Browsing by Publisher "Studio K Krzysztof Molenda"
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Item The effect of parity on first trimester uterine artery doppler waveforms in low-risk singleton pregnancies(Studio K Krzysztof Molenda, 2014) Ulkumen B.A.; Pala H.G.; Uyar Y.; Baytur Y.B.; Koyuncu F.M.Objectives: The aim of the study was to evaluate the effect of parity on uteroplacental blood flow during the first trimester in low-risk singleton pregnancies. Materials and methods: Uterine artery Doppler examinations were performed in 190 singleton pregnancies between 11-14 gestational weeks. Twenty-five pregnancies were excluded from the study due to history of preeclampsia, diabetes mellitus or inherited thrombophilia. A total of 165 low-risk singleton pregnancies were included in the study. Mean uterine artery pulsatility index (PI) was recorded and compared between nulliparous and multiparous women. The relation between maternal age, gestational week, maternal weight, parity, biochemical markers and abnormal uterine artery Doppler flows was evaluated. T-test and logistic regression analyses were used for the statistical analysis. Results: A total of 165 singleton pregnancies without any risk factors for uteroplacental insufficiency were included in the study. Of them, 58 (36.7%) were nulliparous and 107 (63.3%) were parous. Correlation analysis revealed that the uterine artery pulsatility indices during the first trimester were not affected by maternal age and parity. Conclusions: Mean uterine artery pulsatility indices are not different in nulliparous and multiparous low risk pregnancies at 11-14 weeks of gestation. © Polskie Towarzystwo Ginekologiczne.Item The efficacy of complete blood count parameters in the diagnosis of tubal ectopic pregnancy(Studio K Krzysztof Molenda, 2014) Eskicioğlu F.; Özdemir A.T.; Turan G.A.; Gür E.B.; Kasap E.; Genç M.Objective: Ectopic pregnancy (EP) is the major cause of maternal morbidity and is responsible for maternal mortality in the first trimester. In order to reduce undesirable results, it is necessary to find rapid and accurate, non-surgical diagnostic tests for EP. The goal of the study was to investigate the differences in complete blood count parameters between tubal EPs and healthy pregnancies in be used in the diagnosis of ectopic pregnancy. Study design: White blood cell (WBC), neutrophil, monocyte, lymphocyte, platelet (PLT) counts, mean PLT volume (MPV) and PLT distribution width (PDW) levels in the complete blood count samples have been obtained from subjects with diagnosed tubal EP (n=78; study group) and women with healthy intrauterine gestations (n=79; control group). Statistical comparisons between groups were performed using the t test. Results: PDW levels were found to be significantly higher in the control group than EP (p<0.001). However, no differences between the study and control groups with regard to PLT and MPV levels were observed. WBC levels were found to be significantly higher in the EP group as compared to controls (p<0.001). When leukocyte differentials were compared, monocyte counts in the EP group were significantly higher than in controls (p=0.005). No statistically significant differences in neutrophil and lymphocyte values were observed in either group. Conclusion: PDW as an indicator of PLT activation is lower in tubal EP than intrauterine pregnancy so, possibly, endometrial invasion in the intrauterine pregnancy needs more PLT activation. Monocyte counts are higher in tubal EP, indicating that monocyte activation in the pathophysiology of EP could be effective in the formation of tubal motility and microenvironment regulation. © Polskie Towarzystwo Ginekologiczne.Item The role of selectins in the first trimester pregnancy loss(Studio K Krzysztof Molenda, 2014) Eskicioglu F.; Laçin S.; Özbilgin K.; Köse C.Objective: There are no well-defined findings about reasons for first trimester abortion in some pregnancy cases. Selectins are cell adhesion proteins which are important for blastocyst implantation in the decidua. The goal of the study was to investigate the role of selectins in first trimester pregnancy loss by immunohistochemistry. Study design: Decidual and placental tissue samples have been obtained from the women with unwanted pregnancy as the control group (n=40) and missed abortion (n=40) as the study group. Immunohistochemistry technique has been used to compare P, L and E-selectin expression of the fibroblast and the decidual cells in uterine decidual stroma; and fibroblasts and mesenchymal cells in placental villous stroma. Immunostaining for P,L,E-Selectin has been evaluated semiquantitatively by HSCORE analysis. Results: Decidual cells, for E and L-selectin showed stronger staining in the study group than controls, and the difference was statistically significant (p = 0.001, p = 0.001). P-selectin showed stronger staining in the control group, but the difference was not as significant as the E and L-selectins (p=0.04). In the placenta, cytotrophoblasts and syncytiotrophoblasts showed stronger staining for P,E,L-selectins for the control group (p<0.001, p=0.001 and p<0.001, respectively). Conclusion: Strong expression of each of the three investigated selectins in healthy pregnancy villi shows their contribution to implantation and strong placentation. There is a need for better understanding of the functions of adhesive molecules in these events to reveal unknown causes for pregnancy loss.Item Montelukast is effective in preventing of ovarian hyperstimulation syndrome; an experimental study(Studio K Krzysztof Molenda, 2015) Eskicioğlu F.; Turan G.A.; Sivrikoz O.N.; Cengiz H.; Akan Z.; Şahin N.; Yilmaz O.; Yeşil H.; Vatansever S.Objectives: To determine the efficacy of montelukast in comparison with cabergoline in the prevention of ovarian hyperstimulation syndrome (OHSS) in rats. Material and methods: An experimental OHSS model was formed in 35 female Wistar rats. Rats (22 days old) were randomized into 5 groups, each containing 7 animals. The control group received no therapy; the mild OHSS group was administered pregnant mare serum gonadotropin (PMSG) 10 IU for 4 days, hCG 10 IU on the 5th day; the severe OHSS group received PMSG 10 IU for 4 days, hCG 30 IU on the 5th day. The montelukast group: received montelukast 10 mg/kg/day and the cabergoline group was administered cabergoline 100μg/kg/day via oral gavage for 6 days (days 22-27), in addition to those of severe OHSS. All groups were sacrificed on 28th day. Body weight, ovarian diameter and weight, vascular permeability, vascular endothelial growth factor (VEGF), semiquantitative VEGF receptor-1, and VEGF receptor-2 (VEGFR-2) immunohistochemistry were evaluated. Results: Ovarian diameter and VEGF expression were significantly lower in the montelukast and cabergoline groups than in the severe OHSS group. While montelukast was more effective in limiting vascular permeability in the severe OHSS, cabergoline was superior to montelukast with respect to the limiting effect on increased body weight and VEGFR-2 expression. Conclusions: The VEGF/VEGFR-2 interaction plays an important role in OHSS pathogenesis. Montelukast limits VEGF expression, and cabergoline reduces both VEGF and VEGFR-2 expressions; they are both effective therapies for the prevention of severe OHSS.Item Montelukast is effective in preventing of ovarian hyperstimulation syndrome; an experimental study(Studio K Krzysztof Molenda, 2015) Eskicioğlu F.; Turan G.A.; Sivrikoz O.N.; Cengiz H.; Akan Z.; Sahin N.; Yilmaz O.; Yesil H.; Vatansever S.Objectives: To determine the efficacy of montelukast in comparison with cabergoline in the prevention of ovarian hyperstimulation syndrome (OHSS) in rats. Material and methods: An experimental OHSS model was formed in 35 female Wistar rats. Rats (22 days old) were randomized into 5 groups, each containing 7 animals. The control group received no therapy; the mild OHSS group was administered pregnant mare serum gonadotropin (PMSG) 10 IU for 4 days, hCG 10 IU on the 5th day; the severe OHSS group received PMSG 10 IU for 4 days, hCG 30 IU on the 5th day. The montelukast group: received montelukast 10 mg/kg/day and the cabergoline group was administered cabergoline 100μg/kg/day via oral gavage for 6 days (days 22-27), in addition to those of severe OHSS. All groups were sacrificed on 28th day. Body weight, ovarian diameter and weight, vascular permeability, vascular endothelial growth factor (VEGF), semiquantitative VEGF receptor-1, and VEGF receptor-2 (VEGFR-2) immunohistochemistry were evaluated. Results: Ovarian diameter and VEGF expression were significantly lower in the montelukast and cabergoline groups than in the severe OHSS group. While montelukast was more effective in limiting vascular permeability in the severe OHSS, cabergoline was superior to montelukast with respect to the limiting effect on increased body weight and VEGFR-2 expression. Conclusions: The VEGF/VEGFR-2 interaction plays an important role in OHSS pathogenesis. Montelukast limits VEGF expression, and cabergoline reduces both VEGF and VEGFR-2 expressions; they are both effective therapies for the prevention of severe OHSS. © Polskie Towarzystwo Ginekologiczne.Item Carotid intima-media thickness in postmenopausal women is associated with an endometrial thickness greater than 5 mm(Studio K Krzysztof Molenda, 2016) Eskicioğlu F.; Eskicioğlu M.S.; Özdemir A.T.; Özyurt B.Aim: The aim of this study was to investigate the relationship between ultrasonographic carotid intima-media thickness (C-IMT) and visceral fat thickness (VFT) and an endometrial thickness (ET) of more than 5 mm in postmenopausal women. Methods: C-IMT, VFT, and ET measurements were performed in 63 postmenopausal women using ultrasonography. The relationships between ultrasonographic data and demographic data, anthropometric measurements, such as waist circumference, metabolic syndrome parameters, and insulin resistance were examined. Moreover, the role of VFT and C-IMT in predicting an ET of more than 5 mm was investigated. Results: Only the C-IMT was higher in the ultrasonographic measurements of women with an ET >5 mm (p =0.03). Insulin resistance was also significantly higher in these women (p = 0.03). ET showed a positive correlation with VFT and body mass index (BMI) (r = 0.286, p = 0.02 and r = 0.249, p = 0.04), and C-IMT showed a positive correlation with age, pregnancy, parity, and time since menopause (p<0.05). Multivariate analysis showed that high-C-IMT levels were associated with an ET >5 mm (p = 0.04).Conclusions: There was a positive correlation between the ultrasonographic measures of VFT and ET, and high- C-IMT levels were independently associated with an ET>5 mm. Thus, C-IMT may be a predictor of pathologic ET in the postmenopausal period.