging (MRI), infarction in the right anterolateral thalamus in the territory of tuberothalamic artery (TA) and in posterior chiasma in the territory of the posterior communicating artery (PCoA) was revealed. Cerebral MR angiography showed luminal irregularity of the PCoA. The patient was presented to draw attention to the rare entity ischemic chiasmal syndrome. © 2020, Fondazione Società Italiana di Neurologia.Item Erratum to: Building bridges for innovation in ageing: Synergies between action groups of the EIP on AHA (The journal of nutrition, health & aging, (2017), 21, 1, (92-104), 10.1007/s12603-016-0803-1)(Springer-Verlag Italia s.r.l., 2023) Bousquet J.; Bewick M.; Cano A.; Eklund P.; Fico G.; Goswami N.; Guldemond N.A.; Henderson D.; Hinkema M.J.; Liotta G.; Mair A.; Molloy W.; Monaco A.; Monsonis-Paya I.; Nizinska A.; Papadopoulos H.; Pavlickova A.; Pecorelli S.; Prados-Torres A.; Roller-Wirnsberger R.E.; Somekh D.; Vera-Muñoz C.; Visser F.; Farrell J.; Malva J.; Andersen Ranberg K.; Camuzat T.; Carriazo A.M.; Crooks G.; Gutter Z.; Iaccarino G.; de Keenoy E.M.; Moda G.; Rodriguez-Mañas L.; Vontetsianos T.; Abreu C.; Alonso J.; Alonso-Bouzon C.; Ankri J.; Arredondo M.T.; Avolio F.; Bedbrook A.; Białoszewski A.Z.; Blain H.; Bourret R.; Cabrera-Umpierrez M.F.; Catala A.; O’Caoimh R.; Cesari M.; Chavannes N.H.; Correia-Da-Sousa J.; Dedeu T.; Ferrando M.; Ferri M.; Fokkens W.J.; Garcia-Lizana F.; Guérin O.; Hellings P.W.; Haahtela T.; Illario M.; Inzerilli M.C.; Lodrup Carlsen K.C.; Kardas P.; Keil T.; Maggio M.; Mendez-Zorrilla A.; Menditto E.; Mercier J.; Michel J.P.; Murray R.; Nogues M.; O’Byrne-Maguire I.; Pappa D.; Parent A.S.; Pastorino M.; Robalo-Cordeiro C.; Samolinski B.; Siciliano P.; Teixeira A.M.; Tsartara S.I.; Valiulis A.; Vandenplas O.; Vasankari T.; Vellas B.; Vollenbroek-Hutten M.; Wickman M.; Yorgancioglu A.; Zuberbier T.; Barbagallo M.; Canonica G.W.; Klimek L.; Maggi S.; Aberer W.; Akdis C.; Adcock I.M.; Agache I.; Albera C.; Alonso-Trujillo F.; Angel Guarcia M.; Annesi-Maesano I.; Apostolo J.; Arshad S.H.; Attalin V.; Avignon A.; Bachert C.; Baroni I.; Bel E.; Benson M.; Bescos C.; Blasi F.; Barbara C.; Bergmann K.C.; Bernard P.L.; Bonini S.; Bousquet P.J.; Branchini B.; Brightling C.E.; Bruguière V.; Bunu C.; Bush A.; Caimmi D.P.; Calderon M.A.; Canovas G.; Cardona V.; Carlsen K.H.; Cesario A.; Chkhartishvili E.; Chiron R.; Chivato T.; Chung K.F.; D’Angelantonio M.; de Carlo G.; Cholley D.; Chorin F.; Combe B.; Compas B.; Costa D.J.; Costa E.; Coste O.; Coupet A.-L.; Crepaldi G.; Custovic A.; Dahl R.; Dahlen S.E.; Demoly P.; Devillier P.; Didier A.; Dinh-Xuan A.T.; Djukanovic R.; Dokic D.; du Toit G.; Dubakiene R.; Dupeyron A.; Emuzyte R.; Fiocchi A.; Wagner A.; Fletcher M.; Fonseca J.; Fougère B.; Gamkrelidze A.; Garces G.; Garcia-Aymeric J.; Garcia-Zapirain B.; Gemicioğlu B.; Gouder C.; Hellquist-Dahl B.; Hermosilla-Gimeno I.; Héve D.; Holland C.; Humbert M.; Hyland M.; Johnston S.L.; Just J.; Jutel M.; Kaidashev I.P.; Kaitov M.; Kalayci O.; Kalyoncu A.F.; Keijser W.; Kerstjens H.; Knezović J.; Kowalski M.; Koppelman G.H.; Kotska T.; Kovac M.; Kull I.; Kuna P.; Kvedariene V.; Lepore V.; Macnee W.; Maggio M.; Magnan A.; Majer I.; Manning P.; Marcucci M.; Marti T.; Masoli M.; Melen E.; Miculinic N.; Mihaltan F.; Milenkovic B.; Millot-Keurinck J.; Mlinarić H.; Momas I.; Montefort S.; Morais-Almeida M.; Moreno-Casbas T.; Mösges R.; Mullol J.; Nadif R.; Nalin M.; Navarro-Pardo E.; Nekam K.; Ninot G.; Paccard D.; Pais S.; Palummeri E.; Panzner P.; Papadopoulos N.K.; Papanikolaou C.; Passalacqua G.; Pastor E.; Perrot M.; Plavec D.; Popov T.A.; Postma D.S.; Price D.; Raffort N.; Reuzeau J.C.; Robine J.M.; Rodenas F.; Robusto F.; Roche N.; Romano A.; Romano V.; Rosado-Pinto J.; Roubille F.; Ruiz F.; Ryan D.; Salcedo T.; Schmid-Grendelmeier P.; Schulz H.; Schunemann H.J.; Serrano E.; Sheikh A.; Shields M.; Siafakas N.; Scichilone N.; Skrindo I.; Smit H.A.; Sourdet S.; Sousa-Costa E.; Spranger O.; Sooronbaev T.; Sruk V.; Sterk P.J.; Todo-Bom A.; Touchon J.; Tramontano D.; Triggiani M.; Valero A.L.; Valovirta E.; van Ganse E.; van Hage M.; van den Berge M.; Ventura M.T.; Vergara I.; Vezzani G.; Vidal D.; Viegi G.; Wagemann M.; Whalley B.; Wilson N.; Yiallouros P.K.; Žagar M.; Zaidi A.; Zidarn M.; Hoogerwerf E.J.; Usero J.; Zuffada R.; Senn A.; de Oliveira-Alves B.The authors would like to change and use the correct name of M. Khaitov which is M. Kaitov on this manuscript. The authors have incorrectly used her other name during the finalization of this research. With this, the authors hereby publish the correct author names as presented above. © 2016, Serdi and Springer-Verlag International SAS, part of Springer Nature.Item Distinctive sleep complaints and polysomnographic findings in antibody subgroups of autoimmune limbic encephalitis(Springer-Verlag Italia s.r.l., 2024) Küçükali C.İ.; Yılmaz V.; Karadeniz D.; Akyıldız U.O.; İlhan Algın D.; Sarıtaş A.Ş.; Kısabay Ak A.; Bican Demir A.; Yılmaz H.; Domaç F.M.; Elmalı A.D.; Hoş Ü.D.; Gözübatık-Çelik R.G.; Kabeloğlu V.; Bilgin B.; Tuncel Berktaş D.; Türk B.G.; Delil Ş.; Dilber C.; Terzioğlu Öztürk S.; Yeni S.N.; Özkara Ç.; Aksu M.; Tüzün E.; Benbir Şenel G.Introduction: Sleep disturbances are being increasingly recognized in association with autoimmune encephalitis (AIE). We investigated the prevalence of sleep-related symptoms and polysomnographic features of patients with AIE and the long-term outcomes in these patients in a multi-center, prospective study from Turkey. Methods: We prospectively evaluated patients with definite AIE in a common database including demographics, AIE-related and sleep-related symptomatology. Maximum and latest modified Rankin scores (mRS) and Liverpool Outcome Score (LOS) were noted. Results: Of 142 patients, 87 patients (61.3%) fulfilled the criteria for definite AIE (mean age, 46.8+18.8 years; 51.7% women; mean disease duration, 21.0+38.4 months). 78.9% of patients had at least one or more new onset or worsened sleep-related symptomatology: insomnia (55.3%), excessive daytime sleepiness (EDS, 28.0%), sleep apnea (18.7%), REM sleep behavior disorder (RBD, 17.3%), restless legs syndrome (10.7%) and oneiric stupor (9.3%). Sleep efficiency, N3 and REM sleep were decreased and N1 sleep was increased in patients with Ab[+] AIE. LOS points were highest in those with insomnia and sleep apnea, and lowest in those with EDS, RBD and oneiric stupor. RBD and sleep apnea were more common in anti-LG1 Ab[+] group than anti-NMDAR Ab[+] group. Index of periodic leg movements was highest in anti-LG1 Ab[+] group. Patients with EDS and oneiric stupor had more common memory problems. Maximum and latest mRS scores were positively correlated with EDS and oneiric stupor. EDS, RBD and oneiric stupor were negatively correlated with LOS points. Conclusion: Our study emphasizes the presence and importance of early diagnosis of sleep disturbances in AIE in regard to their deteriorative influences on disease prognosis. © The Author(s) 2024.Item Rings whose RD-flat modules have restricted subflat domains(Springer-Verlag Italia s.r.l., 2024) Durğun Y.; Bozkurt M.A module KR is said to be RL-subflat if for every short exact sequence 0→U→D→L→0 of left R-modules, the sequence 0→K⊗U→K⊗D→K⊗L→0 is exact. The subflat domains of (RD-flat) modules somehow tells us how far (or how close) such a module is from being flat. Every right R-module is subflat relative to all flat left R-modules, and flat modules are the only ones sharing the distinction of being in every single subflat domain. A module is called f-test if it is subflat only to flat modules. Similarly, an RD-flat module is called tf-test if it is subflat only to torsion-free modules. In this paper, we consider two families of rings characterized by their RD-flat modules: those whose finitely presented RD-flat modules are either flat or tf-test (property (P)) and those whose finitely presented RD-flat modules are either torsion-free (flat) or f-test (property (Q)). Structural properties of both classes of rings are studied. © The Author(s), under exclusive licence to Springer-Verlag Italia S.r.l., part of Springer Nature 2023.Item Modeling and optimization of hard turning: predictive analysis of surface roughness and cutting forces in AISI 52100 steel using machine learning(Springer-Verlag Italia s.r.l., 2024) Kumar R.; Rafighi M.; Özdemir M.; Şahinoğlu A.; Kulshreshta A.; Singh J.; Singh S.; Prakash C.; Bhowmik A.This study addresses the critical need for high-strength, corrosion-resistant materials in renewable energy, biomedical and maritime applications, necessitating effective heat treatment processes. Focusing on AISI 52100 steel, the research employs finish hard turning with coated carbide inserts under dry cutting conditions. Five machine learning methods are applied to model surface roughness (Ra) and cutting forces (Fx, Fy, Fz) using a Taguchi L36 orthogonal array. Results indicate SVM, XGB, DT, and XGB are superior algorithms for Ra, Fx, Fy, and Fz prediction. Key findings highlight feed rate predominant influence (96.55%) on surface roughness, while depth of cut significantly affects cutting forces. Optimal cutting parameters, 0.1 mm depth of cut, 0.15 mm/rev feed rate, 160 m/min cutting speed, 0.4 mm nose radius, and 40.9 HRC hardness are identified via response surface methodology (RSM) and desirability function. The study underscores the importance of optimizing cutting parameters to enhance surface quality and machining efficiency in challenging material processing scenarios. © The Author(s), under exclusive licence to Springer-Verlag France SAS, part of Springer Nature 2024.