Browsing by Publisher "Swets en Zeitlinger B.V."

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    Chiasmal decussation in tilted disc syndrome PVER in tilted disc
    (Swets en Zeitlinger B.V., 1999) Öztürk F.; Kurt E.; Yoldaş T.; Ilker S.S.; Inan Ü.Ü.
    The tilted disc syndrome is a benign congenital abnormality of the optic nerve head. Since it can be confused with papilledema and chiasmal lesions, differential diagnosis is important. The tilting anomaly may be associated with other abnormalities along the optic nerve. Visual field defects may be similar to those in chiasmal lesions. In order to determine whether the normal crossover of nerve fibers at the chiasm is altered, the crossed and the uncrossed fibers were investigated using the pattern visual evoked responses (PVER) test. Thirty-four eyes of 17 patients diagnosed with tilted disc syndrome were evaluated for refraction, keratometry, color vision with Ishihara, visual field, and PVER. The presence of abnormal nerve fiber decussation was determined by recording PVER from the electrodes mounted on the scalp of both hemispheres. The amplitude and latency differences between the 'crossed' and 'uncrossed' fibers were not statistically significant (p>0.05). As a result, the tilting abnormality of papilla was found to be without chiasmal abnormal decussation.
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    The effect of long-term use and inflammation on the ocular penetration of topical ofloxacin
    (Swets en Zeitlinger B.V., 1999) Öztürk F.; Kortunay S.; Kurt E.; Inan Ü.Ü.; Ilker S.S.; Basci N.; Bozkurt A.
    Purpose. To study the penetration of ofloxacin into the aqueous and vitreous humors after long-term topical administration and to investigate the effects of inflammation on drug penetration in rabbits. Methods. A standardized model of intraocular infection after penetrating injury was achieved in the right eyes of 16 rabbits. The animals were randomly and equally divided into two groups. The intact left eyes of the groups were maintained as the control. Ofloxacin eyedrops (0.3) were instilled into all eyes at a frequency of 2 drops every hour for 7 hours in the first group and for 14 hours in the second group. Half an hour after the last drop, samples of the aqueous and vitreous humors were taken and ofloxacin concentrations were measured by using HPLC. Results. The mean aqueous humor concentrations of ofloxacin in control eyes after 7 and 14 hours of instillation were: 1.45 ± 0.93 μg/ml and 2.48 ± 0.33 μg/ml, respectively; those in infected eyes 2.35 ± 1.84 μg/ml and 3.49 ± 1.47 μg/ml, respectively. However the differences among the groups were not significant (p > 0.05). The vitreous ofloxacin concentrations in the control eyes were similar after 7 and 14 hours of instillation (0.23 ± 0.14 μg/ml, 0.27 ± 0.10 μg/ml, respectively). In infected eyes, the mean vitreous ofloxacin concentration after 14 hour of instillation was significantly higher than that in control eyes (p < 0.05; 0.4 ± 0.09 μg/ml, 0.29 ± 0.11 μg/ml, respectively). The mean vitreous ofloxacin concentration in infected eyes after 14 hours instillation was not significantly higher than that after 7 hours instillation. Conclusions. Topical ofloxacin instillation for 7 or 14 hours yields aqueous concentrations above the MIC90 for common ocular pathogens. Prolonged application and the presence of inflammation increased the penetration of ofloxacin into the vitreous humor.
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    Ocular findings in a measles epidemic among young adults
    (Swets en Zeitlinger B.V., 2000) Kayikçioǧlu Ö.; Kir E.; Söyler M.; Güler C.; Irkeç M.
    Purpose: To present ocular findings in a measles epidemic outbreak among young adults. Methods: Ophthalmic lesions in an unselected group of 61 young military personnel with measles were followed. Eighteen of the patients had symmetric keratitis in both eyes. They were treated with diclofenac sodium eyedrops qid in the right eye, while the left eye was observed untreated. The disappearance of the corneal lesions in both eyes was compared. Results: Forty patients (65.6%) had measles conjunctivitis with bulbar and tarsal conjunctival hyperemia. Five (8.2%) had increased mucous secretion. Thirty-five (57.4%) had superficial punctate conceal epithelial and subepithelial lesions which stained with fluorescein. Ten patients had corneal lesions without evident conjunctival pathology. Fourteen patients had subconjunctival hemorrhages, it of whom had bilateral lesions mostly in the superonasal quadrant. The time to disappearance of corneal lesions was 4.5 ± 3.2 days in the diclophenac-treated right eyes, and 4.1 ± 3.8 days in the left eyes. We did not observe a significant difference in the healing time between the two eyes (P = 0.75) Conclusion: Measles did not cause major ocular complications in healthy patients. Keratitis was unresponsive to diclophenac sodium eyedrops with respect to healing time and end result.